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The map label for this gene is bioF [H]

Identifier: 119358078

GI number: 119358078

Start: 2639735

End: 2640949

Strand: Direct

Name: bioF [H]

Synonym: Cpha266_2306

Alternate gene names: 119358078

Gene position: 2639735-2640949 (Clockwise)

Preceding gene: 119358076

Following gene: 119358081

Centisome position: 84.23

GC content: 49.79

Gene sequence:

>1215_bases
ATGACTATTCCTGTGAACAAGCCAAAAGATCTTTTTAAAAAATGCTTTGATTTCACTCTTGCCGATGAGGTAAAAGCACA
GGGATTATATCCTTTTTTTCATCCAATAGACGAAACAGAGGGTCCGGTAGTATCCTTTGCAGGCAGGCAGCTTGTTATGG
CTGGATCCAACAACTATCTCGGTCTCACGGCCGATCCCAGGGTTAAACAGGCGTCGATAAACGCGATCAACAAATACGGT
ACAAGCTGCTCCGGATCACGCTACATGACCGGCACAGTCAATCTTCACATCGAGCTTGAAGAAAAACTTGCCGATTATTT
TGAAAAAGAACGATGTCTGCTTTTCAGCACCGGATATCAGACAGGTCAGGGCATTATTCCAACCGTTGTACAGCGGGGAG
AGTACATCGTCTCCGACCGCGACAACCACGCGAGCCTCGTAGCCGCATCGATCATGGCGCAGGGTGCGGGCGCAAACCTG
GTTCGTTACAACCACAACAACATGGAAGATCTGGAGCGTGTGCTTCAGAAAATCCCCGAATCAGCAGGACGGCTCATTGT
CTCCGACGGCGTTTTTTCCGTATCGGGTGAAATTGTTGATCTTCCCGAACTGGTAGCACTTGCAAAAAAATACAATGCAA
GAACGCTTATCGACGACGCTCATGCTGTTGGCATCATCGGCAAGGGAGGACGGGGTACCCCGTCAGAGTTTGGTCTTGTA
GACGAGGTTGACCTTATCATGGGTACCTTCTCAAAAACATTCGGCTCACTTGGAGGCTATGTGGTCGGCGAACACACCGT
GATTGACTATATCAAACACAATGCCTCATCCCTGATTTTCAGCGCATCACCTACTCCGGCAAGCGTTGCTGCCGTGCTCG
CAACACTTGAGATCCTTCGTACCGAACCACAACTGACGGAAAAACTTATCGCCAACACGGATTACGTGCGTCAGGGTCTC
CTGAAAGCAGGCTTTACACTCATGCCATCCCGCACGGCAATTGTCACCGTCCTTATCAGCGACCAGATAAAAACCCTCGT
ATTCTGGAAAAAACTCTTTGATGCCGGTGTATACGTCAACGCGTTCATCCGTCCCGGCGTCATGCCTGGCCACGAAGCTC
TCCGTACCAGCTTTATGGCAACCCACGAAAGAGAGCATCTCGACAAGGTAATCACAGAGTTCTGCACCATAGGCAAAGAG
CTTGGCGTCATCTGA

Upstream 100 bases:

>100_bases
CGTGGAAAGCTCCTCGATCAAGACAGCCGGGCGTTTTTTAATGAAATAAAAAGACAATCGGAAAACGAGAAATTACAGCT
TCACAACACAACTGAAGTAA

Downstream 100 bases:

>100_bases
ACGCCTCACCCTGAATCCCGACACTCACGGGATTCAGGAATGAAAAAAGAGTAACAAACCCCGCGTATACAAAATTTATA
TACAGATTCACAGTATTACC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTIPVNKPKDLFKKCFDFTLADEVKAQGLYPFFHPIDETEGPVVSFAGRQLVMAGSNNYLGLTADPRVKQASINAINKYG
TSCSGSRYMTGTVNLHIELEEKLADYFEKERCLLFSTGYQTGQGIIPTVVQRGEYIVSDRDNHASLVAASIMAQGAGANL
VRYNHNNMEDLERVLQKIPESAGRLIVSDGVFSVSGEIVDLPELVALAKKYNARTLIDDAHAVGIIGKGGRGTPSEFGLV
DEVDLIMGTFSKTFGSLGGYVVGEHTVIDYIKHNASSLIFSASPTPASVAAVLATLEILRTEPQLTEKLIANTDYVRQGL
LKAGFTLMPSRTAIVTVLISDQIKTLVFWKKLFDAGVYVNAFIRPGVMPGHEALRTSFMATHEREHLDKVITEFCTIGKE
LGVI

Sequences:

>Translated_404_residues
MTIPVNKPKDLFKKCFDFTLADEVKAQGLYPFFHPIDETEGPVVSFAGRQLVMAGSNNYLGLTADPRVKQASINAINKYG
TSCSGSRYMTGTVNLHIELEEKLADYFEKERCLLFSTGYQTGQGIIPTVVQRGEYIVSDRDNHASLVAASIMAQGAGANL
VRYNHNNMEDLERVLQKIPESAGRLIVSDGVFSVSGEIVDLPELVALAKKYNARTLIDDAHAVGIIGKGGRGTPSEFGLV
DEVDLIMGTFSKTFGSLGGYVVGEHTVIDYIKHNASSLIFSASPTPASVAAVLATLEILRTEPQLTEKLIANTDYVRQGL
LKAGFTLMPSRTAIVTVLISDQIKTLVFWKKLFDAGVYVNAFIRPGVMPGHEALRTSFMATHEREHLDKVITEFCTIGKE
LGVI
>Mature_403_residues
TIPVNKPKDLFKKCFDFTLADEVKAQGLYPFFHPIDETEGPVVSFAGRQLVMAGSNNYLGLTADPRVKQASINAINKYGT
SCSGSRYMTGTVNLHIELEEKLADYFEKERCLLFSTGYQTGQGIIPTVVQRGEYIVSDRDNHASLVAASIMAQGAGANLV
RYNHNNMEDLERVLQKIPESAGRLIVSDGVFSVSGEIVDLPELVALAKKYNARTLIDDAHAVGIIGKGGRGTPSEFGLVD
EVDLIMGTFSKTFGSLGGYVVGEHTVIDYIKHNASSLIFSASPTPASVAAVLATLEILRTEPQLTEKLIANTDYVRQGLL
KAGFTLMPSRTAIVTVLISDQIKTLVFWKKLFDAGVYVNAFIRPGVMPGHEALRTSFMATHEREHLDKVITEFCTIGKEL
GVI

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=370, Percent_Identity=30, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI284448556, Length=350, Percent_Identity=30.8571428571429, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI119220554, Length=394, Percent_Identity=31.7258883248731, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4758668, Length=371, Percent_Identity=31.5363881401617, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI83977444, Length=370, Percent_Identity=28.3783783783784, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI83977442, Length=370, Percent_Identity=28.3783783783784, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI83977440, Length=370, Percent_Identity=28.3783783783784, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4502025, Length=363, Percent_Identity=29.4765840220386, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI40316939, Length=363, Percent_Identity=29.4765840220386, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI5454084, Length=267, Percent_Identity=34.0823970037453, Blast_Score=161, Evalue=9e-40,
Organism=Escherichia coli, GI1790046, Length=384, Percent_Identity=33.59375, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1786993, Length=362, Percent_Identity=32.0441988950276, Blast_Score=178, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71994529, Length=389, Percent_Identity=32.3907455012853, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=421, Percent_Identity=30.166270783848, Blast_Score=191, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17560914, Length=393, Percent_Identity=29.0076335877863, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17560912, Length=393, Percent_Identity=29.0076335877863, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI71982617, Length=299, Percent_Identity=28.0936454849498, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71982625, Length=299, Percent_Identity=28.0936454849498, Blast_Score=136, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320438, Length=375, Percent_Identity=30.4, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6320267, Length=366, Percent_Identity=28.4153005464481, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6323954, Length=256, Percent_Identity=28.515625, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24662918, Length=350, Percent_Identity=33.1428571428571, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17137420, Length=383, Percent_Identity=30.8093994778068, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24653280, Length=306, Percent_Identity=31.6993464052288, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24653276, Length=306, Percent_Identity=31.6993464052288, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24653278, Length=306, Percent_Identity=31.6993464052288, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=31.3513513513514, Blast_Score=162, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.47 [H]

Molecular weight: Translated: 44055; Mature: 43924

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPVNKPKDLFKKCFDFTLADEVKAQGLYPFFHPIDETEGPVVSFAGRQLVMAGSNNYL
CCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCEE
GLTADPRVKQASINAINKYGTSCSGSRYMTGTVNLHIELEEKLADYFEKERCLLFSTGYQ
EECCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEHHHHHHHHHHCCEEEEECCCC
TGQGIIPTVVQRGEYIVSDRDNHASLVAASIMAQGAGANLVRYNHNNMEDLERVLQKIPE
CCCCCHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCH
SAGRLIVSDGVFSVSGEIVDLPELVALAKKYNARTLIDDAHAVGIIGKGGRGTPSEFGLV
HHCCEEEECCEEEECCCEECHHHHHHHHHHCCCCEEECCCCEEEEEECCCCCCCHHCCCH
DEVDLIMGTFSKTFGSLGGYVVGEHTVIDYIKHNASSLIFSASPTPASVAAVLATLEILR
HHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
TEPQLTEKLIANTDYVRQGLLKAGFTLMPSRTAIVTVLISDQIKTLVFWKKLFDAGVYVN
CCHHHHHHHHCCHHHHHHHHHHCCCEECCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEE
AFIRPGVMPGHEALRTSFMATHEREHLDKVITEFCTIGKELGVI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIPVNKPKDLFKKCFDFTLADEVKAQGLYPFFHPIDETEGPVVSFAGRQLVMAGSNNYL
CCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCEEEEECCCCEE
GLTADPRVKQASINAINKYGTSCSGSRYMTGTVNLHIELEEKLADYFEKERCLLFSTGYQ
EECCCCCCHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEEHHHHHHHHHHCCEEEEECCCC
TGQGIIPTVVQRGEYIVSDRDNHASLVAASIMAQGAGANLVRYNHNNMEDLERVLQKIPE
CCCCCHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHCCH
SAGRLIVSDGVFSVSGEIVDLPELVALAKKYNARTLIDDAHAVGIIGKGGRGTPSEFGLV
HHCCEEEECCEEEECCCEECHHHHHHHHHHCCCCEEECCCCEEEEEECCCCCCCHHCCCH
DEVDLIMGTFSKTFGSLGGYVVGEHTVIDYIKHNASSLIFSASPTPASVAAVLATLEILR
HHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
TEPQLTEKLIANTDYVRQGLLKAGFTLMPSRTAIVTVLISDQIKTLVFWKKLFDAGVYVN
CCHHHHHHHHCCHHHHHHHHHHCCCEECCCCCEEEEEEEHHHHHHHHHHHHHHHCCCEEE
AFIRPGVMPGHEALRTSFMATHEREHLDKVITEFCTIGKELGVI
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA