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The map label for this gene is tpa [H]

Identifier: 119386978

GI number: 119386978

Start: 1444586

End: 1445965

Strand: Direct

Name: tpa [H]

Synonym: Pden_4273

Alternate gene names: 119386978

Gene position: 1444586-1445965 (Clockwise)

Preceding gene: 119386965

Following gene: 119386979

Centisome position: 83.5

GC content: 65.29

Gene sequence:

>1380_bases
ATGACGCTCGATCTGAACCCCAACGACATGTCCCATGTGGTCGCGGCCGACCGCGCCCATGTCTGGCACCACCTGAGCCA
GCACAAGCAGTATGAGACCATCGACCCGCGTGTCTTTGTCGAGGGCAAGGGCATGCGGCTGTGGGACGCCACCGGGCGCG
AGTTCCTCGATGCCGTCTCGGGCGGCGTCTGGACCGTCAACGTGGGCTATGGCCGCGAAAGCATCGCCGATGCGATCCGC
GACCAGTTGGTCAAGCTGAACTATTACGCCGGCGCGGCGGGCACCGTGCCGGGCGCGATCTTTGCGCAGAAGCTGATCGA
AAAGATGCCGGGTATGACCCGGGTCTATTACTCGAACTCGGGCTCCGAGGCGAACGAGAAGGTCTACAAGATGGTGCGCC
AGATCGCGGCGCGCCACCATGGCGGCAAGAAATGGAAGATCCTCTATCGCGACCGCGACTATCACGGCACCACCATCGCC
ACGCTGGCGACCAGCGGCCAGGACCAGCGCGCCATCGCCTACGGCCCCTTCCCCGACGGCTTCGTGCGCGTGCCGCATTG
CCTTGAATACCGCAAGCAATGGGACGTGGAAAACTACGGCGAGCGCGCCGCCGACGCCATCGAGGAGGTGATCCTGCGCG
AAGGCCCCGATACCGTCGGCGCCATCGTGCTGGAGCCGGTGACGGCCGGCGGCGGCGTCATCACGCCCCCCGAGGGCTAT
TGGCAGCGCGTGCAGGAGATCTGCCGCAAATACGACATCCTGCTGCATATCGACGAGGTGGTCTGCGGGCTTGGCCGCAC
CGGCACCTGGTTCGGCTATCAGCAATACGGCATCGAGCCTGATTTCGTCACCATGGCCAAGGGCGTCGCCTCGGGCTATG
CGGCGATCTCCTGCACCGTCACCACCGAGCGCGTCTTCGAGATGTTCAAGGACGCGCCCGAGGACGGCATGAGCTTCTTC
CGCGACATCTCGACCTTCGGCGGCTGCACCTCGGGGCCGGTGGCGGCGATCGAGAACATGCGCATCATCGAGGACGAGGG
GCTGCTCGACAACACCGTCGCCATGGGCGAGCGCACGCTGGCGAACCTCAACGCGCTGATGGAGAAGCACAAGGTCATCG
GCGACGTGCGCGGCAAGGGCCTGTTCTGCGGCGCCGAGCTGGTCGCGGACCGCGCCAGCAAGGAGCCGATGGACGAAAAG
AAGGTGCAGGCCGTCGTGGCGGATTGCCTTGCGCAGGGCGTCATCATCGGCGCGACCAACCGGTCGTTGCCGGGCTTCAA
CAACACGCTCTGCCTGTCGCCGGCGCTGATCGCCACGGCCGACAACATCGACCGCATCACCGATGCCATCGACAACGCCC
TGACCAAGGTTTTTGCCTGA

Upstream 100 bases:

>100_bases
TGAGAAACTGGCTCCATCTATTCGCCCAATCTGGCTCTATCCCTTTGCCGCGTTCGGGCGCAGTCAGAGAGAAACGCCCT
TCACCCGCAGGAGTCCGGCC

Downstream 100 bases:

>100_bases
CCCTTGATCCGCGGCGGCATTCGGGGGACTGATAAGCTCCGTCAGCCGCCGCGGATCACTCCATGCCGATTCCCCCCGAC
GCCTTTTTCCTGGACCATGC

Product: aminotransferase class-III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTLDLNPNDMSHVVAADRAHVWHHLSQHKQYETIDPRVFVEGKGMRLWDATGREFLDAVSGGVWTVNVGYGRESIADAIR
DQLVKLNYYAGAAGTVPGAIFAQKLIEKMPGMTRVYYSNSGSEANEKVYKMVRQIAARHHGGKKWKILYRDRDYHGTTIA
TLATSGQDQRAIAYGPFPDGFVRVPHCLEYRKQWDVENYGERAADAIEEVILREGPDTVGAIVLEPVTAGGGVITPPEGY
WQRVQEICRKYDILLHIDEVVCGLGRTGTWFGYQQYGIEPDFVTMAKGVASGYAAISCTVTTERVFEMFKDAPEDGMSFF
RDISTFGGCTSGPVAAIENMRIIEDEGLLDNTVAMGERTLANLNALMEKHKVIGDVRGKGLFCGAELVADRASKEPMDEK
KVQAVVADCLAQGVIIGATNRSLPGFNNTLCLSPALIATADNIDRITDAIDNALTKVFA

Sequences:

>Translated_459_residues
MTLDLNPNDMSHVVAADRAHVWHHLSQHKQYETIDPRVFVEGKGMRLWDATGREFLDAVSGGVWTVNVGYGRESIADAIR
DQLVKLNYYAGAAGTVPGAIFAQKLIEKMPGMTRVYYSNSGSEANEKVYKMVRQIAARHHGGKKWKILYRDRDYHGTTIA
TLATSGQDQRAIAYGPFPDGFVRVPHCLEYRKQWDVENYGERAADAIEEVILREGPDTVGAIVLEPVTAGGGVITPPEGY
WQRVQEICRKYDILLHIDEVVCGLGRTGTWFGYQQYGIEPDFVTMAKGVASGYAAISCTVTTERVFEMFKDAPEDGMSFF
RDISTFGGCTSGPVAAIENMRIIEDEGLLDNTVAMGERTLANLNALMEKHKVIGDVRGKGLFCGAELVADRASKEPMDEK
KVQAVVADCLAQGVIIGATNRSLPGFNNTLCLSPALIATADNIDRITDAIDNALTKVFA
>Mature_458_residues
TLDLNPNDMSHVVAADRAHVWHHLSQHKQYETIDPRVFVEGKGMRLWDATGREFLDAVSGGVWTVNVGYGRESIADAIRD
QLVKLNYYAGAAGTVPGAIFAQKLIEKMPGMTRVYYSNSGSEANEKVYKMVRQIAARHHGGKKWKILYRDRDYHGTTIAT
LATSGQDQRAIAYGPFPDGFVRVPHCLEYRKQWDVENYGERAADAIEEVILREGPDTVGAIVLEPVTAGGGVITPPEGYW
QRVQEICRKYDILLHIDEVVCGLGRTGTWFGYQQYGIEPDFVTMAKGVASGYAAISCTVTTERVFEMFKDAPEDGMSFFR
DISTFGGCTSGPVAAIENMRIIEDEGLLDNTVAMGERTLANLNALMEKHKVIGDVRGKGLFCGAELVADRASKEPMDEKK
VQAVVADCLAQGVIIGATNRSLPGFNNTLCLSPALIATADNIDRITDAIDNALTKVFA

Specific function: Catalyzes the degradation of taurine into alanine and sulfoacetaldehyde. Can also transaminate hypotaurine (2- aminosulfinate), beta-alanine and with low activity cysteine and 3-aminopropanesulfonate. In addition to pyruvate, 2-ketobutyrate and oxaloaceta

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI24119277, Length=436, Percent_Identity=28.8990825688073, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI13994255, Length=451, Percent_Identity=26.1640798226164, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI37574042, Length=440, Percent_Identity=27.7272727272727, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI226442705, Length=440, Percent_Identity=27.9545454545455, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI226442709, Length=372, Percent_Identity=29.0322580645161, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI4557809, Length=372, Percent_Identity=27.6881720430108, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI284507298, Length=267, Percent_Identity=28.0898876404494, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI188536080, Length=395, Percent_Identity=24.8101265822785, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38679950, Length=395, Percent_Identity=24.8101265822785, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI38679946, Length=395, Percent_Identity=24.8101265822785, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1789759, Length=418, Percent_Identity=27.9904306220096, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1789016, Length=430, Percent_Identity=30.2325581395349, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788044, Length=393, Percent_Identity=26.4631043256997, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI145693181, Length=414, Percent_Identity=26.3285024154589, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1787560, Length=378, Percent_Identity=28.042328042328, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786991, Length=447, Percent_Identity=25.7270693512304, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=447, Percent_Identity=27.9642058165548, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32564660, Length=450, Percent_Identity=27.7777777777778, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=356, Percent_Identity=26.685393258427, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=238, Percent_Identity=28.9915966386555, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323470, Length=356, Percent_Identity=30.3370786516854, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6324432, Length=431, Percent_Identity=24.3619489559165, Blast_Score=107, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=371, Percent_Identity=24.7978436657682, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI161085790, Length=464, Percent_Identity=28.448275862069, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28574759, Length=469, Percent_Identity=28.3582089552239, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21356575, Length=466, Percent_Identity=27.6824034334764, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21357415, Length=371, Percent_Identity=26.6846361185984, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.77 [H]

Molecular weight: Translated: 50396; Mature: 50265

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDLNPNDMSHVVAADRAHVWHHLSQHKQYETIDPRVFVEGKGMRLWDATGREFLDAVS
CEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCHHHHHHHC
GGVWTVNVGYGRESIADAIRDQLVKLNYYAGAAGTVPGAIFAQKLIEKMPGMTRVYYSNS
CCEEEEEECCCHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCC
GSEANEKVYKMVRQIAARHHGGKKWKILYRDRDYHGTTIATLATSGQDQRAIAYGPFPDG
CCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEECCCCCCEEEECCCCCC
FVRVPHCLEYRKQWDVENYGERAADAIEEVILREGPDTVGAIVLEPVTAGGGVITPPEGY
CEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCHHH
WQRVQEICRKYDILLHIDEVVCGLGRTGTWFGYQQYGIEPDFVTMAKGVASGYAAISCTV
HHHHHHHHHHHHHHEEHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCEEEEEEE
TTERVFEMFKDAPEDGMSFFRDISTFGGCTSGPVAAIENMRIIEDEGLLDNTVAMGERTL
EHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEECCCCCHHHHHHHHHHH
ANLNALMEKHKVIGDVRGKGLFCGAELVADRASKEPMDEKKVQAVVADCLAQGVIIGATN
HHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEECCC
RSLPGFNNTLCLSPALIATADNIDRITDAIDNALTKVFA
CCCCCCCCCEEECCHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLDLNPNDMSHVVAADRAHVWHHLSQHKQYETIDPRVFVEGKGMRLWDATGREFLDAVS
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCHHHHHHHC
GGVWTVNVGYGRESIADAIRDQLVKLNYYAGAAGTVPGAIFAQKLIEKMPGMTRVYYSNS
CCEEEEEECCCHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECCC
GSEANEKVYKMVRQIAARHHGGKKWKILYRDRDYHGTTIATLATSGQDQRAIAYGPFPDG
CCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEEEECCCCCCEEEECCCCCC
FVRVPHCLEYRKQWDVENYGERAADAIEEVILREGPDTVGAIVLEPVTAGGGVITPPEGY
CEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCCHHH
WQRVQEICRKYDILLHIDEVVCGLGRTGTWFGYQQYGIEPDFVTMAKGVASGYAAISCTV
HHHHHHHHHHHHHHEEHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCEEEEEEE
TTERVFEMFKDAPEDGMSFFRDISTFGGCTSGPVAAIENMRIIEDEGLLDNTVAMGERTL
EHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHCCEEEECCCCCHHHHHHHHHHH
ANLNALMEKHKVIGDVRGKGLFCGAELVADRASKEPMDEKKVQAVVADCLAQGVIIGATN
HHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEECCC
RSLPGFNNTLCLSPALIATADNIDRITDAIDNALTKVFA
CCCCCCCCCEEECCHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11082195 [H]