Click here to switch to the map view.

The map label for this gene is hemN [H]

Identifier: 119358143

GI number: 119358143

Start: 2760925

End: 2762049

Strand: Reverse

Name: hemN [H]

Synonym: Cpha266_2375

Alternate gene names: 119358143

Gene position: 2762049-2760925 (Counterclockwise)

Preceding gene: 119358144

Following gene: 119358142

Centisome position: 88.13

GC content: 51.02

Gene sequence:

>1125_bases
ATGCTGAGCCTATACGTTCACATTCCTTTCTGCCGTACCCGCTGCTCTTATTGCGATTTTTATCTTGTTACCCGTCAGGA
TCTTGTCGATCCATTTTTTGAGGCGCTTTTAGCAGAAACCAGAGCGCGCCTCTCCCTGCTTAAAGGCCGGAGTGTCAAGG
CGATTCATTTTGGAGGAGGTACCCCGTCACTCCTTCCGGTACGCCACCTTGTCCGATGGCTTGAACTTGCCAGTACTTAT
TGCTCGTTTACTCCTGATGTGGAGATAACGCTCGAAGCAAATCCCGAAGATCTGGCCGGAGGGCGCATGTTTGAGTTGCA
TGCAGCAGGAATAAACCGTCTCAGTATCGGCGTTCAGTCGTTCATCCAGCGAAAGCTTGCCGCTCTCGGCCGGTCGCATA
CCCGAGAAGATGCGCTTCGGGCTGTCAGAGCAGCGGGGGATCTCTTTCAATCCGTCAGTGTCGATCTTATTTGTGCTGTC
CCGTGCGAAACCAGGGATGAGTGGGCTTCGGATCTTCGGGATGCGACAGCGCTGCAACTGCCGCATCTTTCGGTCTACAT
GCTTTCGGTCGAGCCTAAAACCCGGCTGCATCGAAAGGTCAGTCGAGGAGAAGTGACTGTTCCCGACGAAGATATTCAGG
CCACGCTGTATGAAGATGCTCTCGGTAATCTTGCCGGGCATGGATACCGACATTACGAAGTATCGAATTTCTCTGTTGAG
GGCCATCACTCGCGATACAACCTTGCCTGCTGGATGCGTGAACCCTATATCGGGTTTGGCCCTTCCGCACACAGTTTTAT
CCGGGAGGGCGGTGTCGAAATTCGGCAGGCCAATGTTTCCGTGCTCTCCCGTTATATCGCCGATCCTCAAAACGCTGTAA
CCTTTTATGAGGAGCTTTCAGAAAAGGAGCGTTTTCTGGAGCAGGTATTTTTAACATTGCGCATAAACAGCGGGCTTGAT
ATTGGGTTTTTGCGAAAAGGGAATAAATTAGGGCATTACATGACAGAAAAAATCGAAGAATTAACGGCAAGAGGATGGGT
GCTTGACGAGGGCGGTCAGCTTTTTCTCACCTCGAAAGGGTTTCTGTTTGCCGATCATATCGCAGGAGAGCTTGTTTCCG
ATTAA

Upstream 100 bases:

>100_bases
GATCATTCCGGACTTCATAGCTGATGATCTTTATCAAGCCATTACCGGGTATATTCTTTCGTGAACCGCCCGCCTCTTGG
TGAGGCGGATCTCTTATTCC

Downstream 100 bases:

>100_bases
CCGTAACTATATATACAGCAGACTTTACGTATGACACATCGGGTAATTAACCGTATTATTGCAGTTATTCTTTTTCTGGT
TGCCGAGCTTCTCTATCTCA

Product: putative oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MLSLYVHIPFCRTRCSYCDFYLVTRQDLVDPFFEALLAETRARLSLLKGRSVKAIHFGGGTPSLLPVRHLVRWLELASTY
CSFTPDVEITLEANPEDLAGGRMFELHAAGINRLSIGVQSFIQRKLAALGRSHTREDALRAVRAAGDLFQSVSVDLICAV
PCETRDEWASDLRDATALQLPHLSVYMLSVEPKTRLHRKVSRGEVTVPDEDIQATLYEDALGNLAGHGYRHYEVSNFSVE
GHHSRYNLACWMREPYIGFGPSAHSFIREGGVEIRQANVSVLSRYIADPQNAVTFYEELSEKERFLEQVFLTLRINSGLD
IGFLRKGNKLGHYMTEKIEELTARGWVLDEGGQLFLTSKGFLFADHIAGELVSD

Sequences:

>Translated_374_residues
MLSLYVHIPFCRTRCSYCDFYLVTRQDLVDPFFEALLAETRARLSLLKGRSVKAIHFGGGTPSLLPVRHLVRWLELASTY
CSFTPDVEITLEANPEDLAGGRMFELHAAGINRLSIGVQSFIQRKLAALGRSHTREDALRAVRAAGDLFQSVSVDLICAV
PCETRDEWASDLRDATALQLPHLSVYMLSVEPKTRLHRKVSRGEVTVPDEDIQATLYEDALGNLAGHGYRHYEVSNFSVE
GHHSRYNLACWMREPYIGFGPSAHSFIREGGVEIRQANVSVLSRYIADPQNAVTFYEELSEKERFLEQVFLTLRINSGLD
IGFLRKGNKLGHYMTEKIEELTARGWVLDEGGQLFLTSKGFLFADHIAGELVSD
>Mature_374_residues
MLSLYVHIPFCRTRCSYCDFYLVTRQDLVDPFFEALLAETRARLSLLKGRSVKAIHFGGGTPSLLPVRHLVRWLELASTY
CSFTPDVEITLEANPEDLAGGRMFELHAAGINRLSIGVQSFIQRKLAALGRSHTREDALRAVRAAGDLFQSVSVDLICAV
PCETRDEWASDLRDATALQLPHLSVYMLSVEPKTRLHRKVSRGEVTVPDEDIQATLYEDALGNLAGHGYRHYEVSNFSVE
GHHSRYNLACWMREPYIGFGPSAHSFIREGGVEIRQANVSVLSRYIADPQNAVTFYEELSEKERFLEQVFLTLRINSGLD
IGFLRKGNKLGHYMTEKIEELTARGWVLDEGGQLFLTSKGFLFADHIAGELVSD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=284, Percent_Identity=38.7323943661972, Blast_Score=183, Evalue=3e-46,
Organism=Escherichia coli, GI1789325, Length=381, Percent_Identity=33.0708661417323, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87082341, Length=309, Percent_Identity=27.831715210356, Blast_Score=115, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 42055; Mature: 42055

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSLYVHIPFCRTRCSYCDFYLVTRQDLVDPFFEALLAETRARLSLLKGRSVKAIHFGGG
CEEEEEECCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
TPSLLPVRHLVRWLELASTYCSFTPDVEITLEANPEDLAGGRMFELHAAGINRLSIGVQS
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHH
FIQRKLAALGRSHTREDALRAVRAAGDLFQSVSVDLICAVPCETRDEWASDLRDATALQL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHEEC
PHLSVYMLSVEPKTRLHRKVSRGEVTVPDEDIQATLYEDALGNLAGHGYRHYEVSNFSVE
CCEEEEEEEECCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECEEEEC
GHHSRYNLACWMREPYIGFGPSAHSFIREGGVEIRQANVSVLSRYIADPQNAVTFYEELS
CCCCEEEEEEEEECCCCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHH
EKERFLEQVFLTLRINSGLDIGFLRKGNKLGHYMTEKIEELTARGWVLDEGGQLFLTSKG
HHHHHHHHHEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCEEEEEECC
FLFADHIAGELVSD
CEEEHHHHHHHCCC
>Mature Secondary Structure
MLSLYVHIPFCRTRCSYCDFYLVTRQDLVDPFFEALLAETRARLSLLKGRSVKAIHFGGG
CEEEEEECCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
TPSLLPVRHLVRWLELASTYCSFTPDVEITLEANPEDLAGGRMFELHAAGINRLSIGVQS
CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHH
FIQRKLAALGRSHTREDALRAVRAAGDLFQSVSVDLICAVPCETRDEWASDLRDATALQL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHEEC
PHLSVYMLSVEPKTRLHRKVSRGEVTVPDEDIQATLYEDALGNLAGHGYRHYEVSNFSVE
CCEEEEEEEECCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECEEEEC
GHHSRYNLACWMREPYIGFGPSAHSFIREGGVEIRQANVSVLSRYIADPQNAVTFYEELS
CCCCEEEEEEEEECCCCCCCCCHHHHHHHCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHH
EKERFLEQVFLTLRINSGLDIGFLRKGNKLGHYMTEKIEELTARGWVLDEGGQLFLTSKG
HHHHHHHHHEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCEEEEEECC
FLFADHIAGELVSD
CEEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]