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The map label for this gene is guaB [H]

Identifier: 118580427

GI number: 118580427

Start: 2159245

End: 2160714

Strand: Reverse

Name: guaB [H]

Synonym: Ppro_2011

Alternate gene names: 118580427

Gene position: 2160714-2159245 (Counterclockwise)

Preceding gene: 118580428

Following gene: 118580426

Centisome position: 53.91

GC content: 63.95

Gene sequence:

>1470_bases
ATGTCCCTCGACAAACTGACCGAAGGTCTCACCTTTGACGATGTCCTCCTTATTCCAGCCCACTCTCTGGTTCTCCCCCG
CGATGCCAATCTCTCCACGCGGCTCTCCCGTAACATCCAGCTGAACATCCCCCTGGTCAGCGCGGCCATGGACACGGTCA
CCGAGTCGCGCACCGCCATCTGCATGGCGAGGGAAGGAGGGCTGGGCATCATCCACAAGAACAGCACCATCGCCCAGCAG
GCCTTCGAGGTTGACAAGGTCAAGAAGAGTGAATCGGGCATGATCGTGGACCCGATCACCATGCGCCCCAACCAGAAGAT
CAGCGAGGCGCTGGAGATAATGTCGCGCTACCGCATCTCCGGCGTTCCGATCACCAAGCCCAACGGCAAGCTGGTGGGCA
TCCTGACCAACCGGGACCTGCGCTTCGAGACCGATTACGATCTGCCGATCTCTGCCCGCATGACCAAGCGCAACCTGGTG
ACGGTAGCGGTGGGGACGACCCTGGAGCAGGCCAAGGAGCACCTCAAGCACACCCGGGTGGAGAAGCTGTTGGTGGTGGA
CAACGATCGTTTCCTCAAGGGGCTGATCACCATCAAGGATATCGAGAAAGTCAAGAAGTACCCCAATTCCTGCAAGGACA
GCCTGGGGCGCCTGCGTGTGGGCGCCGCGGTGGGCCCCACCGATGACATGGAAGCGCGCATGGATGCGCTGCTCAAGGCC
GGGGCCGACGTGATCGTCATCGACACGGCCCACGGCCATTCCCAGGGGGTGATCGAGGCCATCATGCGTGCCAAGTCCAC
CTTCCCCGGCGTGGAGATCATCGCCGGCAACATCGCCACCGCCGAGGCGGCCGAGGCGCTGATCAAGGCCGGCGCCGACG
GCATCAAGGTCGGCATCGGGCCCGGCTCCATCTGTACGACCCGCATGGTGGCCGGCGTGGGCGTGCCGCAGATCACCGCC
ATCATGGACTGCTCCCGCGTTGCCCACAAGCATGGGGTACCGGTCATCGCCGACGGCGGCATCAAGTACTCCGGCGACCT
GCCCAAGGCGATCACCGCCGGCGCCGACTGCGTCATGATCGGATCGCTCTTTGCCGGCACCGAGGAATCGCCGGGCGATA
CGGTGCTTTACCAGGGGCGCACCTACAAGAGCTACCGCGGCATGGGCTCCATCGGCGCCATGCAGGACGGCAGCAAGGAT
CGCTACTTCCAGTCCGACGTGGGGGACGATGTCAAGCTGGTTCCCGAGGGGATCGAGGGGATGGTGCCGCAGCGCGGACC
GCTCTCGGCCAACATCCACCAGCTCTTGGGGGGGCTCCGCTCCGGCATGGGCTACACCGGTTGCGCCAGCATCGACGAGC
TGCAACGGAAGGCGCGCTTCATACGCATCACCGGCGCCGGCCTCAAGGAATCCCACGTGCATGACGTCACCATCACCAAG
GAAGCGCCCAACTACAGGGTGGGAAACTGA

Upstream 100 bases:

>100_bases
TTATTTTTTGGGGTGGGCGCTGCTGCGACAACTTTTACCTTGACTTGCCCGGTTCGCCGTACTAACTTCTGTAAAATTTT
CTTGCGCCAGGAGCTGATCC

Downstream 100 bases:

>100_bases
CCCATGAAAACTGACATCCACAGCCAGAAGATCCTGATCCTCGATTTCGGCTCCCAGTACACCCAGCTGATCGCCCGGCG
GGTGCGCGAGGCCCACGTGT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MSLDKLTEGLTFDDVLLIPAHSLVLPRDANLSTRLSRNIQLNIPLVSAAMDTVTESRTAICMAREGGLGIIHKNSTIAQQ
AFEVDKVKKSESGMIVDPITMRPNQKISEALEIMSRYRISGVPITKPNGKLVGILTNRDLRFETDYDLPISARMTKRNLV
TVAVGTTLEQAKEHLKHTRVEKLLVVDNDRFLKGLITIKDIEKVKKYPNSCKDSLGRLRVGAAVGPTDDMEARMDALLKA
GADVIVIDTAHGHSQGVIEAIMRAKSTFPGVEIIAGNIATAEAAEALIKAGADGIKVGIGPGSICTTRMVAGVGVPQITA
IMDCSRVAHKHGVPVIADGGIKYSGDLPKAITAGADCVMIGSLFAGTEESPGDTVLYQGRTYKSYRGMGSIGAMQDGSKD
RYFQSDVGDDVKLVPEGIEGMVPQRGPLSANIHQLLGGLRSGMGYTGCASIDELQRKARFIRITGAGLKESHVHDVTITK
EAPNYRVGN

Sequences:

>Translated_489_residues
MSLDKLTEGLTFDDVLLIPAHSLVLPRDANLSTRLSRNIQLNIPLVSAAMDTVTESRTAICMAREGGLGIIHKNSTIAQQ
AFEVDKVKKSESGMIVDPITMRPNQKISEALEIMSRYRISGVPITKPNGKLVGILTNRDLRFETDYDLPISARMTKRNLV
TVAVGTTLEQAKEHLKHTRVEKLLVVDNDRFLKGLITIKDIEKVKKYPNSCKDSLGRLRVGAAVGPTDDMEARMDALLKA
GADVIVIDTAHGHSQGVIEAIMRAKSTFPGVEIIAGNIATAEAAEALIKAGADGIKVGIGPGSICTTRMVAGVGVPQITA
IMDCSRVAHKHGVPVIADGGIKYSGDLPKAITAGADCVMIGSLFAGTEESPGDTVLYQGRTYKSYRGMGSIGAMQDGSKD
RYFQSDVGDDVKLVPEGIEGMVPQRGPLSANIHQLLGGLRSGMGYTGCASIDELQRKARFIRITGAGLKESHVHDVTITK
EAPNYRVGN
>Mature_488_residues
SLDKLTEGLTFDDVLLIPAHSLVLPRDANLSTRLSRNIQLNIPLVSAAMDTVTESRTAICMAREGGLGIIHKNSTIAQQA
FEVDKVKKSESGMIVDPITMRPNQKISEALEIMSRYRISGVPITKPNGKLVGILTNRDLRFETDYDLPISARMTKRNLVT
VAVGTTLEQAKEHLKHTRVEKLLVVDNDRFLKGLITIKDIEKVKKYPNSCKDSLGRLRVGAAVGPTDDMEARMDALLKAG
ADVIVIDTAHGHSQGVIEAIMRAKSTFPGVEIIAGNIATAEAAEALIKAGADGIKVGIGPGSICTTRMVAGVGVPQITAI
MDCSRVAHKHGVPVIADGGIKYSGDLPKAITAGADCVMIGSLFAGTEESPGDTVLYQGRTYKSYRGMGSIGAMQDGSKDR
YFQSDVGDDVKLVPEGIEGMVPQRGPLSANIHQLLGGLRSGMGYTGCASIDELQRKARFIRITGAGLKESHVHDVTITKE
APNYRVGN

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=41.2280701754386, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI34328928, Length=456, Percent_Identity=41.2280701754386, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=41.2280701754386, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=41.2280701754386, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=38.7966804979253, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=41.1111111111111, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=40.3508771929825, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=38.1578947368421, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI50541956, Length=266, Percent_Identity=38.7218045112782, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541954, Length=266, Percent_Identity=38.7218045112782, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541952, Length=266, Percent_Identity=38.7218045112782, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541948, Length=266, Percent_Identity=38.7218045112782, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI156104880, Length=268, Percent_Identity=38.8059701492537, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=59.0062111801242, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1786293, Length=257, Percent_Identity=37.7431906614786, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71994385, Length=498, Percent_Identity=35.3413654618474, Blast_Score=267, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=37.2641509433962, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17560440, Length=307, Percent_Identity=34.8534201954397, Blast_Score=184, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322012, Length=487, Percent_Identity=40.6570841889117, Blast_Score=337, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=40.1656314699793, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=483, Percent_Identity=40.9937888198758, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=42.6900584795322, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319353, Length=141, Percent_Identity=35.4609929078014, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=39.375, Blast_Score=321, Evalue=8e-88,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=39.375, Blast_Score=321, Evalue=8e-88,
Organism=Drosophila melanogaster, GI28571163, Length=438, Percent_Identity=39.7260273972603, Blast_Score=289, Evalue=4e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52365; Mature: 52234

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDKLTEGLTFDDVLLIPAHSLVLPRDANLSTRLSRNIQLNIPLVSAAMDTVTESRTAI
CCHHHHHCCCCCCCEEEECCCEEEECCCCCCHHHCCCCEEEECCHHHHHHHHHHCCCEEE
CMAREGGLGIIHKNSTIAQQAFEVDKVKKSESGMIVDPITMRPNQKISEALEIMSRYRIS
EEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEECEECCCCHHHHHHHHHHHHHHCC
GVPITKPNGKLVGILTNRDLRFETDYDLPISARMTKRNLVTVAVGTTLEQAKEHLKHTRV
CCEEECCCCCEEEEEECCCEEEECCCCCCCCCEECCCCEEEEEECCCHHHHHHHHHHHHH
EKLLVVDNDRFLKGLITIKDIEKVKKYPNSCKDSLGRLRVGAAVGPTDDMEARMDALLKA
HEEEEECCCCHHHHHEEHHHHHHHHHCCCHHHHHHHHEEECCCCCCCCCHHHHHHHHHHC
GADVIVIDTAHGHSQGVIEAIMRAKSTFPGVEIIAGNIATAEAAEALIKAGADGIKVGIG
CCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECC
PGSICTTRMVAGVGVPQITAIMDCSRVAHKHGVPVIADGGIKYSGDLPKAITAGADCVMI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCHHHHCCCCEEEE
GSLFAGTEESPGDTVLYQGRTYKSYRGMGSIGAMQDGSKDRYFQSDVGDDVKLVPEGIEG
EHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
MVPQRGPLSANIHQLLGGLRSGMGYTGCASIDELQRKARFIRITGAGLKESHVHDVTITK
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCEEEEEEEC
EAPNYRVGN
CCCCCCCCC
>Mature Secondary Structure 
SLDKLTEGLTFDDVLLIPAHSLVLPRDANLSTRLSRNIQLNIPLVSAAMDTVTESRTAI
CHHHHHCCCCCCCEEEECCCEEEECCCCCCHHHCCCCEEEECCHHHHHHHHHHCCCEEE
CMAREGGLGIIHKNSTIAQQAFEVDKVKKSESGMIVDPITMRPNQKISEALEIMSRYRIS
EEEECCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEECEECCCCHHHHHHHHHHHHHHCC
GVPITKPNGKLVGILTNRDLRFETDYDLPISARMTKRNLVTVAVGTTLEQAKEHLKHTRV
CCEEECCCCCEEEEEECCCEEEECCCCCCCCCEECCCCEEEEEECCCHHHHHHHHHHHHH
EKLLVVDNDRFLKGLITIKDIEKVKKYPNSCKDSLGRLRVGAAVGPTDDMEARMDALLKA
HEEEEECCCCHHHHHEEHHHHHHHHHCCCHHHHHHHHEEECCCCCCCCCHHHHHHHHHHC
GADVIVIDTAHGHSQGVIEAIMRAKSTFPGVEIIAGNIATAEAAEALIKAGADGIKVGIG
CCCEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEECC
PGSICTTRMVAGVGVPQITAIMDCSRVAHKHGVPVIADGGIKYSGDLPKAITAGADCVMI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCCCHHHHCCCCEEEE
GSLFAGTEESPGDTVLYQGRTYKSYRGMGSIGAMQDGSKDRYFQSDVGDDVKLVPEGIEG
EHHHCCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCC
MVPQRGPLSANIHQLLGGLRSGMGYTGCASIDELQRKARFIRITGAGLKESHVHDVTITK
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCEEEEEEEC
EAPNYRVGN
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]