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The map label for this gene is yngE [H]

Identifier: 119714414

GI number: 119714414

Start: 161748

End: 163259

Strand: Direct

Name: yngE [H]

Synonym: Noca_0147

Alternate gene names: 119714414

Gene position: 161748-163259 (Clockwise)

Preceding gene: 119714413

Following gene: 119714415

Centisome position: 3.24

GC content: 71.1

Gene sequence:

>1512_bases
ATGAAGGAGCTGGTGGACGAGCTGCGCGAGCGGCTCGCGACCGCCCGGCAGGGCGGCAGCGAGAAGGCCCGCCGCAAGCA
CACCGACCGCGGCAAGCTGCTGGTGCGCGACCGGGTCGACCGCCTCCTCGATCCCGGCAGCCCGTTCCTGGAGCTCAGCC
CGCTGGCGGCCGACGGGATGTACGGCGGCGCCGTACCGTCGGCCGGCGTCGTGACGGGCATCGGCCGGGTGAGCGGCCGC
GAGGTCGTGGTGGTCGCCAACGACGCCACGGTCAAGGGCGGCACCTACTACCCGATGACGGTCAAGAAGCACCTGCGCGC
GCAGACGGTCGCCGCCGACAACCGGCTGCCGTGCGTCTACCTGGTCGACTCCGGCGGGGCGTTCTTGCCGATGCAGGACG
AGGTGTTCCCCGACCGCGAGCACTTCGGGCGGATCTTCTTCAACCAGGCGAACCTGTCGGCCCGCGGGATCCCGCAGATC
GCCAGCGTGATGGGCTCGTGCACCGCCGGCGGCGCCTACGTCCCCGCGATGTCCGACGAGACCGTGATCGTGCGCAACCA
GGGCACGATCTTCCTCGGCGGCCCCCCGCTGGTGAAGGCCGCGACCGGTGAGGTGGTGACGGCCGAGGAGCTCGGCGGCG
GCGACGTGCACGCGCGCACCTCCGGCGTGGCCGACCATTTGGCCGAGGACGACGCGCACGCGCTGGCGATCGTGCGCAGC
ATCGTCGAGACCGTGGGCCCGCGCGCGGCCGCGCCGTGGGAGGTCCATCCGGTCGAGGAGCCGCACGAGGACCCGACCAG
CCTGTACGACGTGATCCCCGCGGACACCAGGACGCCGTACGACGTGCGCGAGGTGATCCGCCGGGTCGTGGACGGCAGCC
GGTTCCACGAGTTCAAGAAGCTGTACGGCGAGACCCTGGTCACCGGCTTCGCCCGGGTCTGGGGCCACCCGGTCGGCATC
GTCGCCAACAACGGCATCCTCTTCAGCGAGTCCTCGCTGAAGGGCGCCCACTTCATCGAGCTGTGCAACCAGCGCGGCAT
CCCGCTGGTCTTCCTGCAGAACATCACCGGCTTCATGGTCGGCAAGGAGTACGAGAACGGCGGCATCGCCAAGGACGGCG
CCAAGCTCGTCACGGCCGTCGCCTGCTCGGTGGTGCCGAAGTTCACCGTCGTCATCGGCGGCTCGTTCGGCGCCGGCAAC
TACGGCATGTGCGGGCGCGCCTACGACCCGAGGTTCCTGTGGATGTGGCCGAACGCCCGGATCTCGGTGATGGGCGGCGA
GCAGGCCGCCTCGGTGCTGGCGACCGTCGCCGGGCGTCCCGACGACGAGGAGTTCAAGGCGCCGATCCGCGAGCAGTACG
AGACCCAGGGCTCGCCGTACTACTCGACAGCGAGGCTGTGGGACGACGGGATCATCGACCCCGCCGACACCCGCCGCGTC
CTCGGCATGGGCCTCGCGGCCGCGGCCAACGCGCCGGTCCCGGCTCCCACCTACGGCATCTTCCGGATGTGA

Upstream 100 bases:

>100_bases
CCGGGGGTGATCCCCCGGGGCGGACGCCGATGCCCGGCGCCGATCGCTCCCGTCGGTGGACCCACAGGTTAATGATCGCT
AACCTGTGGGAGTGAGCCAC

Downstream 100 bases:

>100_bases
TCTCACCCCACGACGTTCTTCGCTCCCCCGCTCCGCTCCTCCGTGAACAACGCCGCGGGGACCCCGACACCTCGGAGAAA
CCAGTCCTATGACGAATTCC

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MKELVDELRERLATARQGGSEKARRKHTDRGKLLVRDRVDRLLDPGSPFLELSPLAADGMYGGAVPSAGVVTGIGRVSGR
EVVVVANDATVKGGTYYPMTVKKHLRAQTVAADNRLPCVYLVDSGGAFLPMQDEVFPDREHFGRIFFNQANLSARGIPQI
ASVMGSCTAGGAYVPAMSDETVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGDVHARTSGVADHLAEDDAHALAIVRS
IVETVGPRAAAPWEVHPVEEPHEDPTSLYDVIPADTRTPYDVREVIRRVVDGSRFHEFKKLYGETLVTGFARVWGHPVGI
VANNGILFSESSLKGAHFIELCNQRGIPLVFLQNITGFMVGKEYENGGIAKDGAKLVTAVACSVVPKFTVVIGGSFGAGN
YGMCGRAYDPRFLWMWPNARISVMGGEQAASVLATVAGRPDDEEFKAPIREQYETQGSPYYSTARLWDDGIIDPADTRRV
LGMGLAAAANAPVPAPTYGIFRM

Sequences:

>Translated_503_residues
MKELVDELRERLATARQGGSEKARRKHTDRGKLLVRDRVDRLLDPGSPFLELSPLAADGMYGGAVPSAGVVTGIGRVSGR
EVVVVANDATVKGGTYYPMTVKKHLRAQTVAADNRLPCVYLVDSGGAFLPMQDEVFPDREHFGRIFFNQANLSARGIPQI
ASVMGSCTAGGAYVPAMSDETVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGDVHARTSGVADHLAEDDAHALAIVRS
IVETVGPRAAAPWEVHPVEEPHEDPTSLYDVIPADTRTPYDVREVIRRVVDGSRFHEFKKLYGETLVTGFARVWGHPVGI
VANNGILFSESSLKGAHFIELCNQRGIPLVFLQNITGFMVGKEYENGGIAKDGAKLVTAVACSVVPKFTVVIGGSFGAGN
YGMCGRAYDPRFLWMWPNARISVMGGEQAASVLATVAGRPDDEEFKAPIREQYETQGSPYYSTARLWDDGIIDPADTRRV
LGMGLAAAANAPVPAPTYGIFRM
>Mature_503_residues
MKELVDELRERLATARQGGSEKARRKHTDRGKLLVRDRVDRLLDPGSPFLELSPLAADGMYGGAVPSAGVVTGIGRVSGR
EVVVVANDATVKGGTYYPMTVKKHLRAQTVAADNRLPCVYLVDSGGAFLPMQDEVFPDREHFGRIFFNQANLSARGIPQI
ASVMGSCTAGGAYVPAMSDETVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGDVHARTSGVADHLAEDDAHALAIVRS
IVETVGPRAAAPWEVHPVEEPHEDPTSLYDVIPADTRTPYDVREVIRRVVDGSRFHEFKKLYGETLVTGFARVWGHPVGI
VANNGILFSESSLKGAHFIELCNQRGIPLVFLQNITGFMVGKEYENGGIAKDGAKLVTAVACSVVPKFTVVIGGSFGAGN
YGMCGRAYDPRFLWMWPNARISVMGGEQAASVLATVAGRPDDEEFKAPIREQYETQGSPYYSTARLWDDGIIDPADTRRV
LGMGLAAAANAPVPAPTYGIFRM

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=515, Percent_Identity=63.3009708737864, Blast_Score=666, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=509, Percent_Identity=34.1846758349705, Blast_Score=240, Evalue=3e-63,
Organism=Homo sapiens, GI295821216, Length=529, Percent_Identity=33.0812854442344, Blast_Score=229, Evalue=7e-60,
Organism=Homo sapiens, GI310133460, Length=125, Percent_Identity=60.8, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17552936, Length=524, Percent_Identity=59.1603053435115, Blast_Score=651, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=488, Percent_Identity=35.655737704918, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI25147362, Length=488, Percent_Identity=35.655737704918, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24586065, Length=531, Percent_Identity=63.653483992467, Blast_Score=688, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 54008; Mature: 54008

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKELVDELRERLATARQGGSEKARRKHTDRGKLLVRDRVDRLLDPGSPFLELSPLAADGM
CHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEHHHHHHHHHCCCCCCEEECCCCCCCC
YGGAVPSAGVVTGIGRVSGREVVVVANDATVKGGTYYPMTVKKHLRAQTVAADNRLPCVY
CCCCCCCCCHHEECCCCCCCEEEEEECCCEECCCEECCHHHHHHHHHHHHHCCCCCCEEE
LVDSGGAFLPMQDEVFPDREHFGRIFFNQANLSARGIPQIASVMGSCTAGGAYVPAMSDE
EECCCCEECCCCCCCCCCHHHHCEEEEEECCCCCCCCHHHHHHHHCCCCCCEEECCCCCC
TVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGDVHARTSGVADHLAEDDAHALAIVRS
EEEEEECCEEEECCCCEEEECCCCEEEHHHCCCCCEECCHHHHHHHHHCCHHHHHHHHHH
IVETVGPRAAAPWEVHPVEEPHEDPTSLYDVIPADTRTPYDVREVIRRVVDGSRFHEFKK
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
LYGETLVTGFARVWGHPVGIVANNGILFSESSLKGAHFIELCNQRGIPLVFLQNITGFMV
HHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEE
GKEYENGGIAKDGAKLVTAVACSVVPKFTVVIGGSFGAGNYGMCGRAYDPRFLWMWPNAR
ECEECCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCE
ISVMGGEQAASVLATVAGRPDDEEFKAPIREQYETQGSPYYSTARLWDDGIIDPADTRRV
EEEECCHHHHHHHHHHCCCCCCHHHHCHHHHHHHCCCCCCEEEHEECCCCCCCCHHHHHH
LGMGLAAAANAPVPAPTYGIFRM
HHCCHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKELVDELRERLATARQGGSEKARRKHTDRGKLLVRDRVDRLLDPGSPFLELSPLAADGM
CHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEHHHHHHHHHCCCCCCEEECCCCCCCC
YGGAVPSAGVVTGIGRVSGREVVVVANDATVKGGTYYPMTVKKHLRAQTVAADNRLPCVY
CCCCCCCCCHHEECCCCCCCEEEEEECCCEECCCEECCHHHHHHHHHHHHHCCCCCCEEE
LVDSGGAFLPMQDEVFPDREHFGRIFFNQANLSARGIPQIASVMGSCTAGGAYVPAMSDE
EECCCCEECCCCCCCCCCHHHHCEEEEEECCCCCCCCHHHHHHHHCCCCCCEEECCCCCC
TVIVRNQGTIFLGGPPLVKAATGEVVTAEELGGGDVHARTSGVADHLAEDDAHALAIVRS
EEEEEECCEEEECCCCEEEECCCCEEEHHHCCCCCEECCHHHHHHHHHCCHHHHHHHHHH
IVETVGPRAAAPWEVHPVEEPHEDPTSLYDVIPADTRTPYDVREVIRRVVDGSRFHEFKK
HHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
LYGETLVTGFARVWGHPVGIVANNGILFSESSLKGAHFIELCNQRGIPLVFLQNITGFMV
HHHHHHHHHHHHHHCCCEEEEECCCEEEECCCCCCHHHHHHHHCCCCCEEEECCCCEEEE
GKEYENGGIAKDGAKLVTAVACSVVPKFTVVIGGSFGAGNYGMCGRAYDPRFLWMWPNAR
ECEECCCCCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCE
ISVMGGEQAASVLATVAGRPDDEEFKAPIREQYETQGSPYYSTARLWDDGIIDPADTRRV
EEEECCHHHHHHHHHHCCCCCCHHHHCHHHHHHHCCCCCCEEEHEECCCCCCCCHHHHHH
LGMGLAAAANAPVPAPTYGIFRM
HHCCHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]