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The map label for this gene is fba [H]

Identifier: 119718569

GI number: 119718569

Start: 4599986

End: 4601017

Strand: Reverse

Name: fba [H]

Synonym: Noca_4350

Alternate gene names: 119718569

Gene position: 4601017-4599986 (Counterclockwise)

Preceding gene: 119718571

Following gene: 119718567

Centisome position: 92.28

GC content: 69.19

Gene sequence:

>1032_bases
ATGCCCATCGCCACCCCCGAGAAGTACGCCGAGATGCTGGAGGCGGCCAAGAAGAACGCGTTCGCGTTCCCGGCCATCAA
CGTCTCGTCGTCGCAGACCCTCAACGCGGCGCTCCAGGGCTTCGCCGACGCCGGGTCCGACGGGATCATCCAGGTCTCGA
CCGGCGGCGCGGAGTACTTCTCCGGACCGACGATCAAGAACATGGTCACCGGCTCCGTCGCGTTCGCCGCCTACGCCGCC
GAGGTCGCGAAGAACTACCCGATCAACGTCGCGCTGCACACCGACCACTGCCCCAAGGGCAAGCTGGACGGCTTCGTGCG
CCCGCTGCTCGACATCTCCGCCGAGCGCGTCGCCCGCGGCGAGGCCCCGCTGTTCCAGTCGCACATGTGGGACGGCTCCG
CCGTACCGCTCGACGAGAACCTCCAGATCGCCGAGGAGCTCCTGGCCAAGTGCGCGGCCGCGCACATCATCCTCGAGGTC
GAGATCGGCGTCGTGGGCGGCGAGGAGGACGGTGTCGTCGGCGAGATCAACGACAAGCTCTACACCACCCCCGAGGACGC
GCTGGCGACCGTCGCGGCCCTGGGCGCCGGCGAGAACGGCCGCTACATGACCGCGCTGACCTTCGGCAACGTGCACGGCG
TCTACAAGCCGGGCAACGTCAAGCTCCGCCCGGAGATCCTCAAGGCGGCCCAGGAGGCCGTCGCCGAGAAGCTCGGCCTG
GCCGCGGGCTCGAAGCCCTTCGACCTGGTCTTCCACGGCGGGTCCGGCTCGACGGCCGAGGAGATCGGCGCCGCCGTCGA
CTACGGCGTGGTGAAGATGAACGTCGACACCGACACCCAGTACGCGTTCACTCGCCCGGTGGCGACGCACATGTTCCAGA
ACTACGACGGCGTCCTCAAGATCGACGGCGAGGTCGGCAACAAGAAGATGTACGACCCGCGGGCCTGGGGCAAGGCGGCC
GAGAGCGGCATGGCCGCCCGGGTCGTCGAGGCGTGCCAGAACCTGCGCGCCGCGGGCCACTCGATCGGCTGA

Upstream 100 bases:

>100_bases
AGCACGGCCCGGTATCACGGGCCAGAGGTCCCTACGGGCGCCTTCGGGCAGGCACTAGGGTCGAAGACGATCCGTTCAGC
CGTTCGTACGAGGAGTCCGC

Downstream 100 bases:

>100_bases
CCACCCGAGCACAGGCGTCGGACGGACGGAGCCACCTGTGGCTCCGTCCGTCCGACGTTCCGGGGATCATTCGAAGCCGG
CGTGCTGGGGTCGCTCGAAG

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MPIATPEKYAEMLEAAKKNAFAFPAINVSSSQTLNAALQGFADAGSDGIIQVSTGGAEYFSGPTIKNMVTGSVAFAAYAA
EVAKNYPINVALHTDHCPKGKLDGFVRPLLDISAERVARGEAPLFQSHMWDGSAVPLDENLQIAEELLAKCAAAHIILEV
EIGVVGGEEDGVVGEINDKLYTTPEDALATVAALGAGENGRYMTALTFGNVHGVYKPGNVKLRPEILKAAQEAVAEKLGL
AAGSKPFDLVFHGGSGSTAEEIGAAVDYGVVKMNVDTDTQYAFTRPVATHMFQNYDGVLKIDGEVGNKKMYDPRAWGKAA
ESGMAARVVEACQNLRAAGHSIG

Sequences:

>Translated_343_residues
MPIATPEKYAEMLEAAKKNAFAFPAINVSSSQTLNAALQGFADAGSDGIIQVSTGGAEYFSGPTIKNMVTGSVAFAAYAA
EVAKNYPINVALHTDHCPKGKLDGFVRPLLDISAERVARGEAPLFQSHMWDGSAVPLDENLQIAEELLAKCAAAHIILEV
EIGVVGGEEDGVVGEINDKLYTTPEDALATVAALGAGENGRYMTALTFGNVHGVYKPGNVKLRPEILKAAQEAVAEKLGL
AAGSKPFDLVFHGGSGSTAEEIGAAVDYGVVKMNVDTDTQYAFTRPVATHMFQNYDGVLKIDGEVGNKKMYDPRAWGKAA
ESGMAARVVEACQNLRAAGHSIG
>Mature_342_residues
PIATPEKYAEMLEAAKKNAFAFPAINVSSSQTLNAALQGFADAGSDGIIQVSTGGAEYFSGPTIKNMVTGSVAFAAYAAE
VAKNYPINVALHTDHCPKGKLDGFVRPLLDISAERVARGEAPLFQSHMWDGSAVPLDENLQIAEELLAKCAAAHIILEVE
IGVVGGEEDGVVGEINDKLYTTPEDALATVAALGAGENGRYMTALTFGNVHGVYKPGNVKLRPEILKAAQEAVAEKLGLA
AGSKPFDLVFHGGSGSTAEEIGAAVDYGVVKMNVDTDTQYAFTRPVATHMFQNYDGVLKIDGEVGNKKMYDPRAWGKAAE
SGMAARVVEACQNLRAAGHSIG

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789293, Length=351, Percent_Identity=40.4558404558405, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI87082041, Length=325, Percent_Identity=24.9230769230769, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1789526, Length=286, Percent_Identity=26.2237762237762, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322790, Length=342, Percent_Identity=40.6432748538012, Blast_Score=219, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006411
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 36032; Mature: 35901

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIATPEKYAEMLEAAKKNAFAFPAINVSSSQTLNAALQGFADAGSDGIIQVSTGGAEYF
CCCCCHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHC
SGPTIKNMVTGSVAFAAYAAEVAKNYPINVALHTDHCPKGKLDGFVRPLLDISAERVARG
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCC
EAPLFQSHMWDGSAVPLDENLQIAEELLAKCAAAHIILEVEIGVVGGEEDGVVGEINDKL
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCEEEECCCCE
YTTPEDALATVAALGAGENGRYMTALTFGNVHGVYKPGNVKLRPEILKAAQEAVAEKLGL
ECCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEECCCCEEECHHHHHHHHHHHHHHHHH
AAGSKPFDLVFHGGSGSTAEEIGAAVDYGVVKMNVDTDTQYAFTRPVATHMFQNYDGVLK
CCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHCCCCEEE
IDGEVGNKKMYDPRAWGKAAESGMAARVVEACQNLRAAGHSIG
ECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PIATPEKYAEMLEAAKKNAFAFPAINVSSSQTLNAALQGFADAGSDGIIQVSTGGAEYF
CCCCHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHC
SGPTIKNMVTGSVAFAAYAAEVAKNYPINVALHTDHCPKGKLDGFVRPLLDISAERVARG
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCC
EAPLFQSHMWDGSAVPLDENLQIAEELLAKCAAAHIILEVEIGVVGGEEDGVVGEINDKL
CCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEEEEEECCCCCCEEEECCCCE
YTTPEDALATVAALGAGENGRYMTALTFGNVHGVYKPGNVKLRPEILKAAQEAVAEKLGL
ECCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEECCCCEEECHHHHHHHHHHHHHHHHH
AAGSKPFDLVFHGGSGSTAEEIGAAVDYGVVKMNVDTDTQYAFTRPVATHMFQNYDGVLK
CCCCCCEEEEEECCCCCCHHHHHHHHCCCEEEEECCCCCCEEEHHHHHHHHHHCCCCEEE
IDGEVGNKKMYDPRAWGKAAESGMAARVVEACQNLRAAGHSIG
ECCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]