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The map label for this gene is hisD [H]

Identifier: 118581447

GI number: 118581447

Start: 3323587

End: 3324879

Strand: Reverse

Name: hisD [H]

Synonym: Ppro_3042

Alternate gene names: 118581447

Gene position: 3324879-3323587 (Counterclockwise)

Preceding gene: 118581448

Following gene: 118581446

Centisome position: 82.96

GC content: 65.82

Gene sequence:

>1293_bases
ATGAAGCTGATGGACATGCGCGACACCGACTTTGGAGAGCGCTTCGCCGTGATCCTCTCCCGTGGCGAGGAGATCGACCG
CGCCGTTGAGGGGAGCGTGGCGGAGATCATCGCCGATGTGCGCTCGCGGGGGGACCAGGCGCTGCTGGACCTGACCCGTC
GTTTCGACCGCCTCGAGACTTCCTCCGTGGCTGAACTGGAGGTCGGGGAGACGGAGATCGACGCCGCCCTTGCGGCCGTG
GCTGCTGACGACCTGGCCAGCCTGCGACATGCAGTGGAGCGGGTAACCCGCTTTCACGAGAAGCAGCGCCAGCAGACCTG
GCTCTCCACCGAAGAGCCGGATATCATGCTGGGGCAGAAGGTGACCCCTCTGGAGCGGGTCGGTATCTATGTGCCGGGAG
GCAAGGCCAGCTACCCCAGCAGCGTGATCATGAACGCCGTTCCCGCCCGTGTTGCCGGCGTCCGTGAAATCCTCATGGTG
ACGCCGACACCGGGCGGAGAGGTCAACCCCCACGTGCTGGCCGCGGCGCGCCTCTCCGGTGTGGATCGCATCTTCCGCAT
CGGCGGGGCCCAGGCCGTGGCGGCACTGGCCTACGGCACCGCAACCATCCCCCGGGTGGACAAGATCACCGGCCCCGGTA
ACATCTACGTAGCAACGGCCAAGAAGCTGGTGTTCGGGCAGGTGGGCATCGACATGATAGCTGGTCCCAGCGAGATCCTG
GTGATCAACGACGGCAGCGGCGATACCGCCCACGTGGCCTCCGACCTGCTCTCCCAAGCCGAGCACGACGAACTGGCCTC
GTCGATCCTGATCACCACCGACCGTTCCTTTGGCGAAAGGGTGGCGGGCGAGGTCGAGCGCCAGCTGGGGCTCCTCTCCC
GGGAGAGCATCGCCCGGGCTTCCTGGGAGAGTTACGGCGCCATCATCGTGGCTGGTTCGCTGGACGAAGCGGTGGCTTTT
TCCAACCGCATCGCGCCCGAGCACCTGGAACTGGCTGTTGCCGATCCCTTCAGCCTGCTGCCGGCCATCACCAACGCGGG
TGCCATCTTCATGGGGCACTGGACTCCCGAGGCCGCCGGCGACTATCTGGCAGGCCCGAACCACACCCTCCCCACCGGGG
GTACGGCTCGCTTCTTCTCACCGCTCTCGGTGGATGATTTCGTCAAGAAGTCGTCCATCGTCTGCCTCTCTGAAGGGGGA
CTGAAGCGCCTGGGGCGCGACATCGTCAGGATTGCCGGACTGGAGGGGCTGGAGGCGCATGCCAGGTCGGTCTCCATACG
GCTCGATAGATAG

Upstream 100 bases:

>100_bases
CCATAGCCGAAATCACCACCCGCCTGATCGTCAACCGTGCCAGCCTGAAGACCAAGCATGAGCGGATCAGCGGCATCATC
CGCAATTTGGAGCAGGTCAT

Downstream 100 bases:

>100_bases
GTTCTCTCTTCTTTCATATTTAGATCGCAAGGGTTTCTGAAATGATGCTTCTCCGCTCCAACATCGCCAGCATGCAGGGC
TACGTCCCCGGCTATCAGCC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKLMDMRDTDFGERFAVILSRGEEIDRAVEGSVAEIIADVRSRGDQALLDLTRRFDRLETSSVAELEVGETEIDAALAAV
AADDLASLRHAVERVTRFHEKQRQQTWLSTEEPDIMLGQKVTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVREILMV
TPTPGGEVNPHVLAAARLSGVDRIFRIGGAQAVAALAYGTATIPRVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
VINDGSGDTAHVASDLLSQAEHDELASSILITTDRSFGERVAGEVERQLGLLSRESIARASWESYGAIIVAGSLDEAVAF
SNRIAPEHLELAVADPFSLLPAITNAGAIFMGHWTPEAAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVCLSEGG
LKRLGRDIVRIAGLEGLEAHARSVSIRLDR

Sequences:

>Translated_430_residues
MKLMDMRDTDFGERFAVILSRGEEIDRAVEGSVAEIIADVRSRGDQALLDLTRRFDRLETSSVAELEVGETEIDAALAAV
AADDLASLRHAVERVTRFHEKQRQQTWLSTEEPDIMLGQKVTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVREILMV
TPTPGGEVNPHVLAAARLSGVDRIFRIGGAQAVAALAYGTATIPRVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
VINDGSGDTAHVASDLLSQAEHDELASSILITTDRSFGERVAGEVERQLGLLSRESIARASWESYGAIIVAGSLDEAVAF
SNRIAPEHLELAVADPFSLLPAITNAGAIFMGHWTPEAAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVCLSEGG
LKRLGRDIVRIAGLEGLEAHARSVSIRLDR
>Mature_430_residues
MKLMDMRDTDFGERFAVILSRGEEIDRAVEGSVAEIIADVRSRGDQALLDLTRRFDRLETSSVAELEVGETEIDAALAAV
AADDLASLRHAVERVTRFHEKQRQQTWLSTEEPDIMLGQKVTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVREILMV
TPTPGGEVNPHVLAAARLSGVDRIFRIGGAQAVAALAYGTATIPRVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
VINDGSGDTAHVASDLLSQAEHDELASSILITTDRSFGERVAGEVERQLGLLSRESIARASWESYGAIIVAGSLDEAVAF
SNRIAPEHLELAVADPFSLLPAITNAGAIFMGHWTPEAAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVCLSEGG
LKRLGRDIVRIAGLEGLEAHARSVSIRLDR

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=414, Percent_Identity=39.3719806763285, Blast_Score=281, Evalue=8e-77,
Organism=Saccharomyces cerevisiae, GI6319819, Length=407, Percent_Identity=38.5749385749386, Blast_Score=263, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45895; Mature: 45895

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLMDMRDTDFGERFAVILSRGEEIDRAVEGSVAEIIADVRSRGDQALLDLTRRFDRLET
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SSVAELEVGETEIDAALAAVAADDLASLRHAVERVTRFHEKQRQQTWLSTEEPDIMLGQK
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCC
VTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVREILMVTPTPGGEVNPHVLAAARLSG
CCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHH
VDRIFRIGGAQAVAALAYGTATIPRVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
HHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCHHEECCCCEEE
VINDGSGDTAHVASDLLSQAEHDELASSILITTDRSFGERVAGEVERQLGLLSRESIARA
EEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
SWESYGAIIVAGSLDEAVAFSNRIAPEHLELAVADPFSLLPAITNAGAIFMGHWTPEAAG
HHHCCCEEEEECCCHHHHHHHCCCCCCHHEEEECCCHHHHHHHHCCCEEEEECCCCHHCC
DYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVCLSEGGLKRLGRDIVRIAGLEGLEAH
CCCCCCCCCCCCCCCHHHCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCHHHH
ARSVSIRLDR
CCEEEEEECC
>Mature Secondary Structure
MKLMDMRDTDFGERFAVILSRGEEIDRAVEGSVAEIIADVRSRGDQALLDLTRRFDRLET
CCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
SSVAELEVGETEIDAALAAVAADDLASLRHAVERVTRFHEKQRQQTWLSTEEPDIMLGQK
CCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCC
VTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVREILMVTPTPGGEVNPHVLAAARLSG
CCCHHHCCEEECCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHHHHHH
VDRIFRIGGAQAVAALAYGTATIPRVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
HHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHHHHHHCCHHEECCCCEEE
VINDGSGDTAHVASDLLSQAEHDELASSILITTDRSFGERVAGEVERQLGLLSRESIARA
EEECCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
SWESYGAIIVAGSLDEAVAFSNRIAPEHLELAVADPFSLLPAITNAGAIFMGHWTPEAAG
HHHCCCEEEEECCCHHHHHHHCCCCCCHHEEEECCCHHHHHHHHCCCEEEEECCCCHHCC
DYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVCLSEGGLKRLGRDIVRIAGLEGLEAH
CCCCCCCCCCCCCCCHHHCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCHHHH
ARSVSIRLDR
CCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA