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The map label for this gene is hisB

Identifier: 118581445

GI number: 118581445

Start: 3321888

End: 3322475

Strand: Reverse

Name: hisB

Synonym: Ppro_3040

Alternate gene names: 118581445

Gene position: 3322475-3321888 (Counterclockwise)

Preceding gene: 118581446

Following gene: 118581444

Centisome position: 82.9

GC content: 60.2

Gene sequence:

>588_bases
ATGACTCGAACGGCGACCATTGAACGGAATACCAGTGAAACCAGGATACGGCTCACCCTGAATATCGACGGCAGGGGGGA
GACATCCATCGGCAGTGGGGTCCCCTTCCTCGACCACATGCTCAACCTCTTCGCCCGCCACGGGCTCTTCGACCTGAGCC
TGGAGGCGTGTGGCGACACCCAGATCGACTTCCACCATACGGTGGAGGATATCGGCATCGTGCTGGGAGAGGCCTTCAAG
CAGGCCCTGGCCGACAAGCAGGGGATCAACCGCTATGGGCAGGTCACGGTCCCCATGGACGAGACCCTGGCAAGCGCGGT
TGTGGATATCTCCGGCCGCCCCTACCTGGTCTATAACGTCGACCTCCCCAAGGCCAAGGTCGGGGATTTCGATGTTGAGC
TGGCACAGGAATTCTTCCAGGCCTTTGCCAACCACTGTGGCATAAACCTGCACATCAACCTGCTGTACGGCGACAATCTG
CACCACATCATTGAAGCCTGCTTCAAGGCGGTCGGTCGGGCCATGGATATGGCCACCCGCCTGGACCCGCGGGTAGAAGG
TGTCATGTCCACCAAGGGGGTCCTGTAG

Upstream 100 bases:

>100_bases
TCCTGGCCCATGGCCTGAGGATTTCCATCGGCACCCGCCAGGAGATGGAACTGACCCTGGCCGCGCTTGCGGAAATTGCC
TAAGATCCCCGGGAGGAACG

Downstream 100 bases:

>100_bases
CGCTCCCCACAATCCAGCGAAAAAAGGGCGATCCGTTCAAGGACGCCCTTTTTTTGTTGTGCCATGTGATGGAAGGATGA
ACGACGGAAGAGGAGGTGGG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MTRTATIERNTSETRIRLTLNIDGRGETSIGSGVPFLDHMLNLFARHGLFDLSLEACGDTQIDFHHTVEDIGIVLGEAFK
QALADKQGINRYGQVTVPMDETLASAVVDISGRPYLVYNVDLPKAKVGDFDVELAQEFFQAFANHCGINLHINLLYGDNL
HHIIEACFKAVGRAMDMATRLDPRVEGVMSTKGVL

Sequences:

>Translated_195_residues
MTRTATIERNTSETRIRLTLNIDGRGETSIGSGVPFLDHMLNLFARHGLFDLSLEACGDTQIDFHHTVEDIGIVLGEAFK
QALADKQGINRYGQVTVPMDETLASAVVDISGRPYLVYNVDLPKAKVGDFDVELAQEFFQAFANHCGINLHINLLYGDNL
HHIIEACFKAVGRAMDMATRLDPRVEGVMSTKGVL
>Mature_194_residues
TRTATIERNTSETRIRLTLNIDGRGETSIGSGVPFLDHMLNLFARHGLFDLSLEACGDTQIDFHHTVEDIGIVLGEAFKQ
ALADKQGINRYGQVTVPMDETLASAVVDISGRPYLVYNVDLPKAKVGDFDVELAQEFFQAFANHCGINLHINLLYGDNLH
HIIEACFKAVGRAMDMATRLDPRVEGVMSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=195, Percent_Identity=46.1538461538462, Blast_Score=161, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6324776, Length=217, Percent_Identity=38.2488479262673, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_PELPD (A1ATG7)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_902695.1
- ProteinModelPortal:   A1ATG7
- SMR:   A1ATG7
- STRING:   A1ATG7
- GeneID:   4574295
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_3040
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   A1ATG7
- ProtClustDB:   PRK00951
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21504; Mature: 21373

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRTATIERNTSETRIRLTLNIDGRGETSIGSGVPFLDHMLNLFARHGLFDLSLEACGDT
CCCCEEEECCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCC
QIDFHHTVEDIGIVLGEAFKQALADKQGINRYGQVTVPMDETLASAVVDISGRPYLVYNV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHCCCCCEEEEEEC
DLPKAKVGDFDVELAQEFFQAFANHCGINLHINLLYGDNLHHIIEACFKAVGRAMDMATR
CCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LDPRVEGVMSTKGVL
CCCHHHHHHHCCCCC
>Mature Secondary Structure 
TRTATIERNTSETRIRLTLNIDGRGETSIGSGVPFLDHMLNLFARHGLFDLSLEACGDT
CCCEEEECCCCCEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCC
QIDFHHTVEDIGIVLGEAFKQALADKQGINRYGQVTVPMDETLASAVVDISGRPYLVYNV
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHCCCCCEEEEEEC
DLPKAKVGDFDVELAQEFFQAFANHCGINLHINLLYGDNLHHIIEACFKAVGRAMDMATR
CCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
LDPRVEGVMSTKGVL
CCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA