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The map label for this gene is hom [H]

Identifier: 119715979

GI number: 119715979

Start: 1854021

End: 1855346

Strand: Direct

Name: hom [H]

Synonym: Noca_1744

Alternate gene names: 119715979

Gene position: 1854021-1855346 (Clockwise)

Preceding gene: 119715978

Following gene: 119715980

Centisome position: 37.19

GC content: 73.08

Gene sequence:

>1326_bases
ATGGAGAGCGACAAGCTCGCCGCAGAGAAGGCGCTGAGAGTAGCCGTGCTCGGCTGCGGGTCCGTGGGGTCGCAGGTGGT
CCGGCTGCTCGAGGAGCAGGCGCACGACCTCGCAGCCCGGGTCGGTGCGCGGGTCGAGCTGGCCGGCGTCGCCGTACGCC
GGCCGGAGGCGCCGCGCGAGGTGGAGGTCCCCACGGAGCTGATCACGACCGACGCCACCGCGCTCGTCACCCGCGAGGAC
GTCGACCTCGTGGTCGAGGTCATCGGGGGCATCGAGCCGGCCCGCTCGCTGATCCTTGCCGCCCTCGAGAACGGCAAGTC
GGTGGTCACCGCGAACAAGGCGCTGCTGGCCGAGGACGGGCCGACGCTGTTCGAGGCGGCGGAGAAGGCCGGCCGCGACC
TCTACTACGAGGCTGCGGTGGCCGGGGCCATCCCGATCCTGCGCCCGTTGCGCGAGTCGCTGGCCGGAGACCGGGTGACC
CGGGTGCTCGGCATCGTCAACGGCACCACCAACTTCATCCTCGACCGGATGGACAGCTCGGGCGCCGGCTTCGCCGAGGC
GCTCGAGGAGGCCCAGGAGCTCGGGTACGCCGAGGCCGACCCGACGGCCGACGTCGAGGGCTTCGACGCCGCTGCCAAGG
CCGCGATCCTGGCCTCCCTCGCCTTCCACTCGCGGGTCACCGCCTCGGACGTGCACCGCGAGGGCATCTCCGAGGTCACG
GCCGCCGACGTCCAGTCCGCGCGTGAGATGAACAGCGTCGTGAAGCTGCTCGCGATCTGCGAGCTCCGCGTGACCGAGGA
CGGGCAGAGCGCGGTCGCGGTCCGGGTGCACCCGGCGATGATCCCGCGCGACCACCCGCTCGCCTCGGTGCGCGAGGCGT
TCAACGCCGTCTTCGTCGAGTCCGAGGCCGCCGGCCAGCTGATGTTCTACGGCCCCGGGGCCGGTGGTGCGCCGACCGCG
TCGGCGGTCCTCGGTGACCTCGTCACCGTGGCGCGCAACCGGCTCGCGGGCACCCGCGGCGCCGGCGAGTCGGCGTACGC
CGACCGCGCCGTGCTGCCGATGGGCGAGACGCTGACCCGGTACCACGTGGCGATCGACGTCGACGACCGCGCCGGCGTCC
TCGCCTCGGTGGCGACGGCGTTCGCCGAGAACGGCGTGTCGATCCAGACCGTCCGGCAGGAGGGTCGGGGAGCCGACGCG
CAGCTGGTCGTCGTCTCCCACGAGTCGACCGACGCGGCGTTGCGCGCCACCGTCGAGCACCTGCGCGAGATGGACATCGT
GCGCGAGGTGACGTCCGTGATGCGTGTCGAGGGGGCGACCGAGTGA

Upstream 100 bases:

>100_bases
TGCGTCCGCCGGTGGTCGCGGTGCGGGACGGAGTCGCGCGCGTCGTGGTTCGCCGGGAGACTGAGGACGACCTGTTGGCA
ACGGACATGGGTGATCAGTG

Downstream 100 bases:

>100_bases
ATCCGACCGGCTTCACGCCCACCCACCAGTGGCGCGGTGTGATCGAGGAGTACCGGCAGCTGCTGCAGATCCCCGAGGAC
ACGGTGGCGGTGACGCTGCG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MESDKLAAEKALRVAVLGCGSVGSQVVRLLEEQAHDLAARVGARVELAGVAVRRPEAPREVEVPTELITTDATALVTRED
VDLVVEVIGGIEPARSLILAALENGKSVVTANKALLAEDGPTLFEAAEKAGRDLYYEAAVAGAIPILRPLRESLAGDRVT
RVLGIVNGTTNFILDRMDSSGAGFAEALEEAQELGYAEADPTADVEGFDAAAKAAILASLAFHSRVTASDVHREGISEVT
AADVQSAREMNSVVKLLAICELRVTEDGQSAVAVRVHPAMIPRDHPLASVREAFNAVFVESEAAGQLMFYGPGAGGAPTA
SAVLGDLVTVARNRLAGTRGAGESAYADRAVLPMGETLTRYHVAIDVDDRAGVLASVATAFAENGVSIQTVRQEGRGADA
QLVVVSHESTDAALRATVEHLREMDIVREVTSVMRVEGATE

Sequences:

>Translated_441_residues
MESDKLAAEKALRVAVLGCGSVGSQVVRLLEEQAHDLAARVGARVELAGVAVRRPEAPREVEVPTELITTDATALVTRED
VDLVVEVIGGIEPARSLILAALENGKSVVTANKALLAEDGPTLFEAAEKAGRDLYYEAAVAGAIPILRPLRESLAGDRVT
RVLGIVNGTTNFILDRMDSSGAGFAEALEEAQELGYAEADPTADVEGFDAAAKAAILASLAFHSRVTASDVHREGISEVT
AADVQSAREMNSVVKLLAICELRVTEDGQSAVAVRVHPAMIPRDHPLASVREAFNAVFVESEAAGQLMFYGPGAGGAPTA
SAVLGDLVTVARNRLAGTRGAGESAYADRAVLPMGETLTRYHVAIDVDDRAGVLASVATAFAENGVSIQTVRQEGRGADA
QLVVVSHESTDAALRATVEHLREMDIVREVTSVMRVEGATE
>Mature_441_residues
MESDKLAAEKALRVAVLGCGSVGSQVVRLLEEQAHDLAARVGARVELAGVAVRRPEAPREVEVPTELITTDATALVTRED
VDLVVEVIGGIEPARSLILAALENGKSVVTANKALLAEDGPTLFEAAEKAGRDLYYEAAVAGAIPILRPLRESLAGDRVT
RVLGIVNGTTNFILDRMDSSGAGFAEALEEAQELGYAEADPTADVEGFDAAAKAAILASLAFHSRVTASDVHREGISEVT
AADVQSAREMNSVVKLLAICELRVTEDGQSAVAVRVHPAMIPRDHPLASVREAFNAVFVESEAAGQLMFYGPGAGGAPTA
SAVLGDLVTVARNRLAGTRGAGESAYADRAVLPMGETLTRYHVAIDVDDRAGVLASVATAFAENGVSIQTVRQEGRGADA
QLVVVSHESTDAALRATVEHLREMDIVREVTSVMRVEGATE

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=371, Percent_Identity=29.1105121293801, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786183, Length=260, Percent_Identity=30, Blast_Score=81, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322599, Length=127, Percent_Identity=35.4330708661417, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46202; Mature: 46202

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESDKLAAEKALRVAVLGCGSVGSQVVRLLEEQAHDLAARVGARVELAGVAVRRPEAPRE
CCCHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCC
VEVPTELITTDATALVTREDVDLVVEVIGGIEPARSLILAALENGKSVVTANKALLAEDG
CCCCHHHHHCCCHHEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCEEEECCC
PTLFEAAEKAGRDLYYEAAVAGAIPILRPLRESLAGDRVTRVLGIVNGTTNFILDRMDSS
CHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHCCCCCC
GAGFAEALEEAQELGYAEADPTADVEGFDAAAKAAILASLAFHSRVTASDVHREGISEVT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AADVQSAREMNSVVKLLAICELRVTEDGQSAVAVRVHPAMIPRDHPLASVREAFNAVFVE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHEEEE
SEAAGQLMFYGPGAGGAPTASAVLGDLVTVARNRLAGTRGAGESAYADRAVLPMGETLTR
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCEEE
YHVAIDVDDRAGVLASVATAFAENGVSIQTVRQEGRGADAQLVVVSHESTDAALRATVEH
EEEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHCCCCCCEEEEEEECCCCHHHHHHHHHH
LREMDIVREVTSVMRVEGATE
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MESDKLAAEKALRVAVLGCGSVGSQVVRLLEEQAHDLAARVGARVELAGVAVRRPEAPRE
CCCHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCC
VEVPTELITTDATALVTREDVDLVVEVIGGIEPARSLILAALENGKSVVTANKALLAEDG
CCCCHHHHHCCCHHEEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCEEEECCC
PTLFEAAEKAGRDLYYEAAVAGAIPILRPLRESLAGDRVTRVLGIVNGTTNFILDRMDSS
CHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHCCCCCC
GAGFAEALEEAQELGYAEADPTADVEGFDAAAKAAILASLAFHSRVTASDVHREGISEVT
CCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AADVQSAREMNSVVKLLAICELRVTEDGQSAVAVRVHPAMIPRDHPLASVREAFNAVFVE
HHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHEEEE
SEAAGQLMFYGPGAGGAPTASAVLGDLVTVARNRLAGTRGAGESAYADRAVLPMGETLTR
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCEEE
YHVAIDVDDRAGVLASVATAFAENGVSIQTVRQEGRGADAQLVVVSHESTDAALRATVEH
EEEEEEECCCCHHHHHHHHHHHHCCCEEEEHHHCCCCCCEEEEEEECCCCHHHHHHHHHH
LREMDIVREVTSVMRVEGATE
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2835591; 3320973; 9362124; 12948626; 1902466 [H]