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The map label for this gene is kbl [C]

Identifier: 119717978

GI number: 119717978

Start: 3976841

End: 3978034

Strand: Reverse

Name: kbl [C]

Synonym: Noca_3756

Alternate gene names: 119717978

Gene position: 3978034-3976841 (Counterclockwise)

Preceding gene: 119717979

Following gene: 119717975

Centisome position: 79.79

GC content: 70.35

Gene sequence:

>1194_bases
ATGTACGGCGACGTGAAGCAGCAGCTGGCCCAGACCCTTGCGGAGATCGAGAGCGCGGGGCTCTACAAGCGCGAGCGCGA
GATCACCACGCCACAGGCGGCGCACATCGCGACCACCGCGGGCGAGGCGCTGAACTTCTGCGCGAACAACTACCTCGGGT
TCTCCGACCACCCCGACGTGATCGCGGCCAGCAAGGCGGCGCTGGACACCTGGGGCTTCGGGATGAGCTCGGTGCGGTTC
ATCTGCGGCACCCAGACCCAGCACACGGAGCTGGAGCGGCGGCTCTCGGAGTTCCTGCACACCGAGGCGACGATCCTCTA
CAGCTCCTGCTTCGACGCCAACGGCGGCGTCTTCGAGGTGCTGTGCGGTGAGGAGGACGCGATCGTCTCCGACGAGCTCA
ACCACGCCTCGATCATCGACGGCATCCGGCTGAGCAAGGCGGCGCGGTATCGCTACAAGAACGCCGACCTGGCCGATCTG
CGCGACCAGCTGGTCGCGGCCCGCGAAGCCGGCGCACGGCGGGTGCTGATCGCGACCGACGGCGTGTTCTCGATGGACGG
CAGCTTCGCGCCGCTGTCGGAGATCTGCGACCTGGCCGACGAGTTCTCCGCCCTCGTGCTGGTCGACGACTCCCACGCCG
TGGGGTTCGTGGGTCCTGGCGGGCGCGGCACGCCGGAGCTGTTCGGGGTGCTGGACCGGGTCGACATCATCACCGGCACC
CTGGGCAAGGCGCTCGGCGGTGCGTCGGGCGGCTACGTCGCCTCCCACCAGGAGATCGTGGACCTGCTGCGGCAGCGCTC
GCGGCCCTACCTGTTCTCGAACTCGGTCGCACCCGGCGTCGTCGCCGGTTCGCTCGCGGCCCTGGACCTGGTGACCTCCT
CGAGCGAGGCGCGCGACACCCTTGAGGAGAACAGCGCGCTGTTCCGGTCGCTGATGACCGAGGCCGGCTTCTCGCTGCTG
CCCGGCACGCACCCGATCACGCCGGTGATGTTCCCCGGCGAGGACGGCGCCCGGCTCGCCACCGCCATCGCGGACGACAT
GCTCGCCCAGGGTGTCTACGTGATCGCGTTCTCGTTCCCGGTGGTGCCGCGGGGCAAGGCCCGGATCCGGGTCCAGCTCT
CGGCCGCGCACTCGGAGGATGACGTCCGCCGCTGCGTGGCGGCGTTCGTCGCGGCCCGGGACGCCCAGGCCTGA

Upstream 100 bases:

>100_bases
TCCGTGATCACGTGGCGTGGCCCGGCGGAGGACTGGGAGGAAGCCTTCGAGCACACCCGGTCCGGCACCGCCGGCAAGGC
CGTCCTGGATTGGAGCTGAG

Downstream 100 bases:

>100_bases
AGCCGCCCAGGCCTGAAGCCGCCGAGGCTCAGCTCAGTCCGCTTCCCAGTGCTCGCCGGAGAAGGCGAGCCCGCGGTGCG
GCCGGGTGGTGCGGTAGTAG

Product: 2-amino-3-ketobutyrate coenzyme A ligase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MYGDVKQQLAQTLAEIESAGLYKREREITTPQAAHIATTAGEALNFCANNYLGFSDHPDVIAASKAALDTWGFGMSSVRF
ICGTQTQHTELERRLSEFLHTEATILYSSCFDANGGVFEVLCGEEDAIVSDELNHASIIDGIRLSKAARYRYKNADLADL
RDQLVAAREAGARRVLIATDGVFSMDGSFAPLSEICDLADEFSALVLVDDSHAVGFVGPGGRGTPELFGVLDRVDIITGT
LGKALGGASGGYVASHQEIVDLLRQRSRPYLFSNSVAPGVVAGSLAALDLVTSSSEARDTLEENSALFRSLMTEAGFSLL
PGTHPITPVMFPGEDGARLATAIADDMLAQGVYVIAFSFPVVPRGKARIRVQLSAAHSEDDVRRCVAAFVAARDAQA

Sequences:

>Translated_397_residues
MYGDVKQQLAQTLAEIESAGLYKREREITTPQAAHIATTAGEALNFCANNYLGFSDHPDVIAASKAALDTWGFGMSSVRF
ICGTQTQHTELERRLSEFLHTEATILYSSCFDANGGVFEVLCGEEDAIVSDELNHASIIDGIRLSKAARYRYKNADLADL
RDQLVAAREAGARRVLIATDGVFSMDGSFAPLSEICDLADEFSALVLVDDSHAVGFVGPGGRGTPELFGVLDRVDIITGT
LGKALGGASGGYVASHQEIVDLLRQRSRPYLFSNSVAPGVVAGSLAALDLVTSSSEARDTLEENSALFRSLMTEAGFSLL
PGTHPITPVMFPGEDGARLATAIADDMLAQGVYVIAFSFPVVPRGKARIRVQLSAAHSEDDVRRCVAAFVAARDAQA
>Mature_397_residues
MYGDVKQQLAQTLAEIESAGLYKREREITTPQAAHIATTAGEALNFCANNYLGFSDHPDVIAASKAALDTWGFGMSSVRF
ICGTQTQHTELERRLSEFLHTEATILYSSCFDANGGVFEVLCGEEDAIVSDELNHASIIDGIRLSKAARYRYKNADLADL
RDQLVAAREAGARRVLIATDGVFSMDGSFAPLSEICDLADEFSALVLVDDSHAVGFVGPGGRGTPELFGVLDRVDIITGT
LGKALGGASGGYVASHQEIVDLLRQRSRPYLFSNSVAPGVVAGSLAALDLVTSSSEARDTLEENSALFRSLMTEAGFSLL
PGTHPITPVMFPGEDGARLATAIADDMLAQGVYVIAFSFPVVPRGKARIRVQLSAAHSEDDVRRCVAAFVAARDAQA

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=384, Percent_Identity=56.5104166666667, Blast_Score=426, Evalue=1e-119,
Organism=Homo sapiens, GI284448556, Length=407, Percent_Identity=53.3169533169533, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI83977442, Length=357, Percent_Identity=36.1344537815126, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI83977440, Length=357, Percent_Identity=36.1344537815126, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI83977444, Length=357, Percent_Identity=36.1344537815126, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI4502025, Length=340, Percent_Identity=36.1764705882353, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI40316939, Length=340, Percent_Identity=36.1764705882353, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI4758668, Length=356, Percent_Identity=32.3033707865169, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI119220554, Length=358, Percent_Identity=32.122905027933, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI5454084, Length=298, Percent_Identity=28.1879194630872, Blast_Score=122, Evalue=7e-28,
Organism=Escherichia coli, GI1790046, Length=390, Percent_Identity=59.2307692307692, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1786993, Length=347, Percent_Identity=32.5648414985591, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=386, Percent_Identity=54.4041450777202, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI32566772, Length=365, Percent_Identity=30.1369863013699, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560912, Length=363, Percent_Identity=28.9256198347107, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17560914, Length=363, Percent_Identity=28.6501377410468, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI71982625, Length=368, Percent_Identity=22.8260869565217, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71982617, Length=368, Percent_Identity=22.8260869565217, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320438, Length=371, Percent_Identity=33.6927223719677, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6320267, Length=358, Percent_Identity=28.4916201117318, Blast_Score=160, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=292, Percent_Identity=28.4246575342466, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24662918, Length=389, Percent_Identity=53.2133676092545, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI17137420, Length=341, Percent_Identity=34.3108504398827, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17136286, Length=365, Percent_Identity=29.8630136986301, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24653280, Length=381, Percent_Identity=26.7716535433071, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24653276, Length=381, Percent_Identity=26.7716535433071, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24653278, Length=381, Percent_Identity=26.7716535433071, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011282
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 42311; Mature: 42311

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGDVKQQLAQTLAEIESAGLYKREREITTPQAAHIATTAGEALNFCANNYLGFSDHPDV
CCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
IAASKAALDTWGFGMSSVRFICGTQTQHTELERRLSEFLHTEATILYSSCFDANGGVFEV
EEHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LCGEEDAIVSDELNHASIIDGIRLSKAARYRYKNADLADLRDQLVAAREAGARRVLIATD
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEC
GVFSMDGSFAPLSEICDLADEFSALVLVDDSHAVGFVGPGGRGTPELFGVLDRVDIITGT
CEEECCCCCCCHHHHHHHHHCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGKALGGASGGYVASHQEIVDLLRQRSRPYLFSNSVAPGVVAGSLAALDLVTSSSEARDT
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHH
LEENSALFRSLMTEAGFSLLPGTHPITPVMFPGEDGARLATAIADDMLAQGVYVIAFSFP
HHHHHHHHHHHHHHCCCEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEEEECC
VVPRGKARIRVQLSAAHSEDDVRRCVAAFVAARDAQA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MYGDVKQQLAQTLAEIESAGLYKREREITTPQAAHIATTAGEALNFCANNYLGFSDHPDV
CCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
IAASKAALDTWGFGMSSVRFICGTQTQHTELERRLSEFLHTEATILYSSCFDANGGVFEV
EEHHHHHHHHHCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LCGEEDAIVSDELNHASIIDGIRLSKAARYRYKNADLADLRDQLVAAREAGARRVLIATD
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEEC
GVFSMDGSFAPLSEICDLADEFSALVLVDDSHAVGFVGPGGRGTPELFGVLDRVDIITGT
CEEECCCCCCCHHHHHHHHHCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
LGKALGGASGGYVASHQEIVDLLRQRSRPYLFSNSVAPGVVAGSLAALDLVTSSSEARDT
HHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHHHHH
LEENSALFRSLMTEAGFSLLPGTHPITPVMFPGEDGARLATAIADDMLAQGVYVIAFSFP
HHHHHHHHHHHHHHCCCEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEEEECC
VVPRGKARIRVQLSAAHSEDDVRRCVAAFVAARDAQA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]