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The map label for this gene is hisG [H]

Identifier: 118581448

GI number: 118581448

Start: 3324876

End: 3325514

Strand: Reverse

Name: hisG [H]

Synonym: Ppro_3043

Alternate gene names: 118581448

Gene position: 3325514-3324876 (Counterclockwise)

Preceding gene: 118581449

Following gene: 118581447

Centisome position: 82.97

GC content: 58.37

Gene sequence:

>639_bases
ATGAACGATTTCATCACCATCGCCATTCCCAAGGGACGCATCCTTGAAGAATCCGTTGACCTGTTCGGCAGGATCGGCAT
CGACTGCCGGGAACTGCTGGGCGATTCCCGCAAACTGATCTTCGAAAACCCGCTTCAGAAGATGCGCTACATGATCGTAC
GCGCCACCGATGTCCCCACCTACGTGGAGTACGGCAGCGCCGACTTGGGTATCGTGGGCAAGGACACCCTTATGGAGCAG
GACAAGGACCTCTACGAGCCGCTTGACCTGAAGTTCGGCTATTGCCGGATGATGGTGGCCGAGCCTGCCAACCTGGCCAC
CCATGACGACCCCTCTGCTTGGTCACACATCCGCATCGCCACCAAGTATCCCCATGTTGCCGGAAACTACTTTGCCGCCA
AGGGGATCCAGGTGGAGATCATCAAGCTGTATGGCTCCATCGAACTGGCGCCGCTGGTGGGGCTTTCCGAGCGGATCGTG
GACCTGGTTTCCACCGGCGAGACCCTGCGCCAGAATGGCCTGGTTGAGGTGGAGACCATAGCCGAAATCACCACCCGCCT
GATCGTCAACCGTGCCAGCCTGAAGACCAAGCATGAGCGGATCAGCGGCATCATCCGCAATTTGGAGCAGGTCATATGA

Upstream 100 bases:

>100_bases
ATACCACCGAGGTCTCCCGGATCTACCACCTGGACCGTGGCTACGAGTCCATCGAGAAGAAACTGGCCGGCCTGGGCGCA
AACATCGTGAGAGTCCAAGA

Downstream 100 bases:

>100_bases
AGCTGATGGACATGCGCGACACCGACTTTGGAGAGCGCTTCGCCGTGATCCTCTCCCGTGGCGAGGAGATCGACCGCGCC
GTTGAGGGGAGCGTGGCGGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT 2; ATP-PRTase 2 [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNDFITIAIPKGRILEESVDLFGRIGIDCRELLGDSRKLIFENPLQKMRYMIVRATDVPTYVEYGSADLGIVGKDTLMEQ
DKDLYEPLDLKFGYCRMMVAEPANLATHDDPSAWSHIRIATKYPHVAGNYFAAKGIQVEIIKLYGSIELAPLVGLSERIV
DLVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHERISGIIRNLEQVI

Sequences:

>Translated_212_residues
MNDFITIAIPKGRILEESVDLFGRIGIDCRELLGDSRKLIFENPLQKMRYMIVRATDVPTYVEYGSADLGIVGKDTLMEQ
DKDLYEPLDLKFGYCRMMVAEPANLATHDDPSAWSHIRIATKYPHVAGNYFAAKGIQVEIIKLYGSIELAPLVGLSERIV
DLVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHERISGIIRNLEQVI
>Mature_212_residues
MNDFITIAIPKGRILEESVDLFGRIGIDCRELLGDSRKLIFENPLQKMRYMIVRATDVPTYVEYGSADLGIVGKDTLMEQ
DKDLYEPLDLKFGYCRMMVAEPANLATHDDPSAWSHIRIATKYPHVAGNYFAAKGIQVEIIKLYGSIELAPLVGLSERIV
DLVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHERISGIIRNLEQVI

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=222, Percent_Identity=35.1351351351351, Blast_Score=106, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320896, Length=218, Percent_Identity=31.1926605504587, Blast_Score=91, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23806; Mature: 23806

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFITIAIPKGRILEESVDLFGRIGIDCRELLGDSRKLIFENPLQKMRYMIVRATDVPT
CCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHCCCCCHHHHHCHHHHHHHHEEEECCCCC
YVEYGSADLGIVGKDTLMEQDKDLYEPLDLKFGYCRMMVAEPANLATHDDPSAWSHIRIA
HHHCCCCCCCEECCHHHHHCCHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
TKYPHVAGNYFAAKGIQVEIIKLYGSIELAPLVGLSERIVDLVSTGETLRQNGLVEVETI
ECCCCCCCCCEEECCCEEEEEEEECCEEEEHHCCHHHHHHHHHHCCHHHHHCCCEEHHHH
AEITTRLIVNRASLKTKHERISGIIRNLEQVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNDFITIAIPKGRILEESVDLFGRIGIDCRELLGDSRKLIFENPLQKMRYMIVRATDVPT
CCCEEEEEECCCCHHHHHHHHHHHCCCCHHHHCCCCCHHHHHCHHHHHHHHEEEECCCCC
YVEYGSADLGIVGKDTLMEQDKDLYEPLDLKFGYCRMMVAEPANLATHDDPSAWSHIRIA
HHHCCCCCCCEECCHHHHHCCHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEE
TKYPHVAGNYFAAKGIQVEIIKLYGSIELAPLVGLSERIVDLVSTGETLRQNGLVEVETI
ECCCCCCCCCEEECCCEEEEEEEECCEEEEHHCCHHHHHHHHHHCCHHHHHCCCEEHHHH
AEITTRLIVNRASLKTKHERISGIIRNLEQVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA