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The map label for this gene is atoC [H]

Identifier: 119773267

GI number: 119773267

Start: 138447

End: 139829

Strand: Direct

Name: atoC [H]

Synonym: Sama_0125

Alternate gene names: 119773267

Gene position: 138447-139829 (Clockwise)

Preceding gene: 119773257

Following gene: 119773268

Centisome position: 3.22

GC content: 55.68

Gene sequence:

>1383_bases
ATGAACCAGAACGAAGCCATTGCAAAACCTCTGCCTACTGCCGTGTCTGTGCTGATTGTTGATGATGAGCCGGGCATGCG
TTCCTTTTTAAATAAGGCGCTGTCGAAAAAGTTCGCCCTGGTGGAAACCGCCGGCAGCGTGGAAGAAGCAGAACAGCTCA
GAAGTCGCTGCCACTTCGATTTGATCATTGTCGATATTCGTTTGCCGGGGCGTTCCGGTATTGAATGGCATGAAGCCCTG
TCGGACGAGGACAGACGCTCAGACATTATTTTCATGACCGGCTATGCCGATATGGAAGTGGCCATTCAGGCGCTGCGGGC
CGGAGCTTCCGACTTCATCATGAAGCCGTTCCACCTGGAACAAATGCTAAAAGCGGTGGACAGGGCCATAGAGCGCAGGC
TGCTCAAGCGGGAAAACCTGATGCTGCGCCGCGAAGTGTCTATCGGTTATTCCTCCAGCATCATTGGCAACAGTGCTGCC
ATGCAGGAAGTGAAAAACATCATTGCCCGGGTGGCGCCCACCAACGCCGTGGTGCTGATTGAAGGCGAGTCAGGCACGGG
CAAAGAGCTGGTGGCCAGACAACTGCATCAACTCTCTGGCCGTCAGGGACCCTTCGTGCCGGTTAACTGTGGTGCCATCG
CCCCTGAACTGCTGGAGAGTGAACTCTTTGGCCATGCAGCTGGCTCCTTTACCGGCGCCAAGGGTGCCCGTGAAGGGCTG
TTCAGCTTTGCGTCGGGCGGCACCATCTTCCTCGATGAAATCGGTGAAATGCCGCTGAAGATGCAAACTGCGCTGCTTAG
GGTGCTGGAGCAAAAAGCCATCCGTCCTGTCGGCAGTGAAAAAGAGGTCAGTATCGATGTGCGTGTGGTGGCTGCCACCA
ACCGCAAGCTGGCTGATGAAGTGGAAGCTGGACATTTCCGCCGCGATCTCTTCTATCGATTGAACGTGCTCGAAATTCAA
ATACCGCCCCTGAGAGACCGACCCGAAGATGTCGTCGAGTTGACCCATCACTTCACCCGGGTGCTCGGGGCTGAGCTGGG
TGTGCGTGAGCTGGTGTGGAGCCACGAAGACTTAAGCCGCCTTCAGCAACACGACTGGCCGGGGAATATCCGCGAACTGC
GCAACATGATTGAGCGCAGCATCCTCTTGGGTAAGCCCCCGGCGGAATACTGGAAAACTACCATCAAGGAAGTTGAACCG
GGTCAGTTTGGGTTCCCGCTGGAGTGGCCACTCAAGGACGTGGAAAAACATCATGTACTGGCGGTGGTTGAGGCCCATGG
TGGCAATAAGTCGGCAGCAGCCCGTGATTTGGGCGTATCCCGCAAGACCCTGGATCGAAAATTCAAAGAGTGGTTTGGCA
CTGACAGTGACGAGGAAGAATAA

Upstream 100 bases:

>100_bases
TGTCCCAACTCACACTTTAGCTGGTCCATAGTGACCTATCGACCATTTTCCGGTGATAGAATGACCGCATTGTGCGTCAA
AATGTCCAGAAGAAGACAAG

Downstream 100 bases:

>100_bases
CCATGTCCTTCTTCACCCAATTGTTTGGTGTTAACTGGCGCCAGATGCAGGCCAAGGTGCGCTACCGCATTCTTATTCTT
ACCTTGCTGCCAATTTTACT

Product: response regulator receiver protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNQNEAIAKPLPTAVSVLIVDDEPGMRSFLNKALSKKFALVETAGSVEEAEQLRSRCHFDLIIVDIRLPGRSGIEWHEAL
SDEDRRSDIIFMTGYADMEVAIQALRAGASDFIMKPFHLEQMLKAVDRAIERRLLKRENLMLRREVSIGYSSSIIGNSAA
MQEVKNIIARVAPTNAVVLIEGESGTGKELVARQLHQLSGRQGPFVPVNCGAIAPELLESELFGHAAGSFTGAKGAREGL
FSFASGGTIFLDEIGEMPLKMQTALLRVLEQKAIRPVGSEKEVSIDVRVVAATNRKLADEVEAGHFRRDLFYRLNVLEIQ
IPPLRDRPEDVVELTHHFTRVLGAELGVRELVWSHEDLSRLQQHDWPGNIRELRNMIERSILLGKPPAEYWKTTIKEVEP
GQFGFPLEWPLKDVEKHHVLAVVEAHGGNKSAAARDLGVSRKTLDRKFKEWFGTDSDEEE

Sequences:

>Translated_460_residues
MNQNEAIAKPLPTAVSVLIVDDEPGMRSFLNKALSKKFALVETAGSVEEAEQLRSRCHFDLIIVDIRLPGRSGIEWHEAL
SDEDRRSDIIFMTGYADMEVAIQALRAGASDFIMKPFHLEQMLKAVDRAIERRLLKRENLMLRREVSIGYSSSIIGNSAA
MQEVKNIIARVAPTNAVVLIEGESGTGKELVARQLHQLSGRQGPFVPVNCGAIAPELLESELFGHAAGSFTGAKGAREGL
FSFASGGTIFLDEIGEMPLKMQTALLRVLEQKAIRPVGSEKEVSIDVRVVAATNRKLADEVEAGHFRRDLFYRLNVLEIQ
IPPLRDRPEDVVELTHHFTRVLGAELGVRELVWSHEDLSRLQQHDWPGNIRELRNMIERSILLGKPPAEYWKTTIKEVEP
GQFGFPLEWPLKDVEKHHVLAVVEAHGGNKSAAARDLGVSRKTLDRKFKEWFGTDSDEEE
>Mature_460_residues
MNQNEAIAKPLPTAVSVLIVDDEPGMRSFLNKALSKKFALVETAGSVEEAEQLRSRCHFDLIIVDIRLPGRSGIEWHEAL
SDEDRRSDIIFMTGYADMEVAIQALRAGASDFIMKPFHLEQMLKAVDRAIERRLLKRENLMLRREVSIGYSSSIIGNSAA
MQEVKNIIARVAPTNAVVLIEGESGTGKELVARQLHQLSGRQGPFVPVNCGAIAPELLESELFGHAAGSFTGAKGAREGL
FSFASGGTIFLDEIGEMPLKMQTALLRVLEQKAIRPVGSEKEVSIDVRVVAATNRKLADEVEAGHFRRDLFYRLNVLEIQ
IPPLRDRPEDVVELTHHFTRVLGAELGVRELVWSHEDLSRLQQHDWPGNIRELRNMIERSILLGKPPAEYWKTTIKEVEP
GQFGFPLEWPLKDVEKHHVLAVVEAHGGNKSAAARDLGVSRKTLDRKFKEWFGTDSDEEE

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=458, Percent_Identity=40.3930131004367, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=39.9092970521542, Blast_Score=298, Evalue=7e-82,
Organism=Escherichia coli, GI1790299, Length=465, Percent_Identity=38.2795698924731, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1788905, Length=427, Percent_Identity=34.8946135831382, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1786524, Length=321, Percent_Identity=44.8598130841121, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082117, Length=254, Percent_Identity=48.0314960629921, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=40.1253918495298, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1789087, Length=276, Percent_Identity=45.2898550724638, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87082152, Length=256, Percent_Identity=44.140625, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI87081872, Length=234, Percent_Identity=42.7350427350427, Blast_Score=191, Evalue=8e-50,
Organism=Escherichia coli, GI1787583, Length=231, Percent_Identity=42.4242424242424, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1789828, Length=225, Percent_Identity=37.3333333333333, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI87081858, Length=283, Percent_Identity=32.5088339222615, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789809, Length=117, Percent_Identity=30.7692307692308, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51402; Mature: 51402

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNEAIAKPLPTAVSVLIVDDEPGMRSFLNKALSKKFALVETAGSVEEAEQLRSRCHFD
CCCCCCHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEE
LIIVDIRLPGRSGIEWHEALSDEDRRSDIIFMTGYADMEVAIQALRAGASDFIMKPFHLE
EEEEEEEECCCCCCCHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCHHHHCCCHHHH
QMLKAVDRAIERRLLKRENLMLRREVSIGYSSSIIGNSAAMQEVKNIIARVAPTNAVVLI
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEEE
EGESGTGKELVARQLHQLSGRQGPFVPVNCGAIAPELLESELFGHAAGSFTGAKGAREGL
ECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHH
FSFASGGTIFLDEIGEMPLKMQTALLRVLEQKAIRPVGSEKEVSIDVRVVAATNRKLADE
HHHCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCHHHHH
VEAGHFRRDLFYRLNVLEIQIPPLRDRPEDVVELTHHFTRVLGAELGVRELVWSHEDLSR
HHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHH
LQQHDWPGNIRELRNMIERSILLGKPPAEYWKTTIKEVEPGQFGFPLEWPLKDVEKHHVL
HHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCEEE
AVVEAHGGNKSAAARDLGVSRKTLDRKFKEWFGTDSDEEE
EEEEECCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNQNEAIAKPLPTAVSVLIVDDEPGMRSFLNKALSKKFALVETAGSVEEAEQLRSRCHFD
CCCCCCHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEE
LIIVDIRLPGRSGIEWHEALSDEDRRSDIIFMTGYADMEVAIQALRAGASDFIMKPFHLE
EEEEEEEECCCCCCCHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCCCHHHHCCCHHHH
QMLKAVDRAIERRLLKRENLMLRREVSIGYSSSIIGNSAAMQEVKNIIARVAPTNAVVLI
HHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEEE
EGESGTGKELVARQLHQLSGRQGPFVPVNCGAIAPELLESELFGHAAGSFTGAKGAREGL
ECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCHHHHHH
FSFASGGTIFLDEIGEMPLKMQTALLRVLEQKAIRPVGSEKEVSIDVRVVAATNRKLADE
HHHCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEECCCHHHHH
VEAGHFRRDLFYRLNVLEIQIPPLRDRPEDVVELTHHFTRVLGAELGVRELVWSHEDLSR
HHHHHHHHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHH
LQQHDWPGNIRELRNMIERSILLGKPPAEYWKTTIKEVEPGQFGFPLEWPLKDVEKHHVL
HHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCEEE
AVVEAHGGNKSAAARDLGVSRKTLDRKFKEWFGTDSDEEE
EEEEECCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]