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The map label for this gene is mprA [H]

Identifier: 118581362

GI number: 118581362

Start: 3228586

End: 3229257

Strand: Reverse

Name: mprA [H]

Synonym: Ppro_2957

Alternate gene names: 118581362

Gene position: 3229257-3228586 (Counterclockwise)

Preceding gene: 118581363

Following gene: 118581361

Centisome position: 80.57

GC content: 59.82

Gene sequence:

>672_bases
ATGAAAATTCTTGTTGTAGAAGATGAAAAAAAAGTTGCCGGCTTTATCAAGCGCGGTCTGGAGGAGGACGATTATTCGGT
CACCATCGTCCATGATGGCGCCGAGGGGCTCAAACAGGCCCAGTCCGGCGAGTACAGCCTGGCGATCCTGGATGTGATGG
TGCCCAAGAAGGATGGACTGACCGTGATCCGGGAACTGCGCGAGGGAGGCAGCCAGATGCCTGTCCTGATGCTGACCGCC
CGGGGAACGACCGATGACATCGTGTCCGGCCTGGAGGCGGGGGCCGATGACTACCTGACCAAGCCCTTCGCCTTTGCCGA
GCTTCTGGCCCGCGTCAGGGCGCTTCTACGCCGTAGCGAGCATGATCGCGGGGCGGAGATCTTCTTCGCCGACCTGCGCC
TCGATCCGGTCTCCCACAAGGTCTGGCGCAGCGGCAACGAGATCGACCTGACCGCCAAGGAGTACGGCCTGCTGGAATAC
CTGGTCCGCAACCCCAACAAGGTGCTCTCCCGCGCCATGATCGCCGAGCATGTCTGGGACTACGCCTTTGACAGCTTCAC
CAACATCATCGATGTGTACGTCAATTATCTGCGCAAGAAGGTGGACAAGGAATACTCCACGAAGCTGATCCACACCGTGC
GCGGCCAGGGGTATATCCTCAGGGAGGGGTAG

Upstream 100 bases:

>100_bases
TGACCAACAAGTCGGTGGAGGAGGCAGCCTCGGAGATCCTGCGTAAAATGGCTGTACGTGAAAAACGAATTACCGAAGCA
CGCGTAAAAGGAGACATATC

Downstream 100 bases:

>100_bases
ACAGGCCGCATGCGGCGGGGATTGATTTTTTCGGGCGCTATGCTATAGTGCCGACGAAACAGAGCAAGGGGCGGCGTCGT
CACATCAGTGAGACCCGCCC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MKILVVEDEKKVAGFIKRGLEEDDYSVTIVHDGAEGLKQAQSGEYSLAILDVMVPKKDGLTVIRELREGGSQMPVLMLTA
RGTTDDIVSGLEAGADDYLTKPFAFAELLARVRALLRRSEHDRGAEIFFADLRLDPVSHKVWRSGNEIDLTAKEYGLLEY
LVRNPNKVLSRAMIAEHVWDYAFDSFTNIIDVYVNYLRKKVDKEYSTKLIHTVRGQGYILREG

Sequences:

>Translated_223_residues
MKILVVEDEKKVAGFIKRGLEEDDYSVTIVHDGAEGLKQAQSGEYSLAILDVMVPKKDGLTVIRELREGGSQMPVLMLTA
RGTTDDIVSGLEAGADDYLTKPFAFAELLARVRALLRRSEHDRGAEIFFADLRLDPVSHKVWRSGNEIDLTAKEYGLLEY
LVRNPNKVLSRAMIAEHVWDYAFDSFTNIIDVYVNYLRKKVDKEYSTKLIHTVRGQGYILREG
>Mature_223_residues
MKILVVEDEKKVAGFIKRGLEEDDYSVTIVHDGAEGLKQAQSGEYSLAILDVMVPKKDGLTVIRELREGGSQMPVLMLTA
RGTTDDIVSGLEAGADDYLTKPFAFAELLARVRALLRRSEHDRGAEIFFADLRLDPVSHKVWRSGNEIDLTAKEYGLLEY
LVRNPNKVLSRAMIAEHVWDYAFDSFTNIIDVYVNYLRKKVDKEYSTKLIHTVRGQGYILREG

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=51.3274336283186, Blast_Score=217, Evalue=4e-58,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=45.4128440366972, Blast_Score=188, Evalue=3e-49,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=39.1891891891892, Blast_Score=154, Evalue=3e-39,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=37.7272727272727, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35.9090909090909, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=37.719298245614, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=33.920704845815, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=35.4545454545455, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1786911, Length=205, Percent_Identity=34.6341463414634, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=34.5454545454545, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=33.4821428571429, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=33.4801762114537, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=33.6283185840708, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=30.3030303030303, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=32.2314049586777, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790299, Length=110, Percent_Identity=30.9090909090909, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790437, Length=110, Percent_Identity=30.9090909090909, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25210; Mature: 25210

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDEKKVAGFIKRGLEEDDYSVTIVHDGAEGLKQAQSGEYSLAILDVMVPKKDGL
CEEEEECCCHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHCCCCEEEEEEEEECCCCCCH
TVIRELREGGSQMPVLMLTARGTTDDIVSGLEAGADDYLTKPFAFAELLARVRALLRRSE
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHCC
HDRGAEIFFADLRLDPVSHKVWRSGNEIDLTAKEYGLLEYLVRNPNKVLSRAMIAEHVWD
CCCCCEEEEEEEEECCHHHHHHCCCCEEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
YAFDSFTNIIDVYVNYLRKKVDKEYSTKLIHTVRGQGYILREG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
>Mature Secondary Structure
MKILVVEDEKKVAGFIKRGLEEDDYSVTIVHDGAEGLKQAQSGEYSLAILDVMVPKKDGL
CEEEEECCCHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHCCCCEEEEEEEEECCCCCCH
TVIRELREGGSQMPVLMLTARGTTDDIVSGLEAGADDYLTKPFAFAELLARVRALLRRSE
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHCC
HDRGAEIFFADLRLDPVSHKVWRSGNEIDLTAKEYGLLEYLVRNPNKVLSRAMIAEHVWD
CCCCCEEEEEEEEECCHHHHHHCCCCEEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
YAFDSFTNIIDVYVNYLRKKVDKEYSTKLIHTVRGQGYILREG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA