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The map label for this gene is tdh

Identifier: 119773239

GI number: 119773239

Start: 109791

End: 110816

Strand: Reverse

Name: tdh

Synonym: Sama_0097

Alternate gene names: 119773239

Gene position: 110816-109791 (Counterclockwise)

Preceding gene: 119773240

Following gene: 119773238

Centisome position: 2.57

GC content: 55.75

Gene sequence:

>1026_bases
ATGAAAGCACTTGCTAAACTCAAGCCTGAAGAAGGCATTTGGATGGTTGATGCCCCCAAGCCGGAAATGGGCCATAACGA
TCTGCTGATTAAGATCCGTAAAACCGCCATTTGTGGCACCGACGTGCATATCTACAACTGGGACGAGTGGTCGCAAAAAA
CCATTCCCGTGCCTATGGTAGTAGGTCACGAATATGTCGGCGAAGTGGTGGGAATTGGCCAGGAAGTCCGCGGCTTCAAG
ATTGGCGACCGCGTATCCGGTGAAGGCCATATCACCTGTGGCCATTGCCGTAACTGCCGCGCCGGCCGCACTCATCTGTG
CCGCAATACCACGGGCGTGGGTGTAAACCGTGAAGGCTCATTCGCCGAGTATCTGGTGATCCCAGCCTTTAACGCGTTCA
AAATCCCCGATGATATCAGTGACGATCTGGCTGCCATTTTTGACCCATTCGGTAATGCCGTTCACACGGCGCTGTCATTC
GACCTGGTAGGGGAAGACGTGCTTATCACAGGCGCCGGCCCCATCGGTATCATGGCTGCTGCCGTGTGCCGTCACGTGGG
CGCCCGCCATGTGGTGATCACCGACGTGAACGAATATCGTCTGGAACTGGCTCGAAAGATGGGTGCTACCCGTGCGGTGA
ACGTGGCCAAGGAAAACCTCAAAGACGTGATGAAAGACCTCGGCATGACCGAAGGCTTCGACGTTGGCCTGGAAATGTCC
GGCGTACCTGCCGCCTTCCATGCCATGCTGGATACCATGAACCACGGCGGCAAAATCGCCATGCTGGGTATTCCCGGCGG
CGAAATGGCCATCGACTGGAGCAAGGTGATCTTCAAGGGACTCATCATCAAGGGCATCTACGGCCGTGAAATGTTTGAGA
CCTGGTACAAGATGGCCAGCCTGCTGCAATCGGGCCTGGACTTGTCCCCCATTGTTACCCACCACTTCAAGGTGGACGAC
TTCCAGCAAGGCTTCGACGCCATGCGTTCCGGTCAGTCCGGTAAAGTCATCCTCAGCTGGGATTAA

Upstream 100 bases:

>100_bases
TGCCGCCCACACCCGTGCGCAGCTGGACAAGGCCATTGAAGCCTTCACCCGTATTGGTAAGGAAATGGGCATCATCTGAT
GTCCATTTTGGAGTAAGCAC

Downstream 100 bases:

>100_bases
TCTCCCGGTGAGCACGTGCAAGCCACCACAGGTTTGCACGGCTTGGCTATACCAACAGGGCGCTGTACAGACTACAGTGC
CCTGTTGCACACTATCCCTG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKALAKLKPEEGIWMVDAPKPEMGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRGFK
IGDRVSGEGHITCGHCRNCRAGRTHLCRNTTGVGVNREGSFAEYLVIPAFNAFKIPDDISDDLAAIFDPFGNAVHTALSF
DLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELARKMGATRAVNVAKENLKDVMKDLGMTEGFDVGLEMS
GVPAAFHAMLDTMNHGGKIAMLGIPGGEMAIDWSKVIFKGLIIKGIYGREMFETWYKMASLLQSGLDLSPIVTHHFKVDD
FQQGFDAMRSGQSGKVILSWD

Sequences:

>Translated_341_residues
MKALAKLKPEEGIWMVDAPKPEMGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRGFK
IGDRVSGEGHITCGHCRNCRAGRTHLCRNTTGVGVNREGSFAEYLVIPAFNAFKIPDDISDDLAAIFDPFGNAVHTALSF
DLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELARKMGATRAVNVAKENLKDVMKDLGMTEGFDVGLEMS
GVPAAFHAMLDTMNHGGKIAMLGIPGGEMAIDWSKVIFKGLIIKGIYGREMFETWYKMASLLQSGLDLSPIVTHHFKVDD
FQQGFDAMRSGQSGKVILSWD
>Mature_341_residues
MKALAKLKPEEGIWMVDAPKPEMGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMVVGHEYVGEVVGIGQEVRGFK
IGDRVSGEGHITCGHCRNCRAGRTHLCRNTTGVGVNREGSFAEYLVIPAFNAFKIPDDISDDLAAIFDPFGNAVHTALSF
DLVGEDVLITGAGPIGIMAAAVCRHVGARHVVITDVNEYRLELARKMGATRAVNVAKENLKDVMKDLGMTEGFDVGLEMS
GVPAAFHAMLDTMNHGGKIAMLGIPGGEMAIDWSKVIFKGLIIKGIYGREMFETWYKMASLLQSGLDLSPIVTHHFKVDD
FQQGFDAMRSGQSGKVILSWD

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI156627571, Length=335, Percent_Identity=27.7611940298507, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=24.1286863270777, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI71743840, Length=351, Percent_Identity=25.6410256410256, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI262073058, Length=351, Percent_Identity=25.6410256410256, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI34577061, Length=352, Percent_Identity=23.8636363636364, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4501933, Length=375, Percent_Identity=23.7333333333333, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI156523966, Length=350, Percent_Identity=24.8571428571429, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4501939, Length=343, Percent_Identity=24.198250728863, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI71565152, Length=358, Percent_Identity=24.0223463687151, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI71565154, Length=353, Percent_Identity=25.7790368271955, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=88.5630498533724, Blast_Score=635, Evalue=0.0,
Organism=Escherichia coli, GI1788073, Length=329, Percent_Identity=30.3951367781155, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1788075, Length=362, Percent_Identity=29.5580110497238, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1787863, Length=336, Percent_Identity=29.1666666666667, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI226510992, Length=275, Percent_Identity=32.7272727272727, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87082125, Length=330, Percent_Identity=30, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788407, Length=343, Percent_Identity=26.2390670553936, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790718, Length=325, Percent_Identity=26.1538461538462, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1786825, Length=398, Percent_Identity=27.1356783919598, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI87081918, Length=269, Percent_Identity=29.7397769516729, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=27.9569892473118, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786518, Length=282, Percent_Identity=25.886524822695, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=335, Percent_Identity=30.4477611940298, Blast_Score=165, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17562878, Length=335, Percent_Identity=30.7462686567164, Blast_Score=150, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI71988145, Length=229, Percent_Identity=32.3144104803493, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562584, Length=134, Percent_Identity=35.0746268656716, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=271, Percent_Identity=26.9372693726937, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25146526, Length=375, Percent_Identity=24.5333333333333, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=23.9130434782609, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=351, Percent_Identity=23.9316239316239, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=308, Percent_Identity=31.1688311688312, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322619, Length=306, Percent_Identity=28.7581699346405, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319955, Length=306, Percent_Identity=28.4313725490196, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319258, Length=376, Percent_Identity=26.3297872340426, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319257, Length=272, Percent_Identity=29.0441176470588, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6324486, Length=323, Percent_Identity=29.4117647058824, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=364, Percent_Identity=26.6483516483516, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323961, Length=325, Percent_Identity=29.8461538461538, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323729, Length=327, Percent_Identity=28.7461773700306, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=323, Percent_Identity=27.2445820433437, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=267, Percent_Identity=28.4644194756554, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323980, Length=258, Percent_Identity=30.6201550387597, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=27.2455089820359, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI17137530, Length=333, Percent_Identity=26.4264264264264, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17737895, Length=358, Percent_Identity=26.2569832402235, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221457811, Length=182, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550770, Length=182, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551930, Length=182, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TDH_SHEAM (A1S1Q3)

Other databases:

- EMBL:   CP000507
- RefSeq:   YP_925979.1
- ProteinModelPortal:   A1S1Q3
- SMR:   A1S1Q3
- STRING:   A1S1Q3
- GeneID:   4602354
- GenomeReviews:   CP000507_GR
- KEGG:   saz:Sama_0097
- NMPDR:   fig|326297.7.peg.90
- eggNOG:   COG1063
- HOGENOM:   HBG753318
- OMA:   MVDAPKP
- PhylomeDB:   A1S1Q3
- ProtClustDB:   PRK05396
- GO:   GO:0005737
- HAMAP:   MF_00627
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695
- TIGRFAMs:   TIGR00692

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.103

Molecular weight: Translated: 37255; Mature: 37255

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALAKLKPEEGIWMVDAPKPEMGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCCCHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVRGFKIGDRVSGEGHITCGHCRNCRAGRTHLCRNTTGVGVNREGS
ECHHHHHHHHCCCCHHCCEECCCCCCCCCCEEECCCCCCCCCCCHHHCCCCCCCCCCCCC
FAEYLVIPAFNAFKIPDDISDDLAAIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAA
CEEEEEEECCCCEECCCCCHHHHHHHHHHCCHHHHHHHEEEECCCCEEEECCCHHHHHHH
AVCRHVGARHVVITDVNEYRLELARKMGATRAVNVAKENLKDVMKDLGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECC
GVPAAFHAMLDTMNHGGKIAMLGIPGGEMAIDWSKVIFKGLIIKGIYGREMFETWYKMAS
CCCHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LLQSGLDLSPIVTHHFKVDDFQQGFDAMRSGQSGKVILSWD
HHHCCCCCCCHHHEEECCCHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MKALAKLKPEEGIWMVDAPKPEMGHNDLLIKIRKTAICGTDVHIYNWDEWSQKTIPVPMV
CCCCHHCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEECCCEEEEECCCCCCCCCCCEEE
VGHEYVGEVVGIGQEVRGFKIGDRVSGEGHITCGHCRNCRAGRTHLCRNTTGVGVNREGS
ECHHHHHHHHCCCCHHCCEECCCCCCCCCCEEECCCCCCCCCCCHHHCCCCCCCCCCCCC
FAEYLVIPAFNAFKIPDDISDDLAAIFDPFGNAVHTALSFDLVGEDVLITGAGPIGIMAA
CEEEEEEECCCCEECCCCCHHHHHHHHHHCCHHHHHHHEEEECCCCEEEECCCHHHHHHH
AVCRHVGARHVVITDVNEYRLELARKMGATRAVNVAKENLKDVMKDLGMTEGFDVGLEMS
HHHHHCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEECC
GVPAAFHAMLDTMNHGGKIAMLGIPGGEMAIDWSKVIFKGLIIKGIYGREMFETWYKMAS
CCCHHHHHHHHHHCCCCEEEEEECCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
LLQSGLDLSPIVTHHFKVDDFQQGFDAMRSGQSGKVILSWD
HHHCCCCCCCHHHEEECCCHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA