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The map label for this gene is hutU

Identifier: 119718616

GI number: 119718616

Start: 4648593

End: 4650260

Strand: Reverse

Name: hutU

Synonym: Noca_4397

Alternate gene names: 119718616

Gene position: 4650260-4648593 (Counterclockwise)

Preceding gene: 119718617

Following gene: 119718615

Centisome position: 93.27

GC content: 72.42

Gene sequence:

>1668_bases
GTGACCACTCCCGCCAACCCGCGCCTGCCCATCCACGCCGCGCACGGCACCGAGCTGACCGCCCGGTCCTGGCAGACCGA
GGCCCCGCTGCGGATGCTGATGAACAATCTCGACCCCGAGAACGCCGAGCGCCCCGAGGACCTCGTCGTGTACGGCGGCA
CCGGTCGCGCGGCCCGGTCCTGGGAGGCCTACGACGCGCTGGTGCGCACGCTGACCACGCTCGGTGACGACGAGACGATG
CTGGTGCAGTCCGGCAAGCCGGTTGGCGTGATGAGGACGCACGAGTGGGCGCCGCGGGTGCTGATCGCGAACTCCAACCT
GGTCGGCGACTGGGCCAACTGGGAGGAGTTCCGCCGGCTCGAGGACCTCGGCCTGACCATGTACGGCCAGATGACCGCGG
GCTCGTGGATCTACATCGGCACCCAGGGCATCCTCCAGGGCACCTTCGAGACGTTCGCGGCCGTCGCCGACAAGAGGTTC
GGCGGGACCCTCGCCGGGACCATCACCGTGACCGCCGGCCTGGGTGGCATGGGCGGCGCGCAGCCGCTGGCGGTCACGAT
GAACGACGGCGTGGTGATCTGCGTCGAGTGCGACCCCGAGCGGATCCGGCGGCGTATCGACCACCGCTACCTCGACGTCG
AGGCGCCGTCGCTCGAGGCGGCCGTGGCGCTCGCGGTCGAGGCGCGCGACGAGCGGCGGCCGCTGTCGATCGGGCTGCTC
GGCAACGCCGCCGAGGTGCTGCCGCGGATCCTCGAGACCGAGGTGCCGGTGGACATCGTCACCGACCAGACCTCGGCGCA
CGACCCGCTCTACTACCTGCCCGTCGGCGTCCCCTTCGAGGAGTGGGCGGCCCGGCGGGAGGCCGACCCGGAGGGTTTCA
CCAAGGAGGCGCGGGCCTCGATGGCGGCGCACGTGCGGGCCATGGTCGAGCTCCAGGACCGCGGGGCCGAGGTCTTCGAC
TACGGCAACTCGATCCGCGACGAGGCCCGCAAGGGTGGCTACGACCGGGCCTTCGAGTTCCCCGGCTTCGTGCCCGCCTA
CATCCGGCCGCTGTTCTGCGAGGGGAAGGGGCCGTTCCGGTGGGCCGCGCTGTCCGGCGACCCGGCCGACATCGCCGCCA
CCGACCGCGCCATCCTCGAGCTGTTCCCCGCCAACGAGCGGCTGCGGAAGTGGATCACGATGGCCGGTGAGCGGGTGCAC
TTCCAGGGGCTGCCGGCGCGGATCTGCTGGCTCGGGTACGGCGAGCGCCACCTCGCCGGCCTGCGGTTCAACGAGATGGT
GGCCTCCGGTGAGCTGAAGGCCCCGATCGTGATCGGCCGCGACCACCTGGACTGCGGCTCCGTGGCCTCGCCGTACCGCG
AGACCGAGGGCATGCTCGACGGCTCGGACGCCATCGCGGACTGGGCCGTTCTCAACGCCCTGGTCAACACCGCGTCCGGC
GCCAGCTGGGTCTCCTTCCACCACGGCGGCGGCGTCGGCATCGGCCGGTCCCTGCACGCCGGCCAGGTCTGCGTCGCCGA
CGGCACCGACCTCGCCGCGCAGAAGATCGAGCGGGTCCTCACCAACGACCCCGGCATGGGCGTGATCCGCCACGTCGACG
CCGGCTACGACCGCGCCGCCGAGGTCGCCCGCGAGCGCGGCGTCCGGATCCCGATGTCCGAGGGCTGA

Upstream 100 bases:

>100_bases
GACCCGACCGACACCTCTCGCCCGAGATCGAGACCGTGGTCGGCCTGGTCTCCTCCGGCGCCGTACTCCATGCTGCCGAG
ACCGTGATCGGAGAACTGTC

Downstream 100 bases:

>100_bases
GGCGGCGGTCGGTTTCCCCGGTGAACCGGGGAAACCGGAACTGTTGGGCCGAAGTTTCGGCCGAGAAGTGCAGGGATTGC
CCGAGAAGTCCGACCGGCCC

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTTPANPRLPIHAAHGTELTARSWQTEAPLRMLMNNLDPENAERPEDLVVYGGTGRAARSWEAYDALVRTLTTLGDDETM
LVQSGKPVGVMRTHEWAPRVLIANSNLVGDWANWEEFRRLEDLGLTMYGQMTAGSWIYIGTQGILQGTFETFAAVADKRF
GGTLAGTITVTAGLGGMGGAQPLAVTMNDGVVICVECDPERIRRRIDHRYLDVEAPSLEAAVALAVEARDERRPLSIGLL
GNAAEVLPRILETEVPVDIVTDQTSAHDPLYYLPVGVPFEEWAARREADPEGFTKEARASMAAHVRAMVELQDRGAEVFD
YGNSIRDEARKGGYDRAFEFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIAATDRAILELFPANERLRKWITMAGERVH
FQGLPARICWLGYGERHLAGLRFNEMVASGELKAPIVIGRDHLDCGSVASPYRETEGMLDGSDAIADWAVLNALVNTASG
ASWVSFHHGGGVGIGRSLHAGQVCVADGTDLAAQKIERVLTNDPGMGVIRHVDAGYDRAAEVARERGVRIPMSEG

Sequences:

>Translated_555_residues
MTTPANPRLPIHAAHGTELTARSWQTEAPLRMLMNNLDPENAERPEDLVVYGGTGRAARSWEAYDALVRTLTTLGDDETM
LVQSGKPVGVMRTHEWAPRVLIANSNLVGDWANWEEFRRLEDLGLTMYGQMTAGSWIYIGTQGILQGTFETFAAVADKRF
GGTLAGTITVTAGLGGMGGAQPLAVTMNDGVVICVECDPERIRRRIDHRYLDVEAPSLEAAVALAVEARDERRPLSIGLL
GNAAEVLPRILETEVPVDIVTDQTSAHDPLYYLPVGVPFEEWAARREADPEGFTKEARASMAAHVRAMVELQDRGAEVFD
YGNSIRDEARKGGYDRAFEFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIAATDRAILELFPANERLRKWITMAGERVH
FQGLPARICWLGYGERHLAGLRFNEMVASGELKAPIVIGRDHLDCGSVASPYRETEGMLDGSDAIADWAVLNALVNTASG
ASWVSFHHGGGVGIGRSLHAGQVCVADGTDLAAQKIERVLTNDPGMGVIRHVDAGYDRAAEVARERGVRIPMSEG
>Mature_554_residues
TTPANPRLPIHAAHGTELTARSWQTEAPLRMLMNNLDPENAERPEDLVVYGGTGRAARSWEAYDALVRTLTTLGDDETML
VQSGKPVGVMRTHEWAPRVLIANSNLVGDWANWEEFRRLEDLGLTMYGQMTAGSWIYIGTQGILQGTFETFAAVADKRFG
GTLAGTITVTAGLGGMGGAQPLAVTMNDGVVICVECDPERIRRRIDHRYLDVEAPSLEAAVALAVEARDERRPLSIGLLG
NAAEVLPRILETEVPVDIVTDQTSAHDPLYYLPVGVPFEEWAARREADPEGFTKEARASMAAHVRAMVELQDRGAEVFDY
GNSIRDEARKGGYDRAFEFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIAATDRAILELFPANERLRKWITMAGERVHF
QGLPARICWLGYGERHLAGLRFNEMVASGELKAPIVIGRDHLDCGSVASPYRETEGMLDGSDAIADWAVLNALVNTASGA
SWVSFHHGGGVGIGRSLHAGQVCVADGTDLAAQKIERVLTNDPGMGVIRHVDAGYDRAAEVARERGVRIPMSEG

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=544, Percent_Identity=34.375, Blast_Score=305, Evalue=1e-82,
Organism=Homo sapiens, GI260306182, Length=358, Percent_Identity=33.2402234636872, Blast_Score=173, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71997891, Length=561, Percent_Identity=34.5811051693405, Blast_Score=318, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_NOCSJ (A1SQ09)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_925581.1
- ProteinModelPortal:   A1SQ09
- SMR:   A1SQ09
- STRING:   A1SQ09
- GeneID:   4596915
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_4397
- eggNOG:   COG2987
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- BioCyc:   NSP35761:NOCA_4397-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 60399; Mature: 60268

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 409-409

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPANPRLPIHAAHGTELTARSWQTEAPLRMLMNNLDPENAERPEDLVVYGGTGRAARS
CCCCCCCCCEEEECCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCC
WEAYDALVRTLTTLGDDETMLVQSGKPVGVMRTHEWAPRVLIANSNLVGDWANWEEFRRL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCEECCCCCHHHHHHH
EDLGLTMYGQMTAGSWIYIGTQGILQGTFETFAAVADKRFGGTLAGTITVTAGLGGMGGA
HHCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCC
QPLAVTMNDGVVICVECDPERIRRRIDHRYLDVEAPSLEAAVALAVEARDERRPLSIGLL
CEEEEEECCCEEEEEECCHHHHHHHHCCEEEECCCCCCCEEEEEEEECCCCCCCEEEEEE
GNAAEVLPRILETEVPVDIVTDQTSAHDPLYYLPVGVPFEEWAARREADPEGFTKEARAS
CCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHCCCCCCCCHHHHHHH
MAAHVRAMVELQDRGAEVFDYGNSIRDEARKGGYDRAFEFPGFVPAYIRPLFCEGKGPFR
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHCEEEECCCCCEE
WAALSGDPADIAATDRAILELFPANERLRKWITMAGERVHFQGLPARICWLGYGERHLAG
EEEECCCCCCHHHHCCHHHEECCCCHHHHHHHHHCCCEEEECCCCEEEEEECCCCHHHCC
LRFNEMVASGELKAPIVIGRDHLDCGSVASPYRETEGMLDGSDAIADWAVLNALVNTASG
CCHHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
ASWVSFHHGGGVGIGRSLHAGQVCVADGTDLAAQKIERVLTNDPGMGVIRHVDAGYDRAA
CCEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHH
EVARERGVRIPMSEG
HHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTPANPRLPIHAAHGTELTARSWQTEAPLRMLMNNLDPENAERPEDLVVYGGTGRAARS
CCCCCCCCEEEECCCCEEECCCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCC
WEAYDALVRTLTTLGDDETMLVQSGKPVGVMRTHEWAPRVLIANSNLVGDWANWEEFRRL
HHHHHHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCCEECCCCCHHHHHHH
EDLGLTMYGQMTAGSWIYIGTQGILQGTFETFAAVADKRFGGTLAGTITVTAGLGGMGGA
HHCCCEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCC
QPLAVTMNDGVVICVECDPERIRRRIDHRYLDVEAPSLEAAVALAVEARDERRPLSIGLL
CEEEEEECCCEEEEEECCHHHHHHHHCCEEEECCCCCCCEEEEEEEECCCCCCCEEEEEE
GNAAEVLPRILETEVPVDIVTDQTSAHDPLYYLPVGVPFEEWAARREADPEGFTKEARAS
CCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHCCCCCCCCHHHHHHH
MAAHVRAMVELQDRGAEVFDYGNSIRDEARKGGYDRAFEFPGFVPAYIRPLFCEGKGPFR
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHCCCCCCCCCCCCCCHHHHCEEEECCCCCEE
WAALSGDPADIAATDRAILELFPANERLRKWITMAGERVHFQGLPARICWLGYGERHLAG
EEEECCCCCCHHHHCCHHHEECCCCHHHHHHHHHCCCEEEECCCCEEEEEECCCCHHHCC
LRFNEMVASGELKAPIVIGRDHLDCGSVASPYRETEGMLDGSDAIADWAVLNALVNTASG
CCHHHHHHCCCCCCCEEECCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
ASWVSFHHGGGVGIGRSLHAGQVCVADGTDLAAQKIERVLTNDPGMGVIRHVDAGYDRAA
CCEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCHHHHH
EVARERGVRIPMSEG
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA