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The map label for this gene is hutH [H]

Identifier: 119718617

GI number: 119718617

Start: 4650257

End: 4651858

Strand: Reverse

Name: hutH [H]

Synonym: Noca_4398

Alternate gene names: 119718617

Gene position: 4651858-4650257 (Counterclockwise)

Preceding gene: 119718625

Following gene: 119718616

Centisome position: 93.3

GC content: 74.97

Gene sequence:

>1602_bases
ATGAACCACGACTCCCACCCGTCGGTCGGCGTCGGCGTCGGACCGGTCTCCTTCGCCGAGCTCCGCGCCGTGGCGCGCGA
CGGCGCCCCGGTCCACCTGACCGACGACGCACTGGCGGCGATCGCCCGGGCGCGCGCGGTGGTCGAGGAGCTGGCCGCCT
CCGAGACTCCCGTGTACGGCGTCTCGACGGGCTTCGGCGCCCTGGCGACGCGGCACATCCCCGCCGAGATGCGCGCCCAG
CTGCAGCGCTCCCTGGTCCGCTCGCACGCCGCCGGCTCCGGCCCCGAGGTGGAGCGCGAGGTGGTCCGGGGGCTGATGCT
GCTGCGGCTCTCGACGCTGGCCACCGGACACACCGGCGTCCGGGTCGAGACCGCCCGCCTGCTCGCCGGCCTGCTCGAGC
ACGGCATCACACCTGTGGTGCGCGAGTACGGCTCGCTCGGCTGCTCCGGTGACCTCGCCCCGCTGGCCCACTGCGCCCTG
GCCTTGATCGGTGAGGGCGAGGTCCGCGACGCGTCCGGCGCGCTGCTGCCGGCCGCCGACGCGCTGGCCGCCGTCGGGCT
GGAGCCGGTCGAGCTCGCCGCCAAGGAGGGCCTCGCGCTGATCAACGGCACCGACGGGATGCTCGGCATGCTGGTGCTGG
CCATCGAGGACCTGCGGATGCTGCTGCGCACCGCGGACATCGCCGCCGCCATGTCGGTGGAGGGCCAGCTCGGCACCGAC
CGGGTCTTCGCCGCGGAGCTCCAGGCGATCCGGCCGCACCCGGGCCAGGCGCGCTCGGCCGCGAACCTCACCGCGCTGCT
CGCCGACTCAGGCGTGGTGGCGTCGCACCGCGGCCCGGACTGCAACCGGGTCCAGGACGCCTACTCCCTGCGCTGCTCGC
CCCAGGTGCACGGTGCCGCCCGCGACACCGTCGAGCACGCGGCGACGGTCGCCACCCGCGAGCTCGCCTCGGCCGTGGAC
AACCCGGTGGTCGTCTTCGACGACCTGGGCGGGCGGGGGACCGGGGGTCTGGGGGGCGGAGCCCCCGGGCGGGTCGAGTC
GAACGGGAACTTCCACGGGGCGCCGGTCGCCTACGTCCTCGACTTCCTCGCGATCGTCGCGGCCGACGTGGCCTCGATCA
GCGAGCGTCGTACCGACCGGTTCCTCGACAAGGCGCGCAACCACGGGCTGCCGCCGTTCCTCGCCGACGACCCCGGGGTC
GACAGCGGGCACATGATCGCGCAGTACACCCAGGCCGCGATCGTCTCCGAGCTGAAGCGGCTCGCCGTGCCGGCCTCGGT
CGACTCGATCCCCTCCAGCGCGATGCAGGAGGACCACGTGTCGATGGGGTGGTCGGCCGCCCGCAAGCTGCGCCGCTCGG
TCGACGGGCTGACCCGCGTCGTCGCGATCGAGGTGCTCACCGCGGCCCGGGCGCTCGACCTGCGCCGACCGCTCGAGCCG
TCGCCGGCCACCGGTGCCGTCATCGGGCTGCTGCGCGGCGCCGGGGTCGCCGGCCCCGGACCCGACCGACACCTCTCGCC
CGAGATCGAGACCGTGGTCGGCCTGGTCTCCTCCGGCGCCGTACTCCATGCTGCCGAGACCGTGATCGGAGAACTGTCGT
GA

Upstream 100 bases:

>100_bases
GCTGTGGTTACGCATGAGTAGCCTTCGAGTCTCGGATCTCAGACTACGGTGGGTGGCGCCGTACTGGTCGGCGTCCTCGG
CGCGGACGAGGATGGCGGGC

Downstream 100 bases:

>100_bases
CCACTCCCGCCAACCCGCGCCTGCCCATCCACGCCGCGCACGGCACCGAGCTGACCGCCCGGTCCTGGCAGACCGAGGCC
CCGCTGCGGATGCTGATGAA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MNHDSHPSVGVGVGPVSFAELRAVARDGAPVHLTDDALAAIARARAVVEELAASETPVYGVSTGFGALATRHIPAEMRAQ
LQRSLVRSHAAGSGPEVEREVVRGLMLLRLSTLATGHTGVRVETARLLAGLLEHGITPVVREYGSLGCSGDLAPLAHCAL
ALIGEGEVRDASGALLPAADALAAVGLEPVELAAKEGLALINGTDGMLGMLVLAIEDLRMLLRTADIAAAMSVEGQLGTD
RVFAAELQAIRPHPGQARSAANLTALLADSGVVASHRGPDCNRVQDAYSLRCSPQVHGAARDTVEHAATVATRELASAVD
NPVVVFDDLGGRGTGGLGGGAPGRVESNGNFHGAPVAYVLDFLAIVAADVASISERRTDRFLDKARNHGLPPFLADDPGV
DSGHMIAQYTQAAIVSELKRLAVPASVDSIPSSAMQEDHVSMGWSAARKLRRSVDGLTRVVAIEVLTAARALDLRRPLEP
SPATGAVIGLLRGAGVAGPGPDRHLSPEIETVVGLVSSGAVLHAAETVIGELS

Sequences:

>Translated_533_residues
MNHDSHPSVGVGVGPVSFAELRAVARDGAPVHLTDDALAAIARARAVVEELAASETPVYGVSTGFGALATRHIPAEMRAQ
LQRSLVRSHAAGSGPEVEREVVRGLMLLRLSTLATGHTGVRVETARLLAGLLEHGITPVVREYGSLGCSGDLAPLAHCAL
ALIGEGEVRDASGALLPAADALAAVGLEPVELAAKEGLALINGTDGMLGMLVLAIEDLRMLLRTADIAAAMSVEGQLGTD
RVFAAELQAIRPHPGQARSAANLTALLADSGVVASHRGPDCNRVQDAYSLRCSPQVHGAARDTVEHAATVATRELASAVD
NPVVVFDDLGGRGTGGLGGGAPGRVESNGNFHGAPVAYVLDFLAIVAADVASISERRTDRFLDKARNHGLPPFLADDPGV
DSGHMIAQYTQAAIVSELKRLAVPASVDSIPSSAMQEDHVSMGWSAARKLRRSVDGLTRVVAIEVLTAARALDLRRPLEP
SPATGAVIGLLRGAGVAGPGPDRHLSPEIETVVGLVSSGAVLHAAETVIGELS
>Mature_533_residues
MNHDSHPSVGVGVGPVSFAELRAVARDGAPVHLTDDALAAIARARAVVEELAASETPVYGVSTGFGALATRHIPAEMRAQ
LQRSLVRSHAAGSGPEVEREVVRGLMLLRLSTLATGHTGVRVETARLLAGLLEHGITPVVREYGSLGCSGDLAPLAHCAL
ALIGEGEVRDASGALLPAADALAAVGLEPVELAAKEGLALINGTDGMLGMLVLAIEDLRMLLRTADIAAAMSVEGQLGTD
RVFAAELQAIRPHPGQARSAANLTALLADSGVVASHRGPDCNRVQDAYSLRCSPQVHGAARDTVEHAATVATRELASAVD
NPVVVFDDLGGRGTGGLGGGAPGRVESNGNFHGAPVAYVLDFLAIVAADVASISERRTDRFLDKARNHGLPPFLADDPGV
DSGHMIAQYTQAAIVSELKRLAVPASVDSIPSSAMQEDHVSMGWSAARKLRRSVDGLTRVVAIEVLTAARALDLRRPLEP
SPATGAVIGLLRGAGVAGPGPDRHLSPEIETVVGLVSSGAVLHAAETVIGELS

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=504, Percent_Identity=40.4761904761905, Blast_Score=334, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17567831, Length=499, Percent_Identity=40.6813627254509, Blast_Score=318, Evalue=4e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54866; Mature: 54866

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00488 PAL_HISTIDASE ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHDSHPSVGVGVGPVSFAELRAVARDGAPVHLTDDALAAIARARAVVEELAASETPVYG
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCEE
VSTGFGALATRHIPAEMRAQLQRSLVRSHAAGSGPEVEREVVRGLMLLRLSTLATGHTGV
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
RVETARLLAGLLEHGITPVVREYGSLGCSGDLAPLAHCALALIGEGEVRDASGALLPAAD
EEHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
ALAAVGLEPVELAAKEGLALINGTDGMLGMLVLAIEDLRMLLRTADIAAAMSVEGQLGTD
HHHHCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RVFAAELQAIRPHPGQARSAANLTALLADSGVVASHRGPDCNRVQDAYSLRCSPQVHGAA
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCH
RDTVEHAATVATRELASAVDNPVVVFDDLGGRGTGGLGGGAPGRVESNGNFHGAPVAYVL
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
DFLAIVAADVASISERRTDRFLDKARNHGLPPFLADDPGVDSGHMIAQYTQAAIVSELKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LAVPASVDSIPSSAMQEDHVSMGWSAARKLRRSVDGLTRVVAIEVLTAARALDLRRPLEP
HHCCCCHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SPATGAVIGLLRGAGVAGPGPDRHLSPEIETVVGLVSSGAVLHAAETVIGELS
CCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MNHDSHPSVGVGVGPVSFAELRAVARDGAPVHLTDDALAAIARARAVVEELAASETPVYG
CCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCCEE
VSTGFGALATRHIPAEMRAQLQRSLVRSHAAGSGPEVEREVVRGLMLLRLSTLATGHTGV
CCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
RVETARLLAGLLEHGITPVVREYGSLGCSGDLAPLAHCALALIGEGEVRDASGALLPAAD
EEHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
ALAAVGLEPVELAAKEGLALINGTDGMLGMLVLAIEDLRMLLRTADIAAAMSVEGQLGTD
HHHHCCCCHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RVFAAELQAIRPHPGQARSAANLTALLADSGVVASHRGPDCNRVQDAYSLRCSPQVHGAA
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCH
RDTVEHAATVATRELASAVDNPVVVFDDLGGRGTGGLGGGAPGRVESNGNFHGAPVAYVL
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
DFLAIVAADVASISERRTDRFLDKARNHGLPPFLADDPGVDSGHMIAQYTQAAIVSELKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LAVPASVDSIPSSAMQEDHVSMGWSAARKLRRSVDGLTRVVAIEVLTAARALDLRRPLEP
HHCCCCHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
SPATGAVIGLLRGAGVAGPGPDRHLSPEIETVVGLVSSGAVLHAAETVIGELS
CCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1537807; 1612436 [H]