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The map label for this gene is kbl [C]

Identifier: 119773240

GI number: 119773240

Start: 110838

End: 112031

Strand: Reverse

Name: kbl [C]

Synonym: Sama_0098

Alternate gene names: 119773240

Gene position: 112031-110838 (Counterclockwise)

Preceding gene: 119773241

Following gene: 119773239

Centisome position: 2.6

GC content: 56.03

Gene sequence:

>1194_bases
GTGGCATCAACCTCATTCTACGAGCAGATCAAACAACAACTCGCCGACGTTAAGGCCGAAGGCCTCTACAAAAGCGAACG
CGTGATCGTCTCACCGCAACAGGCTGCAATTAAGGTGGGCGGCGATGAAGTCATTAACTTCTGCGCCAACAACTATTTGG
GCCTGGCCAACCATCCTGAGCTGGTCAAAGCCGCTCAAGCAGGTTTGGCCGACCACGGCTTTGGTATGGCCTCAGTGCGC
TTTATCTGCGGCACCCAGGACATCCACAAACAGCTGGAAGCGAAACTGTCTGAATTCCTCGGCACCGAAGATACCATCCT
GTATTCCTCTTGCTTCGATGCCAATGCCGGCCTGTTCGAAACCCTGCTCGGCCCCGAAGATGCCATCGTCTCCGATGCAC
TGAACCACGCTTCTATCATCGACGGTGTGCGCCTGTGTAAAGCCATGCGATTCCGTTATGCCAACAATGATATGGCCGAT
CTGGAAACCCAGCTTAAAGCAGCCCGCGAGGCCGGTGCCCGTCATATCCTGATTGCCACCGATGGTGTGTTCTCCATGGA
TGGCGTAATTGCCAACCTAAAAGGTGTGTGTGACCTTGCCGACCAATACGGCGCCCTGGTGATGGTAGACGACTCCCACG
CGGTGGGCTTTATCGGCCAAAATGGTCGTGGTACTCACGAGTACTGTGACGTGATGGACCGGGTAGACATCATCACAGGT
ACACTGGGCAAGGCTCTGGGCGGCGCCTCGGGTGGTTACACCTCGGGTAAAAAAGAAGTGATCGACTGGCTGCGTCAACG
CTCACGCCCTTATCTGTTCTCCAACTCACTGGCCCCGTCCATTGTGGCCGCCTCTATCCGCGTGCTCGACATGCTCAAAG
ATGGCCAGGCACTGCGTGAAGCCGTATGGGAAAACAGCCGTTATTTCCGTGAAAAAATGTCTGCTGCCGGTTTCACCCTG
GCCGGTGCCGACCATGCCATCGTTCCGGTTATGCTGGGCGATGCCAAGCTGGCTGCCGATTTCTCGGCCCGCCTGCTGAA
AGAAGATATTTACGTGATTGGTTTCTCCTTCCCTGTGGTGCCAAAGGGCCAGGCCCGTATCCGCACCCAGATGTCTGCCG
CCCACACCCGTGCGCAGCTGGACAAGGCCATTGAAGCCTTCACCCGTATTGGTAAGGAAATGGGCATCATCTGA

Upstream 100 bases:

>100_bases
GCGATTGGTGCATCAAAAATAAGCTGCGGGCCGATTAGGTTTAGGGGTAGAATGCCGTCACTCCAGCAAAAGCAGAATAA
AGTTAACTAAGGAGAGACCA

Downstream 100 bases:

>100_bases
TGTCCATTTTGGAGTAAGCACATGAAAGCACTTGCTAAACTCAAGCCTGAAGAAGGCATTTGGATGGTTGATGCCCCCAA
GCCGGAAATGGGCCATAACG

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MASTSFYEQIKQQLADVKAEGLYKSERVIVSPQQAAIKVGGDEVINFCANNYLGLANHPELVKAAQAGLADHGFGMASVR
FICGTQDIHKQLEAKLSEFLGTEDTILYSSCFDANAGLFETLLGPEDAIVSDALNHASIIDGVRLCKAMRFRYANNDMAD
LETQLKAAREAGARHILIATDGVFSMDGVIANLKGVCDLADQYGALVMVDDSHAVGFIGQNGRGTHEYCDVMDRVDIITG
TLGKALGGASGGYTSGKKEVIDWLRQRSRPYLFSNSLAPSIVAASIRVLDMLKDGQALREAVWENSRYFREKMSAAGFTL
AGADHAIVPVMLGDAKLAADFSARLLKEDIYVIGFSFPVVPKGQARIRTQMSAAHTRAQLDKAIEAFTRIGKEMGII

Sequences:

>Translated_397_residues
MASTSFYEQIKQQLADVKAEGLYKSERVIVSPQQAAIKVGGDEVINFCANNYLGLANHPELVKAAQAGLADHGFGMASVR
FICGTQDIHKQLEAKLSEFLGTEDTILYSSCFDANAGLFETLLGPEDAIVSDALNHASIIDGVRLCKAMRFRYANNDMAD
LETQLKAAREAGARHILIATDGVFSMDGVIANLKGVCDLADQYGALVMVDDSHAVGFIGQNGRGTHEYCDVMDRVDIITG
TLGKALGGASGGYTSGKKEVIDWLRQRSRPYLFSNSLAPSIVAASIRVLDMLKDGQALREAVWENSRYFREKMSAAGFTL
AGADHAIVPVMLGDAKLAADFSARLLKEDIYVIGFSFPVVPKGQARIRTQMSAAHTRAQLDKAIEAFTRIGKEMGII
>Mature_396_residues
ASTSFYEQIKQQLADVKAEGLYKSERVIVSPQQAAIKVGGDEVINFCANNYLGLANHPELVKAAQAGLADHGFGMASVRF
ICGTQDIHKQLEAKLSEFLGTEDTILYSSCFDANAGLFETLLGPEDAIVSDALNHASIIDGVRLCKAMRFRYANNDMADL
ETQLKAAREAGARHILIATDGVFSMDGVIANLKGVCDLADQYGALVMVDDSHAVGFIGQNGRGTHEYCDVMDRVDIITGT
LGKALGGASGGYTSGKKEVIDWLRQRSRPYLFSNSLAPSIVAASIRVLDMLKDGQALREAVWENSRYFREKMSAAGFTLA
GADHAIVPVMLGDAKLAADFSARLLKEDIYVIGFSFPVVPKGQARIRTQMSAAHTRAQLDKAIEAFTRIGKEMGII

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=390, Percent_Identity=55.3846153846154, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI284448556, Length=416, Percent_Identity=51.9230769230769, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI83977442, Length=362, Percent_Identity=35.6353591160221, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI83977440, Length=362, Percent_Identity=35.6353591160221, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI83977444, Length=362, Percent_Identity=35.6353591160221, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=38.0821917808219, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI4502025, Length=363, Percent_Identity=32.5068870523416, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI40316939, Length=363, Percent_Identity=32.5068870523416, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI119220554, Length=365, Percent_Identity=35.0684931506849, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI5454084, Length=261, Percent_Identity=31.4176245210728, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1790046, Length=393, Percent_Identity=76.3358778625954, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=32.5648414985591, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=401, Percent_Identity=56.857855361596, Blast_Score=463, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI32566772, Length=370, Percent_Identity=33.5135135135135, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17560912, Length=365, Percent_Identity=34.2465753424658, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17560914, Length=365, Percent_Identity=34.2465753424658, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71982617, Length=303, Percent_Identity=24.0924092409241, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71982625, Length=303, Percent_Identity=24.0924092409241, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320438, Length=379, Percent_Identity=33.7730870712401, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=29.8913043478261, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6323954, Length=261, Percent_Identity=28.735632183908, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24662918, Length=398, Percent_Identity=58.7939698492462, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17137420, Length=349, Percent_Identity=32.0916905444126, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI17136286, Length=381, Percent_Identity=33.0708661417323, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24653280, Length=331, Percent_Identity=27.7945619335347, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24653276, Length=331, Percent_Identity=27.7945619335347, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24653278, Length=331, Percent_Identity=27.7945619335347, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42910; Mature: 42778

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTSFYEQIKQQLADVKAEGLYKSERVIVSPQQAAIKVGGDEVINFCANNYLGLANHPE
CCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHEEEECHHHHHHHHHHCCCCCCCCHH
LVKAAQAGLADHGFGMASVRFICGTQDIHKQLEAKLSEFLGTEDTILYSSCFDANAGLFE
HHHHHHCCCCCCCCCHHHHEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHH
TLLGPEDAIVSDALNHASIIDGVRLCKAMRFRYANNDMADLETQLKAAREAGARHILIAT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEE
DGVFSMDGVIANLKGVCDLADQYGALVMVDDSHAVGFIGQNGRGTHEYCDVMDRVDIITG
CCCEEHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHH
TLGKALGGASGGYTSGKKEVIDWLRQRSRPYLFSNSLAPSIVAASIRVLDMLKDGQALRE
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCHHHHH
AVWENSRYFREKMSAAGFTLAGADHAIVPVMLGDAKLAADFSARLLKEDIYVIGFSFPVV
HHHCCHHHHHHHHHHCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCC
PKGQARIRTQMSAAHTRAQLDKAIEAFTRIGKEMGII
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASTSFYEQIKQQLADVKAEGLYKSERVIVSPQQAAIKVGGDEVINFCANNYLGLANHPE
CCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHEEEECHHHHHHHHHHCCCCCCCCHH
LVKAAQAGLADHGFGMASVRFICGTQDIHKQLEAKLSEFLGTEDTILYSSCFDANAGLFE
HHHHHHCCCCCCCCCHHHHEEEECCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHH
TLLGPEDAIVSDALNHASIIDGVRLCKAMRFRYANNDMADLETQLKAAREAGARHILIAT
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEE
DGVFSMDGVIANLKGVCDLADQYGALVMVDDSHAVGFIGQNGRGTHEYCDVMDRVDIITG
CCCEEHHHHHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHH
TLGKALGGASGGYTSGKKEVIDWLRQRSRPYLFSNSLAPSIVAASIRVLDMLKDGQALRE
HHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCHHHHH
AVWENSRYFREKMSAAGFTLAGADHAIVPVMLGDAKLAADFSARLLKEDIYVIGFSFPVV
HHHCCHHHHHHHHHHCCEEEECCCCCEEEEEECCCHHHHHHHHHHHHCCEEEEEEECCCC
PKGQARIRTQMSAAHTRAQLDKAIEAFTRIGKEMGII
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]