Click here to switch to the map view.

The map label for this gene is echA8 [H]

Identifier: 119387186

GI number: 119387186

Start: 1695640

End: 1696647

Strand: Direct

Name: echA8 [H]

Synonym: Pden_4481

Alternate gene names: 119387186

Gene position: 1695640-1696647 (Clockwise)

Preceding gene: 119387185

Following gene: 119387187

Centisome position: 98.01

GC content: 71.33

Gene sequence:

>1008_bases
ATGGCCGAGATGATCATCCGCAAGGACCGCCGCGCCGGGCGCCTGACCTTCAACCGCCCGCAGGCGCTGAACGCGCTGAG
CCACGAGATGGCGCTGGCCATCGACGCGGCGCTGCAAGAGTGGCGCGACGATCCCGAGGTGGCGCTGGTCGTCATCGATG
CCGAGGGCGAGCGCGCCTTCTGCTCGGGCGGCGACATCGCCGCGGTCTATCGCGCCGGGCTGGAAGGCGACCACCGGGTC
GGCCGCGAGTTCTTTCGCGACGAATACCGCATGAACGCGCGGATCGCCGAATATCCCAAGCCCATCGTCGCCTTCATGCA
GGGCTTCGTGATGGGCGGCGGCGTCGGCGTCGGCGGCCATGCCAGCCACCGCATCGTCGGCGACAGCACCCAGATCGCCA
TGCCCGAAACCGGCATCGGCCTGATCCCGGACGTGGGCGGCAGCTGGCTTCTGGGCCATGCGCCCGGCCGCTGCGGCGAA
TACCTGGGCCTGACCGGCGCGCGGATCGGCGCCGGCGACGCGATCTTCACCGGCTTTGCGGACAGCTATATCCCCGAGGC
GGAATGGCCGGCGCTGATCGAGCGGCTGGCCGAGACCGGCGACGTGGCGGCGCTCGCGCCCCACCCCCGCCCCGAGGCGC
CGCTGGAGGGCCGCGACCTTTCGGCCTTCGGCGGCCATACCGTGGCCGAGATCGTCGCCGCGCTGGAGGCGGCGGGCGAC
GAGGCGGCGCTGAAGCCGCTGCGCCGCAACTCGCCCCTGTCGATGGCGGCTACGCTGGCGCTGGTGCGTGCCGCGCGCGG
CGATGCTAGCCTGCGCGACAGCCTGGCGCGAGAGCTGCGCTTTACCGCCCGCGCCACGGCCGAGAGCGATTTCCTGGAAG
GCGTGCGGGCGCAGATCATCGACAAGGATCGCAACCCGCAATGGTCGGCCGATGCCAGCCCGGCGCATGTCGAGGCGATG
CTGGCACCGCTGGGCGAGGACGAAATCGAATGGGAGAACGGCAAATGA

Upstream 100 bases:

>100_bases
AAAGATCGTGCGCGACCTGCGCGTGCACCAGATCCTGGAAGGCACCAATGAAATCATGCGGCTGATCGTCGGCCGCGGCC
TGCTGGCGGAGCGTGACTGA

Downstream 100 bases:

>100_bases
AGATCGGATTCATCGGCTTGGGCAATATGGGCGGCCCGATGGCGGCCAATCTGGCCAAGGCGGGGCACAAGGTCGCGGGC
TTCGACCTGGCCGCGCCGAT

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MAEMIIRKDRRAGRLTFNRPQALNALSHEMALAIDAALQEWRDDPEVALVVIDAEGERAFCSGGDIAAVYRAGLEGDHRV
GREFFRDEYRMNARIAEYPKPIVAFMQGFVMGGGVGVGGHASHRIVGDSTQIAMPETGIGLIPDVGGSWLLGHAPGRCGE
YLGLTGARIGAGDAIFTGFADSYIPEAEWPALIERLAETGDVAALAPHPRPEAPLEGRDLSAFGGHTVAEIVAALEAAGD
EAALKPLRRNSPLSMAATLALVRAARGDASLRDSLARELRFTARATAESDFLEGVRAQIIDKDRNPQWSADASPAHVEAM
LAPLGEDEIEWENGK

Sequences:

>Translated_335_residues
MAEMIIRKDRRAGRLTFNRPQALNALSHEMALAIDAALQEWRDDPEVALVVIDAEGERAFCSGGDIAAVYRAGLEGDHRV
GREFFRDEYRMNARIAEYPKPIVAFMQGFVMGGGVGVGGHASHRIVGDSTQIAMPETGIGLIPDVGGSWLLGHAPGRCGE
YLGLTGARIGAGDAIFTGFADSYIPEAEWPALIERLAETGDVAALAPHPRPEAPLEGRDLSAFGGHTVAEIVAALEAAGD
EAALKPLRRNSPLSMAATLALVRAARGDASLRDSLARELRFTARATAESDFLEGVRAQIIDKDRNPQWSADASPAHVEAM
LAPLGEDEIEWENGK
>Mature_334_residues
AEMIIRKDRRAGRLTFNRPQALNALSHEMALAIDAALQEWRDDPEVALVVIDAEGERAFCSGGDIAAVYRAGLEGDHRVG
REFFRDEYRMNARIAEYPKPIVAFMQGFVMGGGVGVGGHASHRIVGDSTQIAMPETGIGLIPDVGGSWLLGHAPGRCGEY
LGLTGARIGAGDAIFTGFADSYIPEAEWPALIERLAETGDVAALAPHPRPEAPLEGRDLSAFGGHTVAEIVAALEAAGDE
AALKPLRRNSPLSMAATLALVRAARGDASLRDSLARELRFTARATAESDFLEGVRAQIIDKDRNPQWSADASPAHVEAML
APLGEDEIEWENGK

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=327, Percent_Identity=34.2507645259939, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI37594469, Length=300, Percent_Identity=33, Blast_Score=165, Evalue=5e-41,
Organism=Homo sapiens, GI194097323, Length=179, Percent_Identity=30.1675977653631, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI221142681, Length=175, Percent_Identity=28, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787659, Length=186, Percent_Identity=25.2688172043011, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787660, Length=163, Percent_Identity=30.6748466257669, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI25144157, Length=347, Percent_Identity=34.5821325648415, Blast_Score=200, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI25144160, Length=347, Percent_Identity=34.5821325648415, Blast_Score=200, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI25145438, Length=174, Percent_Identity=29.8850574712644, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=176, Percent_Identity=28.9772727272727, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17549921, Length=195, Percent_Identity=25.6410256410256, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320241, Length=345, Percent_Identity=30.7246376811594, Blast_Score=144, Evalue=2e-35,
Organism=Drosophila melanogaster, GI28571730, Length=333, Percent_Identity=37.5375375375375, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI28571729, Length=333, Percent_Identity=37.5375375375375, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI20129971, Length=181, Percent_Identity=29.8342541436464, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24653477, Length=181, Percent_Identity=29.8342541436464, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 35827; Mature: 35696

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEMIIRKDRRAGRLTFNRPQALNALSHEMALAIDAALQEWRDDPEVALVVIDAEGERAF
CCCCHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEE
CSGGDIAAVYRAGLEGDHRVGREFFRDEYRMNARIAEYPKPIVAFMQGFVMGGGVGVGGH
ECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCC
ASHRIVGDSTQIAMPETGIGLIPDVGGSWLLGHAPGRCGEYLGLTGARIGAGDAIFTGFA
CCCEEECCCCEEECCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCCCCCHHHHCCH
DSYIPEAEWPALIERLAETGDVAALAPHPRPEAPLEGRDLSAFGGHTVAEIVAALEAAGD
HHCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
EAALKPLRRNSPLSMAATLALVRAARGDASLRDSLARELRFTARATAESDFLEGVRAQII
HHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
DKDRNPQWSADASPAHVEAMLAPLGEDEIEWENGK
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
AEMIIRKDRRAGRLTFNRPQALNALSHEMALAIDAALQEWRDDPEVALVVIDAEGERAF
CCCHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEE
CSGGDIAAVYRAGLEGDHRVGREFFRDEYRMNARIAEYPKPIVAFMQGFVMGGGVGVGGH
ECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCC
ASHRIVGDSTQIAMPETGIGLIPDVGGSWLLGHAPGRCGEYLGLTGARIGAGDAIFTGFA
CCCEEECCCCEEECCCCCCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCCCCCHHHHCCH
DSYIPEAEWPALIERLAETGDVAALAPHPRPEAPLEGRDLSAFGGHTVAEIVAALEAAGD
HHCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
EAALKPLRRNSPLSMAATLALVRAARGDASLRDSLARELRFTARATAESDFLEGVRAQII
HHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
DKDRNPQWSADASPAHVEAMLAPLGEDEIEWENGK
CCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]