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The map label for this gene is proC [H]

Identifier: 119714745

GI number: 119714745

Start: 511592

End: 512395

Strand: Direct

Name: proC [H]

Synonym: Noca_0481

Alternate gene names: 119714745

Gene position: 511592-512395 (Clockwise)

Preceding gene: 119714744

Following gene: 119714747

Centisome position: 10.26

GC content: 74.38

Gene sequence:

>804_bases
ATGTCCCAGACCGCCATCCTCGGCGCCGGCGTGATGGGCGAGACCCTGCTCTCCGGCCTGGTGCGCGCCGGCCGCCGCGT
CGACCACCTGCTGGTCGGCGAGAAGCGCCCCGAGCGCGCCCAGGAGCTCGAGGAGCGGTACGGCGTCGCCGTGGTCGGCA
ACGCCGAGGCGGCCCGCAAGGCCGACACGCTCGCCCTGGTCGTCAAGCCCCAGGACATGGGCGACCTGCTCGAGGAGATC
GCCGGCGAGCTGCGCCCGGGCCAGCTGGTCGTCTCCCTTGCGGCCGGCATCACCACCGCCTTCATCGAGGCCCGGGTCCC
CGAGGGCGTCGCCGTGGTCCGGGTGATGCCGAACACGCCCGCGCTGGTCGACGAGGGGATGGCTGCGGTCTCTCCCGGGT
CGCACTGCAGCGAGGAGCACCTCGCCGAGGCCGAGTCGCTGATGGCGTCGGTCGGCCGGGTGCTCCGGATCCCGGAGCGC
CAGCAGGACGCCGTCACCGCGATCTCCGGGTCCGGCCCGGCCTACATCTTCTTCGTCGTGGAGTCGATGATCGAGGCCGG
CGTCCACCTGGGCCTGCCGCGTGCGACCGCCACCGACCTGGTCGTCCAGACCGTCGTGGGCTCGGCCAAGATGCTGCGCG
AGACCGGCACCCACCCGGCCGTGCTGCGCGAGCAGGTCACCTCCCCGGCCGGCACCACCGCGGCGGCCCTGCGCGAGCTG
GAGATCCACAAGGTGCGCGCCGCGTTCCTCGCCGCCATGGAGGCCGCGCGCGACCGGTCGCGTGCGCTCGCCGAGGGCAG
CTGA

Upstream 100 bases:

>100_bases
TCCGCGACGAAGGAGCGGACGCGTTGTGGGTGAAGATCGAGCATGCCCCGCGACCGAGGCACGAGGTCGCGACGGGCGCG
TCGAAAGTCCGGAGGTACCG

Downstream 100 bases:

>100_bases
CCGGCCCCTCCGCTGCCAGCAGCCGACCCCGCGTCCTCACAGCCCCATCGCGGCCTGCGCGGCCGCGAGCACCGGGGCGG
TCACCTCCCGGCAGCGGGCG

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSQTAILGAGVMGETLLSGLVRAGRRVDHLLVGEKRPERAQELEERYGVAVVGNAEAARKADTLALVVKPQDMGDLLEEI
AGELRPGQLVVSLAAGITTAFIEARVPEGVAVVRVMPNTPALVDEGMAAVSPGSHCSEEHLAEAESLMASVGRVLRIPER
QQDAVTAISGSGPAYIFFVVESMIEAGVHLGLPRATATDLVVQTVVGSAKMLRETGTHPAVLREQVTSPAGTTAAALREL
EIHKVRAAFLAAMEAARDRSRALAEGS

Sequences:

>Translated_267_residues
MSQTAILGAGVMGETLLSGLVRAGRRVDHLLVGEKRPERAQELEERYGVAVVGNAEAARKADTLALVVKPQDMGDLLEEI
AGELRPGQLVVSLAAGITTAFIEARVPEGVAVVRVMPNTPALVDEGMAAVSPGSHCSEEHLAEAESLMASVGRVLRIPER
QQDAVTAISGSGPAYIFFVVESMIEAGVHLGLPRATATDLVVQTVVGSAKMLRETGTHPAVLREQVTSPAGTTAAALREL
EIHKVRAAFLAAMEAARDRSRALAEGS
>Mature_266_residues
SQTAILGAGVMGETLLSGLVRAGRRVDHLLVGEKRPERAQELEERYGVAVVGNAEAARKADTLALVVKPQDMGDLLEEIA
GELRPGQLVVSLAAGITTAFIEARVPEGVAVVRVMPNTPALVDEGMAAVSPGSHCSEEHLAEAESLMASVGRVLRIPERQ
QDAVTAISGSGPAYIFFVVESMIEAGVHLGLPRATATDLVVQTVVGSAKMLRETGTHPAVLREQVTSPAGTTAAALRELE
IHKVRAAFLAAMEAARDRSRALAEGS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=264, Percent_Identity=35.2272727272727, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI24797097, Length=264, Percent_Identity=35.2272727272727, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI24797095, Length=264, Percent_Identity=35.2272727272727, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI198041662, Length=260, Percent_Identity=32.3076923076923, Blast_Score=135, Evalue=5e-32,
Organism=Escherichia coli, GI1786585, Length=265, Percent_Identity=36.9811320754717, Blast_Score=167, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17569021, Length=266, Percent_Identity=39.8496240601504, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=27.5, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320861, Length=286, Percent_Identity=32.8671328671329, Blast_Score=136, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=38.9513108614232, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=44.3786982248521, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=30.3249097472924, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27982; Mature: 27850

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00962 RIBOSOMAL_S2_1 ; PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTAILGAGVMGETLLSGLVRAGRRVDHLLVGEKRPERAQELEERYGVAVVGNAEAARK
CCCCCEEECCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCEEEEECCHHHHC
ADTLALVVKPQDMGDLLEEIAGELRPGQLVVSLAAGITTAFIEARVPEGVAVVRVMPNTP
CCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
ALVDEGMAAVSPGSHCSEEHLAEAESLMASVGRVLRIPERQQDAVTAISGSGPAYIFFVV
HHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEECCCCCEEHHHHH
ESMIEAGVHLGLPRATATDLVVQTVVGSAKMLRETGTHPAVLREQVTSPAGTTAAALREL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHH
EIHKVRAAFLAAMEAARDRSRALAEGS
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQTAILGAGVMGETLLSGLVRAGRRVDHLLVGEKRPERAQELEERYGVAVVGNAEAARK
CCCCEEECCHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHCCEEEEECCHHHHC
ADTLALVVKPQDMGDLLEEIAGELRPGQLVVSLAAGITTAFIEARVPEGVAVVRVMPNTP
CCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
ALVDEGMAAVSPGSHCSEEHLAEAESLMASVGRVLRIPERQQDAVTAISGSGPAYIFFVV
HHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHEEECCCCCEEHHHHH
ESMIEAGVHLGLPRATATDLVVQTVVGSAKMLRETGTHPAVLREQVTSPAGTTAAALREL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHH
EIHKVRAAFLAAMEAARDRSRALAEGS
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]