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The map label for this gene is thiD [H]

Identifier: 119717623

GI number: 119717623

Start: 3605057

End: 3605869

Strand: Reverse

Name: thiD [H]

Synonym: Noca_3401

Alternate gene names: 119717623

Gene position: 3605869-3605057 (Counterclockwise)

Preceding gene: 119717624

Following gene: 119717622

Centisome position: 72.32

GC content: 76.26

Gene sequence:

>813_bases
ATGAGAAGCCCCCTGGTCGCCCTCACCGTGGCGGGCACCGACTCCGGCGGTGCCGCCGGAGTCGCCGCCGACCTGGCGAC
GTTCGCGGCACTGGGCGCGCACGGGACGTGCGCCGTCACCGCCGTCACCGCGCAGGACACCACCGGCGTGCACGCCGTGG
TCCACCTCTCCGCCGACCACGTGCGGGCCCAGGTCGACGCGGTCCTCGACGACCTGCCGGTCGCGGTCGCCAAGGCTGGC
ATGCTCGGCTCCGCCGAGATCGCCGGGGTAGTCGCGGACCTGCCGCCGGGCCTGCCGCTCGTGGTCGACCCCGTCCTGCG
CACCACGAGCGGTTCGGTGCTCGCCGACGACGCCCTCGTCGCCGCCTACCGCGACCACATCCTCCCGCGCTGCACCGTCG
TCACCCCCAACCTCGCCGAGGCACGCCGGCTCGCCGGTGCCGGCTCGGAGGAGCCGCTCGAGCACGTGGCGCGGGCCCTC
CAGGCGCTCGGCCCCGCGGTCGTGCTCACCGGCGGCGACCCCGAGTCCGACTGGTGCCGCGACTTCGTCGTCGATGACCG
GGGCCGCGCGCACGTGCTCGAGCACCCCGGCGTACCGACCACCAACGACCACGGCACCGGCTGCACGTTCTCCGCCGCCC
TCGCCGTCCACCTCGCCCGGGGAGAGGCGCTCCCCGCCGCGACCCGGTCAGCCCAAGCCTTCGTCGCGGCCGCACTGCGC
CGCAGCGCCGGCTGGCGCCTGGGCCGCGGTCGCGGCCCCGTCGCCCACACCTTTGCCCATCCCACGACGAACCCATCCCC
ACAGGAGGCGTGA

Upstream 100 bases:

>100_bases
CGATGCGGGCAGCCGGCGCCCACGGGGTCGCCGTCATGGGTGCCGTCATGCGCGCCCCCGACCCGGCCGACGTCGTCGAG
CGCGTGCTGGGGGAGGCCCG

Downstream 100 bases:

>100_bases
TGCAGATCCACCCGAGCCACAGCACCGTCCACCGCACCGGATCGCGCGCCGACATCCGCGTGCCCTTCACCCGGGTCGCG
CTCACCAACGGCGAGACGTT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MRSPLVALTVAGTDSGGAAGVAADLATFAALGAHGTCAVTAVTAQDTTGVHAVVHLSADHVRAQVDAVLDDLPVAVAKAG
MLGSAEIAGVVADLPPGLPLVVDPVLRTTSGSVLADDALVAAYRDHILPRCTVVTPNLAEARRLAGAGSEEPLEHVARAL
QALGPAVVLTGGDPESDWCRDFVVDDRGRAHVLEHPGVPTTNDHGTGCTFSAALAVHLARGEALPAATRSAQAFVAAALR
RSAGWRLGRGRGPVAHTFAHPTTNPSPQEA

Sequences:

>Translated_270_residues
MRSPLVALTVAGTDSGGAAGVAADLATFAALGAHGTCAVTAVTAQDTTGVHAVVHLSADHVRAQVDAVLDDLPVAVAKAG
MLGSAEIAGVVADLPPGLPLVVDPVLRTTSGSVLADDALVAAYRDHILPRCTVVTPNLAEARRLAGAGSEEPLEHVARAL
QALGPAVVLTGGDPESDWCRDFVVDDRGRAHVLEHPGVPTTNDHGTGCTFSAALAVHLARGEALPAATRSAQAFVAAALR
RSAGWRLGRGRGPVAHTFAHPTTNPSPQEA
>Mature_270_residues
MRSPLVALTVAGTDSGGAAGVAADLATFAALGAHGTCAVTAVTAQDTTGVHAVVHLSADHVRAQVDAVLDDLPVAVAKAG
MLGSAEIAGVVADLPPGLPLVVDPVLRTTSGSVLADDALVAAYRDHILPRCTVVTPNLAEARRLAGAGSEEPLEHVARAL
QALGPAVVLTGGDPESDWCRDFVVDDRGRAHVLEHPGVPTTNDHGTGCTFSAALAVHLARGEALPAATRSAQAFVAAALR
RSAGWRLGRGRGPVAHTFAHPTTNPSPQEA

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=260, Percent_Identity=37.3076923076923, Blast_Score=148, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324997, Length=270, Percent_Identity=32.2222222222222, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324517, Length=270, Percent_Identity=30, Blast_Score=89, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325378, Length=271, Percent_Identity=28.0442804428044, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 27316; Mature: 27316

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSPLVALTVAGTDSGGAAGVAADLATFAALGAHGTCAVTAVTAQDTTGVHAVVHLSADH
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECHHH
VRAQVDAVLDDLPVAVAKAGMLGSAEIAGVVADLPPGLPLVVDPVLRTTSGSVLADDALV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEECCCCCCCEEEHHHHHCCCCCEEEHHHHH
AAYRDHILPRCTVVTPNLAEARRLAGAGSEEPLEHVARALQALGPAVVLTGGDPESDWCR
HHHHHHCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHH
DFVVDDRGRAHVLEHPGVPTTNDHGTGCTFSAALAVHLARGEALPAATRSAQAFVAAALR
HHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RSAGWRLGRGRGPVAHTFAHPTTNPSPQEA
HHCCCCCCCCCCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRSPLVALTVAGTDSGGAAGVAADLATFAALGAHGTCAVTAVTAQDTTGVHAVVHLSADH
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECHHH
VRAQVDAVLDDLPVAVAKAGMLGSAEIAGVVADLPPGLPLVVDPVLRTTSGSVLADDALV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHEEECCCCCCCEEEHHHHHCCCCCEEEHHHHH
AAYRDHILPRCTVVTPNLAEARRLAGAGSEEPLEHVARALQALGPAVVLTGGDPESDWCR
HHHHHHCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEECCCCCHHHHH
DFVVDDRGRAHVLEHPGVPTTNDHGTGCTFSAALAVHLARGEALPAATRSAQAFVAAALR
HHHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
RSAGWRLGRGRGPVAHTFAHPTTNPSPQEA
HHCCCCCCCCCCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA