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The map label for this gene is kdsA

Identifier: 118580038

GI number: 118580038

Start: 1731076

End: 1731894

Strand: Direct

Name: kdsA

Synonym: Ppro_1615

Alternate gene names: 118580038

Gene position: 1731076-1731894 (Clockwise)

Preceding gene: 118580037

Following gene: 118580040

Centisome position: 43.19

GC content: 61.66

Gene sequence:

>819_bases
GTGACCCGCGAGATCGTTATCGGCGGCGTGAAAATCGGTGCCAAACGCCCGTTGGCACTGGTGGCTGGCCCCTGCGTGAT
CGAATCAGAGTTGGCCACCATGCGTCAGGCCGAACGCCTGATGACCATCTGCAACGCGCTTTCCCTGCCGCTGATCTTCA
AGGCCTCCTACGACAAGGCCAACCGCACCTCCATCGGCGCCTACCGCGGTCCGGGCATGCGAGAGGGGCTGCGCATCCTG
CGGAAAGTCAAGGAATCCCTCGGCCTGGCAGTGCTCTCCGACGTGCATTCCATAGAGCAGGTGGCGCCCGCCGCCGAAGT
GCTGGACGTTTTGCAGATTCCGGCCTTCCTCTGTCGCCAGACCGATCTGTTGATTGCTGCAGCCGCCACCGGCCGGGTGA
TCAATGTCAAGAAAGGGCAATTTCTAGCTCCTTGGGACATGAAGAACGTGGCTGCCAAAATTGCCTCCAGCGGTAACGAG
AACATCATCCTCACTGAACGGGGTGCCTCCTTCGGCTACAACAACCTGGTGGTGGATATGCGCAGCTTCCCTGTCATGCG
CGCCAGCGGCTACCCGGTGATCTTCGATGCCACCCACAGCGTGCAACTGCCTGGCGGACAAGGTGAAAGCTCCGGTGGGC
AGCGGGAATTCGTGGAATTCCTCTCCCGCGCGGCGGTTGCCGCCGGCGTGGACGGCATATTCATGGAGGTTCACGAGGAG
CCGGAAAAGGCGCTCTGCGACGGCCCCAACTCCATCGCGCTGAACGACCTGCCGGCGCTGCTCGCTACGCTTAAGGCCAT
TGATGCCGTCGTGAAATAG

Upstream 100 bases:

>100_bases
CCAGTTCCACCCCGAATTCAAATCGAAGCCCTTGGCGCCCCATCCCCTGTTCAAGTCGTTTGTGCGCGCTGCCCTGATCC
AGCGCGATGCGAGGTAACCC

Downstream 100 bases:

>100_bases
ATCCGTTTTTTTTGATCTCTTCTCATTGAACAGGATATCGCCCACAGTGGTATCCTGTTTCTGCTGAATCATAATCCTCT
CAGGCTCCACTTTCATCGAA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTREIVIGGVKIGAKRPLALVAGPCVIESELATMRQAERLMTICNALSLPLIFKASYDKANRTSIGAYRGPGMREGLRIL
RKVKESLGLAVLSDVHSIEQVAPAAEVLDVLQIPAFLCRQTDLLIAAAATGRVINVKKGQFLAPWDMKNVAAKIASSGNE
NIILTERGASFGYNNLVVDMRSFPVMRASGYPVIFDATHSVQLPGGQGESSGGQREFVEFLSRAAVAAGVDGIFMEVHEE
PEKALCDGPNSIALNDLPALLATLKAIDAVVK

Sequences:

>Translated_272_residues
MTREIVIGGVKIGAKRPLALVAGPCVIESELATMRQAERLMTICNALSLPLIFKASYDKANRTSIGAYRGPGMREGLRIL
RKVKESLGLAVLSDVHSIEQVAPAAEVLDVLQIPAFLCRQTDLLIAAAATGRVINVKKGQFLAPWDMKNVAAKIASSGNE
NIILTERGASFGYNNLVVDMRSFPVMRASGYPVIFDATHSVQLPGGQGESSGGQREFVEFLSRAAVAAGVDGIFMEVHEE
PEKALCDGPNSIALNDLPALLATLKAIDAVVK
>Mature_271_residues
TREIVIGGVKIGAKRPLALVAGPCVIESELATMRQAERLMTICNALSLPLIFKASYDKANRTSIGAYRGPGMREGLRILR
KVKESLGLAVLSDVHSIEQVAPAAEVLDVLQIPAFLCRQTDLLIAAAATGRVINVKKGQFLAPWDMKNVAAKIASSGNEN
IILTERGASFGYNNLVVDMRSFPVMRASGYPVIFDATHSVQLPGGQGESSGGQREFVEFLSRAAVAAGVDGIFMEVHEEP
EKALCDGPNSIALNDLPALLATLKAIDAVVK

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=275, Percent_Identity=47.2727272727273, Blast_Score=266, Evalue=8e-73,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_PELPD (A1APG0)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901288.1
- ProteinModelPortal:   A1APG0
- SMR:   A1APG0
- STRING:   A1APG0
- GeneID:   4571925
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1615
- eggNOG:   COG2877
- HOGENOM:   HBG575990
- OMA:   RSLPIMA
- PhylomeDB:   A1APG0
- ProtClustDB:   PRK05198
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 28998; Mature: 28867

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTREIVIGGVKIGAKRPLALVAGPCVIESELATMRQAERLMTICNALSLPLIFKASYDKA
CCCEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
NRTSIGAYRGPGMREGLRILRKVKESLGLAVLSDVHSIEQVAPAAEVLDVLQIPAFLCRQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
TDLLIAAAATGRVINVKKGQFLAPWDMKNVAAKIASSGNENIILTERGASFGYNNLVVDM
CCEEEEEECCCCEEEECCCCEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEH
RSFPVMRASGYPVIFDATHSVQLPGGQGESSGGQREFVEFLSRAAVAAGVDGIFMEVHEE
HHCCEEECCCCCEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
PEKALCDGPNSIALNDLPALLATLKAIDAVVK
HHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TREIVIGGVKIGAKRPLALVAGPCVIESELATMRQAERLMTICNALSLPLIFKASYDKA
CCEEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
NRTSIGAYRGPGMREGLRILRKVKESLGLAVLSDVHSIEQVAPAAEVLDVLQIPAFLCRQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
TDLLIAAAATGRVINVKKGQFLAPWDMKNVAAKIASSGNENIILTERGASFGYNNLVVDM
CCEEEEEECCCCEEEECCCCEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEH
RSFPVMRASGYPVIFDATHSVQLPGGQGESSGGQREFVEFLSRAAVAAGVDGIFMEVHEE
HHCCEEECCCCCEEEECCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCC
PEKALCDGPNSIALNDLPALLATLKAIDAVVK
HHHHHHCCCCCEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA