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The map label for this gene is lrp [H]

Identifier: 119717880

GI number: 119717880

Start: 3884110

End: 3884559

Strand: Reverse

Name: lrp [H]

Synonym: Noca_3658

Alternate gene names: 119717880

Gene position: 3884559-3884110 (Counterclockwise)

Preceding gene: 119717882

Following gene: 119717879

Centisome position: 77.91

GC content: 63.33

Gene sequence:

>450_bases
ATGGACCGTACAGATCGCGCAATCATCGAGCACCTGCGTCGGGACGCTCACCTCACAAACACGGAACTTGCCGACCTAGT
AGGACTTACGCCGTCCCCGTGTCTGCGCCGGGTCCGCCGCCTGGAGGCCGAAGGGGTCATCCTCGGCTACCACGCCAGGA
TCAACCCGGCTGCGGTCGGCCGAGCGTTCGAGGTCCATGTCGAGTTCGAACTGGCCAACCAGGCCAAGGCCACGGTCAAG
GACTTCGAGTCCGGCCTGATCGCCTTCGACGAAGTAATCGAGGCACGCCGCATGTTCGGGCAGCCCGACTACCTCGCGCT
GGTGGCGGTAGCCGACCTGCATGCCTACGAGGTCTTCATGACTGAAGAGTTGATGGCGCTGCCGGGGATGGGACGCCTCC
AATCGCGCTTCGCCATGAAGACCATCAAGAGCGAGCTGGCCTCCACTTGA

Upstream 100 bases:

>100_bases
TCCATCGTTCCGGGTGGTGCAGCAGCAACGCTAGGGCGAAAGCCGTGACGACCGATTGCGAACATTGCAGTCGTTCGCCT
CGCCGGCGCACTATTCCGCT

Downstream 100 bases:

>100_bases
CCAGTCGTGGCCGCACGAATCTCGGCATGAGAGCGCGTAGGGACTTCCACGGCTGGAGGGGTCCGAGAAGTGGGACACAC
CCGTAAGAGGGTGGCCGATC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MDRTDRAIIEHLRRDAHLTNTELADLVGLTPSPCLRRVRRLEAEGVILGYHARINPAAVGRAFEVHVEFELANQAKATVK
DFESGLIAFDEVIEARRMFGQPDYLALVAVADLHAYEVFMTEELMALPGMGRLQSRFAMKTIKSELAST

Sequences:

>Translated_149_residues
MDRTDRAIIEHLRRDAHLTNTELADLVGLTPSPCLRRVRRLEAEGVILGYHARINPAAVGRAFEVHVEFELANQAKATVK
DFESGLIAFDEVIEARRMFGQPDYLALVAVADLHAYEVFMTEELMALPGMGRLQSRFAMKTIKSELAST
>Mature_149_residues
MDRTDRAIIEHLRRDAHLTNTELADLVGLTPSPCLRRVRRLEAEGVILGYHARINPAAVGRAFEVHVEFELANQAKATVK
DFESGLIAFDEVIEARRMFGQPDYLALVAVADLHAYEVFMTEELMALPGMGRLQSRFAMKTIKSELAST

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=144, Percent_Identity=36.8055555555556, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI87081742, Length=143, Percent_Identity=32.1678321678322, Blast_Score=89, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 16682; Mature: 16682

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRTDRAIIEHLRRDAHLTNTELADLVGLTPSPCLRRVRRLEAEGVILGYHARINPAAVG
CCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHC
RAFEVHVEFELANQAKATVKDFESGLIAFDEVIEARRMFGQPDYLALVAVADLHAYEVFM
CEEEEEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TEELMALPGMGRLQSRFAMKTIKSELAST
HHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDRTDRAIIEHLRRDAHLTNTELADLVGLTPSPCLRRVRRLEAEGVILGYHARINPAAVG
CCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHC
RAFEVHVEFELANQAKATVKDFESGLIAFDEVIEARRMFGQPDYLALVAVADLHAYEVFM
CEEEEEEEEEECCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TEELMALPGMGRLQSRFAMKTIKSELAST
HHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]