Click here to switch to the map view.

The map label for this gene is nhaK [H]

Identifier: 119714775

GI number: 119714775

Start: 541936

End: 543810

Strand: Direct

Name: nhaK [H]

Synonym: Noca_0511

Alternate gene names: 119714775

Gene position: 541936-543810 (Clockwise)

Preceding gene: 119714774

Following gene: 119714779

Centisome position: 10.87

GC content: 72.59

Gene sequence:

>1875_bases
ATGGCGGACGTGGACACCGCCCTCTTCCTGGTCGCGCTGGCCGTCGCCGTGCTCGCCGGCGTGGTGGTCGCCGGCCGGAT
CGGGGTGCCCGCCCCGCTGCTGCTCGTGGTCGCGGGCGTCGCCGCGTCGTTCCTGCCGTTCCTGCCCGAGGTGCATCTCG
AGCCGGACGTCGTGCTGTTCGGGCTCCTGCCGCCGCTGCTCTACTCGGCGGCGATCACGTCCTCGCTCGTGGACTTCAAC
GCCAACCGCCGCCCGATCCTGCTGTTGTCGGTCGGCCTCGTCGTCTTCACGACCCTCGGCGTCGGCGTTCTCGTCCACGA
GCTGGTGCCCGGCCTGTCCTGGCCGGTCGCGTTCGCGCTCGGGGCGGTCGTCGCGCCACCGGACGCCGTCGCGGCCACCT
CCATCGGCCGGCACATCGGGCTCCCCCGCAGGGTCGTGACGATCCTCGAGGGCGAGTCCCTGTTCAACGACGCGACCGCG
CTGGTCTCGCTGCAGACCGCCCTCGGGGCAACACTGGTGGGGGTCGAGCTCTGGCGTGTCGGCCTGGACTTCGTGGTCGC
CGCGGGCGGGGGCGTGCTGATCGGGGTGGTCGTCTTCCTCGTGGTCGGGGCGATGCGCAGGCGCCTGAGCGATCCGATGC
TCGACGTCGCGATGTCCTTCGTGATCCCGTTCACGGCGTTCCTCGCTGCCGAGGAGGTCCACGCGTCGGGCGTCGTGGCC
GTCGTGACCGCCGGCCTGCTGCTCGGCCACCGGGCGCCCGTCCTGCAGACCGCGCAGTCGCGGATCGCCGAGCGGATCAA
CTGGCGCACGATCGCGTTCCTGCTCGAGAACACCGTGTTCGCGCTGATCGGACTCCAGGCCCGGTGGCTGTTCGACGACC
TGGGGGAGAGCACGCTCTCGCCGGCCCGGATCATCGCAGTCTCGGCCGCCACGCTGGTCGCGGTCATCGTGCTGCGGCTC
GTGTGGGTCTTCCTCTCGCGCTCGCTGCTGGTCCGCCCGCGCGTGGACCCCGCGACCGGACAGGTTCCGCCGTGGTCGTT
CACACTCCTGCTCGGCTGGTCCGGCATGCGCGGGGTGGTCACCCTGGCCGCGGCGTTCCTGATCCCGCCCGACACCCGGC
ACCGCGAGGTGCTGCTCGTCGTCGCGTTCGCCGTCGTGGCGGGCACCCTGCTCGTCCAGGGGCTCAGCCTGCCGTGGCTC
ACCCGCCGGCTGCACGTCCCCGCCCCGGACCCGCTCGACGACGCGCTCGCCCGCGCCACCCTGCTCCAGCAGGCGTCGAA
GGCGGCGGTCGAGGAGCTCGAGCGGCAGGAGTACGACGACCAGGCCGGCGTGGGCGACCTGATCCGGCAACGGCTCGACC
AGCGGAACTTCGCCGCGTGGGAGCGCCTGGGGACCACCGCCGACCAGGAGTCACCGGCCGCCGTCTACTACCGCATCCGG
ATGGCGATGATCGCCGCCGAGCGCCGACGGATCCTGGAGATCCGGCGCTCCGGCACCGTGGCCTCCGAGGTGATCGCCGA
GGTGCTCTCGATGCTCGACGTCGAGGAGTCGATGCTCGACAACGCCCACCAGGAGCGGGACGAGGCCGAGGACTACGCCC
GTCGGCGCTGGACGCTCGGGGAGACCTGCGACGACCTGGGCCGCTACCCGGTCGTCGACGCCGAGCCCGCGACGTACTGC
CAGGCCTGCCTGGACGAGGGCACCCGCTGGGTGGCGTTGCGCCGCTGCCTGGAGTGCGGCAACCTCGCCTGCTGCGACTC
CTCACCCCGCCAGCACGCCACCGCGCACTTCCGGGAGACCCAGCACCCGGTCATGCAGTCCGCCGAGCCCGGCGAGGACT
GGCGCTGGTGCTACCTCCACCACCTGACGGCATGA

Upstream 100 bases:

>100_bases
GGAGGCCGTCGTACGCCGCGACAACCGGCGCGACCTCGACGAGCGGATCCGCGCGCTGCGTCCCTGACAGTCCGGTCCGT
CCGACCGCCGGTCCGCGACA

Downstream 100 bases:

>100_bases
GGCGGAGGTGTCGCCGGCTGGCGGGTCGTGTGCCTGAGCACGCTCCATGGCGCGTTCTCAGGCACACGACCCGATCGGCG
CCGGGTGCTCGAACCGGATC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MADVDTALFLVALAVAVLAGVVVAGRIGVPAPLLLVVAGVAASFLPFLPEVHLEPDVVLFGLLPPLLYSAAITSSLVDFN
ANRRPILLLSVGLVVFTTLGVGVLVHELVPGLSWPVAFALGAVVAPPDAVAATSIGRHIGLPRRVVTILEGESLFNDATA
LVSLQTALGATLVGVELWRVGLDFVVAAGGGVLIGVVVFLVVGAMRRRLSDPMLDVAMSFVIPFTAFLAAEEVHASGVVA
VVTAGLLLGHRAPVLQTAQSRIAERINWRTIAFLLENTVFALIGLQARWLFDDLGESTLSPARIIAVSAATLVAVIVLRL
VWVFLSRSLLVRPRVDPATGQVPPWSFTLLLGWSGMRGVVTLAAAFLIPPDTRHREVLLVVAFAVVAGTLLVQGLSLPWL
TRRLHVPAPDPLDDALARATLLQQASKAAVEELERQEYDDQAGVGDLIRQRLDQRNFAAWERLGTTADQESPAAVYYRIR
MAMIAAERRRILEIRRSGTVASEVIAEVLSMLDVEESMLDNAHQERDEAEDYARRRWTLGETCDDLGRYPVVDAEPATYC
QACLDEGTRWVALRRCLECGNLACCDSSPRQHATAHFRETQHPVMQSAEPGEDWRWCYLHHLTA

Sequences:

>Translated_624_residues
MADVDTALFLVALAVAVLAGVVVAGRIGVPAPLLLVVAGVAASFLPFLPEVHLEPDVVLFGLLPPLLYSAAITSSLVDFN
ANRRPILLLSVGLVVFTTLGVGVLVHELVPGLSWPVAFALGAVVAPPDAVAATSIGRHIGLPRRVVTILEGESLFNDATA
LVSLQTALGATLVGVELWRVGLDFVVAAGGGVLIGVVVFLVVGAMRRRLSDPMLDVAMSFVIPFTAFLAAEEVHASGVVA
VVTAGLLLGHRAPVLQTAQSRIAERINWRTIAFLLENTVFALIGLQARWLFDDLGESTLSPARIIAVSAATLVAVIVLRL
VWVFLSRSLLVRPRVDPATGQVPPWSFTLLLGWSGMRGVVTLAAAFLIPPDTRHREVLLVVAFAVVAGTLLVQGLSLPWL
TRRLHVPAPDPLDDALARATLLQQASKAAVEELERQEYDDQAGVGDLIRQRLDQRNFAAWERLGTTADQESPAAVYYRIR
MAMIAAERRRILEIRRSGTVASEVIAEVLSMLDVEESMLDNAHQERDEAEDYARRRWTLGETCDDLGRYPVVDAEPATYC
QACLDEGTRWVALRRCLECGNLACCDSSPRQHATAHFRETQHPVMQSAEPGEDWRWCYLHHLTA
>Mature_623_residues
ADVDTALFLVALAVAVLAGVVVAGRIGVPAPLLLVVAGVAASFLPFLPEVHLEPDVVLFGLLPPLLYSAAITSSLVDFNA
NRRPILLLSVGLVVFTTLGVGVLVHELVPGLSWPVAFALGAVVAPPDAVAATSIGRHIGLPRRVVTILEGESLFNDATAL
VSLQTALGATLVGVELWRVGLDFVVAAGGGVLIGVVVFLVVGAMRRRLSDPMLDVAMSFVIPFTAFLAAEEVHASGVVAV
VTAGLLLGHRAPVLQTAQSRIAERINWRTIAFLLENTVFALIGLQARWLFDDLGESTLSPARIIAVSAATLVAVIVLRLV
WVFLSRSLLVRPRVDPATGQVPPWSFTLLLGWSGMRGVVTLAAAFLIPPDTRHREVLLVVAFAVVAGTLLVQGLSLPWLT
RRLHVPAPDPLDDALARATLLQQASKAAVEELERQEYDDQAGVGDLIRQRLDQRNFAAWERLGTTADQESPAAVYYRIRM
AMIAAERRRILEIRRSGTVASEVIAEVLSMLDVEESMLDNAHQERDEAEDYARRRWTLGETCDDLGRYPVVDAEPATYCQ
ACLDEGTRWVALRRCLECGNLACCDSSPRQHATAHFRETQHPVMQSAEPGEDWRWCYLHHLTA

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI27734935, Length=423, Percent_Identity=23.1678486997636, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI41872703, Length=415, Percent_Identity=23.855421686747, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI14211919, Length=399, Percent_Identity=23.3082706766917, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI194239733, Length=373, Percent_Identity=25.7372654155496, Blast_Score=81, Evalue=4e-15,
Organism=Homo sapiens, GI15529998, Length=560, Percent_Identity=21.0714285714286, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI5454070, Length=423, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1790501, Length=558, Percent_Identity=28.494623655914, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25147678, Length=436, Percent_Identity=25, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71993582, Length=420, Percent_Identity=23.8095238095238, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71993590, Length=499, Percent_Identity=22.8456913827655, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71999819, Length=410, Percent_Identity=21.9512195121951, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71999817, Length=410, Percent_Identity=21.9512195121951, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71999821, Length=410, Percent_Identity=21.9512195121951, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71987537, Length=520, Percent_Identity=20.9615384615385, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71987535, Length=510, Percent_Identity=21.5686274509804, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71992107, Length=403, Percent_Identity=22.0843672456576, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71992101, Length=403, Percent_Identity=22.0843672456576, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25150332, Length=412, Percent_Identity=21.3592233009709, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980847, Length=375, Percent_Identity=23.4666666666667, Blast_Score=65, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320663, Length=346, Percent_Identity=24.8554913294798, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI281360447, Length=359, Percent_Identity=22.8412256267409, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221510738, Length=379, Percent_Identity=22.9551451187335, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221510734, Length=379, Percent_Identity=22.9551451187335, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221510736, Length=385, Percent_Identity=22.8571428571429, Blast_Score=73, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221510732, Length=385, Percent_Identity=22.8571428571429, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24585580, Length=385, Percent_Identity=22.8571428571429, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24585578, Length=385, Percent_Identity=22.8571428571429, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221510740, Length=385, Percent_Identity=22.8571428571429, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 67546; Mature: 67415

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50271 ZF_UBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVDTALFLVALAVAVLAGVVVAGRIGVPAPLLLVVAGVAASFLPFLPEVHLEPDVVLF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
GLLPPLLYSAAITSSLVDFNANRRPILLLSVGLVVFTTLGVGVLVHELVPGLSWPVAFAL
HHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GAVVAPPDAVAATSIGRHIGLPRRVVTILEGESLFNDATALVSLQTALGATLVGVELWRV
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLDFVVAAGGGVLIGVVVFLVVGAMRRRLSDPMLDVAMSFVIPFTAFLAAEEVHASGVVA
HHHHHEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VVTAGLLLGHRAPVLQTAQSRIAERINWRTIAFLLENTVFALIGLQARWLFDDLGESTLS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PARIIAVSAATLVAVIVLRLVWVFLSRSLLVRPRVDPATGQVPPWSFTLLLGWSGMRGVV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEEEEEECCCCHHHH
TLAAAFLIPPDTRHREVLLVVAFAVVAGTLLVQGLSLPWLTRRLHVPAPDPLDDALARAT
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCHHHHHHHHH
LLQQASKAAVEELERQEYDDQAGVGDLIRQRLDQRNFAAWERLGTTADQESPAAVYYRIR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHH
MAMIAAERRRILEIRRSGTVASEVIAEVLSMLDVEESMLDNAHQERDEAEDYARRRWTLG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ETCDDLGRYPVVDAEPATYCQACLDEGTRWVALRRCLECGNLACCDSSPRQHATAHFRET
CCHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHH
QHPVMQSAEPGEDWRWCYLHHLTA
HHHHHCCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
ADVDTALFLVALAVAVLAGVVVAGRIGVPAPLLLVVAGVAASFLPFLPEVHLEPDVVLF
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
GLLPPLLYSAAITSSLVDFNANRRPILLLSVGLVVFTTLGVGVLVHELVPGLSWPVAFAL
HHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
GAVVAPPDAVAATSIGRHIGLPRRVVTILEGESLFNDATALVSLQTALGATLVGVELWRV
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLDFVVAAGGGVLIGVVVFLVVGAMRRRLSDPMLDVAMSFVIPFTAFLAAEEVHASGVVA
HHHHHEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VVTAGLLLGHRAPVLQTAQSRIAERINWRTIAFLLENTVFALIGLQARWLFDDLGESTLS
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PARIIAVSAATLVAVIVLRLVWVFLSRSLLVRPRVDPATGQVPPWSFTLLLGWSGMRGVV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEEEEEECCCCHHHH
TLAAAFLIPPDTRHREVLLVVAFAVVAGTLLVQGLSLPWLTRRLHVPAPDPLDDALARAT
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHEECCCCCCCHHHHHHHHH
LLQQASKAAVEELERQEYDDQAGVGDLIRQRLDQRNFAAWERLGTTADQESPAAVYYRIR
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHH
MAMIAAERRRILEIRRSGTVASEVIAEVLSMLDVEESMLDNAHQERDEAEDYARRRWTLG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ETCDDLGRYPVVDAEPATYCQACLDEGTRWVALRRCLECGNLACCDSSPRQHATAHFRET
CCHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHH
QHPVMQSAEPGEDWRWCYLHHLTA
HHHHHCCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA