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The map label for this gene is iclR [C]

Identifier: 119385772

GI number: 119385772

Start: 229941

End: 230696

Strand: Direct

Name: iclR [C]

Synonym: Pden_3050

Alternate gene names: 119385772

Gene position: 229941-230696 (Clockwise)

Preceding gene: 119385771

Following gene: 119385773

Centisome position: 13.29

GC content: 60.32

Gene sequence:

>756_bases
ATGACCGGCAGCAAAGAGAAAAGCGGACGTCTCCAGATCAACTCCGTGGTGCGCGGGGTCAATATCCTGACCGCCATCGC
GCGCAGCGATCAGGGGCTGAGCGTGCGCGAAATTGCCGAGGCCATTGGGGTTGAGCGGCAGACGGCCTATCATCTGGTAC
ATACGCTTGAAGATACAGGATTTATTGCTCGCGATGATCAGCGTAATTACCGCCTTGGCCTGCGGGTCGGGGCGCTCGCC
GAGGCTTTTGGCCGACAGTTTTCTGCCCCTGATTATATGCTACCGCTGGTGCGCGGTTTGGCCACGGAAACCGGCGAGAC
CTGCTATGTCGTCGGCTGGTGGCAGGGCGAGATCGTGATCATCGAGGTGGCCGCTGGTGCCAATGCGATCCGCGCAGCCG
AGATGCCGCATGGCCAGTATCTGCATGCCCATGCGCGGGCAGCGGGCAAGGTGCTACTCGCTTATGCGGCCACGGCCCGC
ATGGCGGAATATCTGCTTAATCATCAGCCGCTGGCAAAGCTGACCGAGAATACCATGACCGATTTCAAATCCCTCCAGGC
CGAATTCACCCGTATCCGGGCCGAGGGCATCGGTTATGACAATGAGGAATTCGCCCGCGGTACTTCCTGCATGGCGATGC
CGCTGGAAGCTGGCACCGCCCCCTATGCTCTGGCCTTGTCCGCACCAACCGAGCGCTTTCATGCCTTCCGTGAAACCTAC
CAGCAGAAACTGGCCGCGCTGGTTCAGCGCAACTGA

Upstream 100 bases:

>100_bases
TCCTTCAGGCCGCGCTGCTGCCCGATGCGGCAAAGATCATGGCCGCCGCGAAGGATCTTCTGCAGTCGAATCTCCTGCCC
CAGAACGAGGAATATGTCTG

Downstream 100 bases:

>100_bases
GAGACAGATCCCATGACCATCACGCTTTTTGATTGTAAGGATGTCGCCGCCGCTTTCGGGAATTACGCGCATGGCGTGGT
CATTCCGCCAAGTGCCGTCA

Product: regulatory proteins, IclR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MTGSKEKSGRLQINSVVRGVNILTAIARSDQGLSVREIAEAIGVERQTAYHLVHTLEDTGFIARDDQRNYRLGLRVGALA
EAFGRQFSAPDYMLPLVRGLATETGETCYVVGWWQGEIVIIEVAAGANAIRAAEMPHGQYLHAHARAAGKVLLAYAATAR
MAEYLLNHQPLAKLTENTMTDFKSLQAEFTRIRAEGIGYDNEEFARGTSCMAMPLEAGTAPYALALSAPTERFHAFRETY
QQKLAALVQRN

Sequences:

>Translated_251_residues
MTGSKEKSGRLQINSVVRGVNILTAIARSDQGLSVREIAEAIGVERQTAYHLVHTLEDTGFIARDDQRNYRLGLRVGALA
EAFGRQFSAPDYMLPLVRGLATETGETCYVVGWWQGEIVIIEVAAGANAIRAAEMPHGQYLHAHARAAGKVLLAYAATAR
MAEYLLNHQPLAKLTENTMTDFKSLQAEFTRIRAEGIGYDNEEFARGTSCMAMPLEAGTAPYALALSAPTERFHAFRETY
QQKLAALVQRN
>Mature_250_residues
TGSKEKSGRLQINSVVRGVNILTAIARSDQGLSVREIAEAIGVERQTAYHLVHTLEDTGFIARDDQRNYRLGLRVGALAE
AFGRQFSAPDYMLPLVRGLATETGETCYVVGWWQGEIVIIEVAAGANAIRAAEMPHGQYLHAHARAAGKVLLAYAATARM
AEYLLNHQPLAKLTENTMTDFKSLQAEFTRIRAEGIGYDNEEFARGTSCMAMPLEAGTAPYALALSAPTERFHAFRETYQ
QKLAALVQRN

Specific function: Regulation Of The Glyoxylate Bypass Operon (ACEbak), Which Encodes Isocitrate Lyase, Malate Synthase As Well As Isocitrate Dehydrogenase Kinase/Phosphorylase. [C]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=236, Percent_Identity=27.9661016949153, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1789999, Length=237, Percent_Identity=24.4725738396624, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790752, Length=222, Percent_Identity=27.027027027027, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786715, Length=230, Percent_Identity=26.9565217391304, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1786468, Length=248, Percent_Identity=29.0322580645161, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788581, Length=239, Percent_Identity=28.0334728033473, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788131, Length=241, Percent_Identity=26.1410788381743, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 27573; Mature: 27442

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSKEKSGRLQINSVVRGVNILTAIARSDQGLSVREIAEAIGVERQTAYHLVHTLEDTG
CCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
FIARDDQRNYRLGLRVGALAEAFGRQFSAPDYMLPLVRGLATETGETCYVVGWWQGEIVI
CEEECCCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCEEE
IEVAAGANAIRAAEMPHGQYLHAHARAAGKVLLAYAATARMAEYLLNHQPLAKLTENTMT
EEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DFKSLQAEFTRIRAEGIGYDNEEFARGTSCMAMPLEAGTAPYALALSAPTERFHAFRETY
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHH
QQKLAALVQRN
HHHHHHHHCCC
>Mature Secondary Structure 
TGSKEKSGRLQINSVVRGVNILTAIARSDQGLSVREIAEAIGVERQTAYHLVHTLEDTG
CCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
FIARDDQRNYRLGLRVGALAEAFGRQFSAPDYMLPLVRGLATETGETCYVVGWWQGEIVI
CEEECCCCCEEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCEEE
IEVAAGANAIRAAEMPHGQYLHAHARAAGKVLLAYAATARMAEYLLNHQPLAKLTENTMT
EEEECCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
DFKSLQAEFTRIRAEGIGYDNEEFARGTSCMAMPLEAGTAPYALALSAPTERFHAFRETY
HHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHHH
QQKLAALVQRN
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]