Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 118581446

GI number: 118581446

Start: 3322493

End: 3323545

Strand: Reverse

Name: hisC [H]

Synonym: Ppro_3041

Alternate gene names: 118581446

Gene position: 3323545-3322493 (Counterclockwise)

Preceding gene: 118581447

Following gene: 118581445

Centisome position: 82.92

GC content: 62.87

Gene sequence:

>1053_bases
ATGATGCTTCTCCGCTCCAACATCGCCAGCATGCAGGGCTACGTCCCCGGCTATCAGCCCGAGGACATATCCTCCTGGAT
TAAACTCAACACCAACGAAAACCCCTATCCCCCCTCGCCGAAGGTGCGGGAGGCCATCCTGGCCGAGATGGGCGACGACG
GCGCCTCGCTGCGCACCTACCCCAGCGCTTCCAGCCAGAGGCTGCGAGAAGCTGCCTCGGAGCTGTATGGCTTCGATCCC
TCCTGGATCATCATGGCCAACGGTTCCGACGAACTGCTCAACAACCTGATCCGCGCCTGTGCCTCCGAGGGGGACGAAGT
CGGCTATGTCCACCCCTCCTACTCCTACTACGCTACCCTGTCCGAGATCCAGGGGGCCAAAGTGCGGACCTTCGGCCTGA
CGGAGGATTTTCGCATCGCCGGCTTCCCCGATCGATACCAGGGCAGGGTCTTCTTCCTGACCACCCCCAATGCGCCGCTG
GGCTTCTCGTTCCCGCTCTCCTATGTGGAAGAGATCGCCCGCAGCTGCCAGGGGCTGCTGGTGATCGACGAGGCCTACGC
CGATTTTGCTGATACAAACGCCCTGGAGCTGGTCAGGAAGTACGAGAACGTGGTGGTCACCCGCACCTTCTCCAAGAGCT
ACGCCCTGGCCGGCATGCGCCTGGGGCTGGCCATTGCCCGGCCGGAGATTGTCGCCGCCCTGGACAAGATCCGCGACCAC
TACAACCTTGACCGCCTGGCCCAGGCATCCTGCATCGCCTCGCTGGGCGACCAGGAGTACTTCCGCCAGTCCTGTGCCAG
GATCCGGGAAACCAGGGAGTGGTTTTCCGCCGGACTGCGCTCCATCGGCTTCAGCCTGATCCCCTCCCAGACCAATTTTG
TCTTCGCCTCTCCGCCCGACCGCAACGGCAGGAGGGTCTACGATGCCCTGTACAGCCGCAAGATCCTGGTGCGCCATTTC
TCCGATCCGATCCTGGCCCATGGCCTGAGGATTTCCATCGGCACCCGCCAGGAGATGGAACTGACCCTGGCCGCGCTTGC
GGAAATTGCCTAA

Upstream 100 bases:

>100_bases
CCGGACTGGAGGGGCTGGAGGCGCATGCCAGGTCGGTCTCCATACGGCTCGATAGATAGGTTCTCTCTTCTTTCATATTT
AGATCGCAAGGGTTTCTGAA

Downstream 100 bases:

>100_bases
GATCCCCGGGAGGAACGATGACTCGAACGGCGACCATTGAACGGAATACCAGTGAAACCAGGATACGGCTCACCCTGAAT
ATCGACGGCAGGGGGGAGAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MMLLRSNIASMQGYVPGYQPEDISSWIKLNTNENPYPPSPKVREAILAEMGDDGASLRTYPSASSQRLREAASELYGFDP
SWIIMANGSDELLNNLIRACASEGDEVGYVHPSYSYYATLSEIQGAKVRTFGLTEDFRIAGFPDRYQGRVFFLTTPNAPL
GFSFPLSYVEEIARSCQGLLVIDEAYADFADTNALELVRKYENVVVTRTFSKSYALAGMRLGLAIARPEIVAALDKIRDH
YNLDRLAQASCIASLGDQEYFRQSCARIRETREWFSAGLRSIGFSLIPSQTNFVFASPPDRNGRRVYDALYSRKILVRHF
SDPILAHGLRISIGTRQEMELTLAALAEIA

Sequences:

>Translated_350_residues
MMLLRSNIASMQGYVPGYQPEDISSWIKLNTNENPYPPSPKVREAILAEMGDDGASLRTYPSASSQRLREAASELYGFDP
SWIIMANGSDELLNNLIRACASEGDEVGYVHPSYSYYATLSEIQGAKVRTFGLTEDFRIAGFPDRYQGRVFFLTTPNAPL
GFSFPLSYVEEIARSCQGLLVIDEAYADFADTNALELVRKYENVVVTRTFSKSYALAGMRLGLAIARPEIVAALDKIRDH
YNLDRLAQASCIASLGDQEYFRQSCARIRETREWFSAGLRSIGFSLIPSQTNFVFASPPDRNGRRVYDALYSRKILVRHF
SDPILAHGLRISIGTRQEMELTLAALAEIA
>Mature_350_residues
MMLLRSNIASMQGYVPGYQPEDISSWIKLNTNENPYPPSPKVREAILAEMGDDGASLRTYPSASSQRLREAASELYGFDP
SWIIMANGSDELLNNLIRACASEGDEVGYVHPSYSYYATLSEIQGAKVRTFGLTEDFRIAGFPDRYQGRVFFLTTPNAPL
GFSFPLSYVEEIARSCQGLLVIDEAYADFADTNALELVRKYENVVVTRTFSKSYALAGMRLGLAIARPEIVAALDKIRDH
YNLDRLAQASCIASLGDQEYFRQSCARIRETREWFSAGLRSIGFSLIPSQTNFVFASPPDRNGRRVYDALYSRKILVRHF
SDPILAHGLRISIGTRQEMELTLAALAEIA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=328, Percent_Identity=28.0487804878049, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788722, Length=259, Percent_Identity=28.1853281853282, Blast_Score=78, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322075, Length=355, Percent_Identity=25.3521126760563, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39094; Mature: 39094

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLLRSNIASMQGYVPGYQPEDISSWIKLNTNENPYPPSPKVREAILAEMGDDGASLRTY
CEEECCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEC
PSASSQRLREAASELYGFDPSWIIMANGSDELLNNLIRACASEGDEVGYVHPSYSYYATL
CCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCHHEEEH
SEIQGAKVRTFGLTEDFRIAGFPDRYQGRVFFLTTPNAPLGFSFPLSYVEEIARSCQGLL
HHCCCCEEEEECCCCCCEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEE
VIDEAYADFADTNALELVRKYENVVVTRTFSKSYALAGMRLGLAIARPEIVAALDKIRDH
EEEHHHHCCCCCHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
YNLDRLAQASCIASLGDQEYFRQSCARIRETREWFSAGLRSIGFSLIPSQTNFVFASPPD
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCC
RNGRRVYDALYSRKILVRHFSDPILAHGLRISIGTRQEMELTLAALAEIA
CCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MMLLRSNIASMQGYVPGYQPEDISSWIKLNTNENPYPPSPKVREAILAEMGDDGASLRTY
CEEECCCHHHHHCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEC
PSASSQRLREAASELYGFDPSWIIMANGSDELLNNLIRACASEGDEVGYVHPSYSYYATL
CCHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCHHEEEH
SEIQGAKVRTFGLTEDFRIAGFPDRYQGRVFFLTTPNAPLGFSFPLSYVEEIARSCQGLL
HHCCCCEEEEECCCCCCEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEE
VIDEAYADFADTNALELVRKYENVVVTRTFSKSYALAGMRLGLAIARPEIVAALDKIRDH
EEEHHHHCCCCCHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
YNLDRLAQASCIASLGDQEYFRQSCARIRETREWFSAGLRSIGFSLIPSQTNFVFASPPD
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCC
RNGRRVYDALYSRKILVRHFSDPILAHGLRISIGTRQEMELTLAALAEIA
CCCHHHHHHHHHHHHHHHHCCCHHHHCCEEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA