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The map label for this gene is uao [H]

Identifier: 119715380

GI number: 119715380

Start: 1213911

End: 1214780

Strand: Reverse

Name: uao [H]

Synonym: Noca_1142

Alternate gene names: 119715380

Gene position: 1214780-1213911 (Counterclockwise)

Preceding gene: 119715381

Following gene: 119715379

Centisome position: 24.36

GC content: 71.03

Gene sequence:

>870_bases
ATGGCCACCACGGACGGGTCGAGGATCGTGCTCGGCGCCAACCAGTACGGCAAGGCCGAGGTGCGGCTGCTGCGGGTCGA
CCGGGCGAGCGAGCGGCACACGATCGAGGACCTCGGCATCACCACCCAGCTGCGCGGTGACTTCGAGGCCTGCCACACGC
ACGGTGACAACAGCCAGGTCGTCCCCACCGACACCCAGAAGAACACCATCCAGGCGTTCGCCCGGGACGGCATCGGCGCG
CCCGAGCACCTCCTGCTCCGGCTGGCCCGGCACTTCACCGACGGGTTCGCGTGGGTCACCGGCGGCCGGTTCGACGCCGA
GTCCTACGCCTGGGAGCGGATCGGGCTGCCCGACGGGTCCGGCCACGACCACTCCTTCGTCCGCACCGGGCGGGAGACCC
GCACCGCGACGGTCGAGGTCGACGGCGACGAGGTGGTGGTCACCGCCGGGCTCACCGACTGCACCGTGCTGAAGTCCACC
GGCTCGGAGTTCCACGGCTTCTCGCGCGACCGCTACACGACGCTGCCGGAGACCACCGACCGGATCCTCGCCACCAGCAT
CGCCGCGACCTGGCGCTACGCGACGACCGAGGTGGACTTCGACGCGCGGTACGCCGGGGTCCGGGACACCCTGCTCGCGA
CCTTCGCGACCACGCACTCCCTGGCCCTGCAGCAGACGATCTTCGAGATGGGCAAGGCGGTCCTCGAGCGGTACGACGAC
GTCGCCGAGGTCAGCCTGTCCTGCCCGAACAAGCACCACTTCCTCGTCGACCTCGAGCCGTTCGGGCTGGACAACCCGGG
CGAGGTCTTCTTCCCCGCCGACCGGCCCTACGGCCTGATCCAGGCGACCGTGCGCCGCGAGGGCGCCTGA

Upstream 100 bases:

>100_bases
CTGGTCAACGTCGCCTTCGAGGTCGACGCCGAGGAGGAGCACCACCACGTGGCGCTGCTGCTGAGCCCGTACTCCTACAC
GACCTACAAGGGGAGCTGAG

Downstream 100 bases:

>100_bases
TGGAGGCCGTGACCGACGAGCAGTGGCTCGCGCGGGCCGTCCGGCTCGCCCAGGAGAACGTCGCCGCCGGGGGTGGCCCG
TTCGGTGCCGTCGTCGTGGG

Product: urate oxidase

Products: NA

Alternate protein names: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; Uricase; Urate oxidase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MATTDGSRIVLGANQYGKAEVRLLRVDRASERHTIEDLGITTQLRGDFEACHTHGDNSQVVPTDTQKNTIQAFARDGIGA
PEHLLLRLARHFTDGFAWVTGGRFDAESYAWERIGLPDGSGHDHSFVRTGRETRTATVEVDGDEVVVTAGLTDCTVLKST
GSEFHGFSRDRYTTLPETTDRILATSIAATWRYATTEVDFDARYAGVRDTLLATFATTHSLALQQTIFEMGKAVLERYDD
VAEVSLSCPNKHHFLVDLEPFGLDNPGEVFFPADRPYGLIQATVRREGA

Sequences:

>Translated_289_residues
MATTDGSRIVLGANQYGKAEVRLLRVDRASERHTIEDLGITTQLRGDFEACHTHGDNSQVVPTDTQKNTIQAFARDGIGA
PEHLLLRLARHFTDGFAWVTGGRFDAESYAWERIGLPDGSGHDHSFVRTGRETRTATVEVDGDEVVVTAGLTDCTVLKST
GSEFHGFSRDRYTTLPETTDRILATSIAATWRYATTEVDFDARYAGVRDTLLATFATTHSLALQQTIFEMGKAVLERYDD
VAEVSLSCPNKHHFLVDLEPFGLDNPGEVFFPADRPYGLIQATVRREGA
>Mature_288_residues
ATTDGSRIVLGANQYGKAEVRLLRVDRASERHTIEDLGITTQLRGDFEACHTHGDNSQVVPTDTQKNTIQAFARDGIGAP
EHLLLRLARHFTDGFAWVTGGRFDAESYAWERIGLPDGSGHDHSFVRTGRETRTATVEVDGDEVVVTAGLTDCTVLKSTG
SEFHGFSRDRYTTLPETTDRILATSIAATWRYATTEVDFDARYAGVRDTLLATFATTHSLALQQTIFEMGKAVLERYDDV
AEVSLSCPNKHHFLVDLEPFGLDNPGEVFFPADRPYGLIQATVRREGA

Specific function: Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5- ureidoimidazoline (OHCU) to (S)-allantoin [H]

COG id: COG3648

COG function: function code Q; Uricase (urate oxidase)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the uricase family [H]

Homologues:

Organism=Drosophila melanogaster, GI17136576, Length=310, Percent_Identity=31.2903225806452, Blast_Score=157, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018020
- InterPro:   IPR017580
- InterPro:   IPR002042
- InterPro:   IPR019842 [H]

Pfam domain/function: PF09349 OHCU_decarbox; PF01014 Uricase [H]

EC number: =1.7.3.3 [H]

Molecular weight: Translated: 31896; Mature: 31764

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTDGSRIVLGANQYGKAEVRLLRVDRASERHTIEDLGITTQLRGDFEACHTHGDNSQV
CCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHCCCEEEECCCHHHHHCCCCCCEE
VPTDTQKNTIQAFARDGIGAPEHLLLRLARHFTDGFAWVTGGRFDAESYAWERIGLPDGS
ECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHEECCCCCCC
GHDHSFVRTGRETRTATVEVDGDEVVVTAGLTDCTVLKSTGSEFHGFSRDRYTTLPETTD
CCCCHHHHCCCCCEEEEEEECCCEEEEEECCCCEEEEECCCCHHCCCCCCCEECCCCHHH
RILATSIAATWRYATTEVDFDARYAGVRDTLLATFATTHSLALQQTIFEMGKAVLERYDD
HHHHHHHHHHEEEEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VAEVSLSCPNKHHFLVDLEPFGLDNPGEVFFPADRPYGLIQATVRREGA
HHEEEECCCCCCEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
ATTDGSRIVLGANQYGKAEVRLLRVDRASERHTIEDLGITTQLRGDFEACHTHGDNSQV
CCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHCCCEEEECCCHHHHHCCCCCCEE
VPTDTQKNTIQAFARDGIGAPEHLLLRLARHFTDGFAWVTGGRFDAESYAWERIGLPDGS
ECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHEECCCCCCC
GHDHSFVRTGRETRTATVEVDGDEVVVTAGLTDCTVLKSTGSEFHGFSRDRYTTLPETTD
CCCCHHHHCCCCCEEEEEEECCCEEEEEECCCCEEEEECCCCHHCCCCCCCEECCCCHHH
RILATSIAATWRYATTEVDFDARYAGVRDTLLATFATTHSLALQQTIFEMGKAVLERYDD
HHHHHHHHHHEEEEEEEECCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VAEVSLSCPNKHHFLVDLEPFGLDNPGEVFFPADRPYGLIQATVRREGA
HHEEEECCCCCCEEEEEECCCCCCCCCCEEECCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8907179 [H]