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The map label for this gene is mmgC [H]

Identifier: 119718512

GI number: 119718512

Start: 4535431

End: 4536582

Strand: Reverse

Name: mmgC [H]

Synonym: Noca_4293

Alternate gene names: 119718512

Gene position: 4536582-4535431 (Counterclockwise)

Preceding gene: 119718513

Following gene: 119718511

Centisome position: 90.99

GC content: 70.14

Gene sequence:

>1152_bases
ATGGACCTGTCACTCAACGAGGACCAGCTCAGCTTCAAGAAGCTGGCCCGCGAGTTCCTCGACGCGGAGGTCGTCCCGTA
CCGCGGCGAGTGGGACCGCCGTGAGTCGGTCGACACCGCGATCATCCCCAAGCTCGGCGACCTCGGGTTCTTCGGGCTCA
CCATCCCCGAGGAGTACGGCGGGCTGGGCGGCGACTACATCACCTACTGCATCGGCATGGAGGAGCTCGGCCGCGCCGAC
TCCTCGGTGCGCGGCATCGTGTCGGTCTCGATGGGCCTGGTCGGGAAGGTGATCCTCTCCCACGGGACCGAGGAGCAGAA
GCACCGCTGGCTCCCCGGCATCGCGACCGGCCGGACCCTCGCGTGCTTCGGCCTGACCGAGCCCGACAACGGCTCGGACG
CCGCGAACCTGCGGACCCGGGCGGTCCGCGACGGCGACGACTGGGTGCTCAACGGCGCGAAGATCTTCATCACCAACGGC
ACCTGGGCCGACGTCTGCCTGGTCTTCGCCCGCACCGGCGAGCCCGGCCCCCGCGGGGTGTCGGCGTTCCTCGTGCCGAC
CGACCTCCCCGGGTTCGGGCGCCAGGAGATCCACGGCAAGCTCGGGCTGCGCGGCCAGGCCACCGCCGAGCTCTCCTTCG
ACAACGTGCGGGTGCCCGCCGACGCGATGCTCGGCGCGGAGGGCGAGGGCTTCAAGATCGCCATGCACTCGCTGGACAAG
GGCCGCGTCTCGGTGGGTGCCGGGTGCGTCGGCATCATCCAGGGCTGCCTCGAGGCGGTCGTCGACTACTCGGTGCAGCG
CCGGCAGTTCGGCCGTCAGCTGGCCTCCTTCCAGCTGATCCAGGACATGATCGCGGAGATCTCCGTCGAGGCCGACGCGG
CCCGGCTGCTGGTCTGGCGGGCCGCCGACCTGATCGAGCGCGACCAGCCCTTCGGCACCGAGGCCTCCAAGGCGAAGTAC
TTCGCCAGCGAGGCCGCCGTGCGCGCCGCGAACCTGGCGATCCAGGCGTTCGGCGGCTACGGGTACGTCGACGAGTACCC
GGTCCAGAAGTACATGCGCGACGCTCGGGTGATGACGCTGTACGAAGGCACCAGCCAGATCCAGAAGCTGCTCATCGGGC
GCGCCGAGACCGGCGTCAGCGCCTTCCTCTGA

Upstream 100 bases:

>100_bases
CTGCCGACCTCCCCAGCCGCAGCGTGACCGAGCTCGTCGAGCGCGGCCACCTCGGCCGCAAGACCGGCCGCGGCTGGTAC
ACCTACGAAGGAGTCTGACC

Downstream 100 bases:

>100_bases
AAGGGACCGTCATGACCCAGACCCCGCTCGGCCTCTTCGACACCGACTCCCTCGTCGATGCCGAGACCCTGGCCATCCGC
GACACCGTCCGCCGGTTCGT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MDLSLNEDQLSFKKLAREFLDAEVVPYRGEWDRRESVDTAIIPKLGDLGFFGLTIPEEYGGLGGDYITYCIGMEELGRAD
SSVRGIVSVSMGLVGKVILSHGTEEQKHRWLPGIATGRTLACFGLTEPDNGSDAANLRTRAVRDGDDWVLNGAKIFITNG
TWADVCLVFARTGEPGPRGVSAFLVPTDLPGFGRQEIHGKLGLRGQATAELSFDNVRVPADAMLGAEGEGFKIAMHSLDK
GRVSVGAGCVGIIQGCLEAVVDYSVQRRQFGRQLASFQLIQDMIAEISVEADAARLLVWRAADLIERDQPFGTEASKAKY
FASEAAVRAANLAIQAFGGYGYVDEYPVQKYMRDARVMTLYEGTSQIQKLLIGRAETGVSAFL

Sequences:

>Translated_383_residues
MDLSLNEDQLSFKKLAREFLDAEVVPYRGEWDRRESVDTAIIPKLGDLGFFGLTIPEEYGGLGGDYITYCIGMEELGRAD
SSVRGIVSVSMGLVGKVILSHGTEEQKHRWLPGIATGRTLACFGLTEPDNGSDAANLRTRAVRDGDDWVLNGAKIFITNG
TWADVCLVFARTGEPGPRGVSAFLVPTDLPGFGRQEIHGKLGLRGQATAELSFDNVRVPADAMLGAEGEGFKIAMHSLDK
GRVSVGAGCVGIIQGCLEAVVDYSVQRRQFGRQLASFQLIQDMIAEISVEADAARLLVWRAADLIERDQPFGTEASKAKY
FASEAAVRAANLAIQAFGGYGYVDEYPVQKYMRDARVMTLYEGTSQIQKLLIGRAETGVSAFL
>Mature_383_residues
MDLSLNEDQLSFKKLAREFLDAEVVPYRGEWDRRESVDTAIIPKLGDLGFFGLTIPEEYGGLGGDYITYCIGMEELGRAD
SSVRGIVSVSMGLVGKVILSHGTEEQKHRWLPGIATGRTLACFGLTEPDNGSDAANLRTRAVRDGDDWVLNGAKIFITNG
TWADVCLVFARTGEPGPRGVSAFLVPTDLPGFGRQEIHGKLGLRGQATAELSFDNVRVPADAMLGAEGEGFKIAMHSLDK
GRVSVGAGCVGIIQGCLEAVVDYSVQRRQFGRQLASFQLIQDMIAEISVEADAARLLVWRAADLIERDQPFGTEASKAKY
FASEAAVRAANLAIQAFGGYGYVDEYPVQKYMRDARVMTLYEGTSQIQKLLIGRAETGVSAFL

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=42.3592493297587, Blast_Score=304, Evalue=1e-82,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=37.8016085790885, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI4501857, Length=366, Percent_Identity=36.8852459016393, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=35.8090185676393, Blast_Score=244, Evalue=9e-65,
Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=32.7127659574468, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI21361497, Length=353, Percent_Identity=36.8271954674221, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=36.1256544502618, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=36.1256544502618, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI226958414, Length=335, Percent_Identity=34.0298507462687, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4557235, Length=382, Percent_Identity=35.8638743455497, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI76496475, Length=382, Percent_Identity=35.8638743455497, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI4503943, Length=385, Percent_Identity=33.5064935064935, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=32.3287671232877, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI48976061, Length=293, Percent_Identity=30.7167235494881, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI211971008, Length=294, Percent_Identity=31.2925170068027, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI38505218, Length=393, Percent_Identity=27.2264631043257, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1786223, Length=377, Percent_Identity=30.7692307692308, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87081958, Length=378, Percent_Identity=29.1005291005291, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87081702, Length=276, Percent_Identity=27.536231884058, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082384, Length=277, Percent_Identity=27.4368231046931, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=39.0835579514825, Blast_Score=270, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=37.9581151832461, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=38.1720430107527, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=34.1333333333333, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17534899, Length=378, Percent_Identity=36.7724867724868, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=35.2631578947368, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71985184, Length=349, Percent_Identity=35.8166189111748, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17533517, Length=362, Percent_Identity=32.5966850828729, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71990804, Length=304, Percent_Identity=38.4868421052632, Blast_Score=218, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI17534353, Length=384, Percent_Identity=32.2916666666667, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71985192, Length=283, Percent_Identity=36.7491166077738, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=40.2597402597403, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=34.3065693430657, Blast_Score=167, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=28.6472148541114, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=28.3422459893048, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=239, Percent_Identity=35.1464435146443, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17562446, Length=400, Percent_Identity=28, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17531913, Length=168, Percent_Identity=33.9285714285714, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI86563383, Length=282, Percent_Identity=28.0141843971631, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=282, Percent_Identity=28.0141843971631, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356377, Length=370, Percent_Identity=42.1621621621622, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=42.0911528150134, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=36.9272237196765, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=38.7862796833773, Blast_Score=257, Evalue=7e-69,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=35.4666666666667, Blast_Score=241, Evalue=4e-64,
Organism=Drosophila melanogaster, GI281363737, Length=363, Percent_Identity=35.2617079889807, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI19920834, Length=392, Percent_Identity=34.9489795918367, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24652780, Length=335, Percent_Identity=24.4776119402985, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI281365206, Length=376, Percent_Identity=25.7978723404255, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24585193, Length=376, Percent_Identity=25.7978723404255, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24585195, Length=376, Percent_Identity=25.7978723404255, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24585191, Length=376, Percent_Identity=25.7978723404255, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 41560; Mature: 41560

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSLNEDQLSFKKLAREFLDAEVVPYRGEWDRRESVDTAIIPKLGDLGFFGLTIPEEYG
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCHHHCCCCCCCCEEEEECCHHHC
GLGGDYITYCIGMEELGRADSSVRGIVSVSMGLVGKVILSHGTEEQKHRWLPGIATGRTL
CCCCCHHHEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEE
ACFGLTEPDNGSDAANLRTRAVRDGDDWVLNGAKIFITNGTWADVCLVFARTGEPGPRGV
EEEECCCCCCCCCHHHHHHHHCCCCCCEEEECEEEEEECCCHHHHHEEEEECCCCCCCCE
SAFLVPTDLPGFGRQEIHGKLGLRGQATAELSFDNVRVPADAMLGAEGEGFKIAMHSLDK
EEEEEECCCCCCCCHHHHHCCCCCCCCEEEEECCCEECCHHHHCCCCCCCEEEEEECCCC
GRVSVGAGCVGIIQGCLEAVVDYSVQRRQFGRQLASFQLIQDMIAEISVEADAARLLVWR
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AADLIERDQPFGTEASKAKYFASEAAVRAANLAIQAFGGYGYVDEYPVQKYMRDARVMTL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHCEEEEE
YEGTSQIQKLLIGRAETGVSAFL
ECCHHHHHHHHHCCCCCCHHHCC
>Mature Secondary Structure
MDLSLNEDQLSFKKLAREFLDAEVVPYRGEWDRRESVDTAIIPKLGDLGFFGLTIPEEYG
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCHHHCCCCCCCCEEEEECCHHHC
GLGGDYITYCIGMEELGRADSSVRGIVSVSMGLVGKVILSHGTEEQKHRWLPGIATGRTL
CCCCCHHHEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEE
ACFGLTEPDNGSDAANLRTRAVRDGDDWVLNGAKIFITNGTWADVCLVFARTGEPGPRGV
EEEECCCCCCCCCHHHHHHHHCCCCCCEEEECEEEEEECCCHHHHHEEEEECCCCCCCCE
SAFLVPTDLPGFGRQEIHGKLGLRGQATAELSFDNVRVPADAMLGAEGEGFKIAMHSLDK
EEEEEECCCCCCCCHHHHHCCCCCCCCEEEEECCCEECCHHHHCCCCCCCEEEEEECCCC
GRVSVGAGCVGIIQGCLEAVVDYSVQRRQFGRQLASFQLIQDMIAEISVEADAARLLVWR
CCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AADLIERDQPFGTEASKAKYFASEAAVRAANLAIQAFGGYGYVDEYPVQKYMRDARVMTL
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCHHHHHHHHCEEEEE
YEGTSQIQKLLIGRAETGVSAFL
ECCHHHHHHHHHCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]