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The map label for this gene is kdsB

Identifier: 118580036

GI number: 118580036

Start: 1728674

End: 1729441

Strand: Direct

Name: kdsB

Synonym: Ppro_1613

Alternate gene names: 118580036

Gene position: 1728674-1729441 (Clockwise)

Preceding gene: 118580035

Following gene: 118580037

Centisome position: 43.13

GC content: 59.11

Gene sequence:

>768_bases
ATGAACATCACAGCAGTCATTCCAGCCCGCTTTGCTTCTGTGCGTTTTCCGGGCAAGGCGCTGGCCATCATCGACGGCAA
GCCGATGATCCAACATGTCTACGAGCGCACGGCACGGGCTTCACTGGTGGACTCGGTCATTATCGCTACCGATGACGAGC
GTATCCAGCAGGCGGTTTCGGTCTTCGGCGGTGTCTGTCGCATGACCCGCAATGACCACGAAACAGGAACCGATCGTCTG
GCCGAGGTGGCTGGGACGCTCTCCGCCGACATCATCGTCAATGTCCAGGGGGATGAGCCGCTGATCGCTCCCGAGATGAT
CGACCAGGCTATCCGCCCGCTCCTTGATGACCCGTCCCTGCGCATGGCTACACTCAAGAGCCGCATCCGCTGCCTGCACG
ATTTTTTGAGCCCCAATGTGGTCAAGGTGGTAACCGACCGGGACGGCAATGCGCTGTACTTCTCCCGCTCGCCCCTGCCG
TTCTTCCGGGACAAGTGGCAGGATCTCAAGGACGAGTCATTCGCCAGCGGGAAGCTGCTCTGCTACAAGCATGTGGGGCT
GTACGTCTATCGTCGTGATTTTCTGGTGGAGTTCGCCGCTATGGCGCCCACCTTTCTGGAAACTTCCGAGAAACTGGAGC
AGTTGCGAGCGCTGGAAAACGGCGCCCGTATCCGCGTCGTCGAGACTGAGTTTGAATCCATTGGTGTGGACACCCCCGAT
GACCTGGTCAAGGCCAGGGAGCGGTTCAGAGCCATTCAGTCCAAGTAA

Upstream 100 bases:

>100_bases
CCCCAGACTTTTGCGGTAACTTGACACGTCCTACCACGGACGATCTGCGACGCGCGGTCGCACGCGTAACACACATTCTC
TTTTAATAGGTACAACCCGG

Downstream 100 bases:

>100_bases
TTTTCGCTACAGGAGCTGTATGCATGAAAACAAAATTCATCTTTATTACCGGCGGTGTCGTTTCCTCCATCGGTAAGGGA
CTGGCTGCCGCGTCGCTGGG

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MNITAVIPARFASVRFPGKALAIIDGKPMIQHVYERTARASLVDSVIIATDDERIQQAVSVFGGVCRMTRNDHETGTDRL
AEVAGTLSADIIVNVQGDEPLIAPEMIDQAIRPLLDDPSLRMATLKSRIRCLHDFLSPNVVKVVTDRDGNALYFSRSPLP
FFRDKWQDLKDESFASGKLLCYKHVGLYVYRRDFLVEFAAMAPTFLETSEKLEQLRALENGARIRVVETEFESIGVDTPD
DLVKARERFRAIQSK

Sequences:

>Translated_255_residues
MNITAVIPARFASVRFPGKALAIIDGKPMIQHVYERTARASLVDSVIIATDDERIQQAVSVFGGVCRMTRNDHETGTDRL
AEVAGTLSADIIVNVQGDEPLIAPEMIDQAIRPLLDDPSLRMATLKSRIRCLHDFLSPNVVKVVTDRDGNALYFSRSPLP
FFRDKWQDLKDESFASGKLLCYKHVGLYVYRRDFLVEFAAMAPTFLETSEKLEQLRALENGARIRVVETEFESIGVDTPD
DLVKARERFRAIQSK
>Mature_255_residues
MNITAVIPARFASVRFPGKALAIIDGKPMIQHVYERTARASLVDSVIIATDDERIQQAVSVFGGVCRMTRNDHETGTDRL
AEVAGTLSADIIVNVQGDEPLIAPEMIDQAIRPLLDDPSLRMATLKSRIRCLHDFLSPNVVKVVTDRDGNALYFSRSPLP
FFRDKWQDLKDESFASGKLLCYKHVGLYVYRRDFLVEFAAMAPTFLETSEKLEQLRALENGARIRVVETEFESIGVDTPD
DLVKARERFRAIQSK

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=254, Percent_Identity=45.2755905511811, Blast_Score=185, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_PELPD (A1APF8)

Other databases:

- EMBL:   CP000482
- RefSeq:   YP_901286.1
- ProteinModelPortal:   A1APF8
- SMR:   A1APF8
- STRING:   A1APF8
- GeneID:   4571923
- GenomeReviews:   CP000482_GR
- KEGG:   ppd:Ppro_1613
- eggNOG:   COG1212
- HOGENOM:   HBG637773
- OMA:   IIPARLK
- PhylomeDB:   A1APF8
- ProtClustDB:   PRK05450
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 28657; Mature: 28657

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITAVIPARFASVRFPGKALAIIDGKPMIQHVYERTARASLVDSVIIATDDERIQQAVS
CCEEEEEHHHHHHEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHH
VFGGVCRMTRNDHETGTDRLAEVAGTLSADIIVNVQGDEPLIAPEMIDQAIRPLLDDPSL
HHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCH
RMATLKSRIRCLHDFLSPNVVKVVTDRDGNALYFSRSPLPFFRDKWQDLKDESFASGKLL
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCEE
CYKHVGLYVYRRDFLVEFAAMAPTFLETSEKLEQLRALENGARIRVVETEFESIGVDTPD
EEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCHH
DLVKARERFRAIQSK
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MNITAVIPARFASVRFPGKALAIIDGKPMIQHVYERTARASLVDSVIIATDDERIQQAVS
CCEEEEEHHHHHHEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHH
VFGGVCRMTRNDHETGTDRLAEVAGTLSADIIVNVQGDEPLIAPEMIDQAIRPLLDDPSL
HHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCH
RMATLKSRIRCLHDFLSPNVVKVVTDRDGNALYFSRSPLPFFRDKWQDLKDESFASGKLL
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCEE
CYKHVGLYVYRRDFLVEFAAMAPTFLETSEKLEQLRALENGARIRVVETEFESIGVDTPD
EEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEEHHHHCCCCCHH
DLVKARERFRAIQSK
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA