Click here to switch to the map view.

The map label for this gene is pdhB [H]

Identifier: 119385771

GI number: 119385771

Start: 228088

End: 229941

Strand: Direct

Name: pdhB [H]

Synonym: Pden_3049

Alternate gene names: 119385771

Gene position: 228088-229941 (Clockwise)

Preceding gene: 119385770

Following gene: 119385772

Centisome position: 13.18

GC content: 64.89

Gene sequence:

>1854_bases
ATGGCCGCACTCGGCCCGTGTGATCGCGTTATCGCAACTTATAGAGGTCATGGCTGGGCGTTAGAAACGGGCGTTCCCGC
CCAAGAATTTTTTGCTGAGCTTTGCCACCGTAAGGCAGGTGTGAATGGTGGACGAAGTGGCTCTGCCCTGGTCACCGCGC
CGAATCAGCGTTTTATCGGTGAAAACTCTATAGTCGGTGCGGGCGGGCCGATTGCCTGTGGCATCGCCCTGGCGGCAAAG
ATGGAGGGCGCGGACCGCGTCTGCCTTGTGACATTCGGTGACGGGGCCACCAGCCAGGGCGCTCTGCATGAGGCTTTCGT
CTTCGCCGCCGCCTATAAGCTTCCCGTGATCTTCGTCTGTGAAAACAATGGTTGGTCAGAGATGACCCCGACGCTTTCAA
TCACGGGGCTCGACCGTCTGGCCCGGCGCGCGAATGGCTATGGCATGGCATCCGCCACGATTGACGGCACCGACCCGATG
GCGGTCAAGGACAGCATTGCCCTTGCGCGGGCGGCTGTGCTTGGCGGCAAGGGGCCTGCGCTGATCGAATGCCGGGTGCC
GCGGCTCTGGGGGCATTACAACCGCGATATCGAGCATTACCGGCCGAAATCCGACCGTGAAGACAGCCGCGCCCGCGATC
CGCTGGCGCTGCTGGAGGCCCGGCTCTGCGCTCTCGGTGCCAGCAGCGCGGAAGAGCTGGCGATTCTGCGGGGGCGGCTC
GACCGTGACTGGAGCGCGGTTCTGGACACTGTGAAAGCCATGCCGCTGCCCGATGCCGCCTCTGCCGCAGATCATGTTGT
GGCACCGATCCCCGCCGCCCCGTCCGCGCCGGATCAGCAGGGGGAGAGCCGCGAGATCACCTATATCCAGGCTGTGAATG
AGGCCCTGAAGCGCGAGCTGACCGAGCACTCCGAAGTGATGGTTTTTGGCGAAGATGTCGGCCATGCAGGGGGGATCTTC
GGTGCAACCCGCTATCTGCAAAGGGATTTTGGCGCGGAGAGGGTCTTTGACACCCCGATTGCCGAAGCCGCGATTCTGGG
GTCGGCGGTCGGGCTGGCGCTCGAAGGCAAGCGGCCTGTGGTGGAAATCATGTGGGCCGATTTCCTGCTGGTGGCGCTGG
ATCAGATCATAAATCAGGCCGCGAATATCCGCTATCTGACGCGCGGCACCCGGACTGCGCCGATTGTCGTGCGCGTTCAG
CAGGGCGCGACGCCCGGCTCCACCGCGCAGCATTCACAATCGCTGGAGGCGATGCTGGCCCATGTGCCGGGCCTGCGGGT
GGGGCTGCCGTCGACAGCCGATGACGCCTATCACATGCTGCGCGCCGCAATACATGGCGCGGATCCGACCGTCATCATCG
AATCCCGTGCCCTTTATCAGCGTACAGGGACGGTCTGGCCGGATGCTGCGCGTCAGGCCACCGCAGGGGCGACCCTGCGC
CGCGCGGGGACGAGCGTGACCCTGCTCGGCTGGGGCGCAGTCATGCCCGCGGTCGAGGCTGCCGCCGATGCCCTGGCCGA
GAATTGCATCGACGTTTCTGTTCTGGATCTGCGCTGGCTGTCACCGGTGGACTGGGGTCAGCTCTGCGCCACCGTTTCCG
CAACGGGCGGTCGCGTCGTGGTGGTGCATGAGGCCAATTTGACCGGCGGTTTCGGCGCGGAAATCGTCGCCGGGCTGGCG
GAACGGCTGGGACCAGGGGCGCTCTCTTTCCGCCGGGTCGCGACGCCGGATGTGCGGATGCCGGCTTCGCCGGTCCTTCA
GGCCGCGCTGCTGCCCGATGCGGCAAAGATCATGGCCGCCGCGAAGGATCTTCTGCAGTCGAATCTCCTGCCCCAGAACG
AGGAATATGTCTGA

Upstream 100 bases:

>100_bases
GTTCGAGCAGTCTGCGCTTGATCTTAGCACCAGCAAGGAAGCTCTTATCGCGGGGTCGGTGCATCTGTGCGCCGGTCAGG
AAGCGGTGCCTGTCGGTGCA

Downstream 100 bases:

>100_bases
TGACCGGCAGCAAAGAGAAAAGCGGACGTCTCCAGATCAACTCCGTGGTGCGCGGGGTCAATATCCTGACCGCCATCGCG
CGCAGCGATCAGGGGCTGAG

Product: transketolase, central region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MAALGPCDRVIATYRGHGWALETGVPAQEFFAELCHRKAGVNGGRSGSALVTAPNQRFIGENSIVGAGGPIACGIALAAK
MEGADRVCLVTFGDGATSQGALHEAFVFAAAYKLPVIFVCENNGWSEMTPTLSITGLDRLARRANGYGMASATIDGTDPM
AVKDSIALARAAVLGGKGPALIECRVPRLWGHYNRDIEHYRPKSDREDSRARDPLALLEARLCALGASSAEELAILRGRL
DRDWSAVLDTVKAMPLPDAASAADHVVAPIPAAPSAPDQQGESREITYIQAVNEALKRELTEHSEVMVFGEDVGHAGGIF
GATRYLQRDFGAERVFDTPIAEAAILGSAVGLALEGKRPVVEIMWADFLLVALDQIINQAANIRYLTRGTRTAPIVVRVQ
QGATPGSTAQHSQSLEAMLAHVPGLRVGLPSTADDAYHMLRAAIHGADPTVIIESRALYQRTGTVWPDAARQATAGATLR
RAGTSVTLLGWGAVMPAVEAAADALAENCIDVSVLDLRWLSPVDWGQLCATVSATGGRVVVVHEANLTGGFGAEIVAGLA
ERLGPGALSFRRVATPDVRMPASPVLQAALLPDAAKIMAAAKDLLQSNLLPQNEEYV

Sequences:

>Translated_617_residues
MAALGPCDRVIATYRGHGWALETGVPAQEFFAELCHRKAGVNGGRSGSALVTAPNQRFIGENSIVGAGGPIACGIALAAK
MEGADRVCLVTFGDGATSQGALHEAFVFAAAYKLPVIFVCENNGWSEMTPTLSITGLDRLARRANGYGMASATIDGTDPM
AVKDSIALARAAVLGGKGPALIECRVPRLWGHYNRDIEHYRPKSDREDSRARDPLALLEARLCALGASSAEELAILRGRL
DRDWSAVLDTVKAMPLPDAASAADHVVAPIPAAPSAPDQQGESREITYIQAVNEALKRELTEHSEVMVFGEDVGHAGGIF
GATRYLQRDFGAERVFDTPIAEAAILGSAVGLALEGKRPVVEIMWADFLLVALDQIINQAANIRYLTRGTRTAPIVVRVQ
QGATPGSTAQHSQSLEAMLAHVPGLRVGLPSTADDAYHMLRAAIHGADPTVIIESRALYQRTGTVWPDAARQATAGATLR
RAGTSVTLLGWGAVMPAVEAAADALAENCIDVSVLDLRWLSPVDWGQLCATVSATGGRVVVVHEANLTGGFGAEIVAGLA
ERLGPGALSFRRVATPDVRMPASPVLQAALLPDAAKIMAAAKDLLQSNLLPQNEEYV
>Mature_616_residues
AALGPCDRVIATYRGHGWALETGVPAQEFFAELCHRKAGVNGGRSGSALVTAPNQRFIGENSIVGAGGPIACGIALAAKM
EGADRVCLVTFGDGATSQGALHEAFVFAAAYKLPVIFVCENNGWSEMTPTLSITGLDRLARRANGYGMASATIDGTDPMA
VKDSIALARAAVLGGKGPALIECRVPRLWGHYNRDIEHYRPKSDREDSRARDPLALLEARLCALGASSAEELAILRGRLD
RDWSAVLDTVKAMPLPDAASAADHVVAPIPAAPSAPDQQGESREITYIQAVNEALKRELTEHSEVMVFGEDVGHAGGIFG
ATRYLQRDFGAERVFDTPIAEAAILGSAVGLALEGKRPVVEIMWADFLLVALDQIINQAANIRYLTRGTRTAPIVVRVQQ
GATPGSTAQHSQSLEAMLAHVPGLRVGLPSTADDAYHMLRAAIHGADPTVIIESRALYQRTGTVWPDAARQATAGATLRR
AGTSVTLLGWGAVMPAVEAAADALAENCIDVSVLDLRWLSPVDWGQLCATVSATGGRVVVVHEANLTGGFGAEIVAGLAE
RLGPGALSFRRVATPDVRMPASPVLQAALLPDAAKIMAAAKDLLQSNLLPQNEEYV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=331, Percent_Identity=32.6283987915408, Blast_Score=172, Evalue=1e-42,
Organism=Homo sapiens, GI4557353, Length=338, Percent_Identity=30.4733727810651, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI34101272, Length=338, Percent_Identity=30.4733727810651, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4885543, Length=269, Percent_Identity=33.457249070632, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI291084858, Length=331, Percent_Identity=30.5135951661631, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI291084744, Length=272, Percent_Identity=34.9264705882353, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4505685, Length=272, Percent_Identity=34.9264705882353, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI291084742, Length=272, Percent_Identity=34.9264705882353, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI11386135, Length=278, Percent_Identity=30.2158273381295, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI258645172, Length=278, Percent_Identity=30.2158273381295, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI291084757, Length=272, Percent_Identity=29.0441176470588, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI1786622, Length=282, Percent_Identity=24.468085106383, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17538422, Length=327, Percent_Identity=35.1681957186544, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=33.8461538461538, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32564172, Length=291, Percent_Identity=32.3024054982818, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17536047, Length=291, Percent_Identity=32.3024054982818, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI86563357, Length=196, Percent_Identity=34.6938775510204, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI86563355, Length=196, Percent_Identity=34.6938775510204, Blast_Score=104, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319698, Length=341, Percent_Identity=32.258064516129, Blast_Score=171, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321026, Length=259, Percent_Identity=31.6602316602317, Blast_Score=130, Evalue=7e-31,
Organism=Drosophila melanogaster, GI160714832, Length=334, Percent_Identity=34.4311377245509, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI160714828, Length=334, Percent_Identity=34.4311377245509, Blast_Score=183, Evalue=3e-46,
Organism=Drosophila melanogaster, GI21358145, Length=332, Percent_Identity=35.8433734939759, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24650940, Length=332, Percent_Identity=35.8433734939759, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24639744, Length=293, Percent_Identity=31.740614334471, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI28571106, Length=293, Percent_Identity=31.740614334471, Blast_Score=130, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24639740, Length=293, Percent_Identity=31.740614334471, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24639746, Length=293, Percent_Identity=31.740614334471, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24639748, Length=235, Percent_Identity=33.6170212765957, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21355903, Length=277, Percent_Identity=27.4368231046931, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24650943, Length=93, Percent_Identity=38.7096774193548, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650945, Length=93, Percent_Identity=38.7096774193548, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 65009; Mature: 64878

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAALGPCDRVIATYRGHGWALETGVPAQEFFAELCHRKAGVNGGRSGSALVTAPNQRFIG
CCCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCC
ENSIVGAGGPIACGIALAAKMEGADRVCLVTFGDGATSQGALHEAFVFAAAYKLPVIFVC
CCCEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEE
ENNGWSEMTPTLSITGLDRLARRANGYGMASATIDGTDPMAVKDSIALARAAVLGGKGPA
CCCCCCCCCCCEEECCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCE
LIECRVPRLWGHYNRDIEHYRPKSDREDSRARDPLALLEARLCALGASSAEELAILRGRL
EEEEECCHHHCCCCCCHHHCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC
DRDWSAVLDTVKAMPLPDAASAADHVVAPIPAAPSAPDQQGESREITYIQAVNEALKREL
CCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TEHSEVMVFGEDVGHAGGIFGATRYLQRDFGAERVFDTPIAEAAILGSAVGLALEGKRPV
HCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCEEECCCCCE
VEIMWADFLLVALDQIINQAANIRYLTRGTRTAPIVVRVQQGATPGSTAQHSQSLEAMLA
EHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHH
HVPGLRVGLPSTADDAYHMLRAAIHGADPTVIIESRALYQRTGTVWPDAARQATAGATLR
HCCCCEECCCCCCHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCCHHHHHHCCHHHH
RAGTSVTLLGWGAVMPAVEAAADALAENCIDVSVLDLRWLSPVDWGQLCATVSATGGRVV
HCCCEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEE
VVHEANLTGGFGAEIVAGLAERLGPGALSFRRVATPDVRMPASPVLQAALLPDAAKIMAA
EEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHCCHHHHHHHH
AKDLLQSNLLPQNEEYV
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AALGPCDRVIATYRGHGWALETGVPAQEFFAELCHRKAGVNGGRSGSALVTAPNQRFIG
CCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCC
ENSIVGAGGPIACGIALAAKMEGADRVCLVTFGDGATSQGALHEAFVFAAAYKLPVIFVC
CCCEECCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCEEEEE
ENNGWSEMTPTLSITGLDRLARRANGYGMASATIDGTDPMAVKDSIALARAAVLGGKGPA
CCCCCCCCCCCEEECCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCE
LIECRVPRLWGHYNRDIEHYRPKSDREDSRARDPLALLEARLCALGASSAEELAILRGRL
EEEEECCHHHCCCCCCHHHCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCC
DRDWSAVLDTVKAMPLPDAASAADHVVAPIPAAPSAPDQQGESREITYIQAVNEALKREL
CCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
TEHSEVMVFGEDVGHAGGIFGATRYLQRDFGAERVFDTPIAEAAILGSAVGLALEGKRPV
HCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHCEEECCCCCE
VEIMWADFLLVALDQIINQAANIRYLTRGTRTAPIVVRVQQGATPGSTAQHSQSLEAMLA
EHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHH
HVPGLRVGLPSTADDAYHMLRAAIHGADPTVIIESRALYQRTGTVWPDAARQATAGATLR
HCCCCEECCCCCCHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCCHHHHHHCCHHHH
RAGTSVTLLGWGAVMPAVEAAADALAENCIDVSVLDLRWLSPVDWGQLCATVSATGGRVV
HCCCEEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEE
VVHEANLTGGFGAEIVAGLAERLGPGALSFRRVATPDVRMPASPVLQAALLPDAAKIMAA
EEEECCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHCCHHHHHHHH
AKDLLQSNLLPQNEEYV
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA