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The map label for this gene is mscS [H]

Identifier: 118580039

GI number: 118580039

Start: 1732134

End: 1732955

Strand: Reverse

Name: mscS [H]

Synonym: Ppro_1616

Alternate gene names: 118580039

Gene position: 1732955-1732134 (Counterclockwise)

Preceding gene: 118580041

Following gene: 118580021

Centisome position: 43.24

GC content: 58.03

Gene sequence:

>822_bases
ATGGAAAACGTGAACAGGTACCAGGAACTTGCCGTAACCTACATCACGGCAATCGGCACCAAGATCATCGCCGCGCTTAT
CTTCTGGATCGTCGGCCGCTGGCTGATCGGACTGGTGGGACGCATGATGCAGCAGGCGTTTGAGAGACAGAAGCTGGATC
CCAGCCTGATCCGTTACATCGGCAATTTCGTGGCCGTAACCCTGAACATCATCCTGGTTGTGGCCATCTTGGGATACTTC
GGGGTCCAGACAACCACCTTCGCCGCCCTGGTGGCCGGCGTCGGCATCGCCGTCGGCGCGGCCTGGAGCGGCCTGCTTGC
CAACCTGGCCGCAGGCATATTCCTGATCGTGCTGCGACCGTTCAAGGTGACCGATTTTGTAACCATCGGAGGCATTACCG
GCACCATACAGGAGATCGGGCTCTTTACCACCAGCCTCAACACTCCGGACAACATTCTGACGATTATCGGCAATGGCAAG
ATCTTCGGCGATACGATCCAGAATTATACCCACAATCCCTTCCGCAGGGTGGAGCTGAAATGCCAGCTGGCGGGGAGCGC
CGACCATCTGGCAGCCATGCAGCTCCTGCGTCAGAAGCTGGCGACAATCCCCAATGTCCTCAAGGAACCGGCTGTCGATG
TGGAAATCCTGGAGTTCAATCTGGTGGGGCCGATGCTTGCCGTGCGTCCCTACTGCCACAACGACAACTACTGGCAGGTA
TACTTCGACGGTAATCGCACCATCCGCGAATCACTGACAGAGGCTGGTTTCCCGGCGCCCATGCCGGCCCAGGTAGTGCT
GATGCAGAACCCTCAGGCATAA

Upstream 100 bases:

>100_bases
GCTTGATACGTATTTCATGAAACAGAGGCACGTTTCACAATTGTCCGACAGCGCCTGGACTGGAAATCGGCGCATATGAG
AATCCAAAGGAGGTTAGAGG

Downstream 100 bases:

>100_bases
CACGAGCTTTTAACGGATAACATAGTATTATCAGGCGGCAATCTCCACAGAATACCACAAGGCCTGTATCCGCCGACCAT
GGCGTCGGGATACAGGCCTT

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MENVNRYQELAVTYITAIGTKIIAALIFWIVGRWLIGLVGRMMQQAFERQKLDPSLIRYIGNFVAVTLNIILVVAILGYF
GVQTTTFAALVAGVGIAVGAAWSGLLANLAAGIFLIVLRPFKVTDFVTIGGITGTIQEIGLFTTSLNTPDNILTIIGNGK
IFGDTIQNYTHNPFRRVELKCQLAGSADHLAAMQLLRQKLATIPNVLKEPAVDVEILEFNLVGPMLAVRPYCHNDNYWQV
YFDGNRTIRESLTEAGFPAPMPAQVVLMQNPQA

Sequences:

>Translated_273_residues
MENVNRYQELAVTYITAIGTKIIAALIFWIVGRWLIGLVGRMMQQAFERQKLDPSLIRYIGNFVAVTLNIILVVAILGYF
GVQTTTFAALVAGVGIAVGAAWSGLLANLAAGIFLIVLRPFKVTDFVTIGGITGTIQEIGLFTTSLNTPDNILTIIGNGK
IFGDTIQNYTHNPFRRVELKCQLAGSADHLAAMQLLRQKLATIPNVLKEPAVDVEILEFNLVGPMLAVRPYCHNDNYWQV
YFDGNRTIRESLTEAGFPAPMPAQVVLMQNPQA
>Mature_273_residues
MENVNRYQELAVTYITAIGTKIIAALIFWIVGRWLIGLVGRMMQQAFERQKLDPSLIRYIGNFVAVTLNIILVVAILGYF
GVQTTTFAALVAGVGIAVGAAWSGLLANLAAGIFLIVLRPFKVTDFVTIGGITGTIQEIGLFTTSLNTPDNILTIIGNGK
IFGDTIQNYTHNPFRRVELKCQLAGSADHLAAMQLLRQKLATIPNVLKEPAVDVEILEFNLVGPMLAVRPYCHNDNYWQV
YFDGNRTIRESLTEAGFPAPMPAQVVLMQNPQA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=259, Percent_Identity=30.5019305019305, Blast_Score=128, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 29952; Mature: 29952

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENVNRYQELAVTYITAIGTKIIAALIFWIVGRWLIGLVGRMMQQAFERQKLDPSLIRYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GNFVAVTLNIILVVAILGYFGVQTTTFAALVAGVGIAVGAAWSGLLANLAAGIFLIVLRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FKVTDFVTIGGITGTIQEIGLFTTSLNTPDNILTIIGNGKIFGDTIQNYTHNPFRRVELK
CCCEEEEEECCCHHHHHHHHHHEECCCCCCCEEEEEECCEEEHHHHHCCCCCCCEEEEEE
CQLAGSADHLAAMQLLRQKLATIPNVLKEPAVDVEILEFNLVGPMLAVRPYCHNDNYWQV
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCEECCCCEEEE
YFDGNRTIRESLTEAGFPAPMPAQVVLMQNPQA
EECCCHHHHHHHHHCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MENVNRYQELAVTYITAIGTKIIAALIFWIVGRWLIGLVGRMMQQAFERQKLDPSLIRYI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
GNFVAVTLNIILVVAILGYFGVQTTTFAALVAGVGIAVGAAWSGLLANLAAGIFLIVLRP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FKVTDFVTIGGITGTIQEIGLFTTSLNTPDNILTIIGNGKIFGDTIQNYTHNPFRRVELK
CCCEEEEEECCCHHHHHHHHHHEECCCCCCCEEEEEECCEEEHHHHHCCCCCCCEEEEEE
CQLAGSADHLAAMQLLRQKLATIPNVLKEPAVDVEILEFNLVGPMLAVRPYCHNDNYWQV
EEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHCCEECCCCEEEE
YFDGNRTIRESLTEAGFPAPMPAQVVLMQNPQA
EECCCHHHHHHHHHCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]