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The map label for this gene is lutR [H]

Identifier: 119718282

GI number: 119718282

Start: 4289939

End: 4290667

Strand: Reverse

Name: lutR [H]

Synonym: Noca_4063

Alternate gene names: 119718282

Gene position: 4290667-4289939 (Counterclockwise)

Preceding gene: 119718294

Following gene: 119718281

Centisome position: 86.06

GC content: 71.19

Gene sequence:

>729_bases
GTGACCGGTCTGGACGCGGCAGCCGAGCGACGCCGGCTCCTCGTGGAGCGGGTCCAGCCCGCGTATCGACAGGTCGCCGA
CCAGCTGCGCTCGCTGATCGTCGGGGGGCAGCTCGCGCCCGGCGACCGGCTCCCCTCCGAGGCCGAGCTCTCGGACCTGT
TCGGGGTAAGCAGGAGCACCGTGCGGGAGGCGTTGCGCGCGTTGTCCTCCCGTGATCTCGTGATCACCACCCGCGGGTCC
ACGGGGGGCAGCTTCGTCGCCCATGTGCGGCCGAGCAGCGTGGCCGACTACCTCGAGGCGAGCATCGGCCTGATGAGTGG
GCACCATCTCAGCGTCGAGGAGATCCTCGAGGCGCGCGAGCTGCTCGAGGTCCCTGCAGCCGGCCTCGCCGCGGACCGGC
GCACCGAGCAGCACGTGCGGCGGCTCCAGGAGGCCCTGGAGTCCGAGGGGGAGATCCGTGAGCGCGGGCCGCTGTTCACC
GAGCACCGGCACTTCCATGTCGTCGTGCTGGAGACCGCTCAGAACGGACTCCTCGGACTGATGACCGAACCCGTCTTCCG
GGTGCTGCAGGAGCGTCTCACCCGGCCGGGGCTGGGCGAGGACGTGTGGCATCGGGTCGATTCCGACCATGCCGACATCG
CCGAGCGCATCATCGCGGGTGACCCCGACGGCGCACGCGAGACGATGCGCGCGCACCTGCGGCGTCTGCGCGACATCTAC
CTGGCCTGA

Upstream 100 bases:

>100_bases
TGAAACACCGTTCCGATAATGTTAGGACGGAAGGATCCGGAGGACCAGCCGGCCGCCGGGCGCCGTCGATCTCGCCTGGC
GCATATGTCAGACTGATGCC

Downstream 100 bases:

>100_bases
CCGGACGCTCGACCAAGCATCGTCCGCCGTCACCGATCACTCGAAGGAGCGAGCCCGTGTCCGAGTTCCCTTTGTTCGCG
CTGTCTGAGGAGCACCAGGC

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: L-lactate utilization operon repressor [H]

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTGLDAAAERRRLLVERVQPAYRQVADQLRSLIVGGQLAPGDRLPSEAELSDLFGVSRSTVREALRALSSRDLVITTRGS
TGGSFVAHVRPSSVADYLEASIGLMSGHHLSVEEILEARELLEVPAAGLAADRRTEQHVRRLQEALESEGEIRERGPLFT
EHRHFHVVVLETAQNGLLGLMTEPVFRVLQERLTRPGLGEDVWHRVDSDHADIAERIIAGDPDGARETMRAHLRRLRDIY
LA

Sequences:

>Translated_242_residues
MTGLDAAAERRRLLVERVQPAYRQVADQLRSLIVGGQLAPGDRLPSEAELSDLFGVSRSTVREALRALSSRDLVITTRGS
TGGSFVAHVRPSSVADYLEASIGLMSGHHLSVEEILEARELLEVPAAGLAADRRTEQHVRRLQEALESEGEIRERGPLFT
EHRHFHVVVLETAQNGLLGLMTEPVFRVLQERLTRPGLGEDVWHRVDSDHADIAERIIAGDPDGARETMRAHLRRLRDIY
LA
>Mature_241_residues
TGLDAAAERRRLLVERVQPAYRQVADQLRSLIVGGQLAPGDRLPSEAELSDLFGVSRSTVREALRALSSRDLVITTRGST
GGSFVAHVRPSSVADYLEASIGLMSGHHLSVEEILEARELLEVPAAGLAADRRTEQHVRRLQEALESEGEIRERGPLFTE
HRHFHVVVLETAQNGLLGLMTEPVFRVLQERLTRPGLGEDVWHRVDSDHADIAERIIAGDPDGARETMRAHLRRLRDIYL
A

Specific function: Negatively regulates the transcription of the lutABC operon, which is required for L-lactate utilization. LutR activity is regulated by lactate, since presence of L-lactate, that probably binds to lutR, leads to derepression of the operon. Also appears to

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=234, Percent_Identity=32.4786324786325, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790032, Length=225, Percent_Identity=31.1111111111111, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790780, Length=230, Percent_Identity=30, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1786950, Length=203, Percent_Identity=29.5566502463054, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082208, Length=228, Percent_Identity=28.9473684210526, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789353, Length=233, Percent_Identity=29.1845493562232, Blast_Score=60, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 26880; Mature: 26749

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGLDAAAERRRLLVERVQPAYRQVADQLRSLIVGGQLAPGDRLPSEAELSDLFGVSRST
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHH
VREALRALSSRDLVITTRGSTGGSFVAHVRPSSVADYLEASIGLMSGHHLSVEEILEARE
HHHHHHHHCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LLEVPAAGLAADRRTEQHVRRLQEALESEGEIRERGPLFTEHRHFHVVVLETAQNGLLGL
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHH
MTEPVFRVLQERLTRPGLGEDVWHRVDSDHADIAERIIAGDPDGARETMRAHLRRLRDIY
HHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LA
CC
>Mature Secondary Structure 
TGLDAAAERRRLLVERVQPAYRQVADQLRSLIVGGQLAPGDRLPSEAELSDLFGVSRST
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHH
VREALRALSSRDLVITTRGSTGGSFVAHVRPSSVADYLEASIGLMSGHHLSVEEILEARE
HHHHHHHHCCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LLEVPAAGLAADRRTEQHVRRLQEALESEGEIRERGPLFTEHRHFHVVVLETAQNGLLGL
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHH
MTEPVFRVLQERLTRPGLGEDVWHRVDSDHADIAERIIAGDPDGARETMRAHLRRLRDIY
HHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]