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The map label for this gene is adh [H]

Identifier: 119717546

GI number: 119717546

Start: 3530390

End: 3531406

Strand: Reverse

Name: adh [H]

Synonym: Noca_3322

Alternate gene names: 119717546

Gene position: 3531406-3530390 (Counterclockwise)

Preceding gene: 119717547

Following gene: 119717544

Centisome position: 70.83

GC content: 66.76

Gene sequence:

>1017_bases
ATGCACGCGAACCAGCTCACGACCCCCGCCCACCTCTCGCACCATCCACTCCTCTGGACCGATGTCGACCGTCCCGAACC
GAGCCGAGGCCAGCTGCTGGTCAAGGTGGCAGGCTGCGGAGTCTGCCGGTCGAACCTCCACATGATCGAGGGGGACTGGG
TCGAGGGCGGGGTTCCGGCAATCAGCCCGATCATCCCGGGGCACGAGGTCACCGGCCGGGTCGCCGCGATCGGTGCAGGC
GTCGAGGGATTCGAGGTCGGTGACCCCGTGGGTGTGCAGCCGCTATGGTGGACCTGCGGCGAATGCGAGTTCTGCACGAC
CGGCCGGGAGCAGTTGTGCCACGAGCGGATCATCACCGGGGAACACGTCGACGGCGGATACGCGGAGTACATGCTCTCGT
TTGCCGAGCACACCTACCGGATCCCGGAGTCGCTCGACCTGATCGATGCCGCGCCGTTGTTCTGCCCCGGGATCACTGCC
TATGGGGCCCTCGACAAGATCGATGTAGGGCCGGGAGATGTCGTGGCCGTCTTCGGTCTCGGGGGCGTCGGTCACATGGC
CGTCCAGATGGCGGTGTTGACCGGGGCCGAGGTCGTGGCGGTGGGCCGGACGCCGGCCCACCTGGAGGTCGCGAAAGAGC
TCGGCGCCGCGCGCACGGTCGACTCCACCGATCAGGATGCTCTCGACCTCATCGCGGACACCGCCGACGCCGTCTTGACC
TTCGCCGGATCCGACGAGGTCACTGCACAGGCGATGCGAACCCTCAAGTGGGGCGGCACCCTCGTGAACGGGGTGCCGAT
CAACGTCGAGGAGTTCCACTTCAACAAGGGTCAGACGATCAAGGGCTCGATCTTGGGCAACCGCGAACAGATGCGAGCTG
TCCTGCAGCTCGCCGCGGAAGGCAAGATCCGCACGGTCGTCGAGCGCTTCCCGATGGCTCAGGCCGAGGATGCGTTGACT
CGGCTGGCCAACGGCGAGCTGCGTTCGCGAGGCGTGCTGTACAACTCGACGGAGTAG

Upstream 100 bases:

>100_bases
AACTCCGCGCGTGGGGATGAGTCCGCGGCCCCGGTGTTCATGAGTGATCGCGCCGTCAGCGCCGCACGGGCTGGGCAATA
TAGTCCTCGTTGTGATAACG

Downstream 100 bases:

>100_bases
AGCCCGCGGTGGCCTCAGGCCACCTCGACGACAGGCTTCTCCGCCTCTGCCAGCAGATGGCACTCGAGATCCAGCAGTGG
TGGCCACGCAGGTGTGCGGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MHANQLTTPAHLSHHPLLWTDVDRPEPSRGQLLVKVAGCGVCRSNLHMIEGDWVEGGVPAISPIIPGHEVTGRVAAIGAG
VEGFEVGDPVGVQPLWWTCGECEFCTTGREQLCHERIITGEHVDGGYAEYMLSFAEHTYRIPESLDLIDAAPLFCPGITA
YGALDKIDVGPGDVVAVFGLGGVGHMAVQMAVLTGAEVVAVGRTPAHLEVAKELGAARTVDSTDQDALDLIADTADAVLT
FAGSDEVTAQAMRTLKWGGTLVNGVPINVEEFHFNKGQTIKGSILGNREQMRAVLQLAAEGKIRTVVERFPMAQAEDALT
RLANGELRSRGVLYNSTE

Sequences:

>Translated_338_residues
MHANQLTTPAHLSHHPLLWTDVDRPEPSRGQLLVKVAGCGVCRSNLHMIEGDWVEGGVPAISPIIPGHEVTGRVAAIGAG
VEGFEVGDPVGVQPLWWTCGECEFCTTGREQLCHERIITGEHVDGGYAEYMLSFAEHTYRIPESLDLIDAAPLFCPGITA
YGALDKIDVGPGDVVAVFGLGGVGHMAVQMAVLTGAEVVAVGRTPAHLEVAKELGAARTVDSTDQDALDLIADTADAVLT
FAGSDEVTAQAMRTLKWGGTLVNGVPINVEEFHFNKGQTIKGSILGNREQMRAVLQLAAEGKIRTVVERFPMAQAEDALT
RLANGELRSRGVLYNSTE
>Mature_338_residues
MHANQLTTPAHLSHHPLLWTDVDRPEPSRGQLLVKVAGCGVCRSNLHMIEGDWVEGGVPAISPIIPGHEVTGRVAAIGAG
VEGFEVGDPVGVQPLWWTCGECEFCTTGREQLCHERIITGEHVDGGYAEYMLSFAEHTYRIPESLDLIDAAPLFCPGITA
YGALDKIDVGPGDVVAVFGLGGVGHMAVQMAVLTGAEVVAVGRTPAHLEVAKELGAARTVDSTDQDALDLIADTADAVLT
FAGSDEVTAQAMRTLKWGGTLVNGVPINVEEFHFNKGQTIKGSILGNREQMRAVLQLAAEGKIRTVVERFPMAQAEDALT
RLANGELRSRGVLYNSTE

Specific function: Active with primary alcohols, including methanol [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=324, Percent_Identity=27.7777777777778, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI262073058, Length=323, Percent_Identity=29.1021671826625, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI71743840, Length=323, Percent_Identity=29.1021671826625, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI71565154, Length=323, Percent_Identity=29.7213622291022, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4501929, Length=324, Percent_Identity=27.1604938271605, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI34577061, Length=324, Percent_Identity=27.1604938271605, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI194239676, Length=217, Percent_Identity=29.4930875576037, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI194239674, Length=217, Percent_Identity=29.4930875576037, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI13236495, Length=217, Percent_Identity=29.4930875576037, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1786518, Length=343, Percent_Identity=32.6530612244898, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI87081918, Length=313, Percent_Identity=31.3099041533546, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI87082401, Length=307, Percent_Identity=31.5960912052117, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790045, Length=296, Percent_Identity=31.0810810810811, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87082125, Length=326, Percent_Identity=29.1411042944785, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788073, Length=252, Percent_Identity=29.3650793650794, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1786552, Length=354, Percent_Identity=29.6610169491525, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI226510992, Length=328, Percent_Identity=28.9634146341463, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787863, Length=201, Percent_Identity=32.8358208955224, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788407, Length=203, Percent_Identity=31.0344827586207, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788075, Length=333, Percent_Identity=26.1261261261261, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790718, Length=306, Percent_Identity=26.1437908496732, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562582, Length=333, Percent_Identity=31.5315315315315, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI71988145, Length=326, Percent_Identity=29.7546012269939, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17562584, Length=333, Percent_Identity=30.3303303303303, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17562876, Length=259, Percent_Identity=30.5019305019305, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=202, Percent_Identity=31.1881188118812, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25146526, Length=362, Percent_Identity=26.7955801104972, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=357, Percent_Identity=26.3305322128852, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=334, Percent_Identity=30.5389221556886, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6319621, Length=332, Percent_Identity=32.2289156626506, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323961, Length=336, Percent_Identity=29.4642857142857, Blast_Score=149, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6324486, Length=336, Percent_Identity=29.7619047619048, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319949, Length=326, Percent_Identity=31.5950920245399, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323980, Length=318, Percent_Identity=30.8176100628931, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320033, Length=367, Percent_Identity=26.9754768392371, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=324, Percent_Identity=28.3950617283951, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=313, Percent_Identity=27.4760383386581, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319955, Length=324, Percent_Identity=28.0864197530864, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319258, Length=286, Percent_Identity=23.7762237762238, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737895, Length=367, Percent_Identity=26.9754768392371, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737897, Length=224, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137530, Length=220, Percent_Identity=28.6363636363636, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36007; Mature: 36007

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHANQLTTPAHLSHHPLLWTDVDRPEPSRGQLLVKVAGCGVCRSNLHMIEGDWVEGGVPA
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCHHCCCEEEECCCCCCCCCC
ISPIIPGHEVTGRVAAIGAGVEGFEVGDPVGVQPLWWTCGECEFCTTGREQLCHERIITG
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCEECCCCHHHHHHHHHCCC
EHVDGGYAEYMLSFAEHTYRIPESLDLIDAAPLFCPGITAYGALDKIDVGPGDVVAVFGL
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHCCCCCCCCCCCCEEEEEEC
GGVGHMAVQMAVLTGAEVVAVGRTPAHLEVAKELGAARTVDSTDQDALDLIADTADAVLT
CCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEE
FAGSDEVTAQAMRTLKWGGTLVNGVPINVEEFHFNKGQTIKGSILGNREQMRAVLQLAAE
ECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCC
GKIRTVVERFPMAQAEDALTRLANGELRSRGVLYNSTE
CHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCEEECCCC
>Mature Secondary Structure
MHANQLTTPAHLSHHPLLWTDVDRPEPSRGQLLVKVAGCGVCRSNLHMIEGDWVEGGVPA
CCCCCCCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCHHCCCEEEECCCCCCCCCC
ISPIIPGHEVTGRVAAIGAGVEGFEVGDPVGVQPLWWTCGECEFCTTGREQLCHERIITG
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCCEECCCCHHHHHHHHHCCC
EHVDGGYAEYMLSFAEHTYRIPESLDLIDAAPLFCPGITAYGALDKIDVGPGDVVAVFGL
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCCCHHHCCCCCCCCCCCCEEEEEEC
GGVGHMAVQMAVLTGAEVVAVGRTPAHLEVAKELGAARTVDSTDQDALDLIADTADAVLT
CCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEE
FAGSDEVTAQAMRTLKWGGTLVNGVPINVEEFHFNKGQTIKGSILGNREQMRAVLQLAAE
ECCCCHHHHHHHHHHHCCCEEECCCCCCCEEEECCCCCEEEEEECCCHHHHHHHHHHHCC
GKIRTVVERFPMAQAEDALTRLANGELRSRGVLYNSTE
CHHHHHHHHCCCCHHHHHHHHHHCCCHHHCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8049268 [H]