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The map label for this gene is phr [H]

Identifier: 118580428

GI number: 118580428

Start: 2160964

End: 2162316

Strand: Reverse

Name: phr [H]

Synonym: Ppro_2012

Alternate gene names: 118580428

Gene position: 2162316-2160964 (Counterclockwise)

Preceding gene: 118580429

Following gene: 118580427

Centisome position: 53.95

GC content: 63.41

Gene sequence:

>1353_bases
TTGACAGCCGTGGACATCCGGCGCATACACCCCCTGAACAGGCGGGAAGGGCAGGACGGCCCGGTGGTTTACTGGATGAG
CCGAGACCAGAGGGCAATGGACAACTGGGCCCTGCTCCATGCCCAGGAACTGGCCTTGGAACGGCGGGCGCCGCTGGTGG
TGCTCTTCACTCTGGCCCCTTCCTTCCTGGGAGCGACGCTCCGGCAGTATGGCTTCATGCTGAGGGGGTTGGCGGAGACT
GCTCAACTGCTGGCAAAGATGAACATTCCCTTCTACCTGCTGCGGGGGGAGCCGGTGGGACAGCTCTGTTCGTTCGTGGA
ACGGAATCGGGTCGGCACCGTTGTCACCGACTTCGATCCCCTGCGTGTCAAGCGGGTCTGGCGCGAAGGGGCGGCCCGCT
TGTGCGGGGTTCCCTTTTTCGAGGTGGATAGCCACAACATCGTCCCCTGCCGTTTCGTCTCCGATAAACAGGAGTATGGT
GCCCACACCCTGCGACCGAAGCTTCGGCGCCTGCTCGCCGACTTCCTGCATGAGTTTCCCCCCCTCATCCCCCATCCCCA
TGCCTGGCCCGTCCCGTTTCAACCCCTCGATCCCCAAGGCATTCTCTCCGATCTGTACATGGACAGGAGCGTGTCAGAGC
TGAGCAATCCCCTGCCGGGAACAAGGGCCGCCGGTGAACGGCTGCGGAGCTTCATCGCCCAGGGTCTTGAAGACTATGGT
CTCCGGCGTAACGATCCCTGTTGCGACGGCCAGTCGGAGCTCTCCCCCTGGCTGCACTTCGGCCAGCTCGCTCCCCAGCG
GGTGGCCCTGGAAACAGTGCGCACTCTCTCCGGCTCGCCATCCAGCGAGGCGTTTCTGGATGAACTGATCGTGAGAAGGG
AGCTGTCGGACAATTTCTGTCTCCATAACCAGGCCTATGACCGTCTGGAGGGATTTCCCGCCTGGGCGCTGAAGACCCTC
GGGGAACATCGCCACGACCGGCGCGAGTACCTTTATACGCAGGAACAGTTCCAGGACGCCGAGACCCATGATCCGCTCTG
GAATGCGGCCCAGCGTTCCCTGCTGCTGGGCGGGAAGATGCACGGCTACCTGCGCATGTACTGGGCCAAAAAGATCCTGG
AGTGGAGCGCCTCGCCGGAAGAGGCGCTGGCGGTCGCCATCCGGTTGAACGACCGCTACAGCCTGGATGGCCGCGACCCC
AACGGCTATGCCGGCATCGCCTGGAGCATGGGGGGGGTGCATGACCGCGCCTGGGGTGAACGGCCGGTCTTCGGCAAGAT
CCGGTACATGAACGACAGGGGGTGCAGACGCAAATTCGACGTCGACGCCTATATCCGGCGCTGGGGAGAGTAG

Upstream 100 bases:

>100_bases
GGCTCTCCTTCTTCCCCGGTCTGGCCATCCTGGTGACGGTACTGGCCTACAACCTGCTGGGGGAGGGGATCAGGGACGCC
TTCGATCCCCGGGTGAACCG

Downstream 100 bases:

>100_bases
CGCCGTTCCCGTCGAGCATGCCCGGTGGAATAATGCCTGGCCTGAAACGCCTTGGCCCGGGCGTTGCGGACAGGTAAACC
CCGAAAGGCTACACCTGCGG

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTAVDIRRIHPLNRREGQDGPVVYWMSRDQRAMDNWALLHAQELALERRAPLVVLFTLAPSFLGATLRQYGFMLRGLAET
AQLLAKMNIPFYLLRGEPVGQLCSFVERNRVGTVVTDFDPLRVKRVWREGAARLCGVPFFEVDSHNIVPCRFVSDKQEYG
AHTLRPKLRRLLADFLHEFPPLIPHPHAWPVPFQPLDPQGILSDLYMDRSVSELSNPLPGTRAAGERLRSFIAQGLEDYG
LRRNDPCCDGQSELSPWLHFGQLAPQRVALETVRTLSGSPSSEAFLDELIVRRELSDNFCLHNQAYDRLEGFPAWALKTL
GEHRHDRREYLYTQEQFQDAETHDPLWNAAQRSLLLGGKMHGYLRMYWAKKILEWSASPEEALAVAIRLNDRYSLDGRDP
NGYAGIAWSMGGVHDRAWGERPVFGKIRYMNDRGCRRKFDVDAYIRRWGE

Sequences:

>Translated_450_residues
MTAVDIRRIHPLNRREGQDGPVVYWMSRDQRAMDNWALLHAQELALERRAPLVVLFTLAPSFLGATLRQYGFMLRGLAET
AQLLAKMNIPFYLLRGEPVGQLCSFVERNRVGTVVTDFDPLRVKRVWREGAARLCGVPFFEVDSHNIVPCRFVSDKQEYG
AHTLRPKLRRLLADFLHEFPPLIPHPHAWPVPFQPLDPQGILSDLYMDRSVSELSNPLPGTRAAGERLRSFIAQGLEDYG
LRRNDPCCDGQSELSPWLHFGQLAPQRVALETVRTLSGSPSSEAFLDELIVRRELSDNFCLHNQAYDRLEGFPAWALKTL
GEHRHDRREYLYTQEQFQDAETHDPLWNAAQRSLLLGGKMHGYLRMYWAKKILEWSASPEEALAVAIRLNDRYSLDGRDP
NGYAGIAWSMGGVHDRAWGERPVFGKIRYMNDRGCRRKFDVDAYIRRWGE
>Mature_449_residues
TAVDIRRIHPLNRREGQDGPVVYWMSRDQRAMDNWALLHAQELALERRAPLVVLFTLAPSFLGATLRQYGFMLRGLAETA
QLLAKMNIPFYLLRGEPVGQLCSFVERNRVGTVVTDFDPLRVKRVWREGAARLCGVPFFEVDSHNIVPCRFVSDKQEYGA
HTLRPKLRRLLADFLHEFPPLIPHPHAWPVPFQPLDPQGILSDLYMDRSVSELSNPLPGTRAAGERLRSFIAQGLEDYGL
RRNDPCCDGQSELSPWLHFGQLAPQRVALETVRTLSGSPSSEAFLDELIVRRELSDNFCLHNQAYDRLEGFPAWALKTLG
EHRHDRREYLYTQEQFQDAETHDPLWNAAQRSLLLGGKMHGYLRMYWAKKILEWSASPEEALAVAIRLNDRYSLDGRDPN
GYAGIAWSMGGVHDRAWGERPVFGKIRYMNDRGCRRKFDVDAYIRRWGE

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=451, Percent_Identity=50.3325942350333, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24586398, Length=451, Percent_Identity=50.3325942350333, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24586404, Length=154, Percent_Identity=61.038961038961, Blast_Score=216, Evalue=3e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 51737; Mature: 51605

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: PS01084 DNA_PHOTOLYASES_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVDIRRIHPLNRREGQDGPVVYWMSRDQRAMDNWALLHAQELALERRAPLVVLFTLAP
CCCCCCHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHH
SFLGATLRQYGFMLRGLAETAQLLAKMNIPFYLLRGEPVGQLCSFVERNRVGTVVTDFDP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCH
LRVKRVWREGAARLCGVPFFEVDSHNIVPCRFVSDKQEYGAHTLRPKLRRLLADFLHEFP
HHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHCC
PLIPHPHAWPVPFQPLDPQGILSDLYMDRSVSELSNPLPGTRAAGERLRSFIAQGLEDYG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
LRRNDPCCDGQSELSPWLHFGQLAPQRVALETVRTLSGSPSSEAFLDELIVRRELSDNFC
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCE
LHNQAYDRLEGFPAWALKTLGEHRHDRREYLYTQEQFQDAETHDPLWNAAQRSLLLGGKM
ECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCH
HGYLRMYWAKKILEWSASPEEALAVAIRLNDRYSLDGRDPNGYAGIAWSMGGVHDRAWGE
HHHHHHHHHHHHHHCCCCCHHHEEEEEEECCEEECCCCCCCCCEEEEECCCCCCCCCCCC
RPVFGKIRYMNDRGCRRKFDVDAYIRRWGE
CCCEEEEEEECCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
TAVDIRRIHPLNRREGQDGPVVYWMSRDQRAMDNWALLHAQELALERRAPLVVLFTLAP
CCCCCHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHH
SFLGATLRQYGFMLRGLAETAQLLAKMNIPFYLLRGEPVGQLCSFVERNRVGTVVTDFDP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCH
LRVKRVWREGAARLCGVPFFEVDSHNIVPCRFVSDKQEYGAHTLRPKLRRLLADFLHEFP
HHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEECCHHHHCCHHHHHHHHHHHHHHHHHCC
PLIPHPHAWPVPFQPLDPQGILSDLYMDRSVSELSNPLPGTRAAGERLRSFIAQGLEDYG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
LRRNDPCCDGQSELSPWLHFGQLAPQRVALETVRTLSGSPSSEAFLDELIVRRELSDNFC
CCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCE
LHNQAYDRLEGFPAWALKTLGEHRHDRREYLYTQEQFQDAETHDPLWNAAQRSLLLGGKM
ECHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCH
HGYLRMYWAKKILEWSASPEEALAVAIRLNDRYSLDGRDPNGYAGIAWSMGGVHDRAWGE
HHHHHHHHHHHHHHCCCCCHHHEEEEEEECCEEECCCCCCCCCEEEEECCCCCCCCCCCC
RPVFGKIRYMNDRGCRRKFDVDAYIRRWGE
CCCEEEEEEECCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2668276 [H]