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The map label for this gene is hemC [H]

Identifier: 119357593

GI number: 119357593

Start: 2049195

End: 2050136

Strand: Direct

Name: hemC [H]

Synonym: Cpha266_1796

Alternate gene names: 119357593

Gene position: 2049195-2050136 (Clockwise)

Preceding gene: 119357592

Following gene: 119357594

Centisome position: 65.39

GC content: 48.94

Gene sequence:

>942_bases
TTGAAAAAACAGCTTATTATCGGCACCAGATCCAGCCCTCTTGCTTTGTGGCAGGCAGAATTCACCAAAGCGGAGCTATC
GAGGCACTATCCGGAACTCGACATCACGCTGAAGCTGGTGAAAACCACCGGCGACGTGTTGCTTGACTCCCCCCTTTCAA
AAATCGGGGATATGGGCCTTTTCACAAAAGACATTGAAAAACATCTTATTGCCAAAGAGATTGACCTTGCTGTTCACAGC
CTGAAAGATGTTCCGACCAGCACTCCTGAAGGTCTGATCATAACATCGTTTACCGAGCGGGAAGATACCCGCGATGTCAT
CATCTCCAGATCAGGTGAAACACTGTTAAACCTGCCACAGAATGCCAGGATTGCGACCAGCAGCCTTCGTCGTATGTCAC
AACTTCTGAGCATGCGACCTGATTTTGAAATCTGCGATATCAGAGGCAATCTCAACACGAGATTCAAGAAATTCGACGAA
GGCGAGTTCGACGCCATGATGCTTGCCTATGCCGGCGTGTTCAGACTTAAATTCAGCGATCGCATCTCCGAAATTCTTCC
ACATGACGTCATGCTGCCTGCCGTAGGACAGGGCGCACTCGGAATCGAAACTCGTGTTGATGATGAACAGACTCGCGAAA
TCGTCAGAATTCTGAATCACTCAAATACCGAATACTGCTGCAGAGCTGAACGGGCACTGCTCCGACATCTGCAGGGGGGA
TGCCAGATTCCGATCGGTGCTTACGCATCCTTTAAAAACGGAACACTCAAACTGCTTGCTTTTGTTGGTTCAGTCAATGG
CAAAATCGGACTGCGCAACGAAATCACGAAAACCGGACTTGTTTCACCCGAACAGGCAGAGGAAGCGGGAATTGAACTCG
CTAAAGAGCTCCTGAAACAGGGTGCAGATGAAATTCTGTCAGAAATCCGTAAAACCCGCTGA

Upstream 100 bases:

>100_bases
TGACACAGCCAACAACATTCCGAGCAGAGTCAACCTTGTCCGCAACGTTTTTGACCTTGAAGAACCTAATCAACAACACT
AAACAAAATCTGTCATCGCT

Downstream 100 bases:

>100_bases
TGAAAACAGTTCTTGTCACCCGACCGAAAGATCAGGCAGAGCCGTTTGTCAGGGAACTGGAAAAATACGGGCTGATCTCA
GTGGTGTTTCCCACCATTGA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MKKQLIIGTRSSPLALWQAEFTKAELSRHYPELDITLKLVKTTGDVLLDSPLSKIGDMGLFTKDIEKHLIAKEIDLAVHS
LKDVPTSTPEGLIITSFTEREDTRDVIISRSGETLLNLPQNARIATSSLRRMSQLLSMRPDFEICDIRGNLNTRFKKFDE
GEFDAMMLAYAGVFRLKFSDRISEILPHDVMLPAVGQGALGIETRVDDEQTREIVRILNHSNTEYCCRAERALLRHLQGG
CQIPIGAYASFKNGTLKLLAFVGSVNGKIGLRNEITKTGLVSPEQAEEAGIELAKELLKQGADEILSEIRKTR

Sequences:

>Translated_313_residues
MKKQLIIGTRSSPLALWQAEFTKAELSRHYPELDITLKLVKTTGDVLLDSPLSKIGDMGLFTKDIEKHLIAKEIDLAVHS
LKDVPTSTPEGLIITSFTEREDTRDVIISRSGETLLNLPQNARIATSSLRRMSQLLSMRPDFEICDIRGNLNTRFKKFDE
GEFDAMMLAYAGVFRLKFSDRISEILPHDVMLPAVGQGALGIETRVDDEQTREIVRILNHSNTEYCCRAERALLRHLQGG
CQIPIGAYASFKNGTLKLLAFVGSVNGKIGLRNEITKTGLVSPEQAEEAGIELAKELLKQGADEILSEIRKTR
>Mature_313_residues
MKKQLIIGTRSSPLALWQAEFTKAELSRHYPELDITLKLVKTTGDVLLDSPLSKIGDMGLFTKDIEKHLIAKEIDLAVHS
LKDVPTSTPEGLIITSFTEREDTRDVIISRSGETLLNLPQNARIATSSLRRMSQLLSMRPDFEICDIRGNLNTRFKKFDE
GEFDAMMLAYAGVFRLKFSDRISEILPHDVMLPAVGQGALGIETRVDDEQTREIVRILNHSNTEYCCRAERALLRHLQGG
CQIPIGAYASFKNGTLKLLAFVGSVNGKIGLRNEITKTGLVSPEQAEEAGIELAKELLKQGADEILSEIRKTR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=334, Percent_Identity=39.8203592814371, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI20149500, Length=334, Percent_Identity=39.8203592814371, Blast_Score=222, Evalue=3e-58,
Organism=Escherichia coli, GI48994974, Length=305, Percent_Identity=48.5245901639344, Blast_Score=285, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6319996, Length=320, Percent_Identity=36.5625, Blast_Score=189, Evalue=5e-49,
Organism=Drosophila melanogaster, GI20130425, Length=291, Percent_Identity=40.2061855670103, Blast_Score=204, Evalue=8e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34892; Mature: 34892

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQLIIGTRSSPLALWQAEFTKAELSRHYPELDITLKLVKTTGDVLLDSPLSKIGDMGL
CCCCEEEECCCCCCEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCHHHHHHCCCC
FTKDIEKHLIAKEIDLAVHSLKDVPTSTPEGLIITSFTEREDTRDVIISRSGETLLNLPQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHEEEECCCCCEECCCC
NARIATSSLRRMSQLLSMRPDFEICDIRGNLNTRFKKFDEGEFDAMMLAYAGVFRLKFSD
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHEEEHHH
RISEILPHDVMLPAVGQGALGIETRVDDEQTREIVRILNHSNTEYCCRAERALLRHLQGG
HHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
CQIPIGAYASFKNGTLKLLAFVGSVNGKIGLRNEITKTGLVSPEQAEEAGIELAKELLKQ
CCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHH
GADEILSEIRKTR
CHHHHHHHHHHCC
>Mature Secondary Structure
MKKQLIIGTRSSPLALWQAEFTKAELSRHYPELDITLKLVKTTGDVLLDSPLSKIGDMGL
CCCCEEEECCCCCCEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHCCHHHHHHCCCC
FTKDIEKHLIAKEIDLAVHSLKDVPTSTPEGLIITSFTEREDTRDVIISRSGETLLNLPQ
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHEEEECCCCCEECCCC
NARIATSSLRRMSQLLSMRPDFEICDIRGNLNTRFKKFDEGEFDAMMLAYAGVFRLKFSD
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHCCCCCCHHHHHHHHHHHHEEEHHH
RISEILPHDVMLPAVGQGALGIETRVDDEQTREIVRILNHSNTEYCCRAERALLRHLQGG
HHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCC
CQIPIGAYASFKNGTLKLLAFVGSVNGKIGLRNEITKTGLVSPEQAEEAGIELAKELLKQ
CCCCCCCCCCCCCCCEEEHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHH
GADEILSEIRKTR
CHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA