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The map label for this gene is purH

Identifier: 119717805

GI number: 119717805

Start: 3800072

End: 3801649

Strand: Reverse

Name: purH

Synonym: Noca_3583

Alternate gene names: 119717805

Gene position: 3801649-3800072 (Counterclockwise)

Preceding gene: 119717806

Following gene: 119717804

Centisome position: 76.25

GC content: 72.5

Gene sequence:

>1578_bases
GTGTCCGAACCCGTGTCCACGCCCGAGCACCGCATCCCGATCCGCCGCGCCCTCGTCTCCGTCTACGACAAGACCGACCT
CGAGGACCTGGTCCGCGGCCTGCACGACGCCGGCGTCGAGCTGGTGTCGACGGGCGGCTCAGCGAAGCTGATCGAGGGCC
TGGGCCTCCCGGTCACCAAGGTCGAGGACCTGACCGGCTTCCCGGAGTGCCTCGACGGCCGGGTCAAGACGCTGCACCCG
CGCGTGCACGCGGGGATCCTCGCCGACCGGCGCCTGGACTCCCACGTCCAGCAGCTCGCCGACCTCGGGGTGGAGCCGTT
CGACCTGGTGGTCTCCAACCTCTACCCGTTCCGCGAGACCGTCGCGTCGGGCGCCACGCCCGACGAGTGCGTGGAGCAGA
TCGACATCGGCGGGCCCTCGATGGTCCGGGCCGCCGCCAAGAACCACCCGTCCGTGGCGATCGTGACCTCGCCGGAGCGG
TACGCCGACGTGCTGGCGGCCGTCGCCGCAGGCGGGTTCACCCTCGAGCAGCGCAAGGTGCTGGCAGCCGAGGCGTTCAC
CCACACCGCGGCCTACGACGTCGCGGTCGCGGGCTGGTTCGCCTCGACGTACGTGCCGGCCGAGGACGGCTGGCCCGAGT
TCGCCGGGGAGACCTGGCAGAAGGCCGCCGTGCTGCGGTACGGCGAGAACCCGCACCAGGACGCCGCCCTCTACACCGAT
TCGTCAGGGGGCGGCGGTCTGGCCGGGGCCGAGCAGCTGCACGGCAAGGAGATGTCCTACAACAACTACGTCGACACCGA
CGCGGCGCGGCGCGCGGCGTACGACTTCGACGAGCCTGCCGTCGCGATCATCAAGCACGCCAACCCGTGTGGCATCGCCG
TCGGCGCCGACGTCGCCGAGGCCCACCGCCGCGCCCACGAGTGCGACCCGGTCAGCGCCTTCGGCGGCGTGATCGCGGTC
AACCGGCCCGTCTCGGTCGAGATGGCCCGCCAGGTGGCCGACGTGTTCACCGAGGTGATCGTCGCGCCGTCGTACGACGA
GGGCGCGGTCGAGATCCTGCAGGGCAAGAAGAACATCCGCATCCTGCGCTGCGCCGACCCGGCCGAGGAGCGCTCCACCG
AGCTGCGCCAGATCAGCGGCGGCGTGCTCGTGCAGGTGCGTGACCACGTCGACGCGACGGGCGACGACCCGTCGACCTGG
ACGCTGGCCGCGGGGGAGCCCGCCTCGGCGGAGGTGCTCGCCGACCTCGCGTTCGCCTGGACGGCGTGCCGCGCCGCGAA
GTCCAACGCGATCCTGCTCGCCAAGGACGGCGCCTCGGTCGGCATCGGCATGGGCCAGGTCAACCGGGTCGACTCCTGCC
GGCTCGCCGTCTCGCGGGCCGGGGACCGGGCCGCGGGATCGGTCGCCGCCTCCGACGCGTTCTTCCCCTTCGAGGACGGC
CCGCAGATCCTCATCGACGCCGGCGTCACCGCGATCGTGCAGCCGGGCGGCTCGGTCCGTGACGAGCTCACGGTCGAGGC
GGCCAAGGCCGCCGGCGTCACCATGTACTTCACCGGCACCCGGCACTTCTTCCACTGA

Upstream 100 bases:

>100_bases
TGCTGGACTCCACACGACTGGCGCGGGTGGGTGACCACCGGGGAGTGACGCACGGAGCATCGACCGCCTGGGTGCTCCCC
CTTCCGAGCAGGAGTTCTCT

Downstream 100 bases:

>100_bases
GCCGACAGGCGAGGATGACCACGTGACCGCACAGAAGCTGGACGGGACCGCCACCGCGGCGGCGATCAAGGGCGAGCTGA
CGACCCGGGTGGCGGCCCTG

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSEPVSTPEHRIPIRRALVSVYDKTDLEDLVRGLHDAGVELVSTGGSAKLIEGLGLPVTKVEDLTGFPECLDGRVKTLHP
RVHAGILADRRLDSHVQQLADLGVEPFDLVVSNLYPFRETVASGATPDECVEQIDIGGPSMVRAAAKNHPSVAIVTSPER
YADVLAAVAAGGFTLEQRKVLAAEAFTHTAAYDVAVAGWFASTYVPAEDGWPEFAGETWQKAAVLRYGENPHQDAALYTD
SSGGGGLAGAEQLHGKEMSYNNYVDTDAARRAAYDFDEPAVAIIKHANPCGIAVGADVAEAHRRAHECDPVSAFGGVIAV
NRPVSVEMARQVADVFTEVIVAPSYDEGAVEILQGKKNIRILRCADPAEERSTELRQISGGVLVQVRDHVDATGDDPSTW
TLAAGEPASAEVLADLAFAWTACRAAKSNAILLAKDGASVGIGMGQVNRVDSCRLAVSRAGDRAAGSVAASDAFFPFEDG
PQILIDAGVTAIVQPGGSVRDELTVEAAKAAGVTMYFTGTRHFFH

Sequences:

>Translated_525_residues
MSEPVSTPEHRIPIRRALVSVYDKTDLEDLVRGLHDAGVELVSTGGSAKLIEGLGLPVTKVEDLTGFPECLDGRVKTLHP
RVHAGILADRRLDSHVQQLADLGVEPFDLVVSNLYPFRETVASGATPDECVEQIDIGGPSMVRAAAKNHPSVAIVTSPER
YADVLAAVAAGGFTLEQRKVLAAEAFTHTAAYDVAVAGWFASTYVPAEDGWPEFAGETWQKAAVLRYGENPHQDAALYTD
SSGGGGLAGAEQLHGKEMSYNNYVDTDAARRAAYDFDEPAVAIIKHANPCGIAVGADVAEAHRRAHECDPVSAFGGVIAV
NRPVSVEMARQVADVFTEVIVAPSYDEGAVEILQGKKNIRILRCADPAEERSTELRQISGGVLVQVRDHVDATGDDPSTW
TLAAGEPASAEVLADLAFAWTACRAAKSNAILLAKDGASVGIGMGQVNRVDSCRLAVSRAGDRAAGSVAASDAFFPFEDG
PQILIDAGVTAIVQPGGSVRDELTVEAAKAAGVTMYFTGTRHFFH
>Mature_524_residues
SEPVSTPEHRIPIRRALVSVYDKTDLEDLVRGLHDAGVELVSTGGSAKLIEGLGLPVTKVEDLTGFPECLDGRVKTLHPR
VHAGILADRRLDSHVQQLADLGVEPFDLVVSNLYPFRETVASGATPDECVEQIDIGGPSMVRAAAKNHPSVAIVTSPERY
ADVLAAVAAGGFTLEQRKVLAAEAFTHTAAYDVAVAGWFASTYVPAEDGWPEFAGETWQKAAVLRYGENPHQDAALYTDS
SGGGGLAGAEQLHGKEMSYNNYVDTDAARRAAYDFDEPAVAIIKHANPCGIAVGADVAEAHRRAHECDPVSAFGGVIAVN
RPVSVEMARQVADVFTEVIVAPSYDEGAVEILQGKKNIRILRCADPAEERSTELRQISGGVLVQVRDHVDATGDDPSTWT
LAAGEPASAEVLADLAFAWTACRAAKSNAILLAKDGASVGIGMGQVNRVDSCRLAVSRAGDRAAGSVAASDAFFPFEDGP
QILIDAGVTAIVQPGGSVRDELTVEAAKAAGVTMYFTGTRHFFH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=611, Percent_Identity=33.2242225859247, Blast_Score=241, Evalue=2e-63,
Organism=Escherichia coli, GI1790439, Length=534, Percent_Identity=45.1310861423221, Blast_Score=431, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI71985564, Length=484, Percent_Identity=34.9173553719008, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71985574, Length=316, Percent_Identity=28.4810126582279, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323768, Length=483, Percent_Identity=36.4389233954451, Blast_Score=243, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6323056, Length=474, Percent_Identity=34.8101265822785, Blast_Score=236, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24649832, Length=481, Percent_Identity=36.5904365904366, Blast_Score=229, Evalue=3e-60,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_NOCSJ (A1SMP8)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924770.1
- ProteinModelPortal:   A1SMP8
- SMR:   A1SMP8
- STRING:   A1SMP8
- GeneID:   4599462
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3583
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- ProtClustDB:   PRK00881
- BioCyc:   NSP35761:NOCA_3583-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 55490; Mature: 55358

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPVSTPEHRIPIRRALVSVYDKTDLEDLVRGLHDAGVELVSTGGSAKLIEGLGLPVTK
CCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCCHH
VEDLTGFPECLDGRVKTLHPRVHAGILADRRLDSHVQQLADLGVEPFDLVVSNLYPFRET
HHHCCCCHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHH
VASGATPDECVEQIDIGGPSMVRAAAKNHPSVAIVTSPERYADVLAAVAAGGFTLEQRKV
HHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHH
LAAEAFTHTAAYDVAVAGWFASTYVPAEDGWPEFAGETWQKAAVLRYGENPHQDAALYTD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCEEEEC
SSGGGGLAGAEQLHGKEMSYNNYVDTDAARRAAYDFDEPAVAIIKHANPCGIAVGADVAE
CCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCCCEEECCHHHH
AHRRAHECDPVSAFGGVIAVNRPVSVEMARQVADVFTEVIVAPSYDEGAVEILQGKKNIR
HHHHHCCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEE
ILRCADPAEERSTELRQISGGVLVQVRDHVDATGDDPSTWTLAAGEPASAEVLADLAFAW
EEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
TACRAAKSNAILLAKDGASVGIGMGQVNRVDSCRLAVSRAGDRAAGSVAASDAFFPFEDG
HHHHHCCCCEEEEEECCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCCCC
PQILIDAGVTAIVQPGGSVRDELTVEAAKAAGVTMYFTGTRHFFH
CEEEEECCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCHHCCC
>Mature Secondary Structure 
SEPVSTPEHRIPIRRALVSVYDKTDLEDLVRGLHDAGVELVSTGGSAKLIEGLGLPVTK
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCCHH
VEDLTGFPECLDGRVKTLHPRVHAGILADRRLDSHVQQLADLGVEPFDLVVSNLYPFRET
HHHCCCCHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHH
VASGATPDECVEQIDIGGPSMVRAAAKNHPSVAIVTSPERYADVLAAVAAGGFTLEQRKV
HHCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCHHHHHH
LAAEAFTHTAAYDVAVAGWFASTYVPAEDGWPEFAGETWQKAAVLRYGENPHQDAALYTD
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHCCCCCCCCCEEEEC
SSGGGGLAGAEQLHGKEMSYNNYVDTDAARRAAYDFDEPAVAIIKHANPCGIAVGADVAE
CCCCCCCCCHHHHCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCCCEEECCHHHH
AHRRAHECDPVSAFGGVIAVNRPVSVEMARQVADVFTEVIVAPSYDEGAVEILQGKKNIR
HHHHHCCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEE
ILRCADPAEERSTELRQISGGVLVQVRDHVDATGDDPSTWTLAAGEPASAEVLADLAFAW
EEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
TACRAAKSNAILLAKDGASVGIGMGQVNRVDSCRLAVSRAGDRAAGSVAASDAFFPFEDG
HHHHHCCCCEEEEEECCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCEECCCCCCCCCCC
PQILIDAGVTAIVQPGGSVRDELTVEAAKAAGVTMYFTGTRHFFH
CEEEEECCCEEEECCCCCCCHHHHHHHHHHCCEEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA