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The map label for this gene is folD2

Identifier: 119717804

GI number: 119717804

Start: 3799198

End: 3800049

Strand: Reverse

Name: folD2

Synonym: Noca_3582

Alternate gene names: 119717804

Gene position: 3800049-3799198 (Counterclockwise)

Preceding gene: 119717805

Following gene: 119717803

Centisome position: 76.22

GC content: 73.24

Gene sequence:

>852_bases
GTGACCGCACAGAAGCTGGACGGGACCGCCACCGCGGCGGCGATCAAGGGCGAGCTGACGACCCGGGTGGCGGCCCTGCA
CGAGCGCGGGATCCGTCCCGGGCTCGGCACCATCCTCGTGGGCGACGACCCCGGGTCGCGGTGGTACGTCAACGGCAAGC
ACAAGGACTGCGCCGAGGTCGGCATCGAGTCCATCCGGATCGACCTGCCCGCGACCGCGACCCAGGACGAGATCGAGGAC
GCGGTCCGGGTGCTCAACGACGACCCGGCGTGCACCGGCTACATCGTGCAGCTGCCGTTGCCGAAGGGCCGCGACGAGAA
TCGCGTGCTCGGCTTGATCGACCCGGCCAAGGACGCCGACGGCCTGCACCCGACGAACCTCGGCTGGCTGGTGCTCGGCA
AGGCCGCGCCGCTGCCGTGCACCCCCAACGGCATCGTCGAGCTGTTGCGCCGCCACGGGGTCGAGATCGCCGGCGCCGAG
GTCACCGTGGTCGGGCGCGGCGTCACGGTCGGCCGGCCGCTCGGCCTGCTGCTGACTCGCCGCAGCGAGAACGCCACCGT
GACGCTGTGCCACACGGGCACCCGCGACCTGGCGGCGCACGTGCGCGGCGCCGACATCGTCGTGGCGGCTGCCGGGGTGC
CCGGCATCGTCACCGGCGCGATGGTCAAGCCGGGTGCCGCCGTGCTCGACGTGGGGGTCTCCCGGGTCGACGGCAAGCTC
GCCGGGGACGTGGCCCCCGAGGTGTGGGACGTGGCCCGTTGGGTCTCGCCCAACCCGGGCGGCGTCGGCCCGATGACCCG
GGCGATGCTGCTGTCCAACATCGTGGCGATGGCCGAGCAGACGGATTCGTGA

Upstream 100 bases:

>100_bases
GACGAGCTCACGGTCGAGGCGGCCAAGGCCGCCGGCGTCACCATGTACTTCACCGGCACCCGGCACTTCTTCCACTGAGC
CGACAGGCGAGGATGACCAC

Downstream 100 bases:

>100_bases
GCGACCTCGAGCCTCCCGACGACCTGGAGCCCGTCTCCGCGGAGGACGTGGGCCGGCGCTACCCGTCCACGATCGGGGGC
GCGTTCTACCTCGTGGTCAT

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MTAQKLDGTATAAAIKGELTTRVAALHERGIRPGLGTILVGDDPGSRWYVNGKHKDCAEVGIESIRIDLPATATQDEIED
AVRVLNDDPACTGYIVQLPLPKGRDENRVLGLIDPAKDADGLHPTNLGWLVLGKAAPLPCTPNGIVELLRRHGVEIAGAE
VTVVGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLAAHVRGADIVVAAAGVPGIVTGAMVKPGAAVLDVGVSRVDGKL
AGDVAPEVWDVARWVSPNPGGVGPMTRAMLLSNIVAMAEQTDS

Sequences:

>Translated_283_residues
MTAQKLDGTATAAAIKGELTTRVAALHERGIRPGLGTILVGDDPGSRWYVNGKHKDCAEVGIESIRIDLPATATQDEIED
AVRVLNDDPACTGYIVQLPLPKGRDENRVLGLIDPAKDADGLHPTNLGWLVLGKAAPLPCTPNGIVELLRRHGVEIAGAE
VTVVGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLAAHVRGADIVVAAAGVPGIVTGAMVKPGAAVLDVGVSRVDGKL
AGDVAPEVWDVARWVSPNPGGVGPMTRAMLLSNIVAMAEQTDS
>Mature_282_residues
TAQKLDGTATAAAIKGELTTRVAALHERGIRPGLGTILVGDDPGSRWYVNGKHKDCAEVGIESIRIDLPATATQDEIEDA
VRVLNDDPACTGYIVQLPLPKGRDENRVLGLIDPAKDADGLHPTNLGWLVLGKAAPLPCTPNGIVELLRRHGVEIAGAEV
TVVGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLAAHVRGADIVVAAAGVPGIVTGAMVKPGAAVLDVGVSRVDGKLA
GDVAPEVWDVARWVSPNPGGVGPMTRAMLLSNIVAMAEQTDS

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI222418558, Length=291, Percent_Identity=40.893470790378, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI222136639, Length=292, Percent_Identity=40.4109589041096, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI94721354, Length=291, Percent_Identity=40.893470790378, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI36796743, Length=222, Percent_Identity=29.2792792792793, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1786741, Length=276, Percent_Identity=42.3913043478261, Blast_Score=204, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI17568735, Length=294, Percent_Identity=35.0340136054422, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6321643, Length=300, Percent_Identity=40.3333333333333, Blast_Score=189, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6319558, Length=287, Percent_Identity=38.6759581881533, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17136816, Length=294, Percent_Identity=41.156462585034, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17136818, Length=294, Percent_Identity=41.156462585034, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24645718, Length=289, Percent_Identity=43.598615916955, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17137370, Length=289, Percent_Identity=43.598615916955, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI62472483, Length=289, Percent_Identity=43.598615916955, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI45551871, Length=289, Percent_Identity=43.598615916955, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD2_NOCSJ (A1SMP7)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_924769.1
- ProteinModelPortal:   A1SMP7
- SMR:   A1SMP7
- STRING:   A1SMP7
- GeneID:   4599461
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_3582
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   DVVYETA
- BioCyc:   NSP35761:NOCA_3582-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 29369; Mature: 29238

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAQKLDGTATAAAIKGELTTRVAALHERGIRPGLGTILVGDDPGSRWYVNGKHKDCAEV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCHHHC
GIESIRIDLPATATQDEIEDAVRVLNDDPACTGYIVQLPLPKGRDENRVLGLIDPAKDAD
CCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCC
GLHPTNLGWLVLGKAAPLPCTPNGIVELLRRHGVEIAGAEVTVVGRGVTVGRPLGLLLTR
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEECCEEEEEECCEECCCCCEEEEEE
RSENATVTLCHTGTRDLAAHVRGADIVVAAAGVPGIVTGAMVKPGAAVLDVGVSRVDGKL
CCCCCEEEEEECCCHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCCEEECCHHHCCCCC
AGDVAPEVWDVARWVSPNPGGVGPMTRAMLLSNIVAMAEQTDS
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAQKLDGTATAAAIKGELTTRVAALHERGIRPGLGTILVGDDPGSRWYVNGKHKDCAEV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEECCCCCCHHHC
GIESIRIDLPATATQDEIEDAVRVLNDDPACTGYIVQLPLPKGRDENRVLGLIDPAKDAD
CCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCEEEEECCCCCCC
GLHPTNLGWLVLGKAAPLPCTPNGIVELLRRHGVEIAGAEVTVVGRGVTVGRPLGLLLTR
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCEEECCEEEEEECCEECCCCCEEEEEE
RSENATVTLCHTGTRDLAAHVRGADIVVAAAGVPGIVTGAMVKPGAAVLDVGVSRVDGKL
CCCCCEEEEEECCCHHHHHHCCCCEEEEEECCCCCCEECCCCCCCCCEEECCHHHCCCCC
AGDVAPEVWDVARWVSPNPGGVGPMTRAMLLSNIVAMAEQTDS
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA