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The map label for this gene is degP [H]

Identifier: 118581361

GI number: 118581361

Start: 3227026

End: 3228444

Strand: Reverse

Name: degP [H]

Synonym: Ppro_2956

Alternate gene names: 118581361

Gene position: 3228444-3227026 (Counterclockwise)

Preceding gene: 118581362

Following gene: 118581360

Centisome position: 80.55

GC content: 62.58

Gene sequence:

>1419_bases
ATGTCAACAGCATTCCAATGGTCGCTGCGCCTCGTGATCGGGATGGTGGTCCTCGCCGTCTCTCTTCCGCTACCGTCATT
CGCCAGGGTGATCAGTCCCGATTTCGTCGAACTCTCCACGAAACTGACCCCCACGGTGGTCAACATCCGCACGGTAAAGA
ACATCAAGCCGGCGCAACGCAGCCAGCGCTCGCCCCAGGGCAATCAGCACGACAAGTTCTTCGAGGAATTCTTCGGCCGC
TTTTTCGATGAGATGCCCCAGCAACGTCCCCGTCGCGAGCAGAGCCTGGGCACCGGTTTCATCATCGATGCCGAGGGGTA
CGTGCTCACCAACAACCATGTGGTCAGCGGCGCCGACGAGGTGATGGTCAAGCTGGCCGACGGGCGCGAGCTGAAGGGGG
AGATCAAGGGGGTCGACGAGAAGCTGGACCTGGCCCTGGTCAAGATCAACGATGGCAAGACCTTTCCCTTTGCCGAGCTG
GGTGACAGCGATGCGCTGCAGGTGGGGGAATGGGTCATGGCCATTGGAAACCCCTTCGGCCTGGCCCATACCGTCACTGC
CGGCATCGTCAGCGCCAAGGGGCGCGTGATCGGCAGCGGCCCCTATGACGACTTCATCCAGACCGATGCCTCCATCAACC
CGGGCAACTCCGGCGGCCCGCTCTTCAACGCCAGCGGCAAGGTGATCGGCATCAATACCGCCATCATCGCCGGCGGCGGT
GGCGGCATCGGCTTCGCCATTCCGGTCAATATCGCTAAAGCCACTGTCAGCCAATTGCGCCAGAGCGGCAAGGTCACCCG
CGGCTATCTGGGGGTGCGCTTCCAGCCGCTGACGCCTGAACTGGCCAAATCCTTTGGCCTGGAATCGGACAAGGGTGCCC
TGATCTCCAGTGTGGAAAAAGAGGGGCCGGCGGAGAAGGCCGGACTCAAGGCTGGCGACGTGATCCTGGAGTTCGACGGC
AAGGCGATCAACGAGGGGAGCGAACTCCCCCGCTATGTGGCGGTGACGCCGGTGGGCAAGAAGGTCAAGGTCCTGTTCGC
CCGTGACGGCAAGCGCCAGAGCCTGAATGTGGTCATCGCCAAGCTGAAGGATGGCGAACAGGCGGCGGTGGATGGCGACG
GCGGTGCGGAGAGCGACAAAATCGGCATAACCGTCCAGGAACTGACCAGGGAACTGGCCGGCCGCATCGGCATCAGGGAG
GCAAAGGGACTGGTGGTGACCCAGGTTACGCCCGGATCACCGGCCGAAGAGGCAGGGGTGACCACCGGGGCCGTCATCAT
CGAGATCAACGGCCAGCGTCCCGACAACCTGCAGAAATTCAATGCCGTGCTCTCCACGATCAAGAAGGGGGACATCGTGC
GTCTCCTGTTGCGCCGTTCCGACGGCAGCATCCAGTACGTGGGGATGCGGGCCGAATAA

Upstream 100 bases:

>100_bases
GCTATAGTGCCGACGAAACAGAGCAAGGGGCGGCGTCGTCACATCAGTGAGACCCGCCCCTCGTTGTTCGATTCTCACAC
GCTTCAGGGAGGTTGAAAGC

Downstream 100 bases:

>100_bases
CAACCGATCACAGGGAAAAACAGGCGGGGCGGGTTTCAGACCCGCCCCGCGTTTTGATCATTCCCTGTTCCGCTCCACCC
GATTAGCGAAAGGAACCAAG

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSTAFQWSLRLVIGMVVLAVSLPLPSFARVISPDFVELSTKLTPTVVNIRTVKNIKPAQRSQRSPQGNQHDKFFEEFFGR
FFDEMPQQRPRREQSLGTGFIIDAEGYVLTNNHVVSGADEVMVKLADGRELKGEIKGVDEKLDLALVKINDGKTFPFAEL
GDSDALQVGEWVMAIGNPFGLAHTVTAGIVSAKGRVIGSGPYDDFIQTDASINPGNSGGPLFNASGKVIGINTAIIAGGG
GGIGFAIPVNIAKATVSQLRQSGKVTRGYLGVRFQPLTPELAKSFGLESDKGALISSVEKEGPAEKAGLKAGDVILEFDG
KAINEGSELPRYVAVTPVGKKVKVLFARDGKRQSLNVVIAKLKDGEQAAVDGDGGAESDKIGITVQELTRELAGRIGIRE
AKGLVVTQVTPGSPAEEAGVTTGAVIIEINGQRPDNLQKFNAVLSTIKKGDIVRLLLRRSDGSIQYVGMRAE

Sequences:

>Translated_472_residues
MSTAFQWSLRLVIGMVVLAVSLPLPSFARVISPDFVELSTKLTPTVVNIRTVKNIKPAQRSQRSPQGNQHDKFFEEFFGR
FFDEMPQQRPRREQSLGTGFIIDAEGYVLTNNHVVSGADEVMVKLADGRELKGEIKGVDEKLDLALVKINDGKTFPFAEL
GDSDALQVGEWVMAIGNPFGLAHTVTAGIVSAKGRVIGSGPYDDFIQTDASINPGNSGGPLFNASGKVIGINTAIIAGGG
GGIGFAIPVNIAKATVSQLRQSGKVTRGYLGVRFQPLTPELAKSFGLESDKGALISSVEKEGPAEKAGLKAGDVILEFDG
KAINEGSELPRYVAVTPVGKKVKVLFARDGKRQSLNVVIAKLKDGEQAAVDGDGGAESDKIGITVQELTRELAGRIGIRE
AKGLVVTQVTPGSPAEEAGVTTGAVIIEINGQRPDNLQKFNAVLSTIKKGDIVRLLLRRSDGSIQYVGMRAE
>Mature_471_residues
STAFQWSLRLVIGMVVLAVSLPLPSFARVISPDFVELSTKLTPTVVNIRTVKNIKPAQRSQRSPQGNQHDKFFEEFFGRF
FDEMPQQRPRREQSLGTGFIIDAEGYVLTNNHVVSGADEVMVKLADGRELKGEIKGVDEKLDLALVKINDGKTFPFAELG
DSDALQVGEWVMAIGNPFGLAHTVTAGIVSAKGRVIGSGPYDDFIQTDASINPGNSGGPLFNASGKVIGINTAIIAGGGG
GIGFAIPVNIAKATVSQLRQSGKVTRGYLGVRFQPLTPELAKSFGLESDKGALISSVEKEGPAEKAGLKAGDVILEFDGK
AINEGSELPRYVAVTPVGKKVKVLFARDGKRQSLNVVIAKLKDGEQAAVDGDGGAESDKIGITVQELTRELAGRIGIREA
KGLVVTQVTPGSPAEEAGVTTGAVIIEINGQRPDNLQKFNAVLSTIKKGDIVRLLLRRSDGSIQYVGMRAE

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=258, Percent_Identity=41.8604651162791, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI22129776, Length=253, Percent_Identity=38.3399209486166, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI24308541, Length=248, Percent_Identity=36.2903225806452, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI7019477, Length=262, Percent_Identity=34.7328244274809, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1786356, Length=466, Percent_Identity=38.6266094420601, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1789629, Length=471, Percent_Identity=37.1549893842887, Blast_Score=258, Evalue=6e-70,
Organism=Escherichia coli, GI1789630, Length=358, Percent_Identity=34.6368715083799, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24646839, Length=285, Percent_Identity=33.6842105263158, Blast_Score=145, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 50189; Mature: 50058

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAFQWSLRLVIGMVVLAVSLPLPSFARVISPDFVELSTKLTPTVVNIRTVKNIKPAQR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCEEEEEEEECCCCCHHH
SQRSPQGNQHDKFFEEFFGRFFDEMPQQRPRREQSLGTGFIIDAEGYVLTNNHVVSGADE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCEEEECCEEECCHHH
VMVKLADGRELKGEIKGVDEKLDLALVKINDGKTFPFAELGDSDALQVGEWVMAIGNPFG
EEEEECCCCCCCCHHCCCCCEEEEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHCCCCC
LAHTVTAGIVSAKGRVIGSGPYDDFIQTDASINPGNSGGPLFNASGKVIGINTAIIAGGG
HHHHHHHHHHCCCCEEEECCCCHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEEEEECCC
GGIGFAIPVNIAKATVSQLRQSGKVTRGYLGVRFQPLTPELAKSFGLESDKGALISSVEK
CCEEEEEECHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHCCCCCCCCHHHHHHHH
EGPAEKAGLKAGDVILEFDGKAINEGSELPRYVAVTPVGKKVKVLFARDGKRQSLNVVIA
CCCHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEEEEEEE
KLKDGEQAAVDGDGGAESDKIGITVQELTRELAGRIGIREAKGLVVTQVTPGSPAEEAGV
EECCCCEEEECCCCCCCCCEECEEHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHCCC
TTGAVIIEINGQRPDNLQKFNAVLSTIKKGDIVRLLLRRSDGSIQYVGMRAE
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECC
>Mature Secondary Structure 
STAFQWSLRLVIGMVVLAVSLPLPSFARVISPDFVELSTKLTPTVVNIRTVKNIKPAQR
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCEEEEEEEECCCCCHHH
SQRSPQGNQHDKFFEEFFGRFFDEMPQQRPRREQSLGTGFIIDAEGYVLTNNHVVSGADE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCCEEEECCEEECCHHH
VMVKLADGRELKGEIKGVDEKLDLALVKINDGKTFPFAELGDSDALQVGEWVMAIGNPFG
EEEEECCCCCCCCHHCCCCCEEEEEEEEECCCCCCCHHHCCCCCHHHHHHHHHHHCCCCC
LAHTVTAGIVSAKGRVIGSGPYDDFIQTDASINPGNSGGPLFNASGKVIGINTAIIAGGG
HHHHHHHHHHCCCCEEEECCCCHHHHCCCCCCCCCCCCCCEEECCCCEEEEEEEEEECCC
GGIGFAIPVNIAKATVSQLRQSGKVTRGYLGVRFQPLTPELAKSFGLESDKGALISSVEK
CCEEEEEECHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHCCCCCCCCHHHHHHHH
EGPAEKAGLKAGDVILEFDGKAINEGSELPRYVAVTPVGKKVKVLFARDGKRQSLNVVIA
CCCHHHCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCEEEEEEE
KLKDGEQAAVDGDGGAESDKIGITVQELTRELAGRIGIREAKGLVVTQVTPGSPAEEAGV
EECCCCEEEECCCCCCCCCEECEEHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHCCC
TTGAVIIEINGQRPDNLQKFNAVLSTIKKGDIVRLLLRRSDGSIQYVGMRAE
CCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]