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The map label for this gene is ispD [H]

Identifier: 118581374

GI number: 118581374

Start: 3239001

End: 3239717

Strand: Reverse

Name: ispD [H]

Synonym: Ppro_2969

Alternate gene names: 118581374

Gene position: 3239717-3239001 (Counterclockwise)

Preceding gene: 118581375

Following gene: 118581373

Centisome position: 80.83

GC content: 64.57

Gene sequence:

>717_bases
ATGAAAGCTTGCAAGGCCTTTGCCCTGATACCGGCTGCCGGAATGGGGAAGCGCATGGGCGCTTCCGTGAACAAGCAGTA
CCTGCAACTGGGCGGCCTTCCCATTCTGGCCCACACCCTGGCGGTATTCCAGCAGTGCCCCCGCATCACTGGCATCTGCC
TGGTGACCCCCGCCGACGAGATCGCCTACTGCCGCGACCAGGTGGTCAGTGCCTGCGGCTTCACCAAGGTGATCGAAATC
GTTCCCGGTGGCCGGGAACGCCAGAATTCGGTCATGAACGGCCTCAAGGCCTTGAAGCGCCATGCCGCCGCCGATGACGT
GGTGCTGATCCACGACGGTGTCAGGCCGTTCATCTCCCCTGACCTCTTGCGGGAATCCATTGCCGCGGCAAGCTCCGGCG
ACGGGGCGCTGGTGGCGGTGAGGGCCAAGGATACCATCAAGACGGTGCGGGACGGCGTTGTCCAGGATACGCCGGACCGC
TCGACCCTCTGGCAGGCCCAGACCCCCCAGTCGTTCCGTTACGGCGTTATCTGCGAGGCCCACCAGAGCGCCGAGGAGGC
CGGCTTCGCCGGTACCGACGATTCGTCGCTGGTGGAGCGGCGCGGTGGGCGGGTGCGGATCGTGCCGGGCGATTACCGCA
ACATAAAGATCACCACTCCCGAAGACCTTATTCTGGCGGAAGCCTTTCTGGCCGCTTTTCGGCAGGTGCTCCCATGA

Upstream 100 bases:

>100_bases
AACCGCCGGCATGGCGGCCATGGCTGCTGACCGGCCGGGATATTTCAGCGCTCGCCGCACCACTGAACATGGGCGGTCGC
GGCGCTCGCGAGGAAAGACG

Downstream 100 bases:

>100_bases
GCCCACAGACTCCCCAGAGGGTTTTGATCGTTGATGACGAGATGCTGGTGGCCAAGATCCTCTCCCTGCACCTGGAGGAG
TCCGGCTATCTGACCGAATG

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKACKAFALIPAAGMGKRMGASVNKQYLQLGGLPILAHTLAVFQQCPRITGICLVTPADEIAYCRDQVVSACGFTKVIEI
VPGGRERQNSVMNGLKALKRHAAADDVVLIHDGVRPFISPDLLRESIAAASSGDGALVAVRAKDTIKTVRDGVVQDTPDR
STLWQAQTPQSFRYGVICEAHQSAEEAGFAGTDDSSLVERRGGRVRIVPGDYRNIKITTPEDLILAEAFLAAFRQVLP

Sequences:

>Translated_238_residues
MKACKAFALIPAAGMGKRMGASVNKQYLQLGGLPILAHTLAVFQQCPRITGICLVTPADEIAYCRDQVVSACGFTKVIEI
VPGGRERQNSVMNGLKALKRHAAADDVVLIHDGVRPFISPDLLRESIAAASSGDGALVAVRAKDTIKTVRDGVVQDTPDR
STLWQAQTPQSFRYGVICEAHQSAEEAGFAGTDDSSLVERRGGRVRIVPGDYRNIKITTPEDLILAEAFLAAFRQVLP
>Mature_238_residues
MKACKAFALIPAAGMGKRMGASVNKQYLQLGGLPILAHTLAVFQQCPRITGICLVTPADEIAYCRDQVVSACGFTKVIEI
VPGGRERQNSVMNGLKALKRHAAADDVVLIHDGVRPFISPDLLRESIAAASSGDGALVAVRAKDTIKTVRDGVVQDTPDR
STLWQAQTPQSFRYGVICEAHQSAEEAGFAGTDDSSLVERRGGRVRIVPGDYRNIKITTPEDLILAEAFLAAFRQVLP

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=232, Percent_Identity=28.0172413793103, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1789104, Length=227, Percent_Identity=35.6828193832599, Blast_Score=115, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25571; Mature: 25571

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKACKAFALIPAAGMGKRMGASVNKQYLQLGGLPILAHTLAVFQQCPRITGICLVTPADE
CCCCHHEEECCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCHH
IAYCRDQVVSACGFTKVIEIVPGGRERQNSVMNGLKALKRHAAADDVVLIHDGVRPFISP
HHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCH
DLLRESIAAASSGDGALVAVRAKDTIKTVRDGVVQDTPDRSTLWQAQTPQSFRYGVICEA
HHHHHHHHHCCCCCCCEEEEECHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCEEECC
HQSAEEAGFAGTDDSSLVERRGGRVRIVPGDYRNIKITTPEDLILAEAFLAAFRQVLP
HHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKACKAFALIPAAGMGKRMGASVNKQYLQLGGLPILAHTLAVFQQCPRITGICLVTPADE
CCCCHHEEECCCCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEECCCHH
IAYCRDQVVSACGFTKVIEIVPGGRERQNSVMNGLKALKRHAAADDVVLIHDGVRPFISP
HHHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCH
DLLRESIAAASSGDGALVAVRAKDTIKTVRDGVVQDTPDRSTLWQAQTPQSFRYGVICEA
HHHHHHHHHCCCCCCCEEEEECHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCCCEEECC
HQSAEEAGFAGTDDSSLVERRGGRVRIVPGDYRNIKITTPEDLILAEAFLAAFRQVLP
HHHHHHCCCCCCCCHHHHHHCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA