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The map label for this gene is lysA [H]

Identifier: 119715978

GI number: 119715978

Start: 1852621

End: 1854021

Strand: Direct

Name: lysA [H]

Synonym: Noca_1743

Alternate gene names: 119715978

Gene position: 1852621-1854021 (Clockwise)

Preceding gene: 119715977

Following gene: 119715979

Centisome position: 37.16

GC content: 71.45

Gene sequence:

>1401_bases
ATGAGCCACGAAGCCGGCTGGGCGCACGCGCCCGGCGCCCTCCGCGGTCCCGCCTGGCTGCAGGCGCCCGCAGATCCGGA
CGCCCTGGTCTCGCACCTGTGGTCGTCGACCGCGCACAAGGTCGACGGCGTCCTGCACGTCGGCGGCCTGTCGGTCCCCG
ACGTCGTCGCGAACGTCAACACCCCGGCCTACGTCCTCGACGAAGCCGACTTCCGGATGCGTGCGCGGGCGTTCCGCGAC
GCATTCGCGGCGTACGACGTCTTCTACGCCGGCAAGGCGTTCCTCTGCACCACGGTCGCGCGCTGGGTGCAGGAGGAGGG
GCTGTGCCTCGACGTGTGCTCGAACGGCGAGCTCACCGTGGCGCTGCGGGCCGGCTTCGATCCGGCCCGGATCGGCTACC
ACGGCAACAACAAGACCGTCACCGAGCTGCGCCGCGCGCTCGCGGCCGGAGTCGGGCGGATCATCGTCGATTCCTTCGAC
GAGCTGGCCCGGCTCGAGATGATCACCGCCGACAGCGGCCTGCCCGCCCGCGTGATGATCCGGGTGACGGCGGGCGTCGA
GGCGCACACCCACGAGTACATCGCCACCGCGCACGAGGACCAGAAGTTCGGGTTCTCGATCACTTCCGGGGACGCGTTCG
AGGCGGCCCGCCGGGCCGAGGCCGCGCCGGGGATCGACCTGCTCGGCCTGCACTCGCACATCGGCAGCCAGATCTTCGAC
TCCTCCGGGTTCGAGGTCGCGGCCCGCAGGGTGCTGGCCCTGCAGGCGCGGATCTCCCAGGAGCTGGGGGTCACGCTGCC
CGAGATGGACCTCGGCGGCGGGTTCGGGATCGCCTACACGACGCAGGACGACCCGGCCGAACCCGCGCAGCTGGCACCTG
CGATGACCAAGATCGTCGAGCACGAGTGCCGGGCCCTCGGCATCCCCGAGCCGCGCCTGTCGATCGAGCCCGGTCGCGCG
ATCGTCGGTCCGGCGATGTGCACCGTCTACACCGTCGGGACCGTGAAGCCCGTCCAGCTCGACGGCGGGGCGGTGCGCAC
CTACGTCTCCGTCGACGGCGGGATGAGCGACAACATCCGCACCGCCCTGTACGACGCGGACTACTCCTGCACGCTGGCCT
CCCGGCCGTCGACGATCGGCGGCTCCGTGCTCGCCCGGGTCGTCGGCAAGCACTGCGAGGCCGGTGACATCGTCGTCAAG
GACGAGTTCCTGCCCGCCGACGTCCGCCCCGGCGACCTGGTGGCCGTCCCCGGCACCGGCGCCTACTGTCGCTCGATGGC
CTCCAACTACAACCACGCGCTGCGTCCGCCGGTGGTCGCGGTGCGGGACGGAGTCGCGCGCGTCGTGGTTCGCCGGGAGA
CTGAGGACGACCTGTTGGCAACGGACATGGGTGATCAGTGA

Upstream 100 bases:

>100_bases
TGCACCGCGCCCGGCTCGTGCTCGTCGCGGCCACCCGCACCGTCCTGGCCAACGGCCTCGACCTGGTCGGGGTCTCCGCA
CCCGAGCGGATGTAGGACGG

Downstream 100 bases:

>100_bases
TGGAGAGCGACAAGCTCGCCGCAGAGAAGGCGCTGAGAGTAGCCGTGCTCGGCTGCGGGTCCGTGGGGTCGCAGGTGGTC
CGGCTGCTCGAGGAGCAGGC

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSHEAGWAHAPGALRGPAWLQAPADPDALVSHLWSSTAHKVDGVLHVGGLSVPDVVANVNTPAYVLDEADFRMRARAFRD
AFAAYDVFYAGKAFLCTTVARWVQEEGLCLDVCSNGELTVALRAGFDPARIGYHGNNKTVTELRRALAAGVGRIIVDSFD
ELARLEMITADSGLPARVMIRVTAGVEAHTHEYIATAHEDQKFGFSITSGDAFEAARRAEAAPGIDLLGLHSHIGSQIFD
SSGFEVAARRVLALQARISQELGVTLPEMDLGGGFGIAYTTQDDPAEPAQLAPAMTKIVEHECRALGIPEPRLSIEPGRA
IVGPAMCTVYTVGTVKPVQLDGGAVRTYVSVDGGMSDNIRTALYDADYSCTLASRPSTIGGSVLARVVGKHCEAGDIVVK
DEFLPADVRPGDLVAVPGTGAYCRSMASNYNHALRPPVVAVRDGVARVVVRRETEDDLLATDMGDQ

Sequences:

>Translated_466_residues
MSHEAGWAHAPGALRGPAWLQAPADPDALVSHLWSSTAHKVDGVLHVGGLSVPDVVANVNTPAYVLDEADFRMRARAFRD
AFAAYDVFYAGKAFLCTTVARWVQEEGLCLDVCSNGELTVALRAGFDPARIGYHGNNKTVTELRRALAAGVGRIIVDSFD
ELARLEMITADSGLPARVMIRVTAGVEAHTHEYIATAHEDQKFGFSITSGDAFEAARRAEAAPGIDLLGLHSHIGSQIFD
SSGFEVAARRVLALQARISQELGVTLPEMDLGGGFGIAYTTQDDPAEPAQLAPAMTKIVEHECRALGIPEPRLSIEPGRA
IVGPAMCTVYTVGTVKPVQLDGGAVRTYVSVDGGMSDNIRTALYDADYSCTLASRPSTIGGSVLARVVGKHCEAGDIVVK
DEFLPADVRPGDLVAVPGTGAYCRSMASNYNHALRPPVVAVRDGVARVVVRRETEDDLLATDMGDQ
>Mature_465_residues
SHEAGWAHAPGALRGPAWLQAPADPDALVSHLWSSTAHKVDGVLHVGGLSVPDVVANVNTPAYVLDEADFRMRARAFRDA
FAAYDVFYAGKAFLCTTVARWVQEEGLCLDVCSNGELTVALRAGFDPARIGYHGNNKTVTELRRALAAGVGRIIVDSFDE
LARLEMITADSGLPARVMIRVTAGVEAHTHEYIATAHEDQKFGFSITSGDAFEAARRAEAAPGIDLLGLHSHIGSQIFDS
SGFEVAARRVLALQARISQELGVTLPEMDLGGGFGIAYTTQDDPAEPAQLAPAMTKIVEHECRALGIPEPRLSIEPGRAI
VGPAMCTVYTVGTVKPVQLDGGAVRTYVSVDGGMSDNIRTALYDADYSCTLASRPSTIGGSVLARVVGKHCEAGDIVVKD
EFLPADVRPGDLVAVPGTGAYCRSMASNYNHALRPPVVAVRDGVARVVVRRETEDDLLATDMGDQ

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=410, Percent_Identity=25.609756097561, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789203, Length=420, Percent_Identity=29.0476190476191, Blast_Score=116, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49530; Mature: 49398

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHEAGWAHAPGALRGPAWLQAPADPDALVSHLWSSTAHKVDGVLHVGGLSVPDVVANVN
CCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHCCC
TPAYVLDEADFRMRARAFRDAFAAYDVFYAGKAFLCTTVARWVQEEGLCLDVCSNGELTV
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCEEE
ALRAGFDPARIGYHGNNKTVTELRRALAAGVGRIIVDSFDELARLEMITADSGLPARVMI
EEECCCCHHHCCEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCCCCEEEEE
RVTAGVEAHTHEYIATAHEDQKFGFSITSGDAFEAARRAEAAPGIDLLGLHSHIGSQIFD
EEECCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHC
SSGFEVAARRVLALQARISQELGVTLPEMDLGGGFGIAYTTQDDPAEPAQLAPAMTKIVE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
HECRALGIPEPRLSIEPGRAIVGPAMCTVYTVGTVKPVQLDGGAVRTYVSVDGGMSDNIR
HHHHHCCCCCCCCEECCCCEEECCCEEEEEEECCEEEEEECCCEEEEEEEECCCCCCCCE
TALYDADYSCTLASRPSTIGGSVLARVVGKHCEAGDIVVKDEFLPADVRPGDLVAVPGTG
EEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEECCCC
AYCRSMASNYNHALRPPVVAVRDGVARVVVRRETEDDLLATDMGDQ
HHHHHHHHCCCCCCCCCEEEHHCCCEEEEEECCCCCCEECCCCCCC
>Mature Secondary Structure 
SHEAGWAHAPGALRGPAWLQAPADPDALVSHLWSSTAHKVDGVLHVGGLSVPDVVANVN
CCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHCCC
TPAYVLDEADFRMRARAFRDAFAAYDVFYAGKAFLCTTVARWVQEEGLCLDVCSNGELTV
CCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCEEE
ALRAGFDPARIGYHGNNKTVTELRRALAAGVGRIIVDSFDELARLEMITADSGLPARVMI
EEECCCCHHHCCEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEECCCCCCEEEEE
RVTAGVEAHTHEYIATAHEDQKFGFSITSGDAFEAARRAEAAPGIDLLGLHSHIGSQIFD
EEECCCCHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHC
SSGFEVAARRVLALQARISQELGVTLPEMDLGGGFGIAYTTQDDPAEPAQLAPAMTKIVE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
HECRALGIPEPRLSIEPGRAIVGPAMCTVYTVGTVKPVQLDGGAVRTYVSVDGGMSDNIR
HHHHHCCCCCCCCEECCCCEEECCCEEEEEEECCEEEEEECCCEEEEEEEECCCCCCCCE
TALYDADYSCTLASRPSTIGGSVLARVVGKHCEAGDIVVKDEFLPADVRPGDLVAVPGTG
EEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCEEEECCCC
AYCRSMASNYNHALRPPVVAVRDGVARVVVRRETEDDLLATDMGDQ
HHHHHHHHCCCCCCCCCEEEHHCCCEEEEEECCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]