Click here to switch to the map view.

The map label for this gene is mmgB [H]

Identifier: 119718513

GI number: 119718513

Start: 4536585

End: 4537448

Strand: Reverse

Name: mmgB [H]

Synonym: Noca_4294

Alternate gene names: 119718513

Gene position: 4537448-4536585 (Counterclockwise)

Preceding gene: 119718514

Following gene: 119718512

Centisome position: 91.01

GC content: 71.53

Gene sequence:

>864_bases
ATGCGCAGCGTCCTGGTCGTGGGTGCGGGGGCGATGGGCTCCCAGATCGCGATGGTCTGCGCCCTCGCGGGCCACCAGGT
GTGCCTCCACGACGTCGATCCGGCCATGCTCGAGCGGGCCGATCGCGAGCTGCGCGACCGGATGGCGCGGCAGGTCGAGA
AGGGCCGGCGTACCGCCGACGACGTCACGGCCGCGTTCGAGCGGCTGCGGGTGGCGGACTCGCTCGCCGCCGCCGCCGCC
GCCGCGGACGCGGACCTCGTGATCGAGGCGGTGGTCGAGAGGATCGAGGTGAAGTCGGAGCTGTTCGCCGAGCTCGACCG
GCTCTGCCCGCCGGCCACGATCCTGGCCAGCAACTCCTCGAGCTTCGTGCCGTCCCGGCTCGCGGCCGCGACGGGGCGCG
CGGACCGGGTCTGCAACCTGCACTTCTTCAACCCGGCGCTCGTCATGGCCTGCGTCGAGGTGGTGCCCGGACCGGAGACC
TCGGGGCAGACGGTCGCGAGCTGCGTGGACCTCGTCGAGTCGCTGGGCAAGGTTCCGGTCGTCCTGGAGAAGGAGATCCC
GGGCTTCGTGGCGAACCGGATCCTCAACGCCGTGCGCGACGAGGCGATCCGGCTCTACGAGGGCGGCTACGCCGGTGTCG
AGGCCATCGACACCGCCTGCCGGACCGCTCTCGGCTATCCGATGGGACCGTTCGAGCTGATGGACCTCACCGGCATCGAC
ATCGGCTACCTCACCAAGCAGGCTCGGTACGCCGAGACCGGCGACCCTGCCGACCTCCCCAGCCGCAGCGTGACCGAGCT
CGTCGAGCGCGGCCACCTCGGCCGCAAGACCGGCCGCGGCTGGTACACCTACGAAGGAGTCTGA

Upstream 100 bases:

>100_bases
TCGAGCAGCTGGCCCAGTCGCTGCTCTACACCACCGGGGACAAGCGGGAGGGCGCCGAGGCGTTCCTGGCCAAGCGCACC
CCTGCGTTCCGGGGGGCCTG

Downstream 100 bases:

>100_bases
CCATGGACCTGTCACTCAACGAGGACCAGCTCAGCTTCAAGAAGCTGGCCCGCGAGTTCCTCGACGCGGAGGTCGTCCCG
TACCGCGGCGAGTGGGACCG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MRSVLVVGAGAMGSQIAMVCALAGHQVCLHDVDPAMLERADRELRDRMARQVEKGRRTADDVTAAFERLRVADSLAAAAA
AADADLVIEAVVERIEVKSELFAELDRLCPPATILASNSSSFVPSRLAAATGRADRVCNLHFFNPALVMACVEVVPGPET
SGQTVASCVDLVESLGKVPVVLEKEIPGFVANRILNAVRDEAIRLYEGGYAGVEAIDTACRTALGYPMGPFELMDLTGID
IGYLTKQARYAETGDPADLPSRSVTELVERGHLGRKTGRGWYTYEGV

Sequences:

>Translated_287_residues
MRSVLVVGAGAMGSQIAMVCALAGHQVCLHDVDPAMLERADRELRDRMARQVEKGRRTADDVTAAFERLRVADSLAAAAA
AADADLVIEAVVERIEVKSELFAELDRLCPPATILASNSSSFVPSRLAAATGRADRVCNLHFFNPALVMACVEVVPGPET
SGQTVASCVDLVESLGKVPVVLEKEIPGFVANRILNAVRDEAIRLYEGGYAGVEAIDTACRTALGYPMGPFELMDLTGID
IGYLTKQARYAETGDPADLPSRSVTELVERGHLGRKTGRGWYTYEGV
>Mature_287_residues
MRSVLVVGAGAMGSQIAMVCALAGHQVCLHDVDPAMLERADRELRDRMARQVEKGRRTADDVTAAFERLRVADSLAAAAA
AADADLVIEAVVERIEVKSELFAELDRLCPPATILASNSSSFVPSRLAAATGRADRVCNLHFFNPALVMACVEVVPGPET
SGQTVASCVDLVESLGKVPVVLEKEIPGFVANRILNAVRDEAIRLYEGGYAGVEAIDTACRTALGYPMGPFELMDLTGID
IGYLTKQARYAETGDPADLPSRSVTELVERGHLGRKTGRGWYTYEGV

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=291, Percent_Identity=41.9243986254296, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI296179427, Length=308, Percent_Identity=39.6103896103896, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=32.8813559322034, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=32.8813559322034, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI20127408, Length=298, Percent_Identity=31.2080536912752, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI115430219, Length=253, Percent_Identity=31.6205533596838, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1787661, Length=285, Percent_Identity=42.1052631578947, Blast_Score=194, Evalue=5e-51,
Organism=Escherichia coli, GI1788682, Length=262, Percent_Identity=35.4961832061069, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1790281, Length=279, Percent_Identity=30.1075268817204, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17553560, Length=296, Percent_Identity=37.5, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17549919, Length=293, Percent_Identity=37.542662116041, Blast_Score=185, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=36.8055555555556, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71985923, Length=287, Percent_Identity=33.4494773519164, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17508951, Length=292, Percent_Identity=33.9041095890411, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25144276, Length=292, Percent_Identity=33.9041095890411, Blast_Score=144, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17508953, Length=292, Percent_Identity=33.9041095890411, Blast_Score=144, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17558304, Length=294, Percent_Identity=32.6530612244898, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71985930, Length=286, Percent_Identity=29.7202797202797, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=189, Percent_Identity=29.6296296296296, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115533614, Length=189, Percent_Identity=29.6296296296296, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24583077, Length=293, Percent_Identity=32.7645051194539, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24583079, Length=293, Percent_Identity=32.7645051194539, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI19921000, Length=293, Percent_Identity=32.7645051194539, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=33.75, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI20129993, Length=220, Percent_Identity=31.8181818181818, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30721; Mature: 30721

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVLVVGAGAMGSQIAMVCALAGHQVCLHDVDPAMLERADRELRDRMARQVEKGRRTAD
CCCEEEEECCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
DVTAAFERLRVADSLAAAAAAADADLVIEAVVERIEVKSELFAELDRLCPPATILASNSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
SFVPSRLAAATGRADRVCNLHFFNPALVMACVEVVPGPETSGQTVASCVDLVESLGKVPV
CCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCE
VLEKEIPGFVANRILNAVRDEAIRLYEGGYAGVEAIDTACRTALGYPMGPFELMDLTGID
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
IGYLTKQARYAETGDPADLPSRSVTELVERGHLGRKTGRGWYTYEGV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCC
>Mature Secondary Structure
MRSVLVVGAGAMGSQIAMVCALAGHQVCLHDVDPAMLERADRELRDRMARQVEKGRRTAD
CCCEEEEECCCCHHHHHHHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
DVTAAFERLRVADSLAAAAAAADADLVIEAVVERIEVKSELFAELDRLCPPATILASNSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
SFVPSRLAAATGRADRVCNLHFFNPALVMACVEVVPGPETSGQTVASCVDLVESLGKVPV
CCCHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCE
VLEKEIPGFVANRILNAVRDEAIRLYEGGYAGVEAIDTACRTALGYPMGPFELMDLTGID
EECCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
IGYLTKQARYAETGDPADLPSRSVTELVERGHLGRKTGRGWYTYEGV
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]