Click here to switch to the map view.

The map label for this gene is hemD [H]

Identifier: 119357594

GI number: 119357594

Start: 2050136

End: 2050891

Strand: Direct

Name: hemD [H]

Synonym: Cpha266_1797

Alternate gene names: 119357594

Gene position: 2050136-2050891 (Clockwise)

Preceding gene: 119357593

Following gene: 119357601

Centisome position: 65.42

GC content: 47.62

Gene sequence:

>756_bases
ATGAAAACAGTTCTTGTCACCCGACCGAAAGATCAGGCAGAGCCGTTTGTCAGGGAACTGGAAAAATACGGGCTGATCTC
AGTGGTGTTTCCCACCATTGAGATCCTGCCTGTTCCCGGCTGGTCAGTACCTGATCTGAAAAAATTTGACGGCGCCTTTT
TCACAAGTCCGAACAGCGTTCGATTCTTTCTTGAGCGACTCCTCCAGGAAGCCCCGCTCGAGCTTGAGTCACTCAGGGAT
ATGCATGTATGGGCGGTAGGAAAAACAACATCGAAAGACCTCGGAGTCCACGGCATTGTAACGGAGCCACTTCCTAAAAT
TGCCGATGCAGTCAATCTTATGGCAGAAATCGATGACGCCGAGATTAAAGGAAAATCATTTCTTTTTCTGAAAGGAAATC
TCTCACTTGGGATAATCCCTGAACTTATTGCGGCAAAGGGAGGACTCTGCACCGAAATCACCGTATACGACAATCGGCTG
CCTTCCCTTGAAGATACGGCAAAAATCAAAACAATCCTGCAGGAAGGAGGGCTCTCGTGCCTATCATTCACCAGTCCCTC
AACAGCAGAAAATTTTTTTCAGGCTATCGAAAAAAAATCAATTCCGGAAGGCACTCTCATTGCTGCTATAGGAACCACAA
CCGCTGCTGCGCTTGAGAAGCTTGGCGTAACGGTTGACGTTATACCGGAATACTTTGACGGACCAACCTTTGCAAAAGCG
ATTGCCGACGCACTCAAAAAAGAACCTGAAACCTGA

Upstream 100 bases:

>100_bases
TTTCACCCGAACAGGCAGAGGAAGCGGGAATTGAACTCGCTAAAGAGCTCCTGAAACAGGGTGCAGATGAAATTCTGTCA
GAAATCCGTAAAACCCGCTG

Downstream 100 bases:

>100_bases
ACGCATCTATTGAGGACGGACACCCCTACAAGTTGTCAAGATCATCAAAATCCTCGGGGCAAACCATATATTCCCCATCC
TGAGCAGTAACAGCGTTACT

Product: uroporphyrinogen-III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MKTVLVTRPKDQAEPFVRELEKYGLISVVFPTIEILPVPGWSVPDLKKFDGAFFTSPNSVRFFLERLLQEAPLELESLRD
MHVWAVGKTTSKDLGVHGIVTEPLPKIADAVNLMAEIDDAEIKGKSFLFLKGNLSLGIIPELIAAKGGLCTEITVYDNRL
PSLEDTAKIKTILQEGGLSCLSFTSPSTAENFFQAIEKKSIPEGTLIAAIGTTTAAALEKLGVTVDVIPEYFDGPTFAKA
IADALKKEPET

Sequences:

>Translated_251_residues
MKTVLVTRPKDQAEPFVRELEKYGLISVVFPTIEILPVPGWSVPDLKKFDGAFFTSPNSVRFFLERLLQEAPLELESLRD
MHVWAVGKTTSKDLGVHGIVTEPLPKIADAVNLMAEIDDAEIKGKSFLFLKGNLSLGIIPELIAAKGGLCTEITVYDNRL
PSLEDTAKIKTILQEGGLSCLSFTSPSTAENFFQAIEKKSIPEGTLIAAIGTTTAAALEKLGVTVDVIPEYFDGPTFAKA
IADALKKEPET
>Mature_251_residues
MKTVLVTRPKDQAEPFVRELEKYGLISVVFPTIEILPVPGWSVPDLKKFDGAFFTSPNSVRFFLERLLQEAPLELESLRD
MHVWAVGKTTSKDLGVHGIVTEPLPKIADAVNLMAEIDDAEIKGKSFLFLKGNLSLGIIPELIAAKGGLCTEITVYDNRL
PSLEDTAKIKTILQEGGLSCLSFTSPSTAENFFQAIEKKSIPEGTLIAAIGTTTAAALEKLGVTVDVIPEYFDGPTFAKA
IADALKKEPET

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 27278; Mature: 27278

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVLVTRPKDQAEPFVRELEKYGLISVVFPTIEILPVPGWSVPDLKKFDGAFFTSPNSV
CCCEEEECCCHHCCHHHHHHHHCCCEEEEECCEEEEECCCCCCCCHHHHCCCEECCCCHH
RFFLERLLQEAPLELESLRDMHVWAVGKTTSKDLGVHGIVTEPLPKIADAVNLMAEIDDA
HHHHHHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCC
EIKGKSFLFLKGNLSLGIIPELIAAKGGLCTEITVYDNRLPSLEDTAKIKTILQEGGLSC
EECCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEE
LSFTSPSTAENFFQAIEKKSIPEGTLIAAIGTTTAAALEKLGVTVDVIPEYFDGPTFAKA
EECCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHCCEEEECHHHCCCHHHHHH
IADALKKEPET
HHHHHHCCCCC
>Mature Secondary Structure
MKTVLVTRPKDQAEPFVRELEKYGLISVVFPTIEILPVPGWSVPDLKKFDGAFFTSPNSV
CCCEEEECCCHHCCHHHHHHHHCCCEEEEECCEEEEECCCCCCCCHHHHCCCEECCCCHH
RFFLERLLQEAPLELESLRDMHVWAVGKTTSKDLGVHGIVTEPLPKIADAVNLMAEIDDA
HHHHHHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCCCEECCCHHHHHHHHHHHHHCCCC
EIKGKSFLFLKGNLSLGIIPELIAAKGGLCTEITVYDNRLPSLEDTAKIKTILQEGGLSC
EECCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEE
LSFTSPSTAENFFQAIEKKSIPEGTLIAAIGTTTAAALEKLGVTVDVIPEYFDGPTFAKA
EECCCCCHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHCCEEEECHHHCCCHHHHHH
IADALKKEPET
HHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]