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The map label for this gene is guaD [H]

Identifier: 119715379

GI number: 119715379

Start: 1213435

End: 1213911

Strand: Reverse

Name: guaD [H]

Synonym: Noca_1141

Alternate gene names: 119715379

Gene position: 1213911-1213435 (Counterclockwise)

Preceding gene: 119715380

Following gene: 119715377

Centisome position: 24.35

GC content: 76.52

Gene sequence:

>477_bases
ATGGAGGCCGTGACCGACGAGCAGTGGCTCGCGCGGGCCGTCCGGCTCGCCCAGGAGAACGTCGCCGCCGGGGGTGGCCC
GTTCGGTGCCGTCGTCGTGGGGGCGGGCGTCCGGGTCGGCGAGGGGCAGAACCGGGTCACCCGCGACCTCGACCCGACCG
CGCACGCCGAGGTCACCGCGATCCGCCAGGCGTGCGCGGCGCTCGGCGACTTCTCGCTGACCGGCTGCGTGCTCTACGCC
TCCTGCGAGCCGTGCCCGCTGTGCCTGACCGCCTCGCTGTGGGCCCGGCTGGACCGGGTCGTGTACGCCGCCGACCGCCA
CGACGCCGCCCGCGGCGGGTTCGACGACCGGGAGTTCTACGACCTGCTCGGCCGCGACCGGGCGACCTGGCCGACCCGGG
TCGAGCAGGGCACGCACGCCGCGCCGTTCGCGCCGTTCGAGGCCTGGCTCGGCAAGGCGGACCGCACGGCGTACTGA

Upstream 100 bases:

>100_bases
ACCTCGAGCCGTTCGGGCTGGACAACCCGGGCGAGGTCTTCTTCCCCGCCGACCGGCCCTACGGCCTGATCCAGGCGACC
GTGCGCCGCGAGGGCGCCTG

Downstream 100 bases:

>100_bases
ACGTCCGCCGATCAGACCGCGCGGGCGGCGGCGCGGCCCGCCGTACGGCCCGAGAACAGGCAGCCGCCCAGGAAGGTGCC
CTCGAGCGCGTTGTAGCCCA

Product: guanine deaminase

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MEAVTDEQWLARAVRLAQENVAAGGGPFGAVVVGAGVRVGEGQNRVTRDLDPTAHAEVTAIRQACAALGDFSLTGCVLYA
SCEPCPLCLTASLWARLDRVVYAADRHDAARGGFDDREFYDLLGRDRATWPTRVEQGTHAAPFAPFEAWLGKADRTAY

Sequences:

>Translated_158_residues
MEAVTDEQWLARAVRLAQENVAAGGGPFGAVVVGAGVRVGEGQNRVTRDLDPTAHAEVTAIRQACAALGDFSLTGCVLYA
SCEPCPLCLTASLWARLDRVVYAADRHDAARGGFDDREFYDLLGRDRATWPTRVEQGTHAAPFAPFEAWLGKADRTAY
>Mature_158_residues
MEAVTDEQWLARAVRLAQENVAAGGGPFGAVVVGAGVRVGEGQNRVTRDLDPTAHAEVTAIRQACAALGDFSLTGCVLYA
SCEPCPLCLTASLWARLDRVVYAADRHDAARGGFDDREFYDLLGRDRATWPTRVEQGTHAAPFAPFEAWLGKADRTAY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=100, Percent_Identity=38, Blast_Score=74, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17554608, Length=152, Percent_Identity=42.1052631578947, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17555996, Length=153, Percent_Identity=45.0980392156863, Blast_Score=131, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17541138, Length=107, Percent_Identity=36.4485981308411, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17010; Mature: 17010

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAVTDEQWLARAVRLAQENVAAGGGPFGAVVVGAGVRVGEGQNRVTRDLDPTAHAEVTA
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCEEECCCCCCCCCCCCCCHHHHHHH
IRQACAALGDFSLTGCVLYASCEPCPLCLTASLWARLDRVVYAADRHDAARGGFDDREFY
HHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHH
DLLGRDRATWPTRVEQGTHAAPFAPFEAWLGKADRTAY
HHHCCCCCCCCCHHCCCCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MEAVTDEQWLARAVRLAQENVAAGGGPFGAVVVGAGVRVGEGQNRVTRDLDPTAHAEVTA
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHEEECCEEECCCCCCCCCCCCCCHHHHHHH
IRQACAALGDFSLTGCVLYASCEPCPLCLTASLWARLDRVVYAADRHDAARGGFDDREFY
HHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHH
DLLGRDRATWPTRVEQGTHAAPFAPFEAWLGKADRTAY
HHHCCCCCCCCCHHCCCCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]