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The map label for this gene is mmsB [H]

Identifier: 119387187

GI number: 119387187

Start: 1696644

End: 1697519

Strand: Direct

Name: mmsB [H]

Synonym: Pden_4482

Alternate gene names: 119387187

Gene position: 1696644-1697519 (Clockwise)

Preceding gene: 119387186

Following gene: 119387188

Centisome position: 98.07

GC content: 70.43

Gene sequence:

>876_bases
ATGAAGATCGGATTCATCGGCTTGGGCAATATGGGCGGCCCGATGGCGGCCAATCTGGCCAAGGCGGGGCACAAGGTCGC
GGGCTTCGACCTGGCCGCGCCGATGCCCGGGGGCGTCGTCAAGGCCGCCAGCGCCGCCGAGGCTGCCGCGGGCGCCGAGG
TGGTGATCACCATGCTGCCGAACGGCGCCATCCTGCGCGCGGTCGCGGATGAGATCGTCCCGGCCATGGCCGCGGGCGCG
GTGTTCTGCGATTGCTCGACGGTGGACGTGGAAAGCGCCCGCGCGGTGGCCGGGCAGGCGCAGGCGGCGGGCCTGGGCGC
GCTGGACGCGCCGGTCTCGGGCGGGGTCGGCGGTGCCACCGCCGGCACGCTGACCTTCATGGTCGGCGGTTCGGCCGAGG
CTTTCGACAAGGTGAAGCCGCTCTTCGACATCATGGGCCAGAAGGCGGTGCATTGCGGCGAGGCGGGCGCCGGCCAGGCC
GCCAAGATCTGCAACAACATGATCCTGGGCGTGACCATGATCGCCACCTGCGAGGCATTTGCGCTGGCCGACAAGCTGGG
GCTGGACCGCGCGAGGATGTTCGACGTGGTATCGACCTCCTCGGGCTATAGCTGGTCGATGAACGCCTATTGCCCTGCGC
CGGGGGTGGGGCCGGCGTCGCCTGCCGACAACGGCTACAAGCCGGGCTTCGCCGCCGAGCTGATGCTCAAGGATCTGCGG
CTGTCCCAGCAGGCCGCCGAGGCCGCGGATGCCGACACGCCGATGGGCGAACTGGCCGCCGCGCTCTATGCCCGCTTCGT
CGAGGACGAGGACGGAAAGGGCCGCGATTTCTCGGCCATGCTGCCCAGATTCGAGGCTCGGCACCGGCAGGGCTGA

Upstream 100 bases:

>100_bases
AGGATCGCAACCCGCAATGGTCGGCCGATGCCAGCCCGGCGCATGTCGAGGCGATGCTGGCACCGCTGGGCGAGGACGAA
ATCGAATGGGAGAACGGCAA

Downstream 100 bases:

>100_bases
TTTCTCGCATTCGTGAGGGAGCCGATCGGGGGTTTGCGGCGTTTAACCCTCGATCAAGTTTTCTGTGCCAGGCTGGAGCC
ATGTTACGCAATCGCCAGAG

Product: 3-hydroxyisobutyrate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKIGFIGLGNMGGPMAANLAKAGHKVAGFDLAAPMPGGVVKAASAAEAAAGAEVVITMLPNGAILRAVADEIVPAMAAGA
VFCDCSTVDVESARAVAGQAQAAGLGALDAPVSGGVGGATAGTLTFMVGGSAEAFDKVKPLFDIMGQKAVHCGEAGAGQA
AKICNNMILGVTMIATCEAFALADKLGLDRARMFDVVSTSSGYSWSMNAYCPAPGVGPASPADNGYKPGFAAELMLKDLR
LSQQAAEAADADTPMGELAAALYARFVEDEDGKGRDFSAMLPRFEARHRQG

Sequences:

>Translated_291_residues
MKIGFIGLGNMGGPMAANLAKAGHKVAGFDLAAPMPGGVVKAASAAEAAAGAEVVITMLPNGAILRAVADEIVPAMAAGA
VFCDCSTVDVESARAVAGQAQAAGLGALDAPVSGGVGGATAGTLTFMVGGSAEAFDKVKPLFDIMGQKAVHCGEAGAGQA
AKICNNMILGVTMIATCEAFALADKLGLDRARMFDVVSTSSGYSWSMNAYCPAPGVGPASPADNGYKPGFAAELMLKDLR
LSQQAAEAADADTPMGELAAALYARFVEDEDGKGRDFSAMLPRFEARHRQG
>Mature_291_residues
MKIGFIGLGNMGGPMAANLAKAGHKVAGFDLAAPMPGGVVKAASAAEAAAGAEVVITMLPNGAILRAVADEIVPAMAAGA
VFCDCSTVDVESARAVAGQAQAAGLGALDAPVSGGVGGATAGTLTFMVGGSAEAFDKVKPLFDIMGQKAVHCGEAGAGQA
AKICNNMILGVTMIATCEAFALADKLGLDRARMFDVVSTSSGYSWSMNAYCPAPGVGPASPADNGYKPGFAAELMLKDLR
LSQQAAEAADADTPMGELAAALYARFVEDEDGKGRDFSAMLPRFEARHRQG

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=287, Percent_Identity=40.0696864111498, Blast_Score=197, Evalue=8e-51,
Organism=Homo sapiens, GI40556376, Length=272, Percent_Identity=25.3676470588235, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI145693186, Length=298, Percent_Identity=34.5637583892617, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786719, Length=298, Percent_Identity=30.8724832214765, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790315, Length=293, Percent_Identity=31.0580204778157, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1789092, Length=294, Percent_Identity=28.2312925170068, Blast_Score=77, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17557316, Length=302, Percent_Identity=38.7417218543046, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24655230, Length=285, Percent_Identity=41.7543859649123, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI19922568, Length=285, Percent_Identity=41.7543859649123, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI28574115, Length=281, Percent_Identity=24.5551601423488, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29264; Mature: 29264

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGNMGGPMAANLAKAGHKVAGFDLAAPMPGGVVKAASAAEAAAGAEVVITMLP
CEEEEEEECCCCCHHHHHHHHCCCCEECCEECCCCCCCHHHHHHHHHHHCCCEEEEEECC
NGAILRAVADEIVPAMAAGAVFCDCSTVDVESARAVAGQAQAAGLGALDAPVSGGVGGAT
CCHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCC
AGTLTFMVGGSAEAFDKVKPLFDIMGQKAVHCGEAGAGQAAKICNNMILGVTMIATCEAF
CCEEEEEECCCHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALADKLGLDRARMFDVVSTSSGYSWSMNAYCPAPGVGPASPADNGYKPGFAAELMLKDLR
HHHHHHCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LSQQAAEAADADTPMGELAAALYARFVEDEDGKGRDFSAMLPRFEARHRQG
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIGFIGLGNMGGPMAANLAKAGHKVAGFDLAAPMPGGVVKAASAAEAAAGAEVVITMLP
CEEEEEEECCCCCHHHHHHHHCCCCEECCEECCCCCCCHHHHHHHHHHHCCCEEEEEECC
NGAILRAVADEIVPAMAAGAVFCDCSTVDVESARAVAGQAQAAGLGALDAPVSGGVGGAT
CCHHHHHHHHHHHHHHHHCEEEECCCCCCHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCC
AGTLTFMVGGSAEAFDKVKPLFDIMGQKAVHCGEAGAGQAAKICNNMILGVTMIATCEAF
CCEEEEEECCCHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ALADKLGLDRARMFDVVSTSSGYSWSMNAYCPAPGVGPASPADNGYKPGFAAELMLKDLR
HHHHHHCCCHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LSQQAAEAADADTPMGELAAALYARFVEDEDGKGRDFSAMLPRFEARHRQG
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]