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The map label for this gene is hemK [H]

Identifier: 119715987

GI number: 119715987

Start: 1863524

End: 1864402

Strand: Direct

Name: hemK [H]

Synonym: Noca_1752

Alternate gene names: 119715987

Gene position: 1863524-1864402 (Clockwise)

Preceding gene: 119715986

Following gene: 119715988

Centisome position: 37.38

GC content: 75.2

Gene sequence:

>879_bases
ATGACCCAACGTCGCGCGGTCGTCACGGCCGCTGCCGAGCGGCTCCGCCACGCCGGTGTCCCCAGCCCCGGGCACGACGC
CGAGGCGCTGCTCGCGCACGTCCTCGGCACCACGCGTGCCGGCCTGGTCGCGGTGGAGGACGTGGCCCCCTCGGCGCTGG
AGGAGTACGACGCGCTGGTGGCCCGGCGCGCGGCGCGCGAGCCGCTCCAGCACCTCACCGGCAGCGTCGGCTTCCGCCAC
GTCGAGGTGGCGGTCGGCCCCGGGGTGTTCGTGCCGCGGCCCGAGACGGAGCTGCTCGCCGGCTGGGCCATCGAGCAGTG
TCTTCGGTGGTCGAGTAGCCGTCGCGTCGGAGGAGCGACCGCCGGTCGAAACCCGGTGGTCGTCGACCTCTGCACCGGCT
CGGGCGCGGTCGCCAAGGCGATCGCGGACGAGGTACCCACCGCCGACGTGCACGCCGTCGAGCTCGACGAGGAGGCCCAC
CGCTGGGCGGGCCGCAACCTCGCCCGCACGACCGTCGACCTGCGGCTCGGCGACATGGCGACCGCCTTCGACGACCTGCT
GGGGCAGGTCGACATCGTGACCTGCAACCCGCCCTACATCCCGCTCGACGCCTGGGAGTCGGTCGCGCCCGAGGCCCGTG
ACCACGACCCGCACCTGGCGTTGTTCTCCGGCGCGGACGGCCTCGACGCGATCCGGGCCCTCGAGCGGCGGGCCGCCGAG
CTGCTGCGACCGGGAGGTGTCGTCGGCTTCGAGCACGCGGACGTCCAGGGCGAGTCGGCGCCCGCGGTGTTCACCGCGAC
CGACCGCTGGGTCGACGTCCGCGACCACGACGACCTGGCGGGCCGCGCGCGCTTCACGACCGCGCGACTGGCACGATGA

Upstream 100 bases:

>100_bases
CTCGACCAGGTGCTCGACGGCGACCTCCAACCGGTCCTCGACTCCTGCGTCGAGGCCGACCTCGCCGCCCGCCTCGAGGC
GCTGGAGCAGTGAGCGCCCG

Downstream 100 bases:

>100_bases
CCGGTGTGAGGTCCGAGCAGTGAGCGAGCGCTACCCGACCGGCACCGACGAGGAGCGCGAGGCCGCGGTCGAGGCCGCCA
GCCTGGCCGTCCAGCGCGGC

Product: HemK family modification methylase

Products: NA

Alternate protein names: M.MtuHHemKP [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTQRRAVVTAAAERLRHAGVPSPGHDAEALLAHVLGTTRAGLVAVEDVAPSALEEYDALVARRAAREPLQHLTGSVGFRH
VEVAVGPGVFVPRPETELLAGWAIEQCLRWSSSRRVGGATAGRNPVVVDLCTGSGAVAKAIADEVPTADVHAVELDEEAH
RWAGRNLARTTVDLRLGDMATAFDDLLGQVDIVTCNPPYIPLDAWESVAPEARDHDPHLALFSGADGLDAIRALERRAAE
LLRPGGVVGFEHADVQGESAPAVFTATDRWVDVRDHDDLAGRARFTTARLAR

Sequences:

>Translated_292_residues
MTQRRAVVTAAAERLRHAGVPSPGHDAEALLAHVLGTTRAGLVAVEDVAPSALEEYDALVARRAAREPLQHLTGSVGFRH
VEVAVGPGVFVPRPETELLAGWAIEQCLRWSSSRRVGGATAGRNPVVVDLCTGSGAVAKAIADEVPTADVHAVELDEEAH
RWAGRNLARTTVDLRLGDMATAFDDLLGQVDIVTCNPPYIPLDAWESVAPEARDHDPHLALFSGADGLDAIRALERRAAE
LLRPGGVVGFEHADVQGESAPAVFTATDRWVDVRDHDDLAGRARFTTARLAR
>Mature_291_residues
TQRRAVVTAAAERLRHAGVPSPGHDAEALLAHVLGTTRAGLVAVEDVAPSALEEYDALVARRAAREPLQHLTGSVGFRHV
EVAVGPGVFVPRPETELLAGWAIEQCLRWSSSRRVGGATAGRNPVVVDLCTGSGAVAKAIADEVPTADVHAVELDEEAHR
WAGRNLARTTVDLRLGDMATAFDDLLGQVDIVTCNPPYIPLDAWESVAPEARDHDPHLALFSGADGLDAIRALERRAAEL
LRPGGVVGFEHADVQGESAPAVFTATDRWVDVRDHDDLAGRARFTTARLAR

Specific function: Probable protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI7705409, Length=289, Percent_Identity=28.719723183391, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1787463, Length=286, Percent_Identity=31.1188811188811, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082085, Length=200, Percent_Identity=31, Blast_Score=73, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24582226, Length=292, Percent_Identity=26.3698630136986, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004556
- InterPro:   IPR019874
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.-

Molecular weight: Translated: 31158; Mature: 31027

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRRAVVTAAAERLRHAGVPSPGHDAEALLAHVLGTTRAGLVAVEDVAPSALEEYDALV
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEHHCCHHHHHHHHHHH
ARRAAREPLQHLTGSVGFRHVEVAVGPGVFVPRPETELLAGWAIEQCLRWSSSRRVGGAT
HHHHHHHHHHHHHCCCCCEEEEEEECCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
AGRNPVVVDLCTGSGAVAKAIADEVPTADVHAVELDEEAHRWAGRNLARTTVDLRLGDMA
CCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCHHHEEEEEEECHHH
TAFDDLLGQVDIVTCNPPYIPLDAWESVAPEARDHDPHLALFSGADGLDAIRALERRAAE
HHHHHHHCCEEEEECCCCCCCHHCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
LLRPGGVVGFEHADVQGESAPAVFTATDRWVDVRDHDDLAGRARFTTARLAR
HHCCCCEEECCCCCCCCCCCCEEEEECCCEEECCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TQRRAVVTAAAERLRHAGVPSPGHDAEALLAHVLGTTRAGLVAVEDVAPSALEEYDALV
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEHHCCHHHHHHHHHHH
ARRAAREPLQHLTGSVGFRHVEVAVGPGVFVPRPETELLAGWAIEQCLRWSSSRRVGGAT
HHHHHHHHHHHHHCCCCCEEEEEEECCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCC
AGRNPVVVDLCTGSGAVAKAIADEVPTADVHAVELDEEAHRWAGRNLARTTVDLRLGDMA
CCCCCEEEEEECCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHCCCHHHEEEEEEECHHH
TAFDDLLGQVDIVTCNPPYIPLDAWESVAPEARDHDPHLALFSGADGLDAIRALERRAAE
HHHHHHHCCEEEEECCCCCCCHHCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHH
LLRPGGVVGFEHADVQGESAPAVFTATDRWVDVRDHDDLAGRARFTTARLAR
HHCCCCEEECCCCCCCCCCCCEEEEECCCEEECCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]