Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 119386702

GI number: 119386702

Start: 1133880

End: 1134614

Strand: Direct

Name: uppS [H]

Synonym: Pden_3995

Alternate gene names: 119386702

Gene position: 1133880-1134614 (Clockwise)

Preceding gene: 119386701

Following gene: 119386703

Centisome position: 65.54

GC content: 70.2

Gene sequence:

>735_bases
ATGGCCGAGATCGCAGCCAGCCTGTCGAAGCCCGGCGGAGGGGACCAGCGGCCCCGTCATGTCGCCATCATCATGGATGG
CAACGGCCGCTGGGCCAAGAACCGGGGCTGGCCGCGACTGGTCGGGCATCGGCGCGGCGCCGAGCGCGTCAAGCAGATCG
TCCGCGCCTGTCCCGACCTGGGGGTGAACTGGCTGACGGTCTATGCCTTCTCGACCGAGAACTGGAAGCGCTCGACCGAG
GAAGTGCTGGGCCTGATGGGCATCTTCGCCCGCTATATCGAGCGTGAGGCGGACGGGCTTTCCGCCGAGGGCGTACGCAT
GCGCTTCATCGGCGGGCGCGAGCGGCTGGAACCCAAGCTGCAGCGGCTGATGGCCGGGATCGAGGCGCGCACCGCCGGCA
ACACCCGGCTGAACCTGACCGTGGCGATCAATTACGGCGGCCGGGACGAGCTGACCCGGGCCGCGGCCCGGCTGGCGGCA
CGCATCGGCCGGGGCGAGGTCGCCGAGCCGACCGAGGCCGACCTGGCCGACTGCCTGGACACGGCCGGCCATCCCGACCC
GGACCTGGTCATCCGCACCAGCGGCGAGACGCGGACCTCGAATTTCCTGCCCTTCCAGGCGGCCTATTCGGAATATGAGT
TCACCCAGACGCTCTGGCCGGACTTCACGCCCGAGCATCTGGCCGAGATCCTCGACCGCTACGGGCTGCGCGACCGGCGC
TTCGGCGGCGCATGA

Upstream 100 bases:

>100_bases
GTTCTGGGAGGGCGCCGTGCAGGAACTGACCGACAAGATGATCGCCTCGGTGGATCAGGCGCTCGAGGCCAAGCAAGCCG
AAATCATGCAGGTCTGACGC

Downstream 100 bases:

>100_bases
GCGGGGACGGACCACAGCCGGGCCGGTTGCGCGGCGCCTTGCAGCGCGGACGCGACAAATGGGCCGATCTCTGGCCGCGC
CTTCTGTCGGGCGCGGTGCT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MAEIAASLSKPGGGDQRPRHVAIIMDGNGRWAKNRGWPRLVGHRRGAERVKQIVRACPDLGVNWLTVYAFSTENWKRSTE
EVLGLMGIFARYIEREADGLSAEGVRMRFIGGRERLEPKLQRLMAGIEARTAGNTRLNLTVAINYGGRDELTRAAARLAA
RIGRGEVAEPTEADLADCLDTAGHPDPDLVIRTSGETRTSNFLPFQAAYSEYEFTQTLWPDFTPEHLAEILDRYGLRDRR
FGGA

Sequences:

>Translated_244_residues
MAEIAASLSKPGGGDQRPRHVAIIMDGNGRWAKNRGWPRLVGHRRGAERVKQIVRACPDLGVNWLTVYAFSTENWKRSTE
EVLGLMGIFARYIEREADGLSAEGVRMRFIGGRERLEPKLQRLMAGIEARTAGNTRLNLTVAINYGGRDELTRAAARLAA
RIGRGEVAEPTEADLADCLDTAGHPDPDLVIRTSGETRTSNFLPFQAAYSEYEFTQTLWPDFTPEHLAEILDRYGLRDRR
FGGA
>Mature_243_residues
AEIAASLSKPGGGDQRPRHVAIIMDGNGRWAKNRGWPRLVGHRRGAERVKQIVRACPDLGVNWLTVYAFSTENWKRSTEE
VLGLMGIFARYIEREADGLSAEGVRMRFIGGRERLEPKLQRLMAGIEARTAGNTRLNLTVAINYGGRDELTRAAARLAAR
IGRGEVAEPTEADLADCLDTAGHPDPDLVIRTSGETRTSNFLPFQAAYSEYEFTQTLWPDFTPEHLAEILDRYGLRDRRF
GGA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=37.7777777777778, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=37.7777777777778, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=44.2982456140351, Blast_Score=185, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=224, Percent_Identity=38.8392857142857, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319474, Length=224, Percent_Identity=36.1607142857143, Blast_Score=119, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=213, Percent_Identity=29.1079812206573, Blast_Score=95, Evalue=8e-21,
Organism=Drosophila melanogaster, GI18857969, Length=234, Percent_Identity=43.5897435897436, Blast_Score=164, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 27168; Mature: 27037

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEIAASLSKPGGGDQRPRHVAIIMDGNGRWAKNRGWPRLVGHRRGAERVKQIVRACPDL
CCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCC
GVNWLTVYAFSTENWKRSTEEVLGLMGIFARYIEREADGLSAEGVRMRFIGGRERLEPKL
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHH
QRLMAGIEARTAGNTRLNLTVAINYGGRDELTRAAARLAARIGRGEVAEPTEADLADCLD
HHHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
TAGHPDPDLVIRTSGETRTSNFLPFQAAYSEYEFTQTLWPDFTPEHLAEILDRYGLRDRR
HCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
FGGA
CCCC
>Mature Secondary Structure 
AEIAASLSKPGGGDQRPRHVAIIMDGNGRWAKNRGWPRLVGHRRGAERVKQIVRACPDL
CCHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCCCC
GVNWLTVYAFSTENWKRSTEEVLGLMGIFARYIEREADGLSAEGVRMRFIGGRERLEPKL
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHH
QRLMAGIEARTAGNTRLNLTVAINYGGRDELTRAAARLAARIGRGEVAEPTEADLADCLD
HHHHHHHHHCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
TAGHPDPDLVIRTSGETRTSNFLPFQAAYSEYEFTQTLWPDFTPEHLAEILDRYGLRDRR
HCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
FGGA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]