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The map label for this gene is pyrG

Identifier: 118580037

GI number: 118580037

Start: 1729465

End: 1731072

Strand: Direct

Name: pyrG

Synonym: Ppro_1614

Alternate gene names: 118580037

Gene position: 1729465-1731072 (Clockwise)

Preceding gene: 118580036

Following gene: 118580038

Centisome position: 43.15

GC content: 58.89

Gene sequence:

>1608_bases
ATGAAAACAAAATTCATCTTTATTACCGGCGGTGTCGTTTCCTCCATCGGTAAGGGACTGGCTGCCGCGTCGCTGGGCGC
ATTACTGGAGGCGCGTGGTCTGCGGGTTACGTTGCAGAAGCTGGACCCCTACATCAACGTTGACCCGGGAACCATGTCGC
CGTTTCAGCATGGGGAGGTCTTCGTCACCGACGATGGCGCCGAAACAGACCTGGACCTGGGGCATTACGAGCGTTTCACC
AATGCTCGCCTCTCCAAGAAGAGTAACTTCACCACCGGCCAGGTGTATTTTTCTGTCATCGACAAGGAGCGCCGCGGGGA
TTATCTGGGCGGCACGGTGCAGGTAATCCCGCACATCACCGACGAGATGAAGTGCAAGATCATCGAGAATGCCAAAGGCG
CCGATGTGGCCATCGTCGAAGTGGGCGGAACCGTGGGTGACATCGAGTCGCTCCCCTTCCTGGAAGCCATCCGCCAGTTC
CGCTTCGACCGGGGGGCTGGCAATACCCTCTACGTCCACGTCACCCTGGTGCCCTACATCCGCACGGCTGGCGAGCTTAA
GACCAAGCCGACCCAGCATTCGGTCATGGAACTGCGCAAGATCGGTATCCAGCCGGATATTCTGCTCTGCCGCTCCGAGC
GGGAGATCCCCCAGGAAATGAAGAACAAGATCGCACTGTTCTGCAACGTGGATGTGAAGGACGTCATCCCGGTGGTTGAC
AGCGAACATATCTACTACGTACCGCTGGCGCTGAGCAAGGAGCGACTGGACGAACGGGTGGTGGAAAAGCTTAACATCTG
GACAAAGGCGCCCGACCTGACCCCCTGGCAAGACGTGGTGGAAACGGTCTGCCACCCCGGTCATGGCGAAGTGCGCATCG
CCATCGTGGGCAAATACGTCAACCTGACCGAGTCGTACAAGTCGCTGTCCGAGGCGCTGACCCATGGTGGCATCGCTAAT
GACTGCCGCGTTTCCCTCAAGTACATCGATTCGGAGAAAATCGAGCGGGACGGCATCGATGGCCACCTGGTGGATATGGA
TGCCGTGCTGGTGCCGGGAGGATTCGGCGAGCGTGGCACAGAAGGCAAAGTCATGGCCATCGAATACGCCCGGTTGCACA
AGATTCCCTTCTTCGGCATCTGCCTCGGCATGCAGATGGCGGTGGTGGAATACGCCCGCAACGTCTGCCATATCGACGAC
GCCTGCTCCAGCGAGTTCAAGAAGGGGTGCGGCAATCCGGTGATCCATCTGATGGAGGAGCAGAAGAGTGTCAGCAAGAA
GGGGGGCACCATGCGTCTGGGGGGATACCCCTGCTCCCTGGAGAAGGGCACCCTGGCCCATGTGGCCTACAATGCCCAGG
AGATATCCGAGCGCCACCGCCATCGCTATGAATTCAACAACGCCTATCGGGAGGTTTTGACCAAAAACGGGCTGATCCTC
TCCGGCATCTACCGTGACAAGGATCTGGTGGAGGTGGTGGAGATCGCCGACCATCCCTGGTTCCTGGGATGCCAGTTCCA
CCCCGAATTCAAATCGAAGCCCTTGGCGCCCCATCCCCTGTTCAAGTCGTTTGTGCGCGCTGCCCTGATCCAGCGCGATG
CGAGGTAA

Upstream 100 bases:

>100_bases
TTGAATCCATTGGTGTGGACACCCCCGATGACCTGGTCAAGGCCAGGGAGCGGTTCAGAGCCATTCAGTCCAAGTAATTT
TCGCTACAGGAGCTGTATGC

Downstream 100 bases:

>100_bases
CCCGTGACCCGCGAGATCGTTATCGGCGGCGTGAAAATCGGTGCCAAACGCCCGTTGGCACTGGTGGCTGGCCCCTGCGT
GATCGAATCAGAGTTGGCCA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MKTKFIFITGGVVSSIGKGLAAASLGALLEARGLRVTLQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFT
NARLSKKSNFTTGQVYFSVIDKERRGDYLGGTVQVIPHITDEMKCKIIENAKGADVAIVEVGGTVGDIESLPFLEAIRQF
RFDRGAGNTLYVHVTLVPYIRTAGELKTKPTQHSVMELRKIGIQPDILLCRSEREIPQEMKNKIALFCNVDVKDVIPVVD
SEHIYYVPLALSKERLDERVVEKLNIWTKAPDLTPWQDVVETVCHPGHGEVRIAIVGKYVNLTESYKSLSEALTHGGIAN
DCRVSLKYIDSEKIERDGIDGHLVDMDAVLVPGGFGERGTEGKVMAIEYARLHKIPFFGICLGMQMAVVEYARNVCHIDD
ACSSEFKKGCGNPVIHLMEEQKSVSKKGGTMRLGGYPCSLEKGTLAHVAYNAQEISERHRHRYEFNNAYREVLTKNGLIL
SGIYRDKDLVEVVEIADHPWFLGCQFHPEFKSKPLAPHPLFKSFVRAALIQRDAR

Sequences:

>Translated_535_residues
MKTKFIFITGGVVSSIGKGLAAASLGALLEARGLRVTLQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFT
NARLSKKSNFTTGQVYFSVIDKERRGDYLGGTVQVIPHITDEMKCKIIENAKGADVAIVEVGGTVGDIESLPFLEAIRQF
RFDRGAGNTLYVHVTLVPYIRTAGELKTKPTQHSVMELRKIGIQPDILLCRSEREIPQEMKNKIALFCNVDVKDVIPVVD
SEHIYYVPLALSKERLDERVVEKLNIWTKAPDLTPWQDVVETVCHPGHGEVRIAIVGKYVNLTESYKSLSEALTHGGIAN
DCRVSLKYIDSEKIERDGIDGHLVDMDAVLVPGGFGERGTEGKVMAIEYARLHKIPFFGICLGMQMAVVEYARNVCHIDD
ACSSEFKKGCGNPVIHLMEEQKSVSKKGGTMRLGGYPCSLEKGTLAHVAYNAQEISERHRHRYEFNNAYREVLTKNGLIL
SGIYRDKDLVEVVEIADHPWFLGCQFHPEFKSKPLAPHPLFKSFVRAALIQRDAR
>Mature_535_residues
MKTKFIFITGGVVSSIGKGLAAASLGALLEARGLRVTLQKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFT
NARLSKKSNFTTGQVYFSVIDKERRGDYLGGTVQVIPHITDEMKCKIIENAKGADVAIVEVGGTVGDIESLPFLEAIRQF
RFDRGAGNTLYVHVTLVPYIRTAGELKTKPTQHSVMELRKIGIQPDILLCRSEREIPQEMKNKIALFCNVDVKDVIPVVD
SEHIYYVPLALSKERLDERVVEKLNIWTKAPDLTPWQDVVETVCHPGHGEVRIAIVGKYVNLTESYKSLSEALTHGGIAN
DCRVSLKYIDSEKIERDGIDGHLVDMDAVLVPGGFGERGTEGKVMAIEYARLHKIPFFGICLGMQMAVVEYARNVCHIDD
ACSSEFKKGCGNPVIHLMEEQKSVSKKGGTMRLGGYPCSLEKGTLAHVAYNAQEISERHRHRYEFNNAYREVLTKNGLIL
SGIYRDKDLVEVVEIADHPWFLGCQFHPEFKSKPLAPHPLFKSFVRAALIQRDAR

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=555, Percent_Identity=44.1441441441441, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI28559085, Length=554, Percent_Identity=43.6823104693141, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI28559083, Length=554, Percent_Identity=43.6823104693141, Blast_Score=456, Evalue=1e-128,
Organism=Homo sapiens, GI221316689, Length=554, Percent_Identity=43.6823104693141, Blast_Score=456, Evalue=1e-128,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=54.275092936803, Blast_Score=577, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI25148299, Length=609, Percent_Identity=36.9458128078818, Blast_Score=400, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322563, Length=562, Percent_Identity=40.0355871886121, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319432, Length=568, Percent_Identity=40.3169014084507, Blast_Score=409, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24664469, Length=564, Percent_Identity=43.2624113475177, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI21357815, Length=509, Percent_Identity=41.6502946954813, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_PELPD (A1APF9)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901287.1
- ProteinModelPortal:   A1APF9
- SMR:   A1APF9
- STRING:   A1APF9
- GeneID:   4571924
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1614
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- PhylomeDB:   A1APF9
- ProtClustDB:   PRK05380
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59645; Mature: 59645

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 381-381 ACT_SITE 507-507 ACT_SITE 509-509

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKFIFITGGVVSSIGKGLAAASLGALLEARGLRVTLQKLDPYINVDPGTMSPFQHGEV
CCEEEEEEECHHHHHHHCHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFTNARLSKKSNFTTGQVYFSVIDKERRGDYLGGTVQVIPHIT
EEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECHHHCCCCCCCEEEEECCCC
DEMKCKIIENAKGADVAIVEVGGTVGDIESLPFLEAIRQFRFDRGAGNTLYVHVTLVPYI
CCCEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEEHH
RTAGELKTKPTQHSVMELRKIGIQPDILLCRSEREIPQEMKNKIALFCNVDVKDVIPVVD
HCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHCCEEEEECCCHHHHHHCCC
SEHIYYVPLALSKERLDERVVEKLNIWTKAPDLTPWQDVVETVCHPGHGEVRIAIVGKYV
CCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEH
NLTESYKSLSEALTHGGIANDCRVSLKYIDSEKIERDGIDGHLVDMDAVLVPGGFGERGT
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCCCCEEEEECEEEECCCCCCCCC
EGKVMAIEYARLHKIPFFGICLGMQMAVVEYARNVCHIDDACSSEFKKGCGNPVIHLMEE
CCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHH
QKSVSKKGGTMRLGGYPCSLEKGTLAHVAYNAQEISERHRHRYEFNNAYREVLTKNGLIL
HHHHHHCCCEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
SGIYRDKDLVEVVEIADHPWFLGCQFHPEFKSKPLAPHPLFKSFVRAALIQRDAR
EEECCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTKFIFITGGVVSSIGKGLAAASLGALLEARGLRVTLQKLDPYINVDPGTMSPFQHGEV
CCEEEEEEECHHHHHHHCHHHHHHHHHHHHHCCCEEEEECCCCEEECCCCCCCCCCCCEE
FVTDDGAETDLDLGHYERFTNARLSKKSNFTTGQVYFSVIDKERRGDYLGGTVQVIPHIT
EEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECHHHCCCCCCCEEEEECCCC
DEMKCKIIENAKGADVAIVEVGGTVGDIESLPFLEAIRQFRFDRGAGNTLYVHVTLVPYI
CCCEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEEEHH
RTAGELKTKPTQHSVMELRKIGIQPDILLCRSEREIPQEMKNKIALFCNVDVKDVIPVVD
HCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCHHHHHHCCEEEEECCCHHHHHHCCC
SEHIYYVPLALSKERLDERVVEKLNIWTKAPDLTPWQDVVETVCHPGHGEVRIAIVGKYV
CCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEH
NLTESYKSLSEALTHGGIANDCRVSLKYIDSEKIERDGIDGHLVDMDAVLVPGGFGERGT
HHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCCCCEEEEECEEEECCCCCCCCC
EGKVMAIEYARLHKIPFFGICLGMQMAVVEYARNVCHIDDACSSEFKKGCGNPVIHLMEE
CCCEEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHH
QKSVSKKGGTMRLGGYPCSLEKGTLAHVAYNAQEISERHRHRYEFNNAYREVLTKNGLIL
HHHHHHCCCEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
SGIYRDKDLVEVVEIADHPWFLGCQFHPEFKSKPLAPHPLFKSFVRAALIQRDAR
EEECCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA