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The map label for this gene is zwf [H]

Identifier: 119718745

GI number: 119718745

Start: 4786945

End: 4788393

Strand: Reverse

Name: zwf [H]

Synonym: Noca_4526

Alternate gene names: 119718745

Gene position: 4788393-4786945 (Counterclockwise)

Preceding gene: 119718746

Following gene: 119718744

Centisome position: 96.04

GC content: 69.77

Gene sequence:

>1449_bases
ATGGAGAACCCGCACGTCATCGTGCTCTTCGGAGCCACCGGCGACCTCTCCCGGCGCAAGCTGTTGCCGGGGCTGCTCCG
CCTGTGGCAGGCCGGCCTGATCCAGGACGCCCGCATCGTCGGCACGTCGCTGGAGGACGTCGACACCGAGACGTTCGTGA
AGATCGCCCGGACCGCCTGCGAGGAGTTCGGGCAGAGCCGGTTCGACGAGGCGGACTGGGCCCGGTTCAGCCGGATGCTG
CGCTACGTCCCCCAGTCCGCCGGCCCGGCCGCCCTCGCCGAGGCGGTCCGCGGCTGCCGGGCCGACCTGGGCGCACCGGG
CCGCGACGTCGACTGCCTGCACTACCTCAGCGTGCCGCCGAAGGCCGCGCTCGACGTGGTCCGCCAGCTCGACGAGGCGG
GCCTGGCCGCGCACTCGCGGATCGTCATGGAGAAGCCGTTCGGCACCGACCTGGCCTCGGCCGAGCGGCTCAACGCCCGG
CTGCACGAGGTCTTCGACGAGAGCCAGATCTTCCGCATCGACCACTTCCTCGGCAAGGAGGCGGCCCAGAACATCCTCGC
CTTCCGCTTCGCGAACGGCCTGTTCGAGCCGATCTGGAACCGCAACTTCATCGACCACGTGCAGATCGACGTACCCGAGA
CCCTCGGCCTCGAGGGCCGCACCAGGTTCTACGAGACCACCGGCGCCTACCGCGACATGGTCGTCACCCACCTGATGCAG
GTGCTCGCGTTCATGGCGATGGAGCCGCCGACGTCGCTCGCGCCGGACCCGATCAGCGACGAGAAGCTCAAGGTGTTCCG
TTCGATGCGCCCGATCGAGCCGCGGAACGTGGTGCGCGGCCAGTACGCCGGCTACCGCGACCACCCCGAGGTCGCCGACG
ACTCCGACACCGAGACGTTCGTGGCCCTCAAGGTCGAGATCGACAACTGGCGCTGGGCCGGGGTGCCGTTCTTCCTGCGC
ACCGGGAAGAAGCTGGCCGAGGGGGCGCGGATCATCTCGATCGCGTTCAAGGAGCCGCCGCTGGCGATGTTCCCGGCCGG
GTCCAACGCCGGCACCCAGGGCCCCGACCACCTCACCTTCGACCTGGCCGACCAGTCGCGGATGTCGCTGTCCTTCTACG
GCAAGCGTCCCGGTCCAGGCATGAAGCTGGAGAAGCTCTCCATGCAGTTCGCCACCCACGAGACGATGTCGTCGGGCGGG
GTGCTGGAGGCCTACGAGCGGCTGATCCACGACGCGATCCGCGGCGACCACACGCTGTTCACGACCGCCGACGGCATCGA
GACCCTGTGGGAGAAGTCGATGCCGCTGCTGGAGAACCCGCCCCCGGTGCGCACCTACGCGCCCGGCAGCTGGGGGCCCA
ACGCGATCCACCAGCTGATCGCCCCGCACGCCTGGCGACTGCCGTTCGAGCGGTCCTGGCGCGAGTCCAAGGACCCGTAC
GACGCCTAG

Upstream 100 bases:

>100_bases
TCCGAGGTCGCCGAGGAGTACGCCGAGTCCCGCTGGAAGGCCGACCGGCTGCTGGCTGCGCTCGGCTGAGCCGTTCCACC
CGCCTGGCTACCCTCGACGG

Downstream 100 bases:

>100_bases
CTTCGCTGATATAGGTCGGGGTAGTCCTTCACGGACACCTCCGGAGGTGCTTGGAAGGGACCGACAGGTTCTCTTCATCT
GAGGGTCGGGCGTTGGCGCG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MENPHVIVLFGATGDLSRRKLLPGLLRLWQAGLIQDARIVGTSLEDVDTETFVKIARTACEEFGQSRFDEADWARFSRML
RYVPQSAGPAALAEAVRGCRADLGAPGRDVDCLHYLSVPPKAALDVVRQLDEAGLAAHSRIVMEKPFGTDLASAERLNAR
LHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLEGRTRFYETTGAYRDMVVTHLMQ
VLAFMAMEPPTSLAPDPISDEKLKVFRSMRPIEPRNVVRGQYAGYRDHPEVADDSDTETFVALKVEIDNWRWAGVPFFLR
TGKKLAEGARIISIAFKEPPLAMFPAGSNAGTQGPDHLTFDLADQSRMSLSFYGKRPGPGMKLEKLSMQFATHETMSSGG
VLEAYERLIHDAIRGDHTLFTTADGIETLWEKSMPLLENPPPVRTYAPGSWGPNAIHQLIAPHAWRLPFERSWRESKDPY
DA

Sequences:

>Translated_482_residues
MENPHVIVLFGATGDLSRRKLLPGLLRLWQAGLIQDARIVGTSLEDVDTETFVKIARTACEEFGQSRFDEADWARFSRML
RYVPQSAGPAALAEAVRGCRADLGAPGRDVDCLHYLSVPPKAALDVVRQLDEAGLAAHSRIVMEKPFGTDLASAERLNAR
LHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLEGRTRFYETTGAYRDMVVTHLMQ
VLAFMAMEPPTSLAPDPISDEKLKVFRSMRPIEPRNVVRGQYAGYRDHPEVADDSDTETFVALKVEIDNWRWAGVPFFLR
TGKKLAEGARIISIAFKEPPLAMFPAGSNAGTQGPDHLTFDLADQSRMSLSFYGKRPGPGMKLEKLSMQFATHETMSSGG
VLEAYERLIHDAIRGDHTLFTTADGIETLWEKSMPLLENPPPVRTYAPGSWGPNAIHQLIAPHAWRLPFERSWRESKDPY
DA
>Mature_482_residues
MENPHVIVLFGATGDLSRRKLLPGLLRLWQAGLIQDARIVGTSLEDVDTETFVKIARTACEEFGQSRFDEADWARFSRML
RYVPQSAGPAALAEAVRGCRADLGAPGRDVDCLHYLSVPPKAALDVVRQLDEAGLAAHSRIVMEKPFGTDLASAERLNAR
LHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLEGRTRFYETTGAYRDMVVTHLMQ
VLAFMAMEPPTSLAPDPISDEKLKVFRSMRPIEPRNVVRGQYAGYRDHPEVADDSDTETFVALKVEIDNWRWAGVPFFLR
TGKKLAEGARIISIAFKEPPLAMFPAGSNAGTQGPDHLTFDLADQSRMSLSFYGKRPGPGMKLEKLSMQFATHETMSSGG
VLEAYERLIHDAIRGDHTLFTTADGIETLWEKSMPLLENPPPVRTYAPGSWGPNAIHQLIAPHAWRLPFERSWRESKDPY
DA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=477, Percent_Identity=31.6561844863732, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI109389365, Length=490, Percent_Identity=31.0204081632653, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI52145310, Length=478, Percent_Identity=30.3347280334728, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1788158, Length=492, Percent_Identity=38.4146341463415, Blast_Score=318, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI17538218, Length=500, Percent_Identity=31.8, Blast_Score=254, Evalue=9e-68,
Organism=Saccharomyces cerevisiae, GI6324088, Length=489, Percent_Identity=31.9018404907975, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24643350, Length=496, Percent_Identity=29.2338709677419, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24643352, Length=496, Percent_Identity=29.2338709677419, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI221513548, Length=478, Percent_Identity=27.1966527196653, Blast_Score=158, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54000; Mature: 54000

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENPHVIVLFGATGDLSRRKLLPGLLRLWQAGLIQDARIVGTSLEDVDTETFVKIARTAC
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHCCHHHHHHHHHHHH
EEFGQSRFDEADWARFSRMLRYVPQSAGPAALAEAVRGCRADLGAPGRDVDCLHYLSVPP
HHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
KAALDVVRQLDEAGLAAHSRIVMEKPFGTDLASAERLNARLHEVFDESQIFRIDHFLGKE
HHHHHHHHHHHHHCHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHH
AAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLEGRTRFYETTGAYRDMVVTHLMQ
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHCCCCCCCCEEHHHHHHHHHHHHHHHH
VLAFMAMEPPTSLAPDPISDEKLKVFRSMRPIEPRNVVRGQYAGYRDHPEVADDSDTETF
HHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEE
VALKVEIDNWRWAGVPFFLRTGKKLAEGARIISIAFKEPPLAMFPAGSNAGTQGPDHLTF
EEEEEEECCEEECCCHHHHHCCHHHHCCCEEEEEEECCCCEEEECCCCCCCCCCCCCEEE
DLADQSRMSLSFYGKRPGPGMKLEKLSMQFATHETMSSGGVLEAYERLIHDAIRGDHTLF
EECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEE
TTADGIETLWEKSMPLLENPPPVRTYAPGSWGPNAIHQLIAPHAWRLPFERSWRESKDPY
EECHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DA
CC
>Mature Secondary Structure
MENPHVIVLFGATGDLSRRKLLPGLLRLWQAGLIQDARIVGTSLEDVDTETFVKIARTAC
CCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCHHHCCCCHHHCCHHHHHHHHHHHH
EEFGQSRFDEADWARFSRMLRYVPQSAGPAALAEAVRGCRADLGAPGRDVDCLHYLSVPP
HHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCC
KAALDVVRQLDEAGLAAHSRIVMEKPFGTDLASAERLNARLHEVFDESQIFRIDHFLGKE
HHHHHHHHHHHHHCHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHH
AAQNILAFRFANGLFEPIWNRNFIDHVQIDVPETLGLEGRTRFYETTGAYRDMVVTHLMQ
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHCCCCCCCCEEHHHHHHHHHHHHHHHH
VLAFMAMEPPTSLAPDPISDEKLKVFRSMRPIEPRNVVRGQYAGYRDHPEVADDSDTETF
HHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEE
VALKVEIDNWRWAGVPFFLRTGKKLAEGARIISIAFKEPPLAMFPAGSNAGTQGPDHLTF
EEEEEEECCEEECCCHHHHHCCHHHHCCCEEEEEEECCCCEEEECCCCCCCCCCCCCEEE
DLADQSRMSLSFYGKRPGPGMKLEKLSMQFATHETMSSGGVLEAYERLIHDAIRGDHTLF
EECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEE
TTADGIETLWEKSMPLLENPPPVRTYAPGSWGPNAIHQLIAPHAWRLPFERSWRESKDPY
EECHHHHHHHHCCCCCCCCCCCCCEECCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCC
DA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1643289 [H]