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The map label for this gene is tdh [H]

Identifier: 119717979

GI number: 119717979

Start: 3978036

End: 3979076

Strand: Reverse

Name: tdh [H]

Synonym: Noca_3757

Alternate gene names: 119717979

Gene position: 3979076-3978036 (Counterclockwise)

Preceding gene: 119717980

Following gene: 119717978

Centisome position: 79.81

GC content: 71.57

Gene sequence:

>1041_bases
GTGCGTGCTCTCGTGAAGACGACCGCCGGACCCGGGCTCGAGCTCATCGACGTGCCCGAGCCGGCCTGTGGTGACCGCGA
CGTGAAGATCCGGGTGCTGAGAGCGGGCCTCTGCGGCACCGACCTGCACCTGCTGTCCTGGGACGACTGGGCGGCCGCGA
CGGTGCAGGCGCCGATGACGATCGGCCACGAGTTCTTCGGGGAGGTCGTCGAGGTCGGCGCGGACGTCGACCACGTCTCG
GTCGGCGACCGGGTCTCCGGCGAGGGACACATCGTGTGCGGGGCCTGCCGCAACTGCCGGGCCGGGCGGCGCCAGCTGTG
CATCAACACCGTCGGCGTCGGGGTCAACCGGGACGGCGCGTTCGCCGACTACGTCGTCATCCCGGCGGCCAACGCCTGGG
TCCAGCCGGCCGACCTCGACCCGGACCTGGGTGCGCTGTTCGACCCGCTCGGCAACGCCACCCACACCGCCCTCCAGTGG
CCGGTGGTGGGGGAGGACGTCGTCATTACGGGGGCCGGCCCGATCGGGATCATGGCGACCGCGATCGTGCGGCACGCGGG
CGCCCGGCGGATCGCGGTCACCGACCTCAGCCCCGAGCGGCTGGAGCTGGCGGCAAGCGCGGGCGCCGACCTCACCGTCG
ACGTCTCCCAGGGCCAGGACCTGGCCTGGGCACAGCGGCAGCTCGGCATGCTCGAGGGCTTCGACATCGGCCTGGAGATG
TCGGGTGCTCCCGACGCCGTGCGCGACATGCTCGAGAACCTCAACCACGGGGCCCGGGTCGCGATGCTGGGCCTGCCGCG
GTCGGCGTACGAGATCGACTGGGGCAAGGTGATCACGCACATGATCACGCTGCGCGGGATCTATGGCCGCGAGATGTTCG
AGACGTGGTACCTGATGGGCTCGATGCTGGCGACCACGCCGGCGCTGCGGGACGCCGTACAGTCCGTGATCACGTGGCGT
GGCCCGGCGGAGGACTGGGAGGAAGCCTTCGAGCACACCCGGTCCGGCACCGCCGGCAAGGCCGTCCTGGATTGGAGCTG
A

Upstream 100 bases:

>100_bases
CAGAAGGCCGGCGACCCGGTGGTGCGGACCGTGACCGTCGGGGACGGGTGATGCCCGGGCCGGGCCCGCGGGGCTGGACA
GGAGTGGGCAGGATGGGCAC

Downstream 100 bases:

>100_bases
GATGTACGGCGACGTGAAGCAGCAGCTGGCCCAGACCCTTGCGGAGATCGAGAGCGCGGGGCTCTACAAGCGCGAGCGCG
AGATCACCACGCCACAGGCG

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MRALVKTTAGPGLELIDVPEPACGDRDVKIRVLRAGLCGTDLHLLSWDDWAAATVQAPMTIGHEFFGEVVEVGADVDHVS
VGDRVSGEGHIVCGACRNCRAGRRQLCINTVGVGVNRDGAFADYVVIPAANAWVQPADLDPDLGALFDPLGNATHTALQW
PVVGEDVVITGAGPIGIMATAIVRHAGARRIAVTDLSPERLELAASAGADLTVDVSQGQDLAWAQRQLGMLEGFDIGLEM
SGAPDAVRDMLENLNHGARVAMLGLPRSAYEIDWGKVITHMITLRGIYGREMFETWYLMGSMLATTPALRDAVQSVITWR
GPAEDWEEAFEHTRSGTAGKAVLDWS

Sequences:

>Translated_346_residues
MRALVKTTAGPGLELIDVPEPACGDRDVKIRVLRAGLCGTDLHLLSWDDWAAATVQAPMTIGHEFFGEVVEVGADVDHVS
VGDRVSGEGHIVCGACRNCRAGRRQLCINTVGVGVNRDGAFADYVVIPAANAWVQPADLDPDLGALFDPLGNATHTALQW
PVVGEDVVITGAGPIGIMATAIVRHAGARRIAVTDLSPERLELAASAGADLTVDVSQGQDLAWAQRQLGMLEGFDIGLEM
SGAPDAVRDMLENLNHGARVAMLGLPRSAYEIDWGKVITHMITLRGIYGREMFETWYLMGSMLATTPALRDAVQSVITWR
GPAEDWEEAFEHTRSGTAGKAVLDWS
>Mature_346_residues
MRALVKTTAGPGLELIDVPEPACGDRDVKIRVLRAGLCGTDLHLLSWDDWAAATVQAPMTIGHEFFGEVVEVGADVDHVS
VGDRVSGEGHIVCGACRNCRAGRRQLCINTVGVGVNRDGAFADYVVIPAANAWVQPADLDPDLGALFDPLGNATHTALQW
PVVGEDVVITGAGPIGIMATAIVRHAGARRIAVTDLSPERLELAASAGADLTVDVSQGQDLAWAQRQLGMLEGFDIGLEM
SGAPDAVRDMLENLNHGARVAMLGLPRSAYEIDWGKVITHMITLRGIYGREMFETWYLMGSMLATTPALRDAVQSVITWR
GPAEDWEEAFEHTRSGTAGKAVLDWS

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=343, Percent_Identity=29.7376093294461, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=25.2717391304348, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=25.2717391304348, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4501933, Length=367, Percent_Identity=23.9782016348774, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI34577061, Length=353, Percent_Identity=24.0793201133144, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1790045, Length=345, Percent_Identity=51.304347826087, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1787863, Length=278, Percent_Identity=29.136690647482, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1788075, Length=365, Percent_Identity=28.4931506849315, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788407, Length=334, Percent_Identity=28.7425149700599, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790718, Length=265, Percent_Identity=29.4339622641509, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788073, Length=328, Percent_Identity=27.4390243902439, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI226510992, Length=316, Percent_Identity=27.5316455696203, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082125, Length=355, Percent_Identity=27.887323943662, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1786825, Length=254, Percent_Identity=32.6771653543307, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081918, Length=324, Percent_Identity=26.2345679012346, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786552, Length=305, Percent_Identity=30.4918032786885, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=289, Percent_Identity=26.2975778546713, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=338, Percent_Identity=29.2899408284024, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17562878, Length=205, Percent_Identity=34.6341463414634, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71988145, Length=197, Percent_Identity=29.9492385786802, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=291, Percent_Identity=26.4604810996564, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=299, Percent_Identity=26.0869565217391, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=323, Percent_Identity=27.8637770897833, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323099, Length=333, Percent_Identity=28.2282282282282, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6319955, Length=323, Percent_Identity=27.5541795665635, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=270, Percent_Identity=29.2592592592593, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=25.3369272237197, Blast_Score=76, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=237, Percent_Identity=28.6919831223629, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=367, Percent_Identity=26.4305177111717, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=227, Percent_Identity=29.9559471365639, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=294, Percent_Identity=26.8707482993197, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=279, Percent_Identity=27.2401433691756, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737897, Length=331, Percent_Identity=28.7009063444109, Blast_Score=115, Evalue=4e-26,
Organism=Drosophila melanogaster, GI17137530, Length=330, Percent_Identity=28.1818181818182, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI221457811, Length=194, Percent_Identity=26.8041237113402, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550770, Length=194, Percent_Identity=26.8041237113402, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45551930, Length=194, Percent_Identity=26.8041237113402, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 36999; Mature: 36999

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALVKTTAGPGLELIDVPEPACGDRDVKIRVLRAGLCGTDLHLLSWDDWAAATVQAPMT
CCCEEECCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCHHEEECCHH
IGHEFFGEVVEVGADVDHVSVGDRVSGEGHIVCGACRNCRAGRRQLCINTVGVGVNRDGA
HHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEECCCCCCCCCHHEEEEEEECCCCCCCCC
FADYVVIPAANAWVQPADLDPDLGALFDPLGNATHTALQWPVVGEDVVITGAGPIGIMAT
EEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCEEECCCCCCCEEEECCCHHHHHHH
AIVRHAGARRIAVTDLSPERLELAASAGADLTVDVSQGQDLAWAQRQLGMLEGFDIGLEM
HHHHHCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCEEE
SGAPDAVRDMLENLNHGARVAMLGLPRSAYEIDWGKVITHMITLRGIYGREMFETWYLMG
CCCCHHHHHHHHHCCCCCEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMLATTPALRDAVQSVITWRGPAEDWEEAFEHTRSGTAGKAVLDWS
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MRALVKTTAGPGLELIDVPEPACGDRDVKIRVLRAGLCGTDLHLLSWDDWAAATVQAPMT
CCCEEECCCCCCEEEEECCCCCCCCCCEEEEEEEECCCCCCEEEEECCCCCHHEEECCHH
IGHEFFGEVVEVGADVDHVSVGDRVSGEGHIVCGACRNCRAGRRQLCINTVGVGVNRDGA
HHHHHHHHHHHHCCCCCEECCCCCCCCCCCEEECCCCCCCCCHHEEEEEEECCCCCCCCC
FADYVVIPAANAWVQPADLDPDLGALFDPLGNATHTALQWPVVGEDVVITGAGPIGIMAT
EEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCEEECCCCCCCEEEECCCHHHHHHH
AIVRHAGARRIAVTDLSPERLELAASAGADLTVDVSQGQDLAWAQRQLGMLEGFDIGLEM
HHHHHCCCCEEEEECCCHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCCEEE
SGAPDAVRDMLENLNHGARVAMLGLPRSAYEIDWGKVITHMITLRGIYGREMFETWYLMG
CCCCHHHHHHHHHCCCCCEEEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMLATTPALRDAVQSVITWRGPAEDWEEAFEHTRSGTAGKAVLDWS
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA