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The map label for this gene is nuoD

Identifier: 119714787

GI number: 119714787

Start: 552835

End: 554175

Strand: Direct

Name: nuoD

Synonym: Noca_0523

Alternate gene names: 119714787

Gene position: 552835-554175 (Clockwise)

Preceding gene: 119714786

Following gene: 119714788

Centisome position: 11.09

GC content: 68.23

Gene sequence:

>1341_bases
ATGGCCGACCAGGATCTCTACTCCGGCTCCAGCGAGACGACCGAGGGCCGGGTCTTCACCGTCACCGGGCAGGACTGGGA
CTCGATCGCCGAGGGCCTGGCCGAGGACGAGGCGCAGGAGCGCATCGTCGTCAACATGGGCCCCCAGCACCCTTCGACCC
ACGGGGTGCTCCGGCTGATCCTCGAGCTCGAGGGCGAGACGGTGACCGAGGCGCGGGCCGGCATCGGCTACCTGCACACC
GGCATCGAGAAGAACATGGAGTACCGCACCTGGACGCAGGGCGTGACGTTCTGCACCCGGATGGACTACCTCAGCCCGTT
CTTCAACGAGATGACCTACGTGCTCGGGATCGAGCGGCTCCTCGACATCGAGGACCGGGTGCCCGAGAAGGCCCAGGTCA
TGCGGGTCCTGCTCATGGAGCTCAACCGGATCTCCTCCCACCTGGTCGCCATCGCGACCGGTGGCATGGAGCTCGGTGCG
CTGACCGTGATGACGATCGGCTTCCGCGAGCGCGAGCTGGTGCTCGACCTGTTCGAGCTGATCACCGGCCTGCGGATGAA
CCACGCGTTCATCCGTCCCGGTGGCGTCGCCCAGGACATGCCGCCGGGCGCGCTCGACGAGATCCGCGGCTTCGTGGCGC
TGATGAAGAAGCGGTTGCCGGAGTACGCCGACCTCTGCAACGCGAACCCGATCTTCAAGGGGCGCCTCGAGGGCATCGGC
CACCTCGACCTCGCCGGCTGCCTGGCGCTCGGCCTCACCGGCCCGGTGCTGCGCAGCACCGGCTACCCGTGGGACCTGCG
CAAGACCCAGCCGTACTGCGGCTACGAGACCTACGACTTCGACGTCCAGACGTGGGACACCTCCGACTCCTACGGCCGGT
TCCGCATCCGCTTGAACGAGATGTGGGAGTCGCTGCGGATCATCGAGCAGGCCGCCGACCGGCTGGCCGGTCTCGACGGC
GCCCCGGTGATGATCGAGGACAAGAAGATCGGCTGGCCCAGCCAGCTTGCGATCGGCAGCGACGGCATGGGCAACAGCCT
CGACCACATCCGCCACATCATGGGTGAGTCGATGGAGGCGCTGATCCACCACTTCAAGCTGGTCACCGAGGGCTTCCGGG
TGCCGCCCGGCCAGGCCTACGTGCCGGTGGAGTCCCCGCGTGGCGAGCTCGGCGCCCACGTCGTGTCCGACGGCGGCACC
CGCCCGTTCCGCGCGCACTTCCGCGACCCGTCGTTCACCAACCTGCAGGCGACCAGCGTGATGGCCGAGGGCGGCATGGT
CGCCGACGTCATCGTCGCGATCGCGTCCATCGATCCGGTCATGGGAGGCGTCGACCGATGA

Upstream 100 bases:

>100_bases
CCGGCCACCCGCAGCGCAAGGACTACCCGCTCGGGGGCGTTCCCGTGGAGTACAAGGGCGGCACGGTCCCCCCGCCCGAC
CAGCGGAGGAGCTACAACTG

Downstream 100 bases:

>100_bases
GCTTGACCCAGGAGACGTACGGCGAGCTGCAGGAGATCGCCGCCCGCTACCCGGAGCCCCGCTCCGGCCTGCTGCCGATG
CTCCACCTCGTCCAGTCCGC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MADQDLYSGSSETTEGRVFTVTGQDWDSIAEGLAEDEAQERIVVNMGPQHPSTHGVLRLILELEGETVTEARAGIGYLHT
GIEKNMEYRTWTQGVTFCTRMDYLSPFFNEMTYVLGIERLLDIEDRVPEKAQVMRVLLMELNRISSHLVAIATGGMELGA
LTVMTIGFRERELVLDLFELITGLRMNHAFIRPGGVAQDMPPGALDEIRGFVALMKKRLPEYADLCNANPIFKGRLEGIG
HLDLAGCLALGLTGPVLRSTGYPWDLRKTQPYCGYETYDFDVQTWDTSDSYGRFRIRLNEMWESLRIIEQAADRLAGLDG
APVMIEDKKIGWPSQLAIGSDGMGNSLDHIRHIMGESMEALIHHFKLVTEGFRVPPGQAYVPVESPRGELGAHVVSDGGT
RPFRAHFRDPSFTNLQATSVMAEGGMVADVIVAIASIDPVMGGVDR

Sequences:

>Translated_446_residues
MADQDLYSGSSETTEGRVFTVTGQDWDSIAEGLAEDEAQERIVVNMGPQHPSTHGVLRLILELEGETVTEARAGIGYLHT
GIEKNMEYRTWTQGVTFCTRMDYLSPFFNEMTYVLGIERLLDIEDRVPEKAQVMRVLLMELNRISSHLVAIATGGMELGA
LTVMTIGFRERELVLDLFELITGLRMNHAFIRPGGVAQDMPPGALDEIRGFVALMKKRLPEYADLCNANPIFKGRLEGIG
HLDLAGCLALGLTGPVLRSTGYPWDLRKTQPYCGYETYDFDVQTWDTSDSYGRFRIRLNEMWESLRIIEQAADRLAGLDG
APVMIEDKKIGWPSQLAIGSDGMGNSLDHIRHIMGESMEALIHHFKLVTEGFRVPPGQAYVPVESPRGELGAHVVSDGGT
RPFRAHFRDPSFTNLQATSVMAEGGMVADVIVAIASIDPVMGGVDR
>Mature_445_residues
ADQDLYSGSSETTEGRVFTVTGQDWDSIAEGLAEDEAQERIVVNMGPQHPSTHGVLRLILELEGETVTEARAGIGYLHTG
IEKNMEYRTWTQGVTFCTRMDYLSPFFNEMTYVLGIERLLDIEDRVPEKAQVMRVLLMELNRISSHLVAIATGGMELGAL
TVMTIGFRERELVLDLFELITGLRMNHAFIRPGGVAQDMPPGALDEIRGFVALMKKRLPEYADLCNANPIFKGRLEGIGH
LDLAGCLALGLTGPVLRSTGYPWDLRKTQPYCGYETYDFDVQTWDTSDSYGRFRIRLNEMWESLRIIEQAADRLAGLDGA
PVMIEDKKIGWPSQLAIGSDGMGNSLDHIRHIMGESMEALIHHFKLVTEGFRVPPGQAYVPVESPRGELGAHVVSDGGTR
PFRAHFRDPSFTNLQATSVMAEGGMVADVIVAIASIDPVMGGVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=412, Percent_Identity=41.504854368932, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI260898743, Length=402, Percent_Identity=41.044776119403, Blast_Score=309, Evalue=4e-84,
Organism=Escherichia coli, GI145693162, Length=411, Percent_Identity=37.4695863746959, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1789076, Length=405, Percent_Identity=25.679012345679, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788832, Length=406, Percent_Identity=25.615763546798, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=38.0722891566265, Blast_Score=313, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17555284, Length=416, Percent_Identity=38.4615384615385, Blast_Score=312, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24638644, Length=411, Percent_Identity=41.3625304136253, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI221459469, Length=404, Percent_Identity=42.5742574257426, Blast_Score=333, Evalue=1e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_NOCSJ (A1SE30)

Other databases:

- EMBL:   CP000509
- RefSeq:   YP_921752.1
- ProteinModelPortal:   A1SE30
- SMR:   A1SE30
- STRING:   A1SE30
- GeneID:   4596443
- GenomeReviews:   CP000509_GR
- KEGG:   nca:Noca_0523
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   LRMNHAF
- PhylomeDB:   A1SE30
- ProtClustDB:   PRK06075
- BioCyc:   NSP35761:NOCA_0523-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 49336; Mature: 49205

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADQDLYSGSSETTEGRVFTVTGQDWDSIAEGLAEDEAQERIVVNMGPQHPSTHGVLRLI
CCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHH
LELEGETVTEARAGIGYLHTGIEKNMEYRTWTQGVTFCTRMDYLSPFFNEMTYVLGIERL
HHHCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDIEDRVPEKAQVMRVLLMELNRISSHLVAIATGGMELGALTVMTIGFRERELVLDLFEL
HCHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCEEEEEEECCCHHHHHHHHHHH
ITGLRMNHAFIRPGGVAQDMPPGALDEIRGFVALMKKRLPEYADLCNANPIFKGRLEGIG
HHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCC
HLDLAGCLALGLTGPVLRSTGYPWDLRKTQPYCGYETYDFDVQTWDTSDSYGRFRIRLNE
CHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCEEEECEEEECCCCCCCCEEEEEHHH
MWESLRIIEQAADRLAGLDGAPVMIEDKKIGWPSQLAIGSDGMGNSLDHIRHIMGESMEA
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
LIHHFKLVTEGFRVPPGQAYVPVESPRGELGAHVVSDGGTRPFRAHFRDPSFTNLQATSV
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCCCCHHHH
MAEGGMVADVIVAIASIDPVMGGVDR
HHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ADQDLYSGSSETTEGRVFTVTGQDWDSIAEGLAEDEAQERIVVNMGPQHPSTHGVLRLI
CCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHH
LELEGETVTEARAGIGYLHTGIEKNMEYRTWTQGVTFCTRMDYLSPFFNEMTYVLGIERL
HHHCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDIEDRVPEKAQVMRVLLMELNRISSHLVAIATGGMELGALTVMTIGFRERELVLDLFEL
HCHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHCEEEEEEECCCHHHHHHHHHHH
ITGLRMNHAFIRPGGVAQDMPPGALDEIRGFVALMKKRLPEYADLCNANPIFKGRLEGIG
HHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHCCCC
HLDLAGCLALGLTGPVLRSTGYPWDLRKTQPYCGYETYDFDVQTWDTSDSYGRFRIRLNE
CHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCEEEECEEEECCCCCCCCEEEEEHHH
MWESLRIIEQAADRLAGLDGAPVMIEDKKIGWPSQLAIGSDGMGNSLDHIRHIMGESMEA
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHH
LIHHFKLVTEGFRVPPGQAYVPVESPRGELGAHVVSDGGTRPFRAHFRDPSFTNLQATSV
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCEEECCCCCCCCHHCCCCCCCCCCCHHHH
MAEGGMVADVIVAIASIDPVMGGVDR
HHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA