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The map label for this gene is glcD [H]

Identifier: 119716386

GI number: 119716386

Start: 2303931

End: 2305286

Strand: Reverse

Name: glcD [H]

Synonym: Noca_2155

Alternate gene names: 119716386

Gene position: 2305286-2303931 (Counterclockwise)

Preceding gene: 119716387

Following gene: 119716383

Centisome position: 46.24

GC content: 64.23

Gene sequence:

>1356_bases
ATGACCCCAAACCTCCTCAGCCTGAAGAATCAGGCCCGAACTGTCCTCACCGACCCAAGTGCGATGCTCGGATACGAACG
CGACCAGTGCCTGATCGCGGAAAACGGCAAGGCACTTGCTGTCGTCCTCGCCGACACGGTGGAGGAAGTGGTCAATGTCG
TCCGCTGGTGCAGCGATCACGCGGTACCACTGGTCCCAAGAGGCGCTGGAACCGGGCTCGCCGGAGCCGCCAACGCCATC
GACGGCGGCGTGGTTCTTAGCGTTGCGCGGCTCGACACCATCCTCGCGATCGACCCGATTGCACGAACGGCGCGAGTCCA
GCCAGGGGTCATCAACGGCAACCTCGACCGCGCGGCCCGAGGGCACGGTCTGTGGTACGCCCCAGACCCAGGCAGCAGAG
AGATCTCCTCGATCGGGGGCAATCTCGCCACTAACGCCGGCGGCATGTGCTGCTCAAAGTATGGCGTCACCGCGGACCAC
GCCTTGCGCCTGAAGACCGTCATCGGCACGGGAGAGGTCGTCGAGACTGGCTCGCTGACCCGAAAGAACGTCGTAGGGCT
CGACCTTCGACGTCTCATCATCGGATCCGAAGGAACACTAGGAGTCATCGTCGAAGCAACGGTTCGGCTGCGTCCACGAC
CCGCGCTTGTGGCGACGGTAGCCGCATCCTTCCAATCTCCCGAATCGGCGATAGCCACGGTCCTCGAGTCCCAACAGACC
GGCCTGGAGGCGCTGGCTATGGAGATCATGGACCGACCCACAATCGCCGCGGTCAACGCCCTGACGCGCATGGATCTCGA
CGAAGCAGCAGGCGCGCTCTTGATCGCTCAGTTTGACGGCTCTGAGGCGACCGCCGCCGCACTCTCGTTCAAGGAGATGT
CGACCGCCAATGGCGCGGAGACGTTCCGAACCGAGGATGAGGACGAGGGCGCGGCGATCATGGCGGCTCGTCGTGCCGCG
CTCCCTGCCCTCGAACGGTTCGGAGCCACCATCCTCGACGACGTCGCGGTCCAGCCGCACCTGCTACCCGCGTTGCTCGA
CAAGATCGACCGAATTCGTGACGAGTCGGGCGTCATGATCGGCACCTTTGGACACGCGGGCGACGGCAATCTGCATCCAA
CACTTGTATTCGATGGTTCGTCAGCGGAGCAGCGAGCCAGAGCCGAAACTGCGTTCGGACAGATCGTCGATGCCGCCCTC
GGGCTGGGCGGCACCGCCTCCGGTGAGCATGGGGTCGGCAGCCTCAAACTGCCATGGCTGGAGCGTCAGCTCGGAAGTGC
TGAACGGGACCTTCACCTTCGGATCAAGCAAGCGTTCGACCCGGCCGGCATCCTGAACCCCGGCCGCAGCTATTAG

Upstream 100 bases:

>100_bases
CTGTATCAGCGAACCAGGCGACGACACGGCGAATGGCCGGCGTCGGGTAGTCCGGCTTCGTGAGTAGTCCAATGCACTCC
CCAAGGAAGTCATCACCGCT

Downstream 100 bases:

>100_bases
GGCGTCGCCTGCGACTAGTTCCGTCGCACGACCGCCCTCGCGAAGGTGAACTCGAGCGGCGCCGCAGTACAGCCGTTCCA
CGCTTTGGGTGGCGGGACAG

Product: D-lactate dehydrogenase (cytochrome)

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTPNLLSLKNQARTVLTDPSAMLGYERDQCLIAENGKALAVVLADTVEEVVNVVRWCSDHAVPLVPRGAGTGLAGAANAI
DGGVVLSVARLDTILAIDPIARTARVQPGVINGNLDRAARGHGLWYAPDPGSREISSIGGNLATNAGGMCCSKYGVTADH
ALRLKTVIGTGEVVETGSLTRKNVVGLDLRRLIIGSEGTLGVIVEATVRLRPRPALVATVAASFQSPESAIATVLESQQT
GLEALAMEIMDRPTIAAVNALTRMDLDEAAGALLIAQFDGSEATAAALSFKEMSTANGAETFRTEDEDEGAAIMAARRAA
LPALERFGATILDDVAVQPHLLPALLDKIDRIRDESGVMIGTFGHAGDGNLHPTLVFDGSSAEQRARAETAFGQIVDAAL
GLGGTASGEHGVGSLKLPWLERQLGSAERDLHLRIKQAFDPAGILNPGRSY

Sequences:

>Translated_451_residues
MTPNLLSLKNQARTVLTDPSAMLGYERDQCLIAENGKALAVVLADTVEEVVNVVRWCSDHAVPLVPRGAGTGLAGAANAI
DGGVVLSVARLDTILAIDPIARTARVQPGVINGNLDRAARGHGLWYAPDPGSREISSIGGNLATNAGGMCCSKYGVTADH
ALRLKTVIGTGEVVETGSLTRKNVVGLDLRRLIIGSEGTLGVIVEATVRLRPRPALVATVAASFQSPESAIATVLESQQT
GLEALAMEIMDRPTIAAVNALTRMDLDEAAGALLIAQFDGSEATAAALSFKEMSTANGAETFRTEDEDEGAAIMAARRAA
LPALERFGATILDDVAVQPHLLPALLDKIDRIRDESGVMIGTFGHAGDGNLHPTLVFDGSSAEQRARAETAFGQIVDAAL
GLGGTASGEHGVGSLKLPWLERQLGSAERDLHLRIKQAFDPAGILNPGRSY
>Mature_450_residues
TPNLLSLKNQARTVLTDPSAMLGYERDQCLIAENGKALAVVLADTVEEVVNVVRWCSDHAVPLVPRGAGTGLAGAANAID
GGVVLSVARLDTILAIDPIARTARVQPGVINGNLDRAARGHGLWYAPDPGSREISSIGGNLATNAGGMCCSKYGVTADHA
LRLKTVIGTGEVVETGSLTRKNVVGLDLRRLIIGSEGTLGVIVEATVRLRPRPALVATVAASFQSPESAIATVLESQQTG
LEALAMEIMDRPTIAAVNALTRMDLDEAAGALLIAQFDGSEATAAALSFKEMSTANGAETFRTEDEDEGAAIMAARRAAL
PALERFGATILDDVAVQPHLLPALLDKIDRIRDESGVMIGTFGHAGDGNLHPTLVFDGSSAEQRARAETAFGQIVDAALG
LGGTASGEHGVGSLKLPWLERQLGSAERDLHLRIKQAFDPAGILNPGRSY

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=419, Percent_Identity=31.980906921241, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI37595754, Length=442, Percent_Identity=30.5429864253394, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI119964728, Length=452, Percent_Identity=28.0973451327434, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI4501993, Length=454, Percent_Identity=25.3303964757709, Blast_Score=109, Evalue=5e-24,
Organism=Escherichia coli, GI1789351, Length=440, Percent_Identity=37.2727272727273, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1787977, Length=495, Percent_Identity=25.0505050505051, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI48994907, Length=447, Percent_Identity=25.9507829977629, Blast_Score=95, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71992373, Length=425, Percent_Identity=31.7647058823529, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71992381, Length=421, Percent_Identity=31.1163895486936, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71992392, Length=382, Percent_Identity=30.1047120418848, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17534361, Length=432, Percent_Identity=27.7777777777778, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17556096, Length=460, Percent_Identity=23.9130434782609, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320027, Length=426, Percent_Identity=28.4037558685446, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6320023, Length=469, Percent_Identity=26.226012793177, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320764, Length=450, Percent_Identity=23.3333333333333, Blast_Score=137, Evalue=4e-33,
Organism=Drosophila melanogaster, GI18921117, Length=430, Percent_Identity=26.7441860465116, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24639277, Length=430, Percent_Identity=26.7441860465116, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24639275, Length=430, Percent_Identity=26.7441860465116, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24653753, Length=225, Percent_Identity=31.1111111111111, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 47066; Mature: 46935

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPNLLSLKNQARTVLTDPSAMLGYERDQCLIAENGKALAVVLADTVEEVVNVVRWCSDH
CCCCCHHHHCCCCEEEECCHHHHCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHCCC
AVPLVPRGAGTGLAGAANAIDGGVVLSVARLDTILAIDPIARTARVQPGVINGNLDRAAR
CCEEEECCCCCCCCCCCCCCCCCCEEEHHHHHEHEEECCHHHHHCCCCCEECCCHHHHHC
GHGLWYAPDPGSREISSIGGNLATNAGGMCCSKYGVTADHALRLKTVIGTGEVVETGSLT
CCCEEECCCCCCHHHHHCCCCCCCCCCCCEECCCCCCCCCEEEEEEEECCCCEEECCCCC
RKNVVGLDLRRLIIGSEGTLGVIVEATVRLRPRPALVATVAASFQSPESAIATVLESQQT
CCCCCCCEEEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHC
GLEALAMEIMDRPTIAAVNALTRMDLDEAAGALLIAQFDGSEATAAALSFKEMSTANGAE
CHHHHHHHHHCCCHHHHHHHHHHCCHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCH
TFRTEDEDEGAAIMAARRAALPALERFGATILDDVAVQPHLLPALLDKIDRIRDESGVMI
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEE
GTFGHAGDGNLHPTLVFDGSSAEQRARAETAFGQIVDAALGLGGTASGEHGVGSLKLPWL
EECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCHH
ERQLGSAERDLHLRIKQAFDPAGILNPGRSY
HHHHCCCCCCEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPNLLSLKNQARTVLTDPSAMLGYERDQCLIAENGKALAVVLADTVEEVVNVVRWCSDH
CCCCHHHHCCCCEEEECCHHHHCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHCCC
AVPLVPRGAGTGLAGAANAIDGGVVLSVARLDTILAIDPIARTARVQPGVINGNLDRAAR
CCEEEECCCCCCCCCCCCCCCCCCEEEHHHHHEHEEECCHHHHHCCCCCEECCCHHHHHC
GHGLWYAPDPGSREISSIGGNLATNAGGMCCSKYGVTADHALRLKTVIGTGEVVETGSLT
CCCEEECCCCCCHHHHHCCCCCCCCCCCCEECCCCCCCCCEEEEEEEECCCCEEECCCCC
RKNVVGLDLRRLIIGSEGTLGVIVEATVRLRPRPALVATVAASFQSPESAIATVLESQQT
CCCCCCCEEEEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHC
GLEALAMEIMDRPTIAAVNALTRMDLDEAAGALLIAQFDGSEATAAALSFKEMSTANGAE
CHHHHHHHHHCCCHHHHHHHHHHCCHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCH
TFRTEDEDEGAAIMAARRAALPALERFGATILDDVAVQPHLLPALLDKIDRIRDESGVMI
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEE
GTFGHAGDGNLHPTLVFDGSSAEQRARAETAFGQIVDAALGLGGTASGEHGVGSLKLPWL
EECCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCHH
ERQLGSAERDLHLRIKQAFDPAGILNPGRSY
HHHHCCCCCCEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]